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    Automated measurement of brain injury indices using brain CT images, injury data, and machine learning
    1.
    发明授权
    Automated measurement of brain injury indices using brain CT images, injury data, and machine learning 有权

    公开(公告)号：US10303986B2

    公开(公告)日：2019-05-28

    申请号：US13383351

    申请日：2010-03-17

    Applicant: Kayvan Najarian ,  Wenan Chen ,  Kevin R. Ward

    Inventor： Kayvan Najarian ,  Wenan Chen ,  Kevin R. Ward

    IPC: A61B5/00 ,  G06K9/62 ,  G06T7/00 ,  G06T7/42 ,  G06T7/68 ,  G06F19/00 ,  G16H50/20

    Abstract: A decision-support system and computer implemented method automatically measures the midline shift in a patient's brain using Computed Tomography (CT) images. The decision-support system and computer implemented method applies machine learning methods to features extracted from multiple sources, including midline shift, blood amount, texture pattern and other injury data, to provide a physician an estimate of intracranial pressure (ICP) levels. A hierarchical segmentation method, based on Gaussian Mixture Model (GMM), is used. In this approach, first an Magnetic Resonance Image (MRI) ventricle template, as prior knowledge, is used to estimate the region for each ventricle. Then, by matching the ventricle shape in CT images to the MRI ventricle template set, the corresponding MRI slice is selected. From the shape matching result, the feature points for midline estimation in CT slices, such as the center edge points of the lateral ventricles, are detected. The amount of shift, along with other information such as brain tissue texture features, volume of blood accumulated in the brain, patient demographics, injury information, and features extracted from physiological signals, are used to train a machine learning method to predict a variety of important clinical factors, such as intracranial pressure (ICP), likelihood of success a particular treatment, and the need and/or dosage of particular drugs.

    Device for control of difficult to compress hemorrhage
    4.
    发明授权
    Device for control of difficult to compress hemorrhage 有权
    用于控制难以压缩出血的装置

    公开(公告)号：US09271738B2

    公开(公告)日：2016-03-01

    申请号：US12601706

    申请日：2008-05-30

    Applicant: Kevin R. Ward ,  Mark Licata

    Inventor： Kevin R. Ward ,  Mark Licata

    IPC: A61B17/00 ,  A61B17/132 ,  A61B17/135 ,  A61B17/12

    CPC classification number: A61B17/135 ,  A61B17/12 ,  A61B17/1322 ,  A61B17/1325 ,  A61B2017/12004

    Abstract: Bleeding from blood vessels located in difficult-to-compress regions of the body (especially the abdomen, pelvic or groin region) is controlled by the use of a portable, small-footprint belt-like device that contains multiple inflatable bladders. The inflatable bladders are selectively positioned and inflated over exsanguinating blood vessels, thereby exerting pressure to stop the bleeding. The device may also be used to provide perfusion support in low flow disease states such as hemorrhagic shock and cardiac arrest.

    Abstract translation: 通过使用便携式，占地面积小的带状装置来控制位于身体难以压缩区域（特别是腹部，骨盆或腹股沟区域）的血管的出血，该装置包含多个充气囊。 可膨胀气囊在放血血管上被选择性定位和充气，从而施加压力以止血。 该装置还可用于在低流量疾病状态（例如出血性休克和心脏骤停）中提供灌注支持。

    Tissue interrogation spectroscopy
    6.
    发明授权
    Tissue interrogation spectroscopy 有权
    组织询问光谱学

    公开(公告)号：US07113814B2

    公开(公告)日：2006-09-26

    申请号：US10332613

    申请日：2001-07-13

    Applicant: Kevin R. Ward ,  R. Wayne Barbee ,  James Terner ,  Rao R. Ivatury ,  Fred Hawkridge

    Inventor： Kevin R. Ward ,  R. Wayne Barbee ,  James Terner ,  Rao R. Ivatury ,  Fred Hawkridge

    IPC: A61B5/00

    CPC classification number: G01N21/65 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14551 ,  A61B5/412 ,  A61B5/445

    Abstract: In an emergency medicine patient, accurate measurement of change or lack thereof from non-shock, non-ischemic, non-inflammation, non-tissue injury, non-immune dysfunction conditions is important and is provided, as practical, real-time approaches for accurately characterizing a patient's condition, using Raman (3) and/or fluorescence (30) spectroscopy with a high degree of accuracy. Measurement times are on the order of seconds. High-accuracy measurement is achieved with Raman spectroscopy interrogation of tissue. Simultaneous interrogation by NADH fluorescence spectroscopy may he used. Measurements may be non-invasive to minimally invasive. Preclinical (ultra-early) states of shock can be detected (5), severity can be determined, effectiveness of various treatments can be determined.

    Abstract translation: 在紧急医学病人中，从非休克，非缺血，非炎症，非组织损伤，非免疫功能障碍状况的准确测量变化或缺乏是非常重要的，并提供了实际的实时方法 使用拉曼（3）和/或荧光（30）光谱学准确地表征患者的状况。 测量次数为秒数。 通过拉曼光谱询问组织实现高精度测量。 他可以使用NADH荧光光谱法进行同时询问。 测量可能是非侵入性的微创。 可以检测到临床前（超早期）休克状态（5），可以确定严重程度，可以确定各种治疗的有效性。

    Non-invasive aortic impingement and core and cerebral temperature manipulation
    7.
    发明授权
    Non-invasive aortic impingement and core and cerebral temperature manipulation 失效
    非侵入性主动脉冲击和核心和脑温度操纵

    公开(公告)号：US5716386A

    公开(公告)日：1998-02-10

    申请号：US598734

    申请日：1996-02-08

    Applicant: Kevin R. Ward ,  Charles G. Brown ,  Roger R. Dzwonczyk

    Inventor： Kevin R. Ward ,  Charles G. Brown ,  Roger R. Dzwonczyk

    IPC: A61B17/12 ,  A61F7/12

    CPC classification number: A61B17/12099 ,  A61B17/12022 ,  A61B17/12036 ,  A61B17/12109 ,  A61B17/12136 ,  A61F7/123

    Abstract: A non-invasive method and apparatus for at least partially occluding the descending aorta of a patient and for manipulating core and cerebral temperature includes positioning an elongated tubular member which may have a moveable surface through the esophagus and displacing the moveable surface thereby applying a force posteriorly in the direction of the patient's descending aorta sufficient to partially or substantially completely occlude the descending aorta. The tubular member may include a heat exchange surface and a heat transfer mechanism for transferring heat to the heat transfer surface or for transferring heat from the heat transfer surface in order to modify the temperature of a portion of the patient.

    Abstract translation: 用于至少部分闭塞患者的下降主动脉并用于操纵核心和脑温度的非侵入性方法和装置包括定位细长管状构件，该细长管状构件可具有穿过食道的可移动表面并移动可移动表面，从而施加向后的力 在患者降主动脉的方向上足以部分或基本上完全闭塞降主动脉。 管状构件可以包括热交换表面和用于将热传递到传热表面或用于从热传递表面传递热量以便改变患者部分的温度的热传递机构。

    USE OF HEMOGLOBIN EFFECTORS TO INCREASE THE BIOAVAILABILITY OF THERAPEUTIC GASES
    10.
    发明申请
    USE OF HEMOGLOBIN EFFECTORS TO INCREASE THE BIOAVAILABILITY OF THERAPEUTIC GASES 审中-公开
    HEMOGLOBIN效应使用可以提高治疗气体的生物利用度

    公开(公告)号：US20130266668A1

    公开(公告)日：2013-10-10

    申请号：US13990252

    申请日：2011-12-01

    Applicant: Martin Safo ,  Kevin R. Ward

    Inventor： Martin Safo ,  Kevin R. Ward

    IPC: A61K31/196 ,  A61K31/6615

    CPC classification number: A61K31/196 ,  A61K9/0019 ,  A61K31/02 ,  A61K31/192 ,  A61K31/6615 ,  A61K31/665 ,  A61K33/00 ,  A61K33/16 ,  A61K38/42 ,  Y02A50/411 ,  A61K2300/00

    Abstract: Methods which increase the bioavailability of beneficial gases in the circulatory system are provided. The methods involve administering agents that changes the binding affinity of a medicinal gas such as NO, CO, H2S, N2O, SO, SO2 and O2 for Hb and/or hemoglobin based oxygen carriers (HBOCs). The change results in increased release of gases carried by Hb and HBOCs. As a result, the concentration of the OH gases in circulation is raised, and they are more available to exert their beneficial effects, e.g. in the treatment of disease or conditions caused by low levels of the gases. The methods are optionally used together with administration of medicinal gases and/or administration of HBOCs and/or other non-HBOC gas carriers such as PFC, and as (or in conjunction with) diagnostic methods.

    Abstract translation: 提供了增加循环系统中有益气体的生物利用度的方法。 所述方法涉及改变Hb和/或血红蛋白基氧载体（HBOC）等药物气体如NO，CO，H2S，N2O，SO，SO2和O2的结合亲和力的药剂。 这种变化导致Hb和HBOCs携带的气体释放量增加。 结果，循环中的OH气体的浓度升高，并且它们更有效地发挥其有益效果，例如， 在治疗由低水平的气体引起的疾病或病症。 任选地与药物气体的施用和/或施用HBOC和/或其它非HBOC气体载体（例如PFC）一起使用，以及作为（或与其结合）诊断方法一起使用该方法。

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