公开(公告)号：US5996902A

公开(公告)日：1999-12-07

申请号：US878944

申请日：1997-06-19

申请人： Kiyoshi Morimoto ,  Yasushi Watanabe ,  Kimiaki Hayakawa ,  Sanji Tokuno

发明人： Kiyoshi Morimoto ,  Yasushi Watanabe ,  Kimiaki Hayakawa ,  Sanji Tokuno

IPC分类号： B65B1/16 ,  A61J3/06 ,  B01J2/02 ,  B01J2/18 ,  B01J4/02 ,  B05B7/14 ,  B30B15/00 ,  B65G53/40 ,  B05B17/04

CPC分类号： B05B7/1445 ,  B01J2/02 ,  B01J2/18 ,  B30B15/0011

摘要： A sprayer and method for spraying powdered material activated by pulsating vibration air. The sprayer comprises an elastic membrane, a storage tank for storing powdered material provided with the elastic membrane at the bottom opening, and a pulsating vibration air generator for supplying pulsating vibration air to the elastic membrane. The sprayer so constructed is designed to uniformly and diffusely spray the powdered material stored in the storage tank when the elastic membrane is forcedly vibrated up and down in compliance with the frequency of the pulsating vibration air by receiving pulsating vibration air from the pulsating vibration air generator.

摘要翻译： 一种用于喷射通过脉动振动空气激活的粉末材料的喷雾器和方法。 喷雾器包括弹性膜，用于储存在底部开口处设置有弹性膜的粉末材料的储罐和用于向弹性膜供应脉动振动空气的脉动振动空气发生器。 这样构造的喷雾器被设计成当弹性膜通过从脉动振动空气发生器接收到脉动的振动空气而与脉动振动空气的频率一致地上下强制地振动时，均匀地并且漫射喷射存储在储罐中的粉末材料 。

公开(公告)号：US06062826A

公开(公告)日：2000-05-16

申请号：US713128

申请日：1996-09-16

申请人： Kiyoshi Morimoto ,  Yasushi Watanabe ,  Yoshika Sanada ,  Sanji Tokuno ,  Kazue Murata

发明人： Kiyoshi Morimoto ,  Yasushi Watanabe ,  Yoshika Sanada ,  Sanji Tokuno ,  Kazue Murata

IPC分类号： B06B1/12 ,  B06B1/14 ,  F16K31/524 ,  F04B49/00

CPC分类号： F16K31/52408 ,  Y10T74/18296

摘要： A pulsating vibration air generator in which wave height, frequency and wave shape of the pulsating vibration air can be optionally modified and such pulsating vibration air can be periodically and continuously emitted. The pulsating vibration air generator has a valve chamber with an inlet port and an outlet port where a valve plug and a valve seat with a control opening are provided and a cam mechanism which moves the valve plug to open or close the opening of the valve seat, whereby positive or negative pulsating vibration air is emitted from the outlet port while pressurized air is supplied into the inlet port or air is sucked from the inlet port.

摘要翻译： 脉动振动空气发生器可以可选地改变脉动振动空气的波浪高度，频率和波形，并且可以周期性地连续地发射这种脉动的振动空气。 脉动振动空气发生器具有带有入口和出口的阀室，其中设置有阀塞和具有控制开口的阀座，以及凸轮机构，其使阀塞移动以打开或关闭阀座的开口 从而当加压空气被供给到入口或从入口吸入空气时，从出口端口发出正或负脉动的振动空气。

公开(公告)号：US08357396B2

公开(公告)日：2013-01-22

申请号：US13282271

申请日：2011-10-26

申请人： Motohiro Ohta ,  Eiji Hayakawa ,  Kunio Ito ,  Sanji Tokuno ,  Kiyoshi Morimoto ,  Yasushi Watanabe

发明人： Motohiro Ohta ,  Eiji Hayakawa ,  Kunio Ito ,  Sanji Tokuno ,  Kiyoshi Morimoto ,  Yasushi Watanabe

IPC分类号： A61K9/20

CPC分类号： A61K9/2095 ,  A61J3/10 ,  A61K9/0056 ,  A61K9/2018 ,  A61K9/2027

摘要： An intrabuccally rapidly disintegrating tablet which is manufactured by a simple method, has an enough practical hardness and is rapidly disintegrated in the buccal cavity and its production method. The intrabuccally rapidly disintegrating tablet is produced by growing a powder material into a granulated material with a fixed particle diameter, the powder material including a sugar alcohol or a saccharide as main ingredient, each of which is first particle having an average particle diameter of not more than 30 μm, by mixing thus obtained granulated material with an active ingredient and a disintegrant, and by compressing the mixture into a predetermined shape.

公开(公告)号：US06302573B1

公开(公告)日：2001-10-16

申请号：US09289556

申请日：1999-04-12

申请人： Kiyoshi Morimoto ,  Yasushi Watanabe ,  Yoshika Sanada ,  Sanji Tokuno ,  Kazue Murata

发明人： Kiyoshi Morimoto ,  Yasushi Watanabe ,  Yoshika Sanada ,  Sanji Tokuno ,  Kazue Murata

IPC分类号： B01F1302

CPC分类号： B01F13/0266 ,  B01F3/18 ,  B65G53/22

摘要： A mixing and blending method for powdered or granular material includes supplying pulsating vibration air into an airtight tank from a bottom thereof. An airtight tank having a porous bottom plate on which the material is stored is provided for the mixing and blending method. In the system pulsating vibration air is generated by periodically increasing and decreasing the amount of blowing air at a low frequency. Pulsating vibration air is introduced into the airtight tank from the bottom of the airtight tank so as to generate air flow going upward through the porous bottom of the airtight tank. As a result, powdered or granular material stored on the porous bottom plate in the airtight tank is uniformly mixed and blended in the airtight tank while continuously moving up and down as in a convectional manner.

摘要翻译： 用于粉末或颗粒材料的混合和混合方法包括将脉动振动空气从其底部供应到气密罐中。 提供了一种具有多孔底板的密封罐，其上储存有材料用于混合和混合方法。 在该系统中，通过周期性地增加和减少低频吹送空气的量来产生脉动振动空气。 脉动振动空气从密封罐的底部引入密封罐中，以产生向上通过密封罐的多孔底部的空气流。 结果，将保存在密封罐中的多孔底板上的粉状或颗粒状材料均匀地混合并混合在密封罐中，同时以对流方式连续上下移动。

公开(公告)号：US06432534B1

公开(公告)日：2002-08-13

申请号：US09555660

申请日：2000-09-14

申请人： Eiji Hayakawa ,  Motohiro Ohta ,  Hiroyuki Morimoto ,  Kiyoshi Morimoto ,  Yasushi Watanabe ,  Kunio Ito ,  Sanji Tokuno

发明人： Eiji Hayakawa ,  Motohiro Ohta ,  Hiroyuki Morimoto ,  Kiyoshi Morimoto ,  Yasushi Watanabe ,  Kunio Ito ,  Sanji Tokuno

IPC分类号： B32B516

CPC分类号： A61J3/10 ,  B30B11/08 ,  B30B15/0011 ,  Y10T428/2991

摘要： A method for producing tablet including active component, diluting agent, and lubricant by means of a tabletting machine provided with punches and dies, comprising steps of; preparing molding material including active component, diluting anent, and a part of lubricant; applying most of the remaining amount of the lubricant on surfaces of the punches and a surface of the die; and tabletting the molding material by means of the punches on which surfaces the lubricant is applied and the die on which surface the lubricant is applied

摘要翻译： 一种通过设置有冲头和模具的压片机生产包含活性成分，稀释剂和润滑剂的片剂的方法，包括以下步骤： 制备包括活性组分，稀释剂和润滑剂的一部分的成型材料; 将大部分剩余量的润滑剂施加到冲头的表面和模具的表面上; 并通过施加润滑剂的表面的冲头和施加润滑剂的表面的模具对成型材料进行压片

公开(公告)号：US20120135076A1

公开(公告)日：2012-05-31

申请号：US13282271

申请日：2011-10-26

申请人： Motohiro OHTA ,  Eiji Hayakawa ,  Kunio Ito ,  Sanji Tokuno ,  Kiyoshi Morimoto ,  Yasushi Watanabe

发明人： Motohiro OHTA ,  Eiji Hayakawa ,  Kunio Ito ,  Sanji Tokuno ,  Kiyoshi Morimoto ,  Yasushi Watanabe

IPC分类号： A61K9/20 ,  B02C23/00

CPC分类号： A61K9/2095 ,  A61J3/10 ,  A61K9/0056 ,  A61K9/2018 ,  A61K9/2027

摘要： An intrabuccally rapidly disintegrating tablet which is manufactured by a simple method, has an enough practical hardness and is rapidly disintegrated in the buccal cavity and its production method. The intrabuccally rapidly disintegrating tablet is produced by growing a powder material into a granulated material with a fixed particle diameter, the powder material including a sugar alcohol or a saccharide as main ingredient, each of which is first particle having an average particle diameter of not more than 30 μm, by mixing thus obtained granulated material with an active ingredient and a disintegrant, and by compressing the mixture into a predetermined shape.

摘要翻译： 通过简单的方法制造的口腔内快速崩解片剂具有足够的实用硬度并且在口腔中快速崩解及其制备方法。 通过将粉末材料生长成具有固定粒径的造粒材料，粉末材料包括作为主要成分的糖醇或糖类的粉末材料，其平均粒径不大于 通过将由此获得的造粒材料与活性成分和崩解剂混合，并将混合物压缩成预定形状。

公开(公告)号：US08071128B2

公开(公告)日：2011-12-06

申请号：US10356641

申请日：2003-06-20

申请人： Motohiro Ohta ,  Eiji Hayakawa ,  Kunio Ito ,  Sanji Tokuno ,  Kiyoshi Morimoto ,  Yasushi Watanabe

发明人： Motohiro Ohta ,  Eiji Hayakawa ,  Kunio Ito ,  Sanji Tokuno ,  Kiyoshi Morimoto ,  Yasushi Watanabe

IPC分类号： A61K9/20

CPC分类号： A61K9/2095 ,  A61J3/10 ,  A61K9/0056 ,  A61K9/2018 ,  A61K9/2027

摘要： An intrabuccally rapidly disintegrating tablet which is manufactured by a simple method, has an enough practical hardness and is rapidly disintegrated in the buccal cavity and its production method. The intrabuccally rapidly disintegrating tablet is produced by growing a powder material into a granulated material with a fixed particle diameter, the powder material including a sugar alcohol or a saccharide as main ingredient, each of which is first particle having an average particle diameter of not more than 30 μm, by mixing thus obtained granulated material with an active ingredient and a disintegrant, and by compressing the mixture into a predetermined shape.

摘要翻译： 通过简单的方法制造的口腔内快速崩解片剂具有足够的实用硬度并且在口腔中快速崩解及其制备方法。 通过将粉末材料生长成具有固定粒径的造粒材料，粉末材料包括作为主要成分的糖醇或糖类的粉末材料，其平均粒径不大于 通过将由此获得的造粒材料与活性成分和崩解剂混合，并将混合物压缩成预定形状。

公开(公告)号：US20080031989A1

公开(公告)日：2008-02-07

申请号：US11808619

申请日：2007-06-12

申请人： Yasushi Watanabe ,  Kimiaki Hayakawa ,  Eiichiro Hirota ,  Kiyoshi Morimoto

发明人： Yasushi Watanabe ,  Kimiaki Hayakawa ,  Eiichiro Hirota ,  Kiyoshi Morimoto

IPC分类号： A61K9/20

CPC分类号： C04B41/009 ,  A61J3/10 ,  B01J2/00 ,  B01J2/16 ,  B01J2/22 ,  B30B15/0011 ,  C04B41/5022 ,  C04B2111/00836 ,  C04B41/4523 ,  C04B35/10 ,  C04B35/119 ,  C04B35/443 ,  C04B35/447

摘要： A tablet production apparatus comprising a gas generator G, a lubricant powder discharge means 51 for discharging a lubricant powder into a gas generated from the gas generator G, depending on the supply of the gas from the gas generator G, and mixing the lubricant powder with the gas in dispersed state, a lubricant application means 91 for spraying the lubricant powder discharged from the lubricant powder discharge means 51 and mixed with the gas generated from the gas generation means G in dispersed state, onto each material contacting surface of a die, an upper punch and a lower punch, and an oxygen concentration measuring means 131a for measuring the oxygen concentration of the gas existing near the lubricant application means 91. The apparatus is designed such that the amount of the gas supplied into the lubricant application means is adjusted based on the oxygen concentration measured by the oxygen concentration measuring means 131a.

摘要翻译： 一种片剂生产设备，包括气体发生器G，润滑剂粉末排出装置51，用于根据来自气体发生器G的气体的供应将润滑剂粉末排放到由气体发生器G产生的气体中，并将​​润滑剂粉末与 分散状态的气体，用于喷射从润滑剂粉末排出装置51排出的润滑剂粉末并将其与分散状态的气体产生装置G产生的气体混合的润滑剂施加装置91到模具的每个材料接触表面上 上冲头和下冲头，以及用于测量存在于润滑剂施加装置91附近的气体的氧浓度的氧浓度测量装置131a。 该设备被设计成使得根据由氧浓度测量装置131a测量的氧浓度来调节供应到润滑剂施加装置中的气体的量。

公开(公告)号：US06776361B1

公开(公告)日：2004-08-17

申请号：US10019936

申请日：2002-04-24

申请人： Yasushi Watanabe ,  Kimiaki Hayakawa ,  Kiyoshi Morimoto

发明人： Yasushi Watanabe ,  Kimiaki Hayakawa ,  Kiyoshi Morimoto

IPC分类号： A02C1504

CPC分类号： B30B15/0011 ,  B05B7/1404 ,  B05B7/144

摘要： A powdered material spraying device comprising a quantitative spraying device provided for a material discharge port of the powdered material storage hopper via a material feed valve, a cover being provided for the material feed port of the powdered material storage hopper. The spraying device includes a cylindrical body connected with the material discharge port of the powdered material storage hopper, an elastic membrane with a penetrating aperture provided so as to form a bottom of the cylindrical body at its lower opening end, and a dispersion chamber connected under the lower opening end of the cylindrical body via the elastic membrane. The dispersion chamber has a pulsating vibration air supply port for supplying a positive pulsating vibration air to the dispersion chamber and a discharge port. A bypass pipe is connected between the cylindrical body and the dispersion chamber and the powdered material is sprayed from a tip end of a conduit connected with the discharge port of the dispersion chamber.

摘要翻译： 一种粉末喷涂装置，其特征在于，包括：定量喷射装置，其经由供料阀设置在所述粉料储存料斗的排料口上，为所述粉料储存料斗的料料供给口设置盖。 喷射装置包括与粉料储存料斗的材料排出口连接的圆柱体，具有穿孔的弹性膜，其设置成在其下开口端形成圆柱体的底部，并且分隔室连接在 圆柱体的下开口端经由弹性膜。 分散室具有用于向分散室和排出口供给正脉动振动空气的脉动振动空气供给口。 旁通管连接在圆柱体和分散室之间，并且粉末材料从与分散室的排出口连接的导管的末端喷射。

公开(公告)号：US07766638B2

公开(公告)日：2010-08-03

申请号：US11808619

申请日：2007-06-12

申请人： Yasushi Watanabe ,  Kimiaki Hayakawa ,  Eiichiro Hirota ,  Kiyoshi Morimoto

发明人： Yasushi Watanabe ,  Kimiaki Hayakawa ,  Eiichiro Hirota ,  Kiyoshi Morimoto

IPC分类号： B29C33/60 ,  B29C43/08

CPC分类号： C04B41/009 ,  A61J3/10 ,  B01J2/00 ,  B01J2/16 ,  B01J2/22 ,  B30B15/0011 ,  C04B41/5022 ,  C04B2111/00836 ,  C04B41/4523 ,  C04B35/10 ,  C04B35/119 ,  C04B35/443 ,  C04B35/447

摘要： A tablet production apparatus comprising a gas generator G, a lubricant powder discharge means 51 for discharging a lubricant powder into a gas generated from the gas generator G, depending on the supply of the gas from the gas generator G, and mixing the lubricant powder with the gas in dispersed state, a lubricant application means 91 for spraying the lubricant powder discharged from the lubricant powder discharge means 51 and mixed with the gas generated from the gas generation means G in dispersed state, onto each material contacting surface of a die, an upper punch and a lower punch, and an oxygen concentration measuring means 131a for measuring the oxygen concentration of the gas existing near the lubricant application means 91. The apparatus is designed such that the amount of the gas supplied into the lubricant application means is adjusted based on the oxygen concentration measured by the oxygen concentration measuring means 131a.

摘要翻译： 一种片剂生产设备，包括气体发生器G，润滑剂粉末排出装置51，用于根据来自气体发生器G的气体的供应将润滑剂粉末排放到由气体发生器G产生的气体中，并将​​润滑剂粉末与 分散状态的气体，用于喷射从润滑剂粉末排出装置51排出的润滑剂粉末并将其与分散状态的气体产生装置G产生的气体混合的润滑剂施加装置91到模具的每个材料接触表面上 上冲头和下冲头，以及用于测量存在于润滑剂施加装置91附近的气体的氧浓度的氧浓度测量装置131a。该设备被设计成使得供应到润滑剂施加装置中的气体的量被调整 关于由氧浓度测量装置131a测量的氧浓度。