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    Tissue interrogation spectroscopy
    1.
    发明授权
    Tissue interrogation spectroscopy 有权
    组织询问光谱学

    公开(公告)号：US07113814B2

    公开(公告)日：2006-09-26

    申请号：US10332613

    申请日：2001-07-13

    申请人： Kevin R. Ward ,  R. Wayne Barbee ,  James Terner ,  Rao R. Ivatury ,  Fred Hawkridge

    发明人： Kevin R. Ward ,  R. Wayne Barbee ,  James Terner ,  Rao R. Ivatury ,  Fred Hawkridge

    IPC分类号： A61B5/00

    CPC分类号： G01N21/65 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14551 ,  A61B5/412 ,  A61B5/445

    摘要： In an emergency medicine patient, accurate measurement of change or lack thereof from non-shock, non-ischemic, non-inflammation, non-tissue injury, non-immune dysfunction conditions is important and is provided, as practical, real-time approaches for accurately characterizing a patient's condition, using Raman (3) and/or fluorescence (30) spectroscopy with a high degree of accuracy. Measurement times are on the order of seconds. High-accuracy measurement is achieved with Raman spectroscopy interrogation of tissue. Simultaneous interrogation by NADH fluorescence spectroscopy may he used. Measurements may be non-invasive to minimally invasive. Preclinical (ultra-early) states of shock can be detected (5), severity can be determined, effectiveness of various treatments can be determined.

    摘要翻译： 在紧急医学病人中，从非休克，非缺血，非炎症，非组织损伤，非免疫功能障碍状况的准确测量变化或缺乏是非常重要的，并提供了实际的实时方法 使用拉曼（3）和/或荧光（30）光谱学准确地表征患者的状况。 测量次数为秒数。 通过拉曼光谱询问组织实现高精度测量。 他可以使用NADH荧光光谱法进行同时询问。 测量可能是非侵入性的微创。 可以检测到临床前（超早期）休克状态（5），可以确定严重程度，可以确定各种治疗的有效性。

    Methods for monitoring and optimizing central venous pressure and intravascular volume
    3.
    发明授权
    Methods for monitoring and optimizing central venous pressure and intravascular volume 有权
    监测和优化中心静脉压和血管内容积的方法

    公开(公告)号：US07118534B2

    公开(公告)日：2006-10-10

    申请号：US10380347

    申请日：2001-09-21

    申请人： Kevin R. Ward ,  Robert W. Barbee ,  Rao R. Ivatury ,  Bruce D. Spiess ,  James A. Arrowood

    发明人： Kevin R. Ward ,  Robert W. Barbee ,  Rao R. Ivatury ,  Bruce D. Spiess ,  James A. Arrowood

    IPC分类号： A61B5/02

    CPC分类号： A61B5/412 ,  A61B5/022 ,  A61B5/029 ,  A61B5/0295 ,  A61B5/053

    摘要： Central Venous Pressure (CVP) is non-invasively determined with accuracy comparable to invasive measurement techniques. To do so, curves are plotted based on non-invasively determined patient information obtained by applying a controllable variable (pressure) to a vein of interest at a non-distal point and taking certain measurements (such as pressure and volume measurements) from the patient. An example of a controllable variable is voltage applied in incremental inflation/deflation of a vascular cuff (1). A curve is plotted based on datapoints (such as a volume increase curve or a volume decline curve). Pertinent, accurate CVP and/or blood volume information is obtained from the slope of the non-invasive-based curve. Accurate CVP information is provided without the risks and disadvantages of invasive measurements.

    摘要翻译： 中心静脉压（CVP）是非侵入式确定的，与入侵测量技术相当。 为此，基于非侵入式确定的患者信息绘制曲线，所述患者信息是通过在非远端点对感兴趣的静脉施加可控变量（压力）并从患者进行某些测量（例如压力和体积测量） 。 可控变量的一个例子是在血管袖带的增量充气/放气中施加的电压（1）。 基于数据点（如体积增加曲线或体积下降曲线）绘制曲线。 从非侵入性曲线的斜率获得相关的准确CVP和/或血容量信息。 提供准确的CVP信息，无侵入性测量的风险和缺点。

    Automated measurement of brain injury indices using brain CT images, injury data, and machine learning
    6.
    发明授权
    Automated measurement of brain injury indices using brain CT images, injury data, and machine learning 有权

    公开(公告)号：US10303986B2

    公开(公告)日：2019-05-28

    申请号：US13383351

    申请日：2010-03-17

    申请人： Kayvan Najarian ,  Wenan Chen ,  Kevin R. Ward

    发明人： Kayvan Najarian ,  Wenan Chen ,  Kevin R. Ward

    IPC分类号： A61B5/00 ,  G06K9/62 ,  G06T7/00 ,  G06T7/42 ,  G06T7/68 ,  G06F19/00 ,  G16H50/20

    摘要： A decision-support system and computer implemented method automatically measures the midline shift in a patient's brain using Computed Tomography (CT) images. The decision-support system and computer implemented method applies machine learning methods to features extracted from multiple sources, including midline shift, blood amount, texture pattern and other injury data, to provide a physician an estimate of intracranial pressure (ICP) levels. A hierarchical segmentation method, based on Gaussian Mixture Model (GMM), is used. In this approach, first an Magnetic Resonance Image (MRI) ventricle template, as prior knowledge, is used to estimate the region for each ventricle. Then, by matching the ventricle shape in CT images to the MRI ventricle template set, the corresponding MRI slice is selected. From the shape matching result, the feature points for midline estimation in CT slices, such as the center edge points of the lateral ventricles, are detected. The amount of shift, along with other information such as brain tissue texture features, volume of blood accumulated in the brain, patient demographics, injury information, and features extracted from physiological signals, are used to train a machine learning method to predict a variety of important clinical factors, such as intracranial pressure (ICP), likelihood of success a particular treatment, and the need and/or dosage of particular drugs.

    Device for control of difficult to compress hemorrhage
    7.
    发明授权
    Device for control of difficult to compress hemorrhage 有权
    用于控制难以压缩出血的装置

    公开(公告)号：US09271738B2

    公开(公告)日：2016-03-01

    申请号：US12601706

    申请日：2008-05-30

    申请人： Kevin R. Ward ,  Mark Licata

    发明人： Kevin R. Ward ,  Mark Licata

    IPC分类号： A61B17/00 ,  A61B17/132 ,  A61B17/135 ,  A61B17/12

    CPC分类号： A61B17/135 ,  A61B17/12 ,  A61B17/1322 ,  A61B17/1325 ,  A61B2017/12004

    摘要： Bleeding from blood vessels located in difficult-to-compress regions of the body (especially the abdomen, pelvic or groin region) is controlled by the use of a portable, small-footprint belt-like device that contains multiple inflatable bladders. The inflatable bladders are selectively positioned and inflated over exsanguinating blood vessels, thereby exerting pressure to stop the bleeding. The device may also be used to provide perfusion support in low flow disease states such as hemorrhagic shock and cardiac arrest.

    摘要翻译： 通过使用便携式，占地面积小的带状装置来控制位于身体难以压缩区域（特别是腹部，骨盆或腹股沟区域）的血管的出血，该装置包含多个充气囊。 可膨胀气囊在放血血管上被选择性定位和充气，从而施加压力以止血。 该装置还可用于在低流量疾病状态（例如出血性休克和心脏骤停）中提供灌注支持。

    Non-invasive aortic impingement and core and cerebral temperature manipulation
    9.
    发明授权
    Non-invasive aortic impingement and core and cerebral temperature manipulation 失效
    非侵入性主动脉冲击和核心和脑温度操纵

    公开(公告)号：US5716386A

    公开(公告)日：1998-02-10

    申请号：US598734

    申请日：1996-02-08

    申请人： Kevin R. Ward ,  Charles G. Brown ,  Roger R. Dzwonczyk

    发明人： Kevin R. Ward ,  Charles G. Brown ,  Roger R. Dzwonczyk

    IPC分类号： A61B17/12 ,  A61F7/12

    CPC分类号： A61B17/12099 ,  A61B17/12022 ,  A61B17/12036 ,  A61B17/12109 ,  A61B17/12136 ,  A61F7/123

    摘要： A non-invasive method and apparatus for at least partially occluding the descending aorta of a patient and for manipulating core and cerebral temperature includes positioning an elongated tubular member which may have a moveable surface through the esophagus and displacing the moveable surface thereby applying a force posteriorly in the direction of the patient's descending aorta sufficient to partially or substantially completely occlude the descending aorta. The tubular member may include a heat exchange surface and a heat transfer mechanism for transferring heat to the heat transfer surface or for transferring heat from the heat transfer surface in order to modify the temperature of a portion of the patient.

    摘要翻译： 用于至少部分闭塞患者的下降主动脉并用于操纵核心和脑温度的非侵入性方法和装置包括定位细长管状构件，该细长管状构件可具有穿过食道的可移动表面并移动可移动表面，从而施加向后的力 在患者降主动脉的方向上足以部分或基本上完全闭塞降主动脉。 管状构件可以包括热交换表面和用于将热传递到传热表面或用于从热传递表面传递热量以便改变患者部分的温度的热传递机构。