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    Methods and compositions for fostering and preserving bone growth
    1.
    发明授权
    Methods and compositions for fostering and preserving bone growth 有权
    促进和保留骨骼生长的方法和组合物

    公开(公告)号：US08852240B2

    公开(公告)日：2014-10-07

    申请号：US11796439

    申请日：2007-04-27

    申请人： Agnès Vignery ,  Nozer M. Mehta ,  James P. Gilligan ,  Kieran P. Murphy

    发明人： Agnès Vignery ,  Nozer M. Mehta ,  James P. Gilligan ,  Kieran P. Murphy

    IPC分类号： A61B17/88 ,  A61F2/46 ,  A61L27/54 ,  A61L27/12 ,  A61B17/58 ,  A61B17/56

    CPC分类号： A61B17/58 ,  A61B2017/564 ,  A61L27/12 ,  A61L27/54 ,  A61L2300/112 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2300/43

    摘要： A method for augmenting bone in a subject in need thereof including installing within an interior portion of a bone located in the subject a sufficient amount of a biocompatible material to form a scaffold within the bone interior, wherein the scaffold serves as a support for the formation of new bone within the bone interior portion, and administering to the subject a sufficient amount of at least one bone augmentation agent to elevate blood concentration of at least one anabolic agent in the subject. The method may further include administering at least one anti-resorptive agent to the subject in an amount sufficient to substantially prevent resorption of new bone growth. In another embodiment, the method may further include a step of mechanically inducing an increase in osteoblast activity in the subject, wherein the elevation in blood concentration of the anabolic agent and the increase in osteoblast activity at least partially overlap in time.

    摘要翻译： 一种用于在有需要的受试者中增加骨的方法，包括在位于受试者内的骨的内部部分内安装足够量的生物相容性材料以在骨内部形成支架，其中所述支架用作所述形成的支撑体 的骨内部部分中的新骨，并且向受试者施用足够量的至少一种骨增强剂以提高受试者中至少一种合成代谢物的血液浓度。 该方法还可以包括以足以基本上防止新骨生长再吸收的量向受试者施用至少一种抗吸收剂。 在另一个实施方案中，该方法还可以包括机械诱导受试者中成骨细胞活性增加的步骤，其中合成代谢剂的血液浓度升高和成骨细胞活性的增加在时间上至少部分重叠。

    APPARATUS FOR ADMINSTERING A THERAPEUTIC AGENT INTO TISSUE
    3.
    发明申请
    APPARATUS FOR ADMINSTERING A THERAPEUTIC AGENT INTO TISSUE 有权
    将治疗药物用于组织的装置

    公开(公告)号：US20090209901A1

    公开(公告)日：2009-08-20

    申请号：US12430740

    申请日：2009-04-27

    申请人： Mario Muto ,  Kieran P. Murphy

    发明人： Mario Muto ,  Kieran P. Murphy

    IPC分类号： A61M37/00

    CPC分类号： A61M5/28 ,  A61B17/3478 ,  A61K33/00 ,  A61K33/40 ,  A61K45/06 ,  A61M5/31511 ,  A61M25/065 ,  A61M2005/3114 ,  A61M2005/3128 ,  A61M2202/0208 ,  A61M2202/0216 ,  A61M2210/1003 ,  A61K2300/00

    摘要： An apparatus for administering a therapeutic agent is provided. The apparatus, in an embodiment, includes an ozone generator connected to a scavenger and an ozone administrator via network of tubing and valves. When activated and the valves placed in the proper position, the ozone generator will fill the ozone administrator with ozone. The ozone generator can then be turned off and the valves moved so that the administrator can be disconnected from the remainder of the apparatus. The administrator is typically in the form of a syringe and needle. Once the syringe and needle is filled with ozone, the needle can be inserted into a tissue and the ozone expressed therefrom into the tissue. Various other apparatuses and methods are also contemplated.

    摘要翻译： 提供了一种用于施用治疗剂的装置。 在一个实施例中，该装置包括通过管道和阀网络连接到清除器和臭氧管理器的臭氧发生器。 当被激活并且阀门处于适当位置时，臭氧发生器将向臭氧管理员填充臭氧。 然后可以关闭臭氧发生器并且阀移动，使得管理员可以与设备的其余部分断开连接。 管理员通常是注射器和针头的形式。 一旦注射器和针头充满臭氧，针就可以插入到组织中，并将臭氧从其中进入组织。 还考虑了各种其它装置和方法。

    Apparatus for use in a surgical procedure
    4.
    发明授权
    Apparatus for use in a surgical procedure 有权
    用于外科手术的装置

    公开(公告)号：US09427254B2

    公开(公告)日：2016-08-30

    申请号：US13858609

    申请日：2013-04-08

    申请人： Kieran P. Murphy

    发明人： Kieran P. Murphy

    IPC分类号： A61B5/00 ,  A61B17/34 ,  A61L31/18 ,  A61B6/00 ,  A61B6/03 ,  A61B10/02

    CPC分类号： A61B17/3403 ,  A61B6/03 ,  A61B6/4423 ,  A61B10/0233 ,  A61B46/10 ,  A61B90/39 ,  A61B2090/374 ,  A61B2090/376 ,  A61B2090/3954 ,  A61L31/18 ,  Y10T428/24273

    摘要： An embodiment of the present invention provides a kit of parts for use in a surgical procedure performed under image guidance, and particularly under real time image guidance. The kit includes a sterilized drape for use with the chosen imaging machine and which can be used to provide a sterile operating environment when the procedure is performed under the imaging beam. The kit also includes a needle holder that can keep the surgeon's hand away from the imaging beam. The needle holder is operable to hold a needle that is made from a material suitable for piercing tissue, but also substantially preserves the appearance of the needle when it is viewed under the imaging beam.

    摘要翻译： 本发明的实施例提供了一种用于在图像引导下执行的外科手术中的部件套件，特别是在实时图像引导下。 该套件包括用于所选成像机的无菌悬垂布，并且当在成像光束下进行该过程时可用于提供无菌操作环境。 该套件还包括可以使外科医生的手远离成像光束的针头保持器。 针保持器可操作以保持由适于刺穿组织的材料制成的针，但是当在成像光束下观察时，针保持器基本上保持针的外观。

    Apparatus for administering a therapeutic agent into tissue
    6.
    发明授权
    Apparatus for administering a therapeutic agent into tissue 有权
    用于将治疗剂施用于组织的装置

    公开(公告)号：US08162873B2

    公开(公告)日：2012-04-24

    申请号：US12430740

    申请日：2009-04-27

    申请人： Mario Muto ,  Kieran P. Murphy

    发明人： Mario Muto ,  Kieran P. Murphy

    IPC分类号： A61M37/00

    CPC分类号： A61M5/28 ,  A61B17/3478 ,  A61K33/00 ,  A61K33/40 ,  A61K45/06 ,  A61M5/31511 ,  A61M25/065 ,  A61M2005/3114 ,  A61M2005/3128 ,  A61M2202/0208 ,  A61M2202/0216 ,  A61M2210/1003 ,  A61K2300/00

    摘要： An apparatus for administering a therapeutic agent is provided. The apparatus, in an embodiment, includes an ozone generator connected to a scavenger and an ozone administrator via network of tubing and valves. When activated and the valves placed in the proper position, the ozone generator will fill the ozone administrator with ozone. The ozone generator can then be turned off and the valves moved so that the administrator can be disconnected from the remainder of the apparatus. The administrator is typically in the form of a syringe and needle. Once the syringe and needle is filled with ozone, the needle can be inserted into a tissue and the ozone expressed therefrom into the tissue. Various other apparatuses and methods are also contemplated.

    摘要翻译： 提供了一种用于施用治疗剂的装置。 在一个实施例中，该装置包括通过管道和阀网络连接到清除器和臭氧管理器的臭氧发生器。 当被激活并且阀门处于适当位置时，臭氧发生器将向臭氧管理员填充臭氧。 然后可以关闭臭氧发生器并且阀移动，使得管理员可以与设备的其余部分断开连接。 管理员通常是注射器和针头的形式。 一旦注射器和针头充满臭氧，针就可以插入到组织中，并将臭氧从其中进入组织。 还考虑了各种其它装置和方法。

    KIT FOR ADMINISTERING A THERAPEUTIC AGENT INTO TISSUE
    9.
    发明申请
    KIT FOR ADMINISTERING A THERAPEUTIC AGENT INTO TISSUE 有权
    将治疗药物用于组织的工具包

    公开(公告)号：US20090254021A1

    公开(公告)日：2009-10-08

    申请号：US12431089

    申请日：2009-04-28

    申请人： Mario Muto ,  Kieran P. Murphy

    发明人： Mario Muto ,  Kieran P. Murphy

    IPC分类号： A61M37/00

    CPC分类号： A61M5/28 ,  A61B17/3478 ,  A61K33/00 ,  A61K33/40 ,  A61K45/06 ,  A61M5/31511 ,  A61M25/065 ,  A61M2005/3114 ,  A61M2005/3128 ,  A61M2202/0208 ,  A61M2202/0216 ,  A61M2210/1003 ,  A61K2300/00

    摘要： An apparatus for administering a therapeutic agent is provided. The apparatus, in an embodiment, includes an ozone generator connected to a scavenger and an ozone administrator via network of tubing and valves. When activated and the valves placed in the proper position, the ozone generator will fill the ozone administrator with ozone. The ozone generator can then be turned off and the valves moved so that the administrator can be disconnected from the remainder of the apparatus. The administrator is typically in the form of a syringe and needle. Once the syringe and needle is filled with ozone, the needle can be inserted into a tissue and the ozone expressed therefrom into the tissue. Various other apparatuses and methods are also contemplated.

    摘要翻译： 提供了一种用于施用治疗剂的装置。 在一个实施例中，该装置包括通过管道和阀网络连接到清除器和臭氧管理器的臭氧发生器。 当被激活并且阀门处于适当位置时，臭氧发生器将向臭氧管理员填充臭氧。 然后可以关闭臭氧发生器并且阀移动，使得管理员可以与设备的其余部分断开连接。 管理员通常是注射器和针头的形式。 一旦注射器和针头充满臭氧，针就可以插入到组织中，并将臭氧从其中进入组织。 还考虑了各种其它装置和方法。

    Bone Augmentation Apparatus
    10.
    发明申请
    Bone Augmentation Apparatus 有权
    骨增强装置

    公开(公告)号：US20080195114A1

    公开(公告)日：2008-08-14

    申请号：US12063618

    申请日：2006-08-17

    申请人： Kieran P. Murphy

    发明人： Kieran P. Murphy

    IPC分类号： A61B17/58

    CPC分类号： A61B17/3472 ,  A61B17/8811 ,  A61B17/8816 ,  A61B17/8822 ,  A61F2/44 ,  A61F2/4611 ,  A61F2002/4623 ,  A61F2002/4677

    摘要： A bone cement apparatus (20) is provided. In an embodiment, the apparatus includes a syringe (24) and a needle (120). The syringe and needle are interconnected by a connecting tube (32). Various fittings are employed to join the syringe, needle and connecting tube. The connecting tube and fittings present a pathway along which bone cement is carried. The connecting tube, fittings, and needle are all configured such that a substantially uniform pathway is provided from the end of the syringe to the end of the needle.

    摘要翻译： 提供骨水泥装置（20）。 在一个实施例中，该装置包括注射器（24）和针（120）。 注射器和针通过连接管（32）互连。 使用各种配件来连接注射器，针头和连接管。 连接管和配件提供了一个沿着骨架骨架携带的通道。 连接管，配件和针都被构造成使得从注射器的端部到针的端部提供基本均匀的路径。