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公开(公告)号：US08105261B2
公开(公告)日：2012-01-31
申请号：US11772397
申请日：2007-07-02
CPC分类号： A61B17/1219 , A61B17/12031 , A61B17/12036 , A61B17/12099 , A61B17/12136 , A61F2250/0003
摘要： Embodiments of the invention are related to devices and methods for modulating renal function, amongst other things. In an embodiment, the invention includes an implantable occlusive device including a wall member defining an enclosed volume, the wall member can include a semi-permeable membrane. The device can also include a solution comprising a solvent and a solute disposed within the enclosed volume of the wall member. The semi-permeable membrane can be permeable to the solvent and impermeable to the solute. The enclosed volume can be configured to expand and contract in response to changes in the osmolality of a bodily fluid. The device can include a positioning member configured to maintain the position of the implantable occlusive device relative to a lengthwise axis of a lymphatic vessel. In an embodiment, the invention includes a method of modulating renal function in a patient including implanting an occlusive device in the patient, the occlusive device comprising a semi-permeable membrane and configured to expand or contract based on the passage of a fluid across the semi-permeable membrane. Other aspects and embodiments are provided herein.
摘要翻译： 本发明的实施方案涉及用于调节肾功能的装置和方法等。 在一个实施例中，本发明包括可植入闭塞装置，其包括限定封闭容积的壁构件，所述壁构件可包括半透膜。 该装置还可以包括溶液和溶质，该溶质设置在壁构件的封闭体积内。 半透膜对溶剂是可渗透的，并且对溶质是不可渗透的。 封闭体积可以配置为响应于体液渗透压的变化而膨胀和收缩。 该装置可以包括定位构件，其被配置为相对于淋巴管的纵向轴线保持可植入闭塞装置的位置。 在一个实施方案中，本发明包括调节患者的肾功能的方法，包括在患者体内植入闭塞装置，所述闭塞装置包括半渗透膜，并且构造成基于穿过所述半透膜的流体通过而膨胀或收缩 不渗透膜。 本文提供了其它方面和实施例。
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公开(公告)号：US08475400B2
公开(公告)日：2013-07-02
申请号：US13346485
申请日：2012-01-09
CPC分类号： A61B17/1219 , A61B17/12031 , A61B17/12036 , A61B17/12099 , A61B17/12136 , A61F2250/0003
摘要： Embodiments of the invention are related to devices and methods for modulating renal function, amongst other things. In an embodiment, the invention includes a method of modulating renal function in a patient including implanting an occlusive device in the patient, the occlusive device comprising a semi-permeable membrane and configured to expand or contract based on the passage of a fluid across the semi-permeable membrane. Other aspects and embodiments are provided herein.
摘要翻译： 本发明的实施方案涉及用于调节肾功能的装置和方法等。 在一个实施方案中，本发明包括调节患者的肾功能的方法，包括在患者体内植入闭塞装置，所述闭塞装置包括半渗透膜，并且构造成基于穿过所述半透膜的流体通过而膨胀或收缩 不渗透膜。 本文提供了其它方面和实施例。
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公开(公告)号：US07734349B2
公开(公告)日：2010-06-08
申请号：US11779403
申请日：2007-07-18
IPC分类号： A61B5/14
CPC分类号： A61N1/3702 , A61B5/0006 , A61B5/02028 , A61B5/076 , A61B5/14539 , A61B5/14546 , A61B5/4869 , A61B2562/02 , A61N1/05 , A61N1/36521 , A61N1/36557 , G01N13/04
摘要： Embodiments of the invention are related to monitoring devices and methods with osmometric sensors, amongst other things. In an embodiment, the invention includes an implantable heart failure monitoring system including an osmometric sensor, the osmometric sensor configured to generate a signal corresponding to the osmotic strength of a bodily fluid, and a controller in communication with the osmometric sensor, the controller configured to receive and process the signal corresponding to the osmotic strength of a bodily fluid. Other aspects and embodiments are provided herein.
摘要翻译： 本发明的实施例涉及到具有渗压传感器的监测装置和方法以及其它方面。 在一个实施例中，本发明包括可植入心力衰竭监测系统，其包括渗透传感器，所述渗透传感器被配置为产生对应于体液的渗透强度的信号，以及与所述渗透传感器通信的控制器，所述控制器被配置为 接收和处理对应于体液渗透强度的信号。 本文提供了其它方面和实施例。
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公开(公告)号：US08086309B2
公开(公告)日：2011-12-27
申请号：US12767604
申请日：2010-04-26
CPC分类号： A61N1/3702 , A61B5/0006 , A61B5/02028 , A61B5/076 , A61B5/14539 , A61B5/14546 , A61B5/4869 , A61B2562/02 , A61N1/05 , A61N1/36521 , A61N1/36557 , G01N13/04
摘要： Embodiments of the invention are related to monitoring devices and methods with osmometric sensors, amongst other things. In an embodiment, an implantable heart failure monitoring system includes an implantable osmometric sensor configured to generate a signal corresponding to osmotic strength of a bodily fluid. The osmometric sensor includes a rigid wall member defining an enclosed volume resisting deformation, the rigid wall member comprising a semi-permeable membrane. The sensor also includes a signaling element comprising a first side, a second side, and a plurality of dimples configured to resist deformation until a threshold differential exists between the first and second sides. Other aspects and embodiments are provided herein.
摘要翻译： 本发明的实施例涉及到具有渗压传感器的监测装置和方法以及其它方面。 在一个实施例中，可植入心力衰竭监测系统包括被配置为产生对应于体液渗透强度的信号的可植入渗透传感器。 渗透传感器包括限定封闭体积的抗变形的刚性壁构件，刚性壁构件包括半透膜。 该传感器还包括信令元件，其包括第一侧面，第二侧面和多个凹坑，其被配置为抵抗变形，直到在第一和第二面之间存在阈值差异。 本文提供了其它方面和实施例。
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公开(公告)号：US20090012444A1
公开(公告)日：2009-01-08
申请号：US11772397
申请日：2007-07-02
IPC分类号： A61M1/34
CPC分类号： A61B17/1219 , A61B17/12031 , A61B17/12036 , A61B17/12099 , A61B17/12136 , A61F2250/0003
摘要： Embodiments of the invention are related to devices and methods for modulating renal function, amongst other things. In an embodiment, the invention includes an implantable occlusive device including a wall member defining an enclosed volume, the wall member can include a semi-permeable membrane. The device can also include a solution comprising a solvent and a solute disposed within the enclosed volume of the wall member. The semi-permeable membrane can be permeable to the solvent and impermeable to the solute. The enclosed volume can be configured to expand and contract in response to changes in the osmolality of a bodily fluid. The device can include a positioning member configured to maintain the position of the implantable occlusive device relative to a lengthwise axis of a lymphatic vessel. In an embodiment, the invention includes a method of modulating renal function in a patient including implanting an occlusive device in the patient, the occlusive device comprising a semi-permeable membrane and configured to expand or contract based on the passage of a fluid across the semi-permeable membrane. Other aspects and embodiments are provided herein.
摘要翻译： 本发明的实施方案涉及用于调节肾功能的装置和方法等。 在一个实施例中，本发明包括可植入闭塞装置，其包括限定封闭容积的壁构件，所述壁构件可包括半透膜。 该装置还可以包括溶液和溶质，该溶质设置在壁构件的封闭体积内。 半透膜对溶剂是可渗透的，并且对溶质是不可渗透的。 封闭体积可以配置为响应于体液渗透压的变化而膨胀和收缩。 该装置可以包括定位构件，其被配置为相对于淋巴管的纵向轴线保持可植入闭塞装置的位置。 在一个实施方案中，本发明包括调节患者的肾功能的方法，包括在患者体内植入闭塞装置，所述闭塞装置包括半渗透膜，并且构造成基于穿过所述半透膜的流体通过而膨胀或收缩 不渗透膜。 本文提供了其它方面和实施例。
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公开(公告)号：US20120109038A1
公开(公告)日：2012-05-03
申请号：US13346485
申请日：2012-01-09
IPC分类号： A61M1/34
CPC分类号： A61B17/1219 , A61B17/12031 , A61B17/12036 , A61B17/12099 , A61B17/12136 , A61F2250/0003
摘要： Embodiments of the invention are related to devices and methods for modulating renal function, amongst other things. In an embodiment, the invention includes a method of modulating renal function in a patient including implanting an occlusive device in the patient, the occlusive device comprising a semi-permeable membrane and configured to expand or contract based on the passage of a fluid across the semi-permeable membrane. Other aspects and embodiments are provided herein.
摘要翻译： 本发明的实施方案涉及用于调节肾功能的装置和方法等。 在一个实施方案中，本发明包括调节患者的肾功能的方法，包括在患者体内植入闭塞装置，所述闭塞装置包括半渗透膜，并且构造成基于穿过所述半透膜的流体通过而膨胀或收缩 不渗透膜。 本文提供了其它方面和实施例。
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公开(公告)号：US20100204744A1
公开(公告)日：2010-08-12
申请号：US12767604
申请日：2010-04-26
CPC分类号： A61N1/3702 , A61B5/0006 , A61B5/02028 , A61B5/076 , A61B5/14539 , A61B5/14546 , A61B5/4869 , A61B2562/02 , A61N1/05 , A61N1/36521 , A61N1/36557 , G01N13/04
摘要： Embodiments of the invention are related to monitoring devices and methods with osmometric sensors, amongst other things. In an embodiment, the invention includes an implantable heart failure monitoring system including an implantable osmometric sensor configured to generate a signal corresponding to osmotic strength of a bodily fluid, the osmometric sensor comprising a rigid wall member defining an enclosed volume resisting deformation, the rigid wall member comprising a semi-permeable membrane; a signaling element comprising a first pressure sensor; and a second pressure sensor. Other aspects and embodiments are provided herein.
摘要翻译： 本发明的实施例涉及到具有渗压传感器的监测装置和方法以及其它方面。 在一个实施例中，本发明包括可植入心力衰竭监测系统，其包括被配置为产生对应于体液渗透强度的信号的可植入渗透压传感器，所述渗透传感器包括限定封闭体积抵抗变形的刚性壁构件，所述刚性壁 包括半透膜的构件; 信号元件，包括第一压力传感器; 和第二压力传感器。 本文提供了其它方面和实施例。
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公开(公告)号：US20090024177A1
公开(公告)日：2009-01-22
申请号：US11779403
申请日：2007-07-18
IPC分类号： A61N1/36
CPC分类号： A61N1/3702 , A61B5/0006 , A61B5/02028 , A61B5/076 , A61B5/14539 , A61B5/14546 , A61B5/4869 , A61B2562/02 , A61N1/05 , A61N1/36521 , A61N1/36557 , G01N13/04
摘要： Embodiments of the invention are related to monitoring devices and methods with osmometric sensors, amongst other things. In an embodiment, the invention includes an implantable heart failure monitoring system including an osmometric sensor, the osmometric sensor configured to generate a signal corresponding to the osmotic strength of a bodily fluid, and a controller in communication with the osmometric sensor, the controller configured to receive and process the signal corresponding to the osmotic strength of a bodily fluid. Other aspects and embodiments are provided herein.
摘要翻译： 本发明的实施例涉及到具有渗压传感器的监测装置和方法以及其它方面。 在一个实施例中，本发明包括可植入心力衰竭监测系统，其包括渗透传感器，所述渗透传感器被配置为产生对应于体液的渗透强度的信号，以及与所述渗透传感器通信的控制器，所述控制器被配置为 接收和处理对应于体液渗透强度的信号。 本文提供了其它方面和实施例。
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公开(公告)号：US20100056858A1
公开(公告)日：2010-03-04
申请号：US12547316
申请日：2009-08-25
申请人： Eric A. Mokelke , Allan C. Shuros
发明人： Eric A. Mokelke , Allan C. Shuros
CPC分类号： A61B17/0218 , A61B17/3207 , A61B2017/0243 , A61B2017/22001 , A61B2017/308 , A61B2090/3784 , A61N1/056 , A61N1/08 , A61N1/3625 , G16H40/63
摘要： Cardioprotective pacing is applied to prevent and/or reduce cardiac injury associated with cardiac catheterization or surgery. Pacing pulses are generated from a pacemaker and delivered through one or more pacing electrodes incorporated onto one or more devices used in the cardiac catheterization or surgery. The pacemaker controls the delivery of the pacing pulses by executing a cardioprotective pacing protocol. In one embodiment, the one or more pacing electrodes are incorporated onto an intravascular ultrasound (IVUS) catheter. In another embodiment, the one or more pacing electrodes are incorporated onto one or more cardiac surgical instruments such as a heart stabilizer and a sternal retractor.
摘要翻译： 应用心脏保护起搏来预防和/或减少与心脏导管插入术或手术相关的心脏损伤。 起搏脉冲从起搏器产生并通过一个或多个起搏电极输送，该起搏电极并入到用于心脏导管插入术或手术中的一个或多个装置上。 起搏器通过执行心脏保护起搏协议来控制起搏脉冲的输送。 在一个实施例中，将一个或多个起搏电极并入到血管内超声（IVUS）导管中。 在另一个实施例中，将一个或多个起搏电极并入一个或多个心脏外科器械，例如心脏稳定器和胸骨牵开器。
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公开(公告)号：US20090299420A1
公开(公告)日：2009-12-03
申请号：US12474448
申请日：2009-05-29
CPC分类号： A61N1/06 , A61B18/02 , A61B2017/22002 , A61B2018/0022 , A61B2018/0212 , A61B2018/0243 , A61F2/958 , A61N1/362
摘要： A method and apparatus are described for delivering myocardial pacing and cryotherapy in conjunction with a coronary revascularization procedure using one catheter/stent system. In one embodiment, a balloon-stent delivery platform incorporates pacing electrode(s) on or near the distal tip for myocardial pacing.
摘要翻译： 描述了一种用于使用一个导管/支架系统与冠状动脉血运重建术一起递送心肌起搏和冷冻治疗的方法和装置。 在一个实施例中，球囊支架递送平台包括用于心肌起搏的远侧末端上或附近的起搏电极。
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