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    Efomycin G and it's use as yield promoter in animals
    2.
    发明授权
    Efomycin G and it's use as yield promoter in animals 失效
    Efomycin G，它用作动物的产量促进剂

    公开(公告)号：US4927810A

    公开(公告)日：1990-05-22

    申请号：US22915

    申请日：1987-03-06

    申请人： Klaus Frobel ,  Hartwig Muller ,  Erwin Bischoff ,  Olga Salcher ,  Anno de Jong ,  Friedrich Berschauer ,  Martin Scheer

    发明人： Klaus Frobel ,  Hartwig Muller ,  Erwin Bischoff ,  Olga Salcher ,  Anno de Jong ,  Friedrich Berschauer ,  Martin Scheer

    IPC分类号： A23K20/195 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61K35/74 ,  A61P3/00 ,  C07H7/06 ,  C07H15/26 ,  C07H17/04 ,  C12P19/12 ,  C12P19/44 ,  C12R1/465

    CPC分类号： C12R1/465 ,  C07H15/26 ,  C07H17/04 ,  C07H7/06 ,  C12P19/12 ,  Y10S435/886

    摘要： An animal growth promoter, efomycin G, is obtained by culturing Streptomycetes strain BS 1261. Efomycin G has the following properties:(a) The empirical formula: C.sub.53 H.sub.86 O.sub.18(b) The mass spectrum (fast atom bombardment) Molecular weight+Na.sup.+ : 1033(c) The .sup.1 H-nuclear magnetic resonance spectrum, stated in parts per million, shown in FIG. 1.(d) The .sup.13 C-nuclear magnetic resonance spectrum, stated in parts per million shown in FIG. 2, with chemical shifts of the CC-NMR signals as follows:______________________________________ 170.0 77.9 65.9 32.9 7.0 145.4 73.4 48.5 19.4 144.7 71.2 43.6 19.1 131.9 70.6 41.9 16.8 121.1 70.1 41.1 16.7 99.6 69.9 38.8 15.1 99.5 66.9 38.5 13.4 93.6 66.5 36.2 9.0 93.3 66.4 33.0 8.9 ______________________________________ (ppm values are relative to tetramethylsilane at 0 ppm) (e) A UV absorption maximum at 251-254 nm in methanolic solution(f) The structure according to FIG. 3.

    摘要翻译： 通过培养链霉菌菌株BS1261获得动物生长促进剂efomycin G。Efomycin G具有以下性质：（a）经验式：C53H86O18（b）质谱（快速原子轰击）分子量+ Na +：1033（ c）1H-核磁共振谱，以百万分之几表示，如图1所示。 （d）13C-核磁共振谱，以图1所示的百万分之几表示。 2，CC-NMR信号的化学位移如下：-170.0 77.9 65.9 32.9 7.0 -145.4 73.4 48.5 19.4 -144.7 71.2 43.6 19.1 -131.9 70.6 41.9 16.8 -121.1 70.1 41.1 16.7 -99.6 69.9 38.8 15.1 -99.5 66.9 38.5 13.4 -93.6 66.5 36.2 9.0 -93.3 66.4 33.0 8.9 - （ppm值相对于四甲基硅烷在0ppm） - （e）在甲醇溶液中在251-254nm处的UV吸收最大值（f）根据图1的结构。 3。

    Promoting production of useful livestock with silylated aminophenylethylamine derivatives
    4.
    发明授权
    Promoting production of useful livestock with silylated aminophenylethylamine derivatives 失效
    促进用甲硅烷基化氨基苯乙胺衍生物生产有用的家畜

    公开(公告)号：US4806667A

    公开(公告)日：1989-02-21

    申请号：US937759

    申请日：1986-12-04

    申请人： Horst Boshagen ,  Jurgen Stoltefuss ,  Friedrich Berschauer ,  Anno de Jong ,  Martin Scheer

    发明人： Horst Boshagen ,  Jurgen Stoltefuss ,  Friedrich Berschauer ,  Anno de Jong ,  Martin Scheer

    IPC分类号： A23K1/16 ,  C07F7/18 ,  C07F7/10

    CPC分类号： C07F7/1852 ,  A23K20/111

    摘要： A method for promoting production of useful livestock comprising administering to such livestock an amount effective therefor of a monosilylated aminopheylethylamine derivative of the formula ##STR1## in which X and Y are identical or different and represent hydrogen or CN,R.sup.2 represents hydrogen or methyl,R.sup.3 represents t-butyl, isopropyl, monofluoro-t-butyl or 1-cyclohexyl-ethyl, andR.sup.4, R.sup.5 and R.sup.6 denote a straight-chain or branched alkyl rdical,or a physiologically tolerated salt thereof.Those compounds wherein R.sup.3 is monofluoro-t-butyl or 1-cyclohexyl-ethyl are new, as is its intermediate ##STR2##

    摘要翻译： 一种用于促进有用牲畜生产的方法，其包括向所述家畜施用一种有效量的式“IMAGE”的单甲硅烷基化氨基乙基乙胺衍生物，其中X和Y相同或不同，代表氢或CN，R2代表氢或甲基，R3 代表叔丁基，异丙基，一氟叔丁基或1-环己基 - 乙基，R 4，R 5和R 6表示直链或支链烷基或其生理上耐受的盐。 其中R3是单氟叔丁基或1-环己基乙基的那些化合物是新的，它的中间体是“IMAGE”

    Novel arylethanolamines for promoting livestock production
    5.
    发明授权
    Novel arylethanolamines for promoting livestock production 失效
    用于促进畜牧生产的新型芳基乙醇胺

    公开(公告)号：US4845262A

    公开(公告)日：1989-07-04

    申请号：US89691

    申请日：1987-08-25

    申请人： Hans Lindel ,  Werner Hallenbach ,  Friedrich Berschauer ,  Anno de Jong ,  Martin Scheer

    发明人： Hans Lindel ,  Werner Hallenbach ,  Friedrich Berschauer ,  Anno de Jong ,  Martin Scheer

    IPC分类号： A23K1/16 ,  A61K31/135 ,  A61K31/275 ,  A61P3/00 ,  C07C67/00 ,  C07C255/58 ,  C07C255/59 ,  C07C313/00 ,  C07C315/04 ,  C07C317/48 ,  C07C317/50

    CPC分类号： C07C255/00 ,  A23K20/111

    摘要： The growth of livestock is promoted by the novel arylethanolamines of the formula ##STR1## in which R.sup.1 represents cyano,R.sup.2 represents amino, alkylamino or acylamino,R.sup.3 represents hydrogen, halogen, alkyl, halogenoalkyl, alkoxy, halogenoalkoxy, hydroxymethyl, nitro or methylsulphonylmethyl,R.sup.4 represents hydrogen, alkyl or acyl,R.sup.5 represents hydrogen or alkyl,R.sup.6 represents alkyl,n represents 1, 2 or 3,R.sup.7 represents the radicals --COR.sup.9, --O-alkylene-COR.sup.9, -alkylene-R.sup.10 or --O-alkylene-R.sup.10,R.sup.8 represents hydrogen, alkyl or halogen,R.sup.9 represents hydroxyl, alkoxy or the radical --NR.sup.11 R.sup.12,R.sup.10 represents hydroxyl, alkoxy or the radical NR.sup.11 R.sup.12,R.sup.11 represents hydrogen or alkyl, andR.sup.12 represents hydrogen or alkyl,and the physiologically acceptable salts thereof.

    摘要翻译： 通过式（I）的新型芳基乙醇胺促进家畜的生长，其中R1代表氰基，R2代表氨基，烷基氨基或酰氨基，R3代表氢，卤素，烷基，卤代烷基，烷氧基，卤代烷氧基，羟基甲基，硝基 或甲基磺酰基甲基，R 4表示氢，烷基或酰基，R 5表示氢或烷基，R 6表示烷基，n表示1,2或3，R 7表示基团-COR 9，-O-亚烷基-CON 9， - 亚烷基-R 10或-O - 亚烷基-R 10，R 8表示氢，烷基或卤素，R 9表示羟基，烷氧基或基团-NR 11 R 12，R 10表示羟基，烷氧基或基团NR 11 R 12，R 11表示氢或烷基，R 12表示氢或烷基， 其可接受的盐。

    Monosilylated aminophenylethylamine derivatives, a process for their preparation, and their use for promoting growth
    10.
    发明授权
    Monosilylated aminophenylethylamine derivatives, a process for their preparation, and their use for promoting growth 失效
    单甲基氨基苯乙胺衍生物，其制备方法及其促进生长的用途

    公开(公告)号：US4670423A

    公开(公告)日：1987-06-02

    申请号：US709624

    申请日：1985-03-08

    申请人： Horst Boshagen ,  Jurgen Stoltefuss ,  Friedrich Berschauer ,  Anno de Jong ,  Martin Scheer

    发明人： Horst Boshagen ,  Jurgen Stoltefuss ,  Friedrich Berschauer ,  Anno de Jong ,  Martin Scheer

    IPC分类号： A23K1/16 ,  A61K31/695 ,  A61P3/00 ,  C07F7/18 ,  C07F7/10

    CPC分类号： C07F7/1824

    摘要： Monosilylated aminophenylethylamine derivative of the formula ##STR1## in which X and Y each independently is hydrogen or halogen,R.sub.1 is the radical ##STR2## R.sub.2 is hydrogen or an aliphatic hydrocarbon radical having up to 10 C atoms,R.sub.3 is hydrogen, an aliphatic hydrocarbon radical which can optionally be substituted by halogen, a phenyl radical which can optionally be substituted by halogen, hydroxyl, alkyl, aryl, alkoxy, alkylthio, optionally substituted phenoxy, optionally substituted phenylthio, cyano or trifluoromethyl, or a heterocyclic radical, or, together with R.sub.2 is a nitrogen-containing saturated heterocyclic radical, andR.sub.4, R.sub.5 and R.sub.6 each independently is an alkyl radical,or physiologically tolerated salts thereof, promote the growth of animals.

    摘要翻译： 其中X和Y各自独立地是氢或卤素，R1是基团R 2是氢或具有至多10个C原子的脂族烃基，R 3是氢，脂族烃 羟基，烷基，芳基，烷氧基，烷硫基，任选取代的苯氧基，任选取代的苯硫基，氰基或三氟甲基，或杂环基，或一起为卤素取代的苯基， 其中R 2是含氮的饱和杂环基团，并且R 4，R 5和R 6各自独立地是烷基或其生理上耐受的盐，促进动物的生长。