公开(公告)号：US06548081B2

公开(公告)日：2003-04-15

申请号：US09863029

申请日：2001-05-22

申请人： Khalid K. Sadozai ,  Jing-wen Kuo ,  Charles H. Sherwood

发明人： Khalid K. Sadozai ,  Jing-wen Kuo ,  Charles H. Sherwood

IPC分类号： A61F202

CPC分类号： C08B37/0072 ,  A61K47/61 ,  A61L31/10 ,  A61L31/129 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00 ,  C08L5/08

摘要： The present invention relates to a composite and a method for reducing post-operative adhesion of tissues. The composite includes a biocompatible, biodegradable support, and a water-insoluble hyaluronic acid derivative at the support. The hyaluronic acid derivative includes an N-acylurea that results from cross-linking by the reaction of hyaluronic acid with a multifunctional carbodiimide. Optionally, a monocarbodiimide also may be employed. A pharmaceutically-active molecule may be added to the N-acylurea derivative of hyaluronic acid. Although the composite includes material that prevents adhesion between tissues, in order to reduce the need for suturing when the composite is being used during a surgical procedure, a material that enhances adhesion of the composite to tissues may be applied to a surface of the composite. A method of forming the composite for reducing post-operative adhesion of tissues, including the step of applying an N-acylurea derivative of hyaluronic acid resulting from cross-linking with a multifunctional carbodiimide, to a biocompatible, biodegradable support; a method of preparing a drug delivery vehicle that includes a pharmaceutically-active molecule with the N-acylurea derivative of hyaluronic acid resulting from cross-linking with a multifunctional carbodiimide; and a method of reducing post-operative adhesion of tissues are disclosed.

公开(公告)号：US5621093A

公开(公告)日：1997-04-15

申请号：US468262

申请日：1995-06-06

申请人： David A. Swann ,  Jing-wen Kuo ,  Vladimir Pinsky

发明人： David A. Swann ,  Jing-wen Kuo ,  Vladimir Pinsky

IPC分类号： C08B37/08 ,  C07H5/06 ,  C07H1/06 ,  C07H13/02

CPC分类号： C08B37/0072

摘要： A method for sterilizing solid hyaluronic acid includes autoclaving solid hyaluronic acid, whereby the solid hyaluronic acid is exposed to saturated steam at positive gauge pressure for a period of time that is sufficient to sterilize the solid hyaluronic acid. In one embodiment, autoclaving includes exposing the solid hyaluronic acid to saturated steam at a gauge pressure of about one atmosphere for a period of time between about fifteen and thirty minutes.

摘要翻译： 用于灭菌固体透明质酸的方法包括高压灭菌固体透明质酸，由此固体透明质酸暴露于正表压下的饱和蒸汽一段足以对固体透明质酸进行灭菌的时间。 在一个实施方案中，高压灭菌包括将固体透明质酸暴露于大约一个大气压的表压下的饱和蒸汽约15至30分钟之间的时间。

公开(公告)号：US5149331A

公开(公告)日：1992-09-22

申请号：US695704

申请日：1991-05-03

申请人： Ariel Ferdman ,  Jing-wen Kuo ,  David Miller ,  Vladimir Pinsky ,  William D. Richards ,  David Swann

发明人： Ariel Ferdman ,  Jing-wen Kuo ,  David Miller ,  Vladimir Pinsky ,  William D. Richards ,  David Swann

IPC分类号： A61F13/00 ,  A61F13/02 ,  A61M27/00

CPC分类号： A61M1/0088 ,  A61F13/00051 ,  A61F13/00063 ,  A61F13/00068 ,  A61F13/0233 ,  A61F2013/00174 ,  A61F2013/00195 ,  A61F2013/0028 ,  A61F2013/00451 ,  A61F2013/00778 ,  A61M27/00 ,  Y10S604/902

摘要： A method of treating a wound site wherein a porous, adhesive backed dressing is utilized. A vacuum and/or heat is applied to the wound site through the dressing so as to draw the tissue adjacent the wound site to the dressing so as to minimize trauma to the wound and increase the adherence of the adhesive.

摘要翻译： 一种治疗创伤部位的方法，其中使用多孔的，粘合剂的敷料。 通过敷料将真空和/或热量施加到伤口部位，以将邻近伤口部位的组织拉到敷料上，以便最小化对伤口的伤害并增加粘合剂的粘附。