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公开(公告)号：US20040254550A1
公开(公告)日：2004-12-16
申请号：US10652126
申请日：2003-08-29
发明人： Lei Huang , Cheryl A. Perkins , Jaeho Kim , Jeffrey E. Fish , Yanbin Huang
IPC分类号： A61F013/15 , A61F013/20
CPC分类号： A61F13/42 , A61F2013/429
摘要： There is provided a temperature change element for use in personal care products where the temperature change element has a reactive component and a gel-forming agent. Upon exposure to liquids such as urine, the temperature change element will change in temperature substantially, thus letting the wearer know that he has urinated. The temperature change element may also have a binder to help keep the ingredients together and may have a colorant to further alert the user that the personal care product has been wetted
摘要翻译： 提供了用于个人护理产品中的温度变化元件，其中温度变化元件具有反应性组分和凝胶形成剂。 在暴露于液体如尿液时，温度变化元件将基本上改变温度，从而使佩戴者知道他已经排尿了。 温度变化元件还可以具有粘合剂以帮助将成分保持在一起并且可以具有着色剂以进一步警告使用者个人护理产品已被润湿
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公开(公告)号：US20040254549A1
公开(公告)日：2004-12-16
申请号：US10462166
申请日：2003-06-16
发明人： Christopher P. Olson , Shirlee Ann Weber , Lawrence Howell Sawyer , Lei Huang , Cheryl A. Perkins , Jaeho Kim , Jeffrey E. Fish , Yanbin Huang
IPC分类号： A61F013/15 , A61F013/20
CPC分类号： A61F13/42 , A61F2013/426 , A61F2013/428 , A61F2013/530525 , A61F2013/5307 , A61L15/56
摘要： A personal wear article capable of alerting a wearer to the wearer's release of liquid body exudates. The article includes an absorbent structure and a wetness indicator adapted to receive said liquid body exudates. The wetness indicator stiffens as it absorbs the liquid body exudates and applies a tactile sensation against the wearer's skin. The wetness indicator is positioned relative to a portion of the absorbent structure having an absorbent capacity gradient such that the absorbent capacity of the absorbent structure increases as the absorbent structure extends generally from the position of the wetness indicator in a direction generally away from the position of the wetness indicator. In another embodiment, the article includes a temperature change agent responsive to the liquid body exudates to change the temperature of the liquid body exudates to thereby facilitate a temperature change sensation against the wearer's skin.
摘要翻译： 一种能够使穿着者警惕穿用者释放液体渗出物的个人用品。 该制品包括适于接收所述液体体液的吸收结构和湿度指示器。 湿度指示器随着吸收液体渗出物而变硬，并对穿着者的皮肤施加触感。 湿度指示器相对于具有吸收能力梯度的吸收结构的一部分定位，使得吸收性结构的吸收能力随着吸湿结构大致从湿度指示器的位置沿着大致远离位置 湿度指示器。 在另一个实施方案中，制品包括响应于液体渗出物的温度变化剂，以改变液体排出物的温度，从而促进对穿着者皮肤的温度变化感。
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公开(公告)号：US20040197820A1
公开(公告)日：2004-10-07
申请号：US10406631
申请日：2003-04-03
发明人： Ning Wei , Yanbin Huang , Kaiyuan Yang
IPC分类号： G01N033/53 , G01N033/558
CPC分类号： G01N33/587 , G01N33/54393 , G01N33/558
摘要： A membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes conjugated probes that contain a specific binding member for the analyte of interest. The specific binding member preferentially complexes with the analyte within a test sample when contacted therewith. Excess analyte that remains uncomplexed with the specific binding member undergoes non-specific binding, such as to a hydrophobic domain. As a result, the ability of the uncomplexed analyte to compete with the complexed analyte at the detection zone of the device is restricted. Thus, the incidence of nullfalse negativesnull is limited in a simple, efficient, and relatively inexpensive manner.
摘要翻译： 提供了一种用于检测驻留在测试样品中的分析物的存在或数量的基于膜的测定装置。 该装置使用包含感兴趣分析物的特异性结合成员的缀合探针。 当与其接触时，特异性结合成分优先与测试样品内的分析物复合。 与特异性结合成员保持未复合的过量分析物经历非特异性结合，例如疏水结构域。 因此，未配合的分析物在装置的检测区域与复合分析物竞争的能力受到限制。 因此，“假阴性”的发生率以简单，有效和相对便宜的方式受到限制。
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公开(公告)号：US20040121334A1
公开(公告)日：2004-06-24
申请号：US10325429
申请日：2002-12-19
发明人： Ning Wei , Yanbin Huang , Xuedong Song , Rosann Kaylor
IPC分类号： C12Q001/68 , C12M001/34
CPC分类号： G01N33/558 , G01N33/54393
摘要： An internal, self-calibrated system for flow-through assay devices is provided. In particular, the present invention employs the use of a single calibration/detection zone defined by a porous membrane of the assay. It has been discovered that the internal, self-calibrated system provides an accurate, inexpensive, and readily controllable method of determining the presence of an analyte in a test sample.
摘要翻译： 提供了一种用于流通测定装置的内部自校准系统。 特别地，本发明使用由测定的多孔膜限定的单个校准/检测区域。 已经发现，内部的自校准系统提供了确定测试样品中分析物的存在的精确，便宜且易于控制的方法。
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公开(公告)号：US20030232088A1
公开(公告)日：2003-12-18
申请号：US10302484
申请日：2002-11-22
发明人： Yanbin Huang , Jaeho Kim
IPC分类号： A61K009/14
CPC分类号： C08F290/061 , A61K9/0014 , A61K47/32 , A61K47/34
摘要： The current invention concerns new bioadhesive polymers incorporated with biodegradable components. The bioadhesive components used are polycarboxylic acids, while the biodegradable components can be any synthetic degradable polymers, particularly biodegradable polyesters whose degradation products are small molecular esters. The two polymer components may be covalently bound to each forming graft, block or random copolymers, examples of which include poly(acrylic acid)-graft-poly(lactic acid) (PAA-g-PLA) and pol(lactic-co-glycolic acid)-g-poly(acrylic acid) (PLGA-g-PAA). The two components may also be incorporated into one material by forming non-covalent interpolymer complex via, for examples, hydrogen bonding, ionic bonding or hydrophobic bonding. Typical examples in this category include the hydrogen bonding interpolymer complex formed between poly(methacrylic acid) and poly(lactic acid)-b-poly(ethylene glycol)-b-poly(lactic acid) tri-block copolymers. The new materials may be used without a treatment agent to provide a lasting acidic pH environment or used with a treatment agent as a delivery system.
摘要翻译： 本发明涉及结合有可生物降解组分的新的生物粘合剂聚合物。 所使用的生物粘合剂组分是多元羧酸，而可生物降解的组分可以是任何合成的可降解聚合物，特别是其降解产物是小分子酯的可生物降解的聚酯。 两种聚合物组分可以共价结合到每个形成接枝，嵌段或无规共聚物上，其实例包括聚（丙烯酸） - 接枝聚（乳酸）（PAA-g-PLA）和聚（乳酸 - 共 - 乙醇酸） 酸）-g-聚（丙烯酸）（PLGA-g-PAA）。 通过例如氢键，离子键合或疏水键合形成非共价互聚物络合物，两种组分也可以并入一种材料中。 该类别的典型实例包括在聚（甲基丙烯酸）和聚（乳酸）-b-聚（乙二醇）-b-聚（乳酸）三嵌段共聚物之间形成的氢键互聚物络合物。 新材料可以不经处理剂使用以提供持久的酸性pH环境或与处理剂一起用作输送系统。
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公开(公告)号：US20040121480A1
公开(公告)日：2004-06-24
申请号：US10325614
申请日：2002-12-19
发明人： Ning Wei , Yanbin Huang
IPC分类号： G01N030/02 , G01N031/22
CPC分类号： G01N33/558 , G01N33/538 , G01N33/5432 , Y10S436/805 , Y10S436/809
摘要： A membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes a chromatographic zone on which is disposed a plurality of microporous particles. The chromatographic zone can effectively reduce the nullhook effectnull in a simple, efficient, and relatively inexpensive manner. In particular, the plurality of microporous particles allows larger-sized analyte/probe complexes to reach the detection zone before the uncomplexed analyte. Because the uncomplexed analyte is substantially inhibited from competing with the complexes for the binding sites at the detection zone, the incidence of nullfalse negativesnull may be limited, even at relatively high analyte concentrations.
摘要翻译： 提供了一种用于检测驻留在测试样品中的分析物的存在或数量的基于膜的测定装置。 该装置利用其上设置有多个微孔颗粒的色谱区。 色谱区域可以以简单，高效，相对便宜的方式有效降低“钩效应”。 特别地，多个微孔颗粒允许更大尺寸的分析物/探针复合物在未复合分析物之前到达检测区。 由于未配合的分析物被基本上抑制在与检测区域的结合位点的配合物竞争中，所以即使在相对高的分析物浓度下，“假阴性”的发生率可能受到限制。
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公开(公告)号：US20030232929A1
公开(公告)日：2003-12-18
申请号：US10302483
申请日：2002-11-22
发明人： Yanbin Huang , Jaeho Kim
IPC分类号： C08F283/02
CPC分类号： C08F283/02 , C08F283/00
摘要： There is provided a method to modify biodegradable polymers using the direct reaction of a biodegradable polymer in a vinyl monomer and may take place in the presence of initiators. The initiator may be free radical initiators, heat, ionic initiators, UV irradiation, ionizing irradiation and other high energy irradiation. Suitable biodegradable polymer include polycaprolactone, poly(lactic acid), poly(glycolic acid) and poly(lactic-co-glycolic acid). Suitable vinyl monomers include acrylates, methacrylates and the like.
摘要翻译： 提供了使用可生物降解的聚合物在乙烯基单体中的直接反应来修饰可生物降解聚合物的方法，并且可以在引发剂的存在下进行。 引发剂可以是自由基引发剂，热，离子引发剂，UV照射，电离辐照等高能量照射。 合适的可生物降解聚合物包括聚己内酯，聚（乳酸），聚（乙醇酸）和聚（乳酸 - 共 - 乙醇酸）。 合适的乙烯基单体包括丙烯酸酯，甲基丙烯酸酯等。
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公开(公告)号：US20030204180A1
公开(公告)日：2003-10-30
申请号：US10135805
申请日：2002-04-30
发明人： Yanbin Huang , Bashir Musse Sheikh-Ali , Jaeho Kim
IPC分类号： A61K031/785 , A61K009/14 , A61K009/22
摘要： There is provided a new aqueous temperature responsive delivery system made with a temperature responsive polymer and a bioadhesive which is intrinsically cationic. This system may also have an effective amount of a treating agent, which may be a medical or cosmetic agent. The bioadhesive, temperature responsive delivery system is useful in delivering moisturizers or pharmaceutically active agents to the user in controlled release manners, through the tissues in a body cavity.
摘要翻译： 提供了一种由温度敏感聚合物和固有阳离子的生物粘附剂制成的新的水性温度响应递送系统。 该系统还可以具有有效量的治疗剂，其可以是医疗或美容剂。 生物粘合剂，温度敏感递送系统可用于通过体腔内的组织以控制释放的方式将保湿剂或药物活性剂递送给使用者。
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