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公开(公告)号：US20080031989A1
公开(公告)日：2008-02-07
申请号：US11808619
申请日：2007-06-12
IPC分类号： A61K9/20
CPC分类号： C04B41/009 , A61J3/10 , B01J2/00 , B01J2/16 , B01J2/22 , B30B15/0011 , C04B41/5022 , C04B2111/00836 , C04B41/4523 , C04B35/10 , C04B35/119 , C04B35/443 , C04B35/447
摘要： A tablet production apparatus comprising a gas generator G, a lubricant powder discharge means 51 for discharging a lubricant powder into a gas generated from the gas generator G, depending on the supply of the gas from the gas generator G, and mixing the lubricant powder with the gas in dispersed state, a lubricant application means 91 for spraying the lubricant powder discharged from the lubricant powder discharge means 51 and mixed with the gas generated from the gas generation means G in dispersed state, onto each material contacting surface of a die, an upper punch and a lower punch, and an oxygen concentration measuring means 131a for measuring the oxygen concentration of the gas existing near the lubricant application means 91. The apparatus is designed such that the amount of the gas supplied into the lubricant application means is adjusted based on the oxygen concentration measured by the oxygen concentration measuring means 131a.
摘要翻译： 一种片剂生产设备，包括气体发生器G，润滑剂粉末排出装置51，用于根据来自气体发生器G的气体的供应将润滑剂粉末排放到由气体发生器G产生的气体中，并将润滑剂粉末与 分散状态的气体，用于喷射从润滑剂粉末排出装置51排出的润滑剂粉末并将其与分散状态的气体产生装置G产生的气体混合的润滑剂施加装置91到模具的每个材料接触表面上 上冲头和下冲头，以及用于测量存在于润滑剂施加装置91附近的气体的氧浓度的氧浓度测量装置131a。 该设备被设计成使得根据由氧浓度测量装置131a测量的氧浓度来调节供应到润滑剂施加装置中的气体的量。
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公开(公告)号：US07766638B2
公开(公告)日：2010-08-03
申请号：US11808619
申请日：2007-06-12
CPC分类号： C04B41/009 , A61J3/10 , B01J2/00 , B01J2/16 , B01J2/22 , B30B15/0011 , C04B41/5022 , C04B2111/00836 , C04B41/4523 , C04B35/10 , C04B35/119 , C04B35/443 , C04B35/447
摘要： A tablet production apparatus comprising a gas generator G, a lubricant powder discharge means 51 for discharging a lubricant powder into a gas generated from the gas generator G, depending on the supply of the gas from the gas generator G, and mixing the lubricant powder with the gas in dispersed state, a lubricant application means 91 for spraying the lubricant powder discharged from the lubricant powder discharge means 51 and mixed with the gas generated from the gas generation means G in dispersed state, onto each material contacting surface of a die, an upper punch and a lower punch, and an oxygen concentration measuring means 131a for measuring the oxygen concentration of the gas existing near the lubricant application means 91. The apparatus is designed such that the amount of the gas supplied into the lubricant application means is adjusted based on the oxygen concentration measured by the oxygen concentration measuring means 131a.
摘要翻译： 一种片剂生产设备，包括气体发生器G，润滑剂粉末排出装置51，用于根据来自气体发生器G的气体的供应将润滑剂粉末排放到由气体发生器G产生的气体中，并将润滑剂粉末与 分散状态的气体，用于喷射从润滑剂粉末排出装置51排出的润滑剂粉末并将其与分散状态的气体产生装置G产生的气体混合的润滑剂施加装置91到模具的每个材料接触表面上 上冲头和下冲头，以及用于测量存在于润滑剂施加装置91附近的气体的氧浓度的氧浓度测量装置131a。该设备被设计成使得供应到润滑剂施加装置中的气体的量被调整 关于由氧浓度测量装置131a测量的氧浓度。
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3.发明授权Spray for spraying powdered material activated by pulsating vibration air and method 失效用于喷雾通过脉动振动空气激活的粉末材料的喷雾器和方法
公开(公告)号：US5996902A
公开(公告)日：1999-12-07
申请号：US878944
申请日：1997-06-19
IPC分类号： B65B1/16 , A61J3/06 , B01J2/02 , B01J2/18 , B01J4/02 , B05B7/14 , B30B15/00 , B65G53/40 , B05B17/04
CPC分类号： B05B7/1445 , B01J2/02 , B01J2/18 , B30B15/0011
摘要： A sprayer and method for spraying powdered material activated by pulsating vibration air. The sprayer comprises an elastic membrane, a storage tank for storing powdered material provided with the elastic membrane at the bottom opening, and a pulsating vibration air generator for supplying pulsating vibration air to the elastic membrane. The sprayer so constructed is designed to uniformly and diffusely spray the powdered material stored in the storage tank when the elastic membrane is forcedly vibrated up and down in compliance with the frequency of the pulsating vibration air by receiving pulsating vibration air from the pulsating vibration air generator.
摘要翻译： 一种用于喷射通过脉动振动空气激活的粉末材料的喷雾器和方法。 喷雾器包括弹性膜，用于储存在底部开口处设置有弹性膜的粉末材料的储罐和用于向弹性膜供应脉动振动空气的脉动振动空气发生器。 这样构造的喷雾器被设计成当弹性膜通过从脉动振动空气发生器接收到脉动的振动空气而与脉动振动空气的频率一致地上下强制地振动时，均匀地并且漫射喷射存储在储罐中的粉末材料 。
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公开(公告)号：US06776361B1
公开(公告)日：2004-08-17
申请号：US10019936
申请日：2002-04-24
IPC分类号： A02C1504
CPC分类号： B30B15/0011 , B05B7/1404 , B05B7/144
摘要： A powdered material spraying device comprising a quantitative spraying device provided for a material discharge port of the powdered material storage hopper via a material feed valve, a cover being provided for the material feed port of the powdered material storage hopper. The spraying device includes a cylindrical body connected with the material discharge port of the powdered material storage hopper, an elastic membrane with a penetrating aperture provided so as to form a bottom of the cylindrical body at its lower opening end, and a dispersion chamber connected under the lower opening end of the cylindrical body via the elastic membrane. The dispersion chamber has a pulsating vibration air supply port for supplying a positive pulsating vibration air to the dispersion chamber and a discharge port. A bypass pipe is connected between the cylindrical body and the dispersion chamber and the powdered material is sprayed from a tip end of a conduit connected with the discharge port of the dispersion chamber.
摘要翻译： 一种粉末喷涂装置，其特征在于，包括：定量喷射装置，其经由供料阀设置在所述粉料储存料斗的排料口上，为所述粉料储存料斗的料料供给口设置盖。 喷射装置包括与粉料储存料斗的材料排出口连接的圆柱体，具有穿孔的弹性膜，其设置成在其下开口端形成圆柱体的底部，并且分隔室连接在 圆柱体的下开口端经由弹性膜。 分散室具有用于向分散室和排出口供给正脉动振动空气的脉动振动空气供给口。 旁通管连接在圆柱体和分散室之间，并且粉末材料从与分散室的排出口连接的导管的末端喷射。
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公开(公告)号：US07237571B2
公开(公告)日：2007-07-03
申请号：US10492535
申请日：2002-10-25
CPC分类号： B06B1/20 , F15B21/125 , Y10T137/86405 , Y10T137/86421
摘要： A pulsating vibration air generation apparatus capable of sharply and quickly controlling air flow in turning on and off operation, thereby generating a pulsating vibration air with sharp and hardly attenuated peak and valley, and capable of operation without occurrence of so much mechanical vibration. The pulsating vibration air generation apparatus is comprised of a main body having a tubular hollow space R2 with which two air communication ports are associated, and a rotary body situated for rotation in the tubular hollow space R2 and which has a peripheral side surface S4c so as to slide on the inner surface S2c forming the tubular hollow space R2.
摘要翻译： 一种脉动振动空气产生装置，其能够在打开和关闭操作中快速和快速地控制空气流动，从而产生具有锐利且几乎不衰减的峰谷的脉动振动空气，并且能够在没有发生太多机械振动的情况下进行操作。 脉动振动空气产生装置包括：主体，其具有两个空气连通口连接的管状中空空间R 2;以及旋转体，其位于管状中空空间R 2中，并且具有周向侧面S 以便在形成管状中空空间R 2的内表面S 2 c上滑动。
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公开(公告)号：US06764695B1
公开(公告)日：2004-07-20
申请号：US09806761
申请日：2001-04-03
申请人： Yasushi Watanabe , Kiyoshi Morimoto , Yuji Iwase
发明人： Yasushi Watanabe , Kiyoshi Morimoto , Yuji Iwase
IPC分类号： A61K920
CPC分类号： B30B15/0011 , A61K9/282
摘要： A tablet including active substance affected by lubricant, wherein the tablet is comprised of compressed mixture of active substance and adjuvant except for lubricant, and lubricant exists only on the surface of the tablet but is not included in the tablet. Such a tablet production method comprising the steps of producing mixture of active substance affected by lubricant and adjuvant, mixing lubricant powder with positive pulsating vibration air for dispersion, spraying the lubricant powder dispersed by the positive vibration air on a lower surface of an upper punch, an upper surface of a lower punch and an inner circumferential wall of a die, and tabletting the mixture by means of the upper and lower punches and the die.
摘要翻译： 包含受润滑剂影响的活性物质的片剂，其中片剂由活性物质和辅助剂的压缩混合物组成，除了润滑剂，润滑剂仅存在于片剂的表面上，但不包括在片剂中。 这样的片剂的制造方法，其特征在于，包括：将由润滑剂和助剂影响的活性物质的混合物混合，将润滑剂粉末与用于分散的正脉动振动空气混合，将由正振动空气分散的润滑剂粉末喷洒在上冲头的下表面上， 下冲头的上表面和模具的内周壁，并且通过上下冲头和模具对混合物进行压片。
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公开(公告)号：US06062826A
公开(公告)日：2000-05-16
申请号：US713128
申请日：1996-09-16
IPC分类号： B06B1/12 , B06B1/14 , F16K31/524 , F04B49/00
CPC分类号： F16K31/52408 , Y10T74/18296
摘要： A pulsating vibration air generator in which wave height, frequency and wave shape of the pulsating vibration air can be optionally modified and such pulsating vibration air can be periodically and continuously emitted. The pulsating vibration air generator has a valve chamber with an inlet port and an outlet port where a valve plug and a valve seat with a control opening are provided and a cam mechanism which moves the valve plug to open or close the opening of the valve seat, whereby positive or negative pulsating vibration air is emitted from the outlet port while pressurized air is supplied into the inlet port or air is sucked from the inlet port.
摘要翻译： 脉动振动空气发生器可以可选地改变脉动振动空气的波浪高度，频率和波形，并且可以周期性地连续地发射这种脉动的振动空气。 脉动振动空气发生器具有带有入口和出口的阀室，其中设置有阀塞和具有控制开口的阀座，以及凸轮机构，其使阀塞移动以打开或关闭阀座的开口 从而当加压空气被供给到入口或从入口吸入空气时，从出口端口发出正或负脉动的振动空气。
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8.发明授权Mixing method of powdered or granular material utilizing pulsating vibration air 失效使用脉动振动空气的粉末或颗粒材料的混合方法公开(公告)号：US06302573B1
公开(公告)日：2001-10-16
申请号：US09289556
申请日：1999-04-12
IPC分类号： B01F1302
CPC分类号： B01F13/0266 , B01F3/18 , B65G53/22
摘要： A mixing and blending method for powdered or granular material includes supplying pulsating vibration air into an airtight tank from a bottom thereof. An airtight tank having a porous bottom plate on which the material is stored is provided for the mixing and blending method. In the system pulsating vibration air is generated by periodically increasing and decreasing the amount of blowing air at a low frequency. Pulsating vibration air is introduced into the airtight tank from the bottom of the airtight tank so as to generate air flow going upward through the porous bottom of the airtight tank. As a result, powdered or granular material stored on the porous bottom plate in the airtight tank is uniformly mixed and blended in the airtight tank while continuously moving up and down as in a convectional manner.
摘要翻译： 用于粉末或颗粒材料的混合和混合方法包括将脉动振动空气从其底部供应到气密罐中。 提供了一种具有多孔底板的密封罐，其上储存有材料用于混合和混合方法。 在该系统中，通过周期性地增加和减少低频吹送空气的量来产生脉动振动空气。 脉动振动空气从密封罐的底部引入密封罐中，以产生向上通过密封罐的多孔底部的空气流。 结果，将保存在密封罐中的多孔底板上的粉状或颗粒状材料均匀地混合并混合在密封罐中，同时以对流方式连续上下移动。
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公开(公告)号：US08357396B2
公开(公告)日：2013-01-22
申请号：US13282271
申请日：2011-10-26
申请人： Motohiro Ohta , Eiji Hayakawa , Kunio Ito , Sanji Tokuno , Kiyoshi Morimoto , Yasushi Watanabe
发明人： Motohiro Ohta , Eiji Hayakawa , Kunio Ito , Sanji Tokuno , Kiyoshi Morimoto , Yasushi Watanabe
IPC分类号： A61K9/20
CPC分类号： A61K9/2095 , A61J3/10 , A61K9/0056 , A61K9/2018 , A61K9/2027
摘要： An intrabuccally rapidly disintegrating tablet which is manufactured by a simple method, has an enough practical hardness and is rapidly disintegrated in the buccal cavity and its production method. The intrabuccally rapidly disintegrating tablet is produced by growing a powder material into a granulated material with a fixed particle diameter, the powder material including a sugar alcohol or a saccharide as main ingredient, each of which is first particle having an average particle diameter of not more than 30 μm, by mixing thus obtained granulated material with an active ingredient and a disintegrant, and by compressing the mixture into a predetermined shape.
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公开(公告)号：US07131828B2
公开(公告)日：2006-11-07
申请号：US10257068
申请日：2001-04-12
申请人： Yasushi Watanabe , Kiyoshi Morimoto , Yuji Iwase , Satoru Hiruta
发明人： Yasushi Watanabe , Kiyoshi Morimoto , Yuji Iwase , Satoru Hiruta
CPC分类号： B30B11/08 , B30B15/0011 , Y10T83/9423
摘要： A powder material application apparatus capable of applying powder material uniformly onto lower surfaces of plural upper punches, upper surfaces of plural lower punches and inner circumferences of plural dies of a tabletting machine. Powder material is applied on a material contacting surface of the lower punch by spraying powder material mixed with air from a powder material spray port for lower punch of a powder material application part for lower punch. Powder material is applied on a material contacting surface of the upper punch wherein powder material is not applied enough according to gravity by spraying powder material mixed with air from a powder material spray port for upper punch while the upper punch moves from an initial end to a terminal end of the powder material spray port for upper punch. The powder material spray port for upper punch is provided along the rotary orbit of the upper punches and is elongated more than the powder material spray port for lower punch.
摘要翻译： 一种粉末材料施加装置，其能够将粉末材料均匀地施加到多个上冲头的下表面，多个下冲头的上表面和压片机的多个模具的内周。 粉末材料通过喷射与空气混合的粉末材料施加在下冲头的材料接触表面上，粉末材料喷雾口用于下冲头的粉末材料施加部件的下冲头。 将粉末材料施加在上冲头的材料接触表面上，其中粉末材料根据重力不能充分施加，喷射与来自上冲头的粉末材料喷雾口的空气混合的粉末材料，同时上冲头从初始端移动到 粉末末端末端用于上冲头喷雾口。 上冲头的粉料喷射口沿着上冲头的旋转轨道设置，并且比用于下冲头的粉末喷射口更细。
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