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公开(公告)号：US4927810A
公开(公告)日：1990-05-22
申请号：US22915
申请日：1987-03-06
申请人： Klaus Frobel , Hartwig Muller , Erwin Bischoff , Olga Salcher , Anno de Jong , Friedrich Berschauer , Martin Scheer
发明人： Klaus Frobel , Hartwig Muller , Erwin Bischoff , Olga Salcher , Anno de Jong , Friedrich Berschauer , Martin Scheer
IPC分类号： A23K20/195 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61K35/74 , A61P3/00 , C07H7/06 , C07H15/26 , C07H17/04 , C12P19/12 , C12P19/44 , C12R1/465
摘要： An animal growth promoter, efomycin G, is obtained by culturing Streptomycetes strain BS 1261. Efomycin G has the following properties:(a) The empirical formula: C.sub.53 H.sub.86 O.sub.18(b) The mass spectrum (fast atom bombardment) Molecular weight+Na.sup.+ : 1033(c) The .sup.1 H-nuclear magnetic resonance spectrum, stated in parts per million, shown in FIG. 1.(d) The .sup.13 C-nuclear magnetic resonance spectrum, stated in parts per million shown in FIG. 2, with chemical shifts of the CC-NMR signals as follows:______________________________________ 170.0 77.9 65.9 32.9 7.0 145.4 73.4 48.5 19.4 144.7 71.2 43.6 19.1 131.9 70.6 41.9 16.8 121.1 70.1 41.1 16.7 99.6 69.9 38.8 15.1 99.5 66.9 38.5 13.4 93.6 66.5 36.2 9.0 93.3 66.4 33.0 8.9 ______________________________________ (ppm values are relative to tetramethylsilane at 0 ppm) (e) A UV absorption maximum at 251-254 nm in methanolic solution(f) The structure according to FIG. 3.
摘要翻译： 通过培养链霉菌菌株BS1261获得动物生长促进剂efomycin G。Efomycin G具有以下性质：（a）经验式：C53H86O18（b）质谱（快速原子轰击）分子量+ Na +：1033（ c）1H-核磁共振谱，以百万分之几表示，如图1所示。 （d）13C-核磁共振谱，以图1所示的百万分之几表示。 2，CC-NMR信号的化学位移如下：-170.0 77.9 65.9 32.9 7.0 -145.4 73.4 48.5 19.4 -144.7 71.2 43.6 19.1 -131.9 70.6 41.9 16.8 -121.1 70.1 41.1 16.7 -99.6 69.9 38.8 15.1 -99.5 66.9 38.5 13.4 -93.6 66.5 36.2 9.0 -93.3 66.4 33.0 8.9 - （ppm值相对于四甲基硅烷在0ppm） - （e）在甲醇溶液中在251-254nm处的UV吸收最大值（f）根据图1的结构。 3。
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公开(公告)号：US4845262A
公开(公告)日：1989-07-04
申请号：US89691
申请日：1987-08-25
IPC分类号： A23K1/16 , A61K31/135 , A61K31/275 , A61P3/00 , C07C67/00 , C07C255/58 , C07C255/59 , C07C313/00 , C07C315/04 , C07C317/48 , C07C317/50
CPC分类号： C07C255/00 , A23K20/111
摘要： The growth of livestock is promoted by the novel arylethanolamines of the formula ##STR1## in which R.sup.1 represents cyano,R.sup.2 represents amino, alkylamino or acylamino,R.sup.3 represents hydrogen, halogen, alkyl, halogenoalkyl, alkoxy, halogenoalkoxy, hydroxymethyl, nitro or methylsulphonylmethyl,R.sup.4 represents hydrogen, alkyl or acyl,R.sup.5 represents hydrogen or alkyl,R.sup.6 represents alkyl,n represents 1, 2 or 3,R.sup.7 represents the radicals --COR.sup.9, --O-alkylene-COR.sup.9, -alkylene-R.sup.10 or --O-alkylene-R.sup.10,R.sup.8 represents hydrogen, alkyl or halogen,R.sup.9 represents hydroxyl, alkoxy or the radical --NR.sup.11 R.sup.12,R.sup.10 represents hydroxyl, alkoxy or the radical NR.sup.11 R.sup.12,R.sup.11 represents hydrogen or alkyl, andR.sup.12 represents hydrogen or alkyl,and the physiologically acceptable salts thereof.
摘要翻译： 通过式（I）的新型芳基乙醇胺促进家畜的生长，其中R1代表氰基，R2代表氨基，烷基氨基或酰氨基，R3代表氢，卤素，烷基，卤代烷基，烷氧基，卤代烷氧基，羟基甲基，硝基 或甲基磺酰基甲基，R 4表示氢，烷基或酰基，R 5表示氢或烷基，R 6表示烷基，n表示1,2或3，R 7表示基团-COR 9，-O-亚烷基-CON 9， - 亚烷基-R 10或-O - 亚烷基-R 10，R 8表示氢，烷基或卤素，R 9表示羟基，烷氧基或基团-NR 11 R 12，R 10表示羟基，烷氧基或基团NR 11 R 12，R 11表示氢或烷基，R 12表示氢或烷基， 其可接受的盐。
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3.发明授权N-glycosylated carboxamide derivatives as growth-promoters in livestock feeding 失效N-糖基化的甲酰胺衍生物作为家畜饲养中的生长促进剂
公开(公告)号：US4680287A
公开(公告)日：1987-07-14
申请号：US665241
申请日：1984-10-26
IPC分类号： A23K1/16 , A61K31/70 , A61K31/7008 , A61K31/7024 , A61K31/7028 , A61P3/00 , C07H5/06 , C07H13/04 , C07H13/06 , C07H15/04 , C07H15/12 , C07H15/18
CPC分类号： C07H13/04 , A23K20/163 , C07H13/06 , C07H15/04 , C07H15/18
摘要： Growth of animals is promoted by inclusion in their feed of compounds of the formula ##STR1## in which Z is a glycosyl radical bonded via the anomeric carbon atom,R.sub.1 is hydrogen or an optionally substituted hydrocarbon radical having up to 30 Carbon atoms optionally interrupted by O, N or S, andR.sub.2 is hydrogen or an alkyl or aralkyl radical having up to 30 Carbon atoms optionally interrupted by O or substituted by groups containing oxygen or by halogen, with the proviso that COR.sub.1 is not an acyl group having 1-5 Carbon atoms when R.sub.2 is an alkyl group having 10-20 Carbon atoms.
摘要翻译： 动物的生长通过包含在它们的式“IMAGE”的化合物的饲料中得到促进，其中Z是通过端基异构碳原子键合的糖基，R 1是氢或任选取代的具有至多30个碳原子的烃基，任选地被 O，N或S，并且R 2是氢或具有至多30个碳原子的烷基或芳烷基，其任选被O中断或被含有氧或被卤素的基团取代，条件是COR1不是具有1-5个 当R2是具有10-20个碳原子的烷基时，碳原子。
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4.发明授权Thienooxazinones, processes for their preparation, and their use as growth promoters 失效噻吩并恶嗪酮，其制备方法及其作为生长促进剂的用途
公开(公告)号：US4760063A
公开(公告)日：1988-07-26
申请号：US929921
申请日：1986-11-12
IPC分类号： A23K1/16 , A61K31/535 , A61P15/00 , A61P15/14 , C07D333/38 , C07D333/42 , C07D333/68 , C07D333/78 , C07D498/04 , A61K31/38 , C07D265/04
CPC分类号： C07D333/38 , C07D333/68 , C07D333/78
摘要： Novel thienooxazines of the formula ##STR1## in which R.sup.1 and R.sup.2, together with the adjacent C atoms, represent an optionally substituted thiophene ring,R.sup.3 represents hydrogen, optionally substituted alkyl, cycloalkyl, alkenyl or aryl, andR.sup.4 represents optionally substituted alkyl, cycloalkyl, alkenyl or aryl, orR.sup.3 and R.sup.4, together with the adjacent nitrogen atom, form a saturated heterocyclic structure which may optionally contain further hetero atoms,promote the yield of animals, e.g. rate of growth, ratio of meat to fat, etc. They are made from new intermediates of the formulas ##STR2## in which R.sup.5 and R.sup.6 may be hydrogen or various organic radicals, or together form a ring.
摘要翻译： 式中，R1和R2与相邻的C原子一起代表任选取代的噻吩环，R3代表氢，任选取代的烷基，环烷基，烯基或芳基，R4代表任意取代的烷基，环烷基 ，烯基或芳基，或者R 3和R 4与相邻的氮原子一起形成饱和的杂环结构，其可以任选地含有另外的杂原子，促进动物的产量，例如 生长速度，肉类与脂肪的比例等。它们是由新型的中间体，其中R5和R6可以是氢或各种有机基团，或者一起形成一个环。
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公开(公告)号：US4678797A
公开(公告)日：1987-07-07
申请号：US733449
申请日：1985-05-10
申请人： Axel Ingendoh , Friedrich Berschauer , Benedikt Becker , Wilhelm Stendel , Bernhard Homeyer , Martin Scheer , Anno de Jong , Gerd Hanssler , Paul Reinecke
发明人： Axel Ingendoh , Friedrich Berschauer , Benedikt Becker , Wilhelm Stendel , Bernhard Homeyer , Martin Scheer , Anno de Jong , Gerd Hanssler , Paul Reinecke
IPC分类号： A01N43/80 , A23K1/16 , A61K31/42 , A61K31/44 , A61P3/00 , A61P33/00 , C07C67/00 , C07C209/00 , C07C211/52 , C07C239/00 , C07C239/08 , C07D261/02 , C07D317/00 , C07D413/04
CPC分类号： C07D261/02 , A01N43/80 , A23K20/137 , C07D413/04
摘要： Substituted isoxazolidines of the formula ##STR1## in which R.sup.1 represents optionally substituted alkyl, cycloalkyl, aralkyl, aryl or heteroaryl or radicals of the formula --COR.sup.4,R.sup.4 represents optionally substituted alkyl, aryl, alkoxy, alkylthio, aroxy, arylthio, amino, alkylamino, dialkylamino, arylamino, arylalkylamino, diarylamino or cycloalkylamino, or optionally substituted heterocyclic radicals which are bonded via nitrogen,R.sup.2 represents hydrogen or the radicals mentioned for R.sup.1, it being possible for R.sup.1 and R.sup.2 to be identical or different, andR.sup.3 represents optionally substituted alkyl, cycloalkyl, alkenyl, alkinyl or aryl, or saturated heterocyclic radicals, which are optionally substituted,and acid salts thereof, are pesticidally active and increase animals' utilization of feed. Intermediates therefor are also new.
摘要翻译： 取代的式“IMAGE”的异恶唑烷，其中R 1表示任选取代的烷基，环烷基，芳烷基，芳基或杂芳基或式-COR 4的基团，R 4表示任选取代的烷基，芳基，烷氧基，烷硫基，芳氧基，芳硫基，氨基， ，二烷基氨基，芳基氨基，芳基烷基氨基，二芳基氨基或环烷基氨基，或通过氮键合的任选取代的杂环基，R 2表示氢或R1所述的基团，R 1和R 2可以相同或不同，并且R 3表示任选取代 烷基，环烷基，烯基，炔基或芳基，或任选被取代的饱和杂环基，及其酸式盐是杀虫活性的并增加动物饲料的利用。 中间体也是新的。
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公开(公告)号：US5073369A
公开(公告)日：1991-12-17
申请号：US840638
申请日：1986-03-17
申请人： Klaus Frobel , Erwin Bischoff , Hartwig Muller , Olga Salcher , Anno De Jong , Friedrich Berschauer , Martin Scheer
发明人： Klaus Frobel , Erwin Bischoff , Hartwig Muller , Olga Salcher , Anno De Jong , Friedrich Berschauer , Martin Scheer
IPC分类号： A23K20/195 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P15/00 , A61P31/00 , A61P31/12 , C07H7/06 , C07H15/26 , C07H17/04 , C12P1/04 , C12P1/06 , C12P19/58 , C12R1/465
CPC分类号： C07H17/04 , A23K20/195 , C07H15/26 , C07H7/06 , C12P1/06 , Y10S426/807 , Y10S435/886
摘要： The present invention relates to the use of microbiologically prepared compounds and their mixtures, which are called efomycins, as performance promoters in farm animals and processes for their preparation, and furthermore new efomycins and their mixtures as new chemical compounds. The invention also relates to microorganisms which can be used for the preparation of the efomycins and their mixtures.
摘要翻译： 本发明涉及微生物制备的化合物及其混合物，其被称为efomycins，作为农场动物中的性能促进剂及其制备方法，此外还涉及新的efomycins及其混合物作为新的化合物。 本发明还涉及可用于制备efomycins及其混合物的微生物。
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7.发明授权Promoting production of useful livestock with silylated aminophenylethylamine derivatives 失效促进用甲硅烷基化氨基苯乙胺衍生物生产有用的家畜
公开(公告)号：US4806667A
公开(公告)日：1989-02-21
申请号：US937759
申请日：1986-12-04
CPC分类号： C07F7/1852 , A23K20/111
摘要： A method for promoting production of useful livestock comprising administering to such livestock an amount effective therefor of a monosilylated aminopheylethylamine derivative of the formula ##STR1## in which X and Y are identical or different and represent hydrogen or CN,R.sup.2 represents hydrogen or methyl,R.sup.3 represents t-butyl, isopropyl, monofluoro-t-butyl or 1-cyclohexyl-ethyl, andR.sup.4, R.sup.5 and R.sup.6 denote a straight-chain or branched alkyl rdical,or a physiologically tolerated salt thereof.Those compounds wherein R.sup.3 is monofluoro-t-butyl or 1-cyclohexyl-ethyl are new, as is its intermediate ##STR2##
摘要翻译： 一种用于促进有用牲畜生产的方法，其包括向所述家畜施用一种有效量的式“IMAGE”的单甲硅烷基化氨基乙基乙胺衍生物，其中X和Y相同或不同，代表氢或CN，R2代表氢或甲基，R3 代表叔丁基，异丙基，一氟叔丁基或1-环己基 - 乙基，R 4，R 5和R 6表示直链或支链烷基或其生理上耐受的盐。 其中R3是单氟叔丁基或1-环己基乙基的那些化合物是新的，它的中间体是“IMAGE”
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公开(公告)号：US4863939A
公开(公告)日：1989-09-05
申请号：US80284
申请日：1987-07-30
IPC分类号： C07D213/84 , A23K20/132 , A61K31/44 , A61K31/4402 , A61K31/4412 , A61K31/4418 , A61P15/00 , C07D213/36 , C07D213/38 , C07D213/61 , C07D213/70 , C07D213/72 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/79 , C07D213/81
CPC分类号： C07D213/73 , A23K20/132 , C07D213/38 , C07D213/61
摘要： The growth of livestock is promoted by the new compounds of the formula ##STR1## in which R.sup.1 represents hydrogen, alkyl, halogen, halogenoalkyl, hydroxyl, cyano, alkoxycarbonyl, aminocarbonyl, mono- and dialkylaminocarbonyl, alkoxy, halogenoalkoxy, halogenoalkylthio or NHSO.sub.2 -alkyl,R.sup.2 represents hydrogen, hydroxyl, alkoxy or the --NR.sup.11 R.sup.12 radical,R.sup.3 represents the radicals mentioned in the case of R.sup.1R.sup.4 represents hydroxyl, acyloxy or alkoxy,R.sup.5 represents hydrogen or alkyl,R.sup.6 represents hydrogen or alkyl,R.sup.7 represents hydrogen or alkyl,R.sup.8 represents hydrogen or alkyl,X represents C.sub.1 -C.sub.10 -alkylene or a direct bond,Y represents oxygen or a direct bond,R.sup.9 represents hydrogen, C.sub.1 -C.sub.10 -alkyl which is optionally substituted by hydroxyl, alkoxy, acyloxy or the --NR.sup.13 R.sup.14 radical, or represents the COR.sup.15 radical or the O--Z--R.sup.16 radical,Z represents C.sub.1 -C.sub.10 -alkylene, C.sub.1 -C.sub.10 -alkenylene or C.sub.1 -C.sub.10 -alkinylene,R.sup.10 represents hydrogen, halogen, alkyl, alkoxy, hydroxyl or the COR.sup.15 radical,R.sup.11 represents hydrogen or alkyl,R.sup.12 represents hydrogen, alkyl, halogenoalkyl or acyl,R.sup.13 represents hydrogen, optionally substituted alkyl or optionally substituted aryl,R.sup.14 represents the radicals mentioned in the case of R.sup.13,R.sup.15 represents hydroxyl, alkoxy or the NR.sup.13 R.sup.14 radical, andR.sup.16 represents hydroxyl, alkoxy, acyloxy, the NR.sup.13 R.sup.14 radical or the COR.sup.15 radical,and the physiologically acceptable salts and N-oxides thereof. Several new intermediates are also disclosed.
摘要翻译： 新型化合物“IMAGE”促进了家畜的生长，其中R1代表氢，烷基，卤素，卤代烷基，羟基，氰基，烷氧基羰基，氨基羰基，一烷基氨基羰基和二烷基氨基羰基，烷氧基，卤代烷氧基，卤代烷硫基或NHSO2-烷基 ，R 2表示氢，羟基，烷氧基或-NR 11 R 12基团，R 3表示在R 4表示羟基，酰氧基或烷氧基的情况下提及的基团，R 5表示氢或烷基，R 6表示氢或烷基，R 7表示氢或烷基， R8表示氢或烷基，X表示C1-C10-亚烷基或直接键，Y表示氧或直接键，R9表示氢，任选被羟基，烷氧基，酰氧基或-NR13R14基团取代的C1-C10-烷基 ，或表示COR15基团或OZ-R16基团，Z表示C1-C10-亚烷基，C1-C10亚烯基或C1-C10亚烯基，R10表示氢，卤素，烷基，烷氧基，羟基或COR15基，R11 代理人 R12表示氢，烷基，卤代烷基或酰基，R13表示氢，任选取代的烷基或任选取代的芳基，R 14表示在R 13的情况下提及的基团，R 15表示羟基，烷氧基或NR 13 R 14基，R 16 表示羟基，烷氧基，酰氧基，NR 13 R 14基或COR 15基，及其生理上可接受的盐和N-氧化物。 还披露了几个新的中间体。
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公开(公告)号：US4847291A
公开(公告)日：1989-07-11
申请号：US884709
申请日：1986-07-11
IPC分类号： A23K1/16 , A23K1/18 , A61K31/135 , A61P3/00 , C07C67/00 , C07C239/00 , C07C239/12 , C07C291/02 , C07C291/04 , C07D211/58 , C07D241/06
CPC分类号： C07C291/02 , A23K20/111 , A23K20/116 , A23K50/30
摘要： Aryl ethanol-hydroxylamines of the formula ##STR1## in which Ar represents aryl or heteroaryl, each of which can optionally be substituted, andR represents alkyl, aryl, aralkyl, heteroaryl, heteroaralkyl or cycloalkyl, each of which can optionally be substituted,or physiologically tolerated salts thereof, exhibit animal growth-promoting properties. Intermediates therefor of the formula ##STR2## with the exception of phenyl and p-bromophenyl, are also new.
摘要翻译： 其中Ar表示芳基或杂芳基，其各自可任选被取代，R代表烷基，芳基，芳烷基，杂芳基，杂芳烷基或环烷基，其中每一个可任选被取代;或 其生理上耐受的盐具有动物生长促进特性。 除了苯基和对溴苯基之外，具有式“IMAGE”的中间体也是新的。
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公开(公告)号：US4770876A
公开(公告)日：1988-09-13
申请号：US89390
申请日：1987-08-25
申请人： Erwin Bischoff , Hartwig Muller , Olga Salcher , Friedrich Berschauer , Martin Scheer , Anno de Jong , Klaus Frobel
发明人： Erwin Bischoff , Hartwig Muller , Olga Salcher , Friedrich Berschauer , Martin Scheer , Anno de Jong , Klaus Frobel
IPC分类号： C07G11/00 , A23K20/195 , C12P1/06 , C12R1/465 , A61K35/74
CPC分类号： C12P1/06
摘要： Promoting the growth of animals with a novel compound, named annomycin, by cultivation of Streptomyces strain BS 572, DSM 3817.
摘要翻译： 通过培养Streptomyces菌株BS 572，DSM 3817，通过新型化合物（称为环孢霉素）促进动物的生长。
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