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    Method and compositions for RNA interference
    2.
    发明申请
    Method and compositions for RNA interference 审中-公开
    RNA干扰的方法和组成

    公开(公告)号：US20060078902A1

    公开(公告)日：2006-04-13

    申请号：US11105594

    申请日：2005-04-14

    申请人： Michaeline Bunting ,  Knut Madden ,  Adam Harris

    发明人： Michaeline Bunting ,  Knut Madden ,  Adam Harris

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6897 ,  C12N15/111 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2320/11 ,  C12N2330/30

    摘要： The invention provides methods and compositions related to the field of gene expression regulation. In particular, methods and compositions of the invention can be used to identify RNAi cleavage sites along a target RNA molecule. Methods and compositions of the invention may also be used to knockdown expression of nucleic acid molecules which encode reporters.

    摘要翻译： 本发明提供了与基因表达调控领域相关的方法和组合。 特别地，本发明的方法和组合物可用于鉴定沿靶RNA分子的RNAi切割位点。 本发明的方法和组合物也可用于敲低编码报道子的核酸分子的表达。

    Rewarding classes of purchasers
    5.
    发明授权
    Rewarding classes of purchasers 有权

    公开(公告)号：US10325266B2

    公开(公告)日：2019-06-18

    申请号：US12473668

    申请日：2009-05-28

    申请人： Adam Harris

    发明人： Adam Harris

    IPC分类号： G06Q30/02 ,  G06Q30/00

    摘要： Rewarding a first classification of purchasers of digital media is provided. Such a classification may include initial purchasers (e.g., purchasers of new items) and secondary purchasers (e.g., purchasers of previously used items). A digital medium is played on a digital device and a notification is sent to a server. The server identifies the user of the digital device based on a unique device identifier associated with the digital device and a stored association of that digital device with the user. The user is determined to belong to the first classification of purchasers of the digital medium based on a unique identifier associated with the digital medium. The user, belonging to the first classification of purchasers, is provided with access to a reward that is not generally accessible to users belonging to a second classification. Users that are identified as belonging to the second classification may be offered a chance to upgrade their classification and access the reward.

    Hand-Held Fetal Head Elevator
    6.
    发明申请
    Hand-Held Fetal Head Elevator 审中-公开
    手持式胎垫电梯

    公开(公告)号：US20170065298A1

    公开(公告)日：2017-03-09

    申请号：US15257500

    申请日：2016-09-06

    申请人： Adam Harris ,  Anu Alturu ,  Sandeep Ganji ,  Elizabeth Carstens ,  Daniel Walk

    发明人： Adam Harris ,  Anu Alturu ,  Sandeep Ganji ,  Elizabeth Carstens ,  Daniel Walk

    IPC分类号： A61B17/44 ,  A61B5/00 ,  A61B5/03 ,  A61B5/145 ,  A61B5/024 ,  A61B8/00

    CPC分类号： A61B17/442 ,  A61B5/02411 ,  A61B5/4362 ,  A61B8/02 ,  A61B90/30 ,  A61B2017/00022 ,  A61B2017/00035 ,  A61B2017/00039 ,  A61B2017/00115 ,  A61B2017/445 ,  A61B2090/065

    摘要： A surgical device, and related method to aid in delivery by vaginal or cesarean section delivery to dislodge the fetal head when it has become wedged in the birth canal is provided. The device has a body and a handle for an operator to hold and brace against the mother, and a head plate with an inflatable bladder for gently applying force to the fetal head. The head plate is inserted into the birth canal and the bladder is filled with air or biocompatible fluid. The combination of insertion and inflation gently elevates the fetal head out of the birth canal into the pelvis to facilitate repositioning or extraction of the fetus. The device may have an adjustable neck to accommodate different anatomies and scenarios. The device may have sensors to monitor the health of both the neonate and the mother and to aid in the operation of the device.

    摘要翻译： 提供了外科手术装置和相关方法，以帮助通过阴道或剖宫产输送以在胎头已经楔入产道时移除胎头。 该装置具有用于操作者握住和支撑母体的主体和手柄，以及具有用于轻轻地对胎头施加力的可充气囊的头板。 头板插入产道，膀胱充满空气或生物相容的液体。 插入和通气的组合轻轻地将胎头从产道中提升到骨盆中，以便于重新定位或提取胎儿。 该装置可以具有可调整的颈部以适应不同的解剖结构和情况。 该装置可以具有用于监测新生儿和母亲的健康的传感器，并且有助于装置的操作。

    SHARING AND LENDING OF DIGITAL CONTENT
    7.
    发明申请
    SHARING AND LENDING OF DIGITAL CONTENT 有权
    数据内容的共享和借用

    公开(公告)号：US20110314560A1

    公开(公告)日：2011-12-22

    申请号：US13220157

    申请日：2011-08-29

    申请人： Adam Harris

    发明人： Adam Harris

    IPC分类号： G06F21/24

    CPC分类号： G06F21/10 ,  G06Q30/02

    摘要： An individual may wish to make a gift of digital media to a designated recipient. The digital media may be previously purchased by the individual or may be new, unused digital media purchased specifically as a gift for the recipient. The sender of the gift sends a gift notification. The sender is then verified to ensure that the sender is authorized to make the gift by matching an identifier of the digital media with an identifier associated with the sender. The digital media may be associated with a set of rights and privileges. Further rights and privileges associated with the digital media may be offered to the recipient.

    摘要翻译： 个人可能希望向指定的收件人发送数字媒体的礼物。 数字媒体可以由个人先前购买，或者可以是专门作为接收者的礼物购买的新的未使用的数字媒体。 礼物的发件人发送礼物通知。 然后验证发送者以确保发送者被授权通过将数字媒体的标识符与与发送者相关联的标识符进行匹配来制作礼物。 数字媒体可能与一组权限和权限相关联。 与数字媒体相关的进一步的权利和特权可以提供给接收者。

    Managing Gifts of Digital Media
    8.
    发明申请
    Managing Gifts of Digital Media 审中-公开
    管理数字媒体的礼物

    公开(公告)号：US20110016182A1

    公开(公告)日：2011-01-20

    申请号：US12506076

    申请日：2009-07-20

    申请人： Adam Harris

    发明人： Adam Harris

    IPC分类号： G06F15/16

    CPC分类号： G06F21/10 ,  G06Q30/02

    摘要： An individual may wish to make a gift of digital media to a designated recipient. The digital media may be previously purchased by the individual or may be new, unused digital media purchased specifically as a gift for the recipient. The sender of the gift sends a gift notification. The sender is then verified to ensure that the sender is authorized to make the gift by matching an identifier of the digital media with an identifier associated with the sender. The digital media may be associated with a set of rights and privileges. Further rights and privileges associated with the digital media may be offered to the recipient.

    摘要翻译： 个人可能希望向指定的收件人发送数字媒体的礼物。 数字媒体可以由个人先前购买，或者可以是专门作为接收者的礼物购买的新的未使用的数字媒体。 礼物的发件人发送礼物通知。 然后验证发送者以确保发送者被授权通过将数字媒体的标识符与与发送者相关联的标识符进行匹配来制作礼物。 数字媒体可能与一组权限和权限相关联。 与数字媒体相关的进一步的权利和特权可以提供给接收者。

    Automated skin biopsy device
    9.
    发明申请
    Automated skin biopsy device 审中-公开
    自动皮肤活检装置

    公开(公告)号：US20070232954A1

    公开(公告)日：2007-10-04

    申请号：US11397775

    申请日：2006-04-04

    申请人： Jeffrey Harris ,  George Houghton ,  Adam Harris

    发明人： Jeffrey Harris ,  George Houghton ,  Adam Harris

    IPC分类号： A61B10/00 ,  A61B17/32 ,  A61B17/08

    CPC分类号： A61B10/02 ,  A61B10/0266 ,  A61B17/0643 ,  A61B17/0682 ,  A61B17/076 ,  A61B17/322 ,  A61B2017/0688

    摘要： An automatic skin biopsy device that includes a drive unit and a variety of shapes and sizes of disposable cartridges. The device is capable of automatic extraction of a small and precisely located portion of skin having a shape similar to a wide canoe. A disposable cartridge is mounted onto and driven by the drive unit which incorporates at least one gear motor. In a preferred embodiment the gear motor in the drive unit drives, via gears and cams, two cutter blades in the disposable cartridge through separate curved paths to extract from the skin the generally wide canoe-shaped skin sample. Preferably another gear motor via gear and cam action produces back and forth oscillation of the blades to assure easy slicing of the skin tissue. The canoe-shape incision that is about 1 to 4 mm deep produces a good biopsy sample and the incision is easily closed with a medical staple or sutures. In preferred embodiments a stapler is provided as a part of the sample acquisition device. Materials used to fabricate the driver and the cartridge preferably transparent to permit accurate placement of the incision.

    摘要翻译： 一种自动皮肤活检装置，其包括驱动单元和各种形状和尺寸的一次性盒。 该装置能够自动提取具有类似于宽独木舟的形状的皮肤的小而精确定位的部分。 一次性盒被安装到驱动单元上并由驱动单元驱动，该驱动单元包括至少一个齿轮马达。 在优选实施例中，驱动单元中的齿轮马达通过齿轮和凸轮通过单独的弯曲路径驱动一次性筒中的两个切割刀片，以从皮肤提取通常宽的独木舟状皮肤样品。 优选地，通过齿轮和凸轮动作的另一齿轮马达产生叶片的前后振动，以确保容易地切片皮肤组织。 约1至4毫米深的独木舟形切口产生良好的活检样本，并且用医用缝合线或缝合线容易地切开切口。 在优选实施例中，提供订书机作为样本采集装置的一部分。 用于制造驾驶员和药筒的材料优选是透明的，以允许切口的准确放置。

    Peer to peer network communication
    10.
    发明申请
    Peer to peer network communication 审中-公开
    对等网络通信

    公开(公告)号：US20070150552A1

    公开(公告)日：2007-06-28

    申请号：US11708988

    申请日：2007-02-21

    申请人： Adam Harris ,  Jeremy Gordon ,  Mark Jacob

    发明人： Adam Harris ,  Jeremy Gordon ,  Mark Jacob

    IPC分类号： G06F15/16

    CPC分类号： H04L29/1233 ,  H04L29/12009 ,  H04L29/12367 ,  H04L29/12415 ,  H04L29/12471 ,  H04L41/0853 ,  H04L41/0856 ,  H04L41/0866 ,  H04L43/50 ,  H04L61/2514 ,  H04L61/2532 ,  H04L61/2553 ,  H04L69/22

    摘要： Methods and apparatus for peer to peer network communication. In one implementation, a method of communicating between a first client system and a second client system includes: discovering first address information for a first client system connected to a first network address translation device; sharing the first address information with a second client system; receiving second address information for the second client system; and establishing communication between the first client system and the second client system using the second address information.

    摘要翻译： 对等网络通信的方法和装置。 在一个实现中，在第一客户端系统和第二客户端系统之间通信的方法包括：发现连接到第一网络地址转换设备的第一客户端系统的第一地址信息; 与第二客户端系统共享第一地址信息; 接收第二客户端系统的第二地址信息; 以及使用所述第二地址信息建立所述第一客户系统和所述第二客户端系统之间的通信。