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    Para-hydrogen labelled agents and their use in magnetic resonance imaging
    1.
    发明授权
    Para-hydrogen labelled agents and their use in magnetic resonance imaging 有权
    对位氢标记的药物及其在磁共振成像中的应用

    公开(公告)号：US06574495B1

    公开(公告)日：2003-06-03

    申请号：US09565450

    申请日：2000-05-05

    申请人： Klaes Golman ,  Oskar Axelsson ,  Haukur Johanneson ,  Charlotte Olofsson ,  Sven Mansson ,  Stefan Petersson

    发明人： Klaes Golman ,  Oskar Axelsson ,  Haukur Johanneson ,  Charlotte Olofsson ,  Sven Mansson ,  Stefan Petersson

    IPC分类号： A61B505

    CPC分类号： A61K49/06 ,  A61K49/08 ,  A61K49/10 ,  A61K49/18 ,  A61K49/1815 ,  G01R33/5601 ,  G01R33/62

    摘要： The invention provides a method of magnetic resonance investigation of a sample, said method comprising: (i) reacting para-hydrogen enriched hydrogen with a hydrogenatable MR imaging agent precursor containing a non-hydrogen non-zero nuclear spin nucleus to produce a hydrogenated MR imaging agent; (ii) administering said hydrogenated MR imaging agent to said sample; (iii) exposing said sample to radiation of a frequency selected to excite nuclear spin transitions of said non-zero nuclear spin nucleus in said hydrogenated MR imaging agent; (v) detecting magnetic resonance signals of said non-zero nuclear spin nucleus from said sample; and (vi) optionally, generating an image or biological functional data or dynamic flow data from said detected signals.

    摘要翻译： 本发明提供了一种对样品进行磁共振研究的方法，所述方法包括：（i）将富氢氢与含有非氢非零核自旋核的可氢化MR成像剂前体反应以产生氢化MR成像 代理人 （ii）将所述氢化MR成像剂施用于所述样品; （iii）将所述样品暴露于所选择的频率的辐射以激发所述氢化MR成像剂中所述非零核自旋核的核自旋跃迁; （v）从所述样品检测所述非零核自旋核的磁共振信号; 和（vi）可选地，从所述检测到的信号生成图像或生物功能数据或动态流量数据。

    Method of magnetic resonance imaging
    2.
    发明申请
    Method of magnetic resonance imaging 审中-公开
    磁共振成像方法

    公开(公告)号：US20060173283A1

    公开(公告)日：2006-08-03

    申请号：US10536480

    申请日：2003-11-27

    申请人： Oskar Axelsson ,  Klaes Golman ,  Sven Mansson ,  Stefan Petersson

    发明人： Oskar Axelsson ,  Klaes Golman ,  Sven Mansson ,  Stefan Petersson

    IPC分类号： A61B5/05

    CPC分类号： A61B5/055 ,  A61B5/7289 ,  A61K49/06

    摘要： The present invention provides methods for passive visualisation of invasive devices by employing a hyperpolarised solution of a high T1 agent having a T1 value of at least 5 seconds at a field strength in the range of 0.001-5 T and a temperature in the range of 20-40° C. Devices and instruments particularly useful for being employed in the methods are also provided as well as use of the methods in imaging, surgery and therapy.

    摘要翻译： 本发明提供了通过在0.001-5T范围内的场强和20°范围内的温度下使用具有至少5秒的T1值的高T1试剂的超极化溶液来提供侵入性装置的被动可视化的方法 -40°C。还提供了特别可用于方法中使用的装置和仪器以及成像，手术和治疗中的方法的使用。

    System and method for fast MR imaging of metabolites at selective excitation frequencies
    4.
    发明授权
    System and method for fast MR imaging of metabolites at selective excitation frequencies 有权
    选择性激发频率下代谢物MR快速成像的系统和方法

    公开(公告)号：US07952354B2

    公开(公告)日：2011-05-31

    申请号：US12719081

    申请日：2010-03-08

    申请人： Stefan Petersson ,  Sven Mansson

    发明人： Stefan Petersson ,  Sven Mansson

    IPC分类号： G01V3/00

    CPC分类号： G01R33/4828 ,  G01R33/281 ,  G01R33/446 ,  G01R33/485 ,  G01R33/5601 ,  G01R33/5614 ,  G01R33/5616 ,  G01R33/5617

    摘要： A system and method are provided for imaging multiple substances, such as contrast agents and metabolites in vivo, with selective excitation frequencies. A first substance is excited with a frequency selective pulse, then a second substance is excited with another frequency selective pulse. The signals resulting from these pulses are acquired in an order reversed from the order in which the pulses were applied. In some embodiments, more than two substances may be imaged. The system and method thus provide for quick and efficient utilization of the magnetization of multiple substances for spectral-spatial imaging.

    摘要翻译： 提供了一种系统和方法，用于以选择性激发频率对体内多种物质（如造影剂和代谢物）进行成像。 第一物质用频率选择脉冲激发，然后用另一个频率选择脉冲激发第二物质。 从这些脉冲产生的信号以与施加脉冲的顺序相反的顺序获取。 在一些实施方案中，可以对两种以上的物质进行成像。 因此，该系统和方法能够快速有效地利用多种物质的磁化来进行光谱空间成像。

    SYSTEM AND METHOD FOR FAST MR IMAGING OF METABOLITES AT SELECTIVE EXCITATION FREQUENCIES
    6.
    发明申请
    SYSTEM AND METHOD FOR FAST MR IMAGING OF METABOLITES AT SELECTIVE EXCITATION FREQUENCIES 有权
    在选择性激发频率下快速成像代谢物的系统和方法

    公开(公告)号：US20080116893A1

    公开(公告)日：2008-05-22

    申请号：US11562391

    申请日：2006-11-21

    申请人： Stefan Petersson ,  Sven Mansson

    发明人： Stefan Petersson ,  Sven Mansson

    IPC分类号： G01R33/48

    CPC分类号： G01R33/4828 ,  G01R33/281 ,  G01R33/446 ,  G01R33/485 ,  G01R33/5601 ,  G01R33/5614 ,  G01R33/5616 ,  G01R33/5617

    摘要： A system and method are provided for imaging multiple substances, such as contrast agents and metabolites in vivo, with selective excitation frequencies. A first substance is excited with a frequency selective pulse, then a second substance is excited with another frequency selective pulse. The signals resulting from these pulses are acquired in an order reversed from the order in which the pulses were applied. In some embodiments, more than two substances may be imaged. The system and method thus provide for quick and efficient utilization of the magnetization of multiple substances for spectral-spatial imaging.

    摘要翻译： 提供了一种系统和方法，用于以选择性激发频率对体内多种物质（如造影剂和代谢物）进行成像。 第一物质用频率选择脉冲激发，然后用另一个频率选择脉冲激发第二物质。 从这些脉冲产生的信号以与施加脉冲的顺序相反的顺序被获取。 在一些实施方案中，可以对两种以上的物质进行成像。 因此，该系统和方法能够快速有效地利用多种物质的磁化来进行光谱空间成像。

    METHODS FOR IN VIVO EVALUATION OF PULMONARY PHYSIOLOGY AND/OR FUNCTION USING NMR SIGNALS OF POLARIZED 129XE
    8.
    发明申请
    METHODS FOR IN VIVO EVALUATION OF PULMONARY PHYSIOLOGY AND/OR FUNCTION USING NMR SIGNALS OF POLARIZED 129XE 审中-公开
    使用极化129XE的NMR信号进行血管生成和/或功能的血管生成评估方法

    公开(公告)号：US20110104067A1

    公开(公告)日：2011-05-05

    申请号：US12987313

    申请日：2011-01-10

    申请人： Bastiaan Driehuys ,  Margaret Hall ,  Claudio Marelli ,  Sven Mansson ,  Jan Wolber

    发明人： Bastiaan Driehuys ,  Margaret Hall ,  Claudio Marelli ,  Sven Mansson ,  Jan Wolber

    IPC分类号： A61B5/055

    CPC分类号： A61K49/06 ,  A61B5/02755 ,  A61B5/055 ,  A61B5/0813 ,  A61B5/411 ,  A61B5/413 ,  G01N24/08 ,  G01R33/46 ,  G01R33/485 ,  G01R33/5601 ,  G01R33/563 ,  G01R33/56308

    摘要： In certain embodiments, methods of the present invention obtain dynamic data sets of an NMR spectroscopy signal of polarized 129Xe in a selected structure, environment, or system. The signal data can be used to evaluate: (a) the physiology of a membrane or tissue; (b) the operational condition or function of a body system or portion thereof (when at rest or under stimulation); and/or (c) the efficacy of a therapeutic treatment used to treat a diagnosed disorder, disease, or condition. Thus, the present invention provides methods for screening and/or diagnosing a respiratory, cardiopulmonary disorder or disease such as chronic heart failure, and/or methods for monitoring the efficacy of therapeutics administered to subject to treat the disorder or disease.

    摘要翻译： 在某些实施方案中，本发明的方法获得在所选结构，环境或系统中的极化129Xe的NMR光谱信号的动态数据集。 信号数据可用于评估：（a）膜或组织的生理学; （b）身体系统或其部分的运行状况或功能（休息时或刺激时）; 和/或（c）用于治疗诊断的病症，疾病或病症的治疗性治疗的功效。 因此，本发明提供了用于筛选和/或诊断呼吸，心肺病或疾病如慢性心力衰竭的方法和/或用于监测施用于受治疗疾病或疾病的治疗剂的功效的方法。