公开(公告)号：US20080045890A1

公开(公告)日：2008-02-21

申请号：US11567539

申请日：2006-12-06

申请人： Kirk Seward ,  Juan Granada

发明人： Kirk Seward ,  Juan Granada

IPC分类号： A61M31/00

CPC分类号： A61M25/1002 ,  A61M25/0084 ,  A61M2025/0096 ,  A61M2025/018 ,  A61M2025/1086

摘要： Methods and systems for treating patients requiring tissue ablation for volumetric tissue reduction rely on the injection of ethanol and other tissue-ablating agents into the perivascular space surrounding body lumens, particularly blood vessels or vessels of the alimentary canal, reproductive system and urinary tract. Injection of tissue-ablating agents is intended treat conditions such as hypertrophic cardiomyopathy, benign and malignant tumors, benign prostatic hyperplasia, and uterine fibroids, for example. Injection may be achieved using intravascular catheters which advance needles radially outward from a body vessel lumen or by transmyocardial injection from an epicardial or endocardial surface of the heart.

摘要翻译： 用于治疗需要组织消融用于体积组织减少的患者的方法和系统依赖于将乙醇和其他组织消融剂注射到体腔内的血管周围空间中，特别是消化道，生殖系统和尿道的血管或血管。 注射组织消融剂是例如肥大性心肌病，良性和恶性肿瘤，良性前列腺增生症和子宫肌瘤等治疗条件。 可以使用血管内导管实现注射，所述血管内导管使针从体管腔径向向外推进，或者通过从心脏的心外膜或心内膜表面进行的经心肌注射。

公开(公告)号：US20070225795A1

公开(公告)日：2007-09-27

申请号：US11726986

申请日：2007-03-24

申请人： Juan Granada ,  Simon M. Furnish

发明人： Juan Granada ,  Simon M. Furnish

IPC分类号： A61F2/82

CPC分类号： A61F2/91 ,  A61F2210/0076 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2250/003 ,  A61F2250/0067

摘要： A novel treatment for atherosclerotic vascular disease is described utilizing the implantation of a thin, conformable biocompatible prosthesis constructed from a composite of various structural and therapeutic scaffolds in combination with one or more bioactive agents. This prosthesis can be delivered into position over a lesion in order to passivate atherosclerotic plaques with minimal remodeling of the artery, or alternatively can be applied with a balloon to passivate the remodeled site. The composite prosthesis itself provides mild structural reinforcement of the vessel wall and an evenly distributed platform for the introduction of bioactive therapeutic agents.

摘要翻译： 描述了使用由一种或多种生物活性剂组合的由各种结构和治疗性支架的复合物构成的薄的，一致的生物相容性假体的植入来描述动脉粥样硬化性血管疾病的新型治疗。 该假体可以被传送到病变上方的位置，以便以最小的动脉重塑来钝化动脉粥样硬化斑块，或者可以应用气球来钝化重塑的部位。 复合假体本身提供血管壁的轻度结构加强和用于引入生物活性治疗剂的均匀分布的平台。

公开(公告)号：US20090118673A1

公开(公告)日：2009-05-07

申请号：US12138201

申请日：2008-06-12

申请人： Jerett Creed ,  Emerson Parin ,  Knut Sauertaig ,  Juan Granada

发明人： Jerett Creed ,  Emerson Parin ,  Knut Sauertaig ,  Juan Granada

IPC分类号： A61M5/178

CPC分类号： A61M25/0108 ,  A61B2017/00026 ,  A61M25/0133 ,  A61M25/06

摘要： A needle injection catheter includes a delivery tube that slidably surrounds a hypotube that has at least three hollow needle portions connected to and extending outwardly at its distal end. The needle portions are formed of resilient material and curve outwardly from the delivery tube. The ends of the needle portions are shaped to penetrate tissue when the hypotube is urged out of the delivery tube. A first sensor is located adjacent the distal end of the delivery tube and a second sensor is located adjacent the end of the needle portion. The sensors are electrically connected to first and second notification devices located adjacent a first end of the delivery tube. Radiopaque markers are affixed to the delivery tube to locate the tip using an enhanced imaging system. The markers are sized, shaped, positioned and of different densities to locate the tip both axially and radially within body structures.

摘要翻译： 针注射导管包括可滑动地围绕海波管的输送管，所述海波管具有至少三个中空针部分，所述中空针部分在其远端处连接并向外延伸。 针部分由弹性材料形成，并从输送管向外弯曲。 针刺部分的端部被成形为当海波管被推出输送管时穿透组织。 第一传感器位于邻近输送管的远端并且第二传感器位于邻近针部分的端部处。 传感器电连接到邻近输送管第一端的第一和第二通知装置。 使用增强的成像系统将不透射线标记固定到输送管以定位末端。 标记的尺寸，形状，定位和不同的密度，以使得顶端轴向和径向地定位在主体结构内。

公开(公告)号：US20070225792A1

公开(公告)日：2007-09-27

申请号：US11726987

申请日：2007-03-24

申请人： Juan Granada ,  Simon M. Furnish

发明人： Juan Granada ,  Simon M. Furnish

IPC分类号： A61F2/84

CPC分类号： A61F2/958 ,  A61M25/0119

摘要： Novel approaches for a conformable vascular prosthesis delivery system are provided which overcome the limitations of existing high pressure balloons for delivering intravascular prostheses to the site of high-risk plaques. One embodiment involves a short balloon segment which is inflated at one end of the prosthesis and then pulled to traverse the length of the prosthesis, dilating the surrounding prosthesis and securing it to the vessel wall as it traverses the length of the prosthesis. The short balloon segment causes less local trauma to the vessel relative to a full length balloon. Another embodiment involves use of a self-expandable mesh to expand the surrounding prosthesis and secure it to the vessel wall. The self expandable mesh is less traumatic than a typical angioplasty balloon because of the lower radial forces applied and the relatively higher transverse flexibility of the mesh.

摘要翻译： 提供了一种适用于血管假体输送系统的新方法，其克服了用于将血管内假体递送至高危斑块位置的现有高压球囊的局限性。 一个实施例涉及一种短气囊段，其在假体的一端处被充气，然后被拉动以穿过假体的长度，扩张周围的假体并且当其穿过假体的长度时将其固定到血管壁。 短气囊段相对于全长气囊对血管造成更少的局部创伤。 另一个实施例涉及使用自扩张网来扩展周围假体并将其固定到血管壁。 由于施加较小的径向力和网状物的相对较高的横向柔性，自膨胀网格比典型的血管成形术球囊创伤小。

公开(公告)号：US20110313502A1

公开(公告)日：2011-12-22

申请号：US13222741

申请日：2011-08-31

申请人： Juan Granada ,  Simon M. Furnish

发明人： Juan Granada ,  Simon M. Furnish

IPC分类号： A61F2/82

CPC分类号： A61F2/91 ,  A61F2210/0076 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2250/003 ,  A61F2250/0067

摘要： A novel treatment for atherosclerotic vascular disease is described utilizing the implantation of a thin, conformable biocompatible prosthesis constructed from a composite of various structural and therapeutic scaffolds in combination with one or more bioactive agents. This prosthesis can be delivered into position over a lesion in order to passivate atherosclerotic plaques with minimal remodeling of the artery, or alternatively can be applied with a balloon to passivate the remodeled site. The composite prosthesis itself provides mild structural reinforcement of the vessel wall and an evenly distributed platform for the introduction of bioactive therapeutic agents.

摘要翻译： 描述了使用由一种或多种生物活性剂组合的由各种结构和治疗性支架的复合物构成的薄的，一致的生物相容性假体的植入来描述动脉粥样硬化性血管疾病的新型治疗。 该假体可以被传送到病变上方的位置，以便以最小的动脉重塑来钝化动脉粥样硬化斑块，或者可以应用气球来钝化重塑的部位。 复合假体本身提供血管壁的轻度结构加强和用于引入生物活性治疗剂的均匀分布的平台。

公开(公告)号：US20090312617A1

公开(公告)日：2009-12-17

申请号：US12249826

申请日：2008-10-10

申请人： Jerett Creed ,  Emerson Perin ,  Knut Sauerteig ,  Juan Granada

发明人： Jerett Creed ,  Emerson Perin ,  Knut Sauerteig ,  Juan Granada

IPC分类号： A61B5/042 ,  A61B5/055 ,  A61B18/18 ,  A61B8/14 ,  A61M1/00

CPC分类号： A61B17/3478 ,  A61B18/1477 ,  A61B18/1492 ,  A61B90/39 ,  A61B2017/00026 ,  A61B2017/00035 ,  A61B2017/00044 ,  A61B2017/00084 ,  A61B2017/00092 ,  A61B2017/00106 ,  A61B2017/00115 ,  A61B2017/00221 ,  A61B2017/00243 ,  A61B2018/1425 ,  A61M2025/0086 ,  A61M2025/0089

摘要： The needle injection catheter includes a delivery tube and at least one hypotube that fits slidably within the delivery tube. The hypotube has at least three hollow needle portions extending outwardly at its distal end. The needle portions curve outwardly and have ends shaped to penetrate tissue. At least one reference electrode is located on the delivery tube, spaced from the second end. At least one proximal electrode is located adjacent and spaced from the end of the needle portion. The proximal electrode is electrically connected to a first notification device. A microcircuit is electrically connected to the proximal electrode, the reference electrode and to a power supply. A distal electrode is located adjacent the end of the needle portion and electrically connected to the microcircuit. A tip electrode is located adjacent the second end of the delivery tube and electrically connected to a second notification device and the microcircuit.

摘要翻译： 针注射导管包括输送管和可滑动地配合在输送管内的至少一个海波波。 海波管具有至少三个在其远端向外延伸的中空针部分。 针部分向外弯曲并具有成形为穿透组织的端部。 至少一个参考电极位于输送管上，与第二端间隔开。 至少一个近端电极位于与针部分的端部相邻并间隔开的位置。 近端电极电连接到第一通知装置。 微电路电连接到近端电极，参考电极和电源。 远端电极定位成邻近针部分的端部并电连接到微电路。 尖端电极位于输送管的第二端附近并电连接到第二通知装置和微电路。

公开(公告)号：US20090099652A1

公开(公告)日：2009-04-16

申请号：US12212474

申请日：2008-09-17

申请人： Juan Granada ,  Simon M. Furnish

发明人： Juan Granada ,  Simon M. Furnish

IPC分类号： A61F2/06

CPC分类号： A61F2/91 ,  A61F2210/0076 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2250/003 ,  A61F2250/0067

摘要： A novel treatment for atherosclerotic vascular disease is described utilizing the implantation of a thin, conformable biocompatible prosthesis constructed from a composite of various structural and therapeutic scaffolds in combination with one or more bioactive agents. This prosthesis can be delivered into position over a lesion in order to passivate atherosclerotic plaques with minimal remodeling of the artery, or alternatively can be applied with a balloon to passivate the remodeled site. The composite prosthesis itself provides mild structural reinforcement of the vessel wall and an evenly distributed platform for the introduction of bioactive therapeutic agents.

摘要翻译： 描述了使用由一种或多种生物活性剂组合的由各种结构和治疗性支架的复合物构成的薄的，一致的生物相容性假体的植入来描述动脉粥样硬化性血管疾病的新型治疗。 该假体可以被传送到病变上方的位置，以便以最小的动脉重塑来钝化动脉粥样硬化斑块，或者可以应用气球来钝化重塑的部位。 复合假体本身提供血管壁的轻度结构加强和用于引入生物活性治疗剂的均匀分布的平台。

公开(公告)号：US20090216309A1

公开(公告)日：2009-08-27

申请号：US12397689

申请日：2009-03-04

申请人： Juan Granada ,  Simon M. Furnish

发明人： Juan Granada ,  Simon M. Furnish

IPC分类号： A61F2/84

CPC分类号： A61F2/958 ,  A61M25/0119

摘要： Novel approaches for a conformable vascular prosthesis delivery system are provided which overcome the limitations of existing high pressure balloons for delivering intravascular prostheses to the site of high-risk plaques. One embodiment involves a short balloon segment which is inflated at one end of the prosthesis and then pulled to traverse the length of the prosthesis, dilating the surrounding prosthesis and securing it to the vessel wall as it traverses the length of the prosthesis. The short balloon segment causes less local trauma to the vessel relative to a full length balloon. Another embodiment involves use of a self-expandable mesh to expand the surrounding prosthesis and secure it to the vessel wall. The self expandable mesh is less traumatic than a typical angioplasty balloon because of the lower radial forces applied and the relatively higher transverse flexibility of the mesh.

摘要翻译： 提供了一种适用于血管假体输送系统的新方法，其克服了用于将血管内假体递送至高危斑块位置的现有高压球囊的局限性。 一个实施例涉及一种短气囊段，其在假体的一端处被充气，然后被拉动以穿过假体的长度，扩张周围的假体并且当其穿过假体的长度时将其固定到血管壁。 短气囊段相对于全长气囊对血管造成更少的局部创伤。 另一个实施例涉及使用自扩张网来扩展周围假体并将其固定到血管壁。 由于施加较小的径向力和网状物的相对较高的横向柔性，自膨胀网格比典型的血管成形术球囊创伤小。