公开(公告)号：US06916410B2

公开(公告)日：2005-07-12

申请号：US10147213

申请日：2002-05-15

申请人： Koji Katsuki ,  Katsumi Hamamoto ,  Yuji Yagi ,  Takao Fukuoka

发明人： Koji Katsuki ,  Katsumi Hamamoto ,  Yuji Yagi ,  Takao Fukuoka

IPC分类号： C12Q1/00 ,  G01N27/327

CPC分类号： C12Q1/001

摘要： A biosensor is constituted by disposing an electrode system including a working electrode and a counter electrode on a substrate, forming an inorganic particulate-containing layer containing inorganic particulates thereon, and forming a reagent layer containing a reagent thereon. The inorganic particulates make it possible to prevent impurities in a sample from being in contact with the electrode system and being adsorbed therein, so that measurement is performed with high precision. The inorganic particulate-containing layer can be formed by applying a dispersion system of inorganic particulates and drying them, and it is preferable that the inorganic particulates are contained in the form of aggregates.

摘要翻译： 生物传感器通过在基板上设置包括工作电极和对电极的电极系统构成，在其上形成含有无机微粒的无机颗粒含有层，并在其上形成含有试剂的试剂层。 无机颗粒使得可以防止样品中的杂质与电极系统接触并被吸附，从而以高精度进行测量。 无机颗粒层可以通过涂布无机颗粒的分散体并进行干燥而形成，优选以聚集体的形式含有无机微粒。

公开(公告)号：US09795327B2

公开(公告)日：2017-10-24

申请号：US13377994

申请日：2010-09-13

申请人： Tomohiro Shoshihara ,  Yasunori Shiraki ,  Koji Katsuki

发明人： Tomohiro Shoshihara ,  Yasunori Shiraki ,  Koji Katsuki

IPC分类号： A61B5/05 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/00

CPC分类号： A61B5/14532 ,  A61B5/0015 ,  A61B5/14865 ,  A61B5/6805

摘要： Disclosed is a measuring device for obtaining numerical information concerning a substance present in the interstitial subcutaneous fluid, the device being equipped with a sensor unit that outputs signals in accordance with the numerical information concerning the substance and an arithmetic unit (control unit) that receives the signals outputted from the sensor unit and arithmetically processes the signals. The sensor unit is equipped with a sensor, some of which is punctured into the skin. The arithmetic unit (control unit) has been disposed so as to be separate from the sensor unit.

公开(公告)号：US08679310B2

公开(公告)日：2014-03-25

申请号：US13091325

申请日：2011-04-21

申请人： Yosuke Murase ,  Koji Katsuki

发明人： Yosuke Murase ,  Koji Katsuki

IPC分类号： G01N27/327

CPC分类号： C12Q1/001 ,  A61B5/14532 ,  A61B5/14865 ,  A61B5/7203 ,  G01N27/3274

摘要： A biosensor includes a first working electrode that a biocatalyst, which has a property that reacts on a specified ground substance, is disposed, a second working electrode that the biocatalyst, which the property is lost, is disposed, and at least one counter electrode for respectively applying a voltage to the first working electrode and the second working electrode.

摘要翻译： 一种生物传感器包括具有对规定的研磨物质进行反应的特性的生物催化剂的第一工作电极，配置有该特性丧失的生物催化剂的第二工作电极，以及至少一个对置电极 分别向第一工作电极和第二工作电极施加电压。

公开(公告)号：US08647488B2

公开(公告)日：2014-02-11

申请号：US13091325

申请日：2011-04-21

申请人： Yosuke Murase ,  Koji Katsuki

发明人： Yosuke Murase ,  Koji Katsuki

IPC分类号： G01N27/327

摘要： A biosensor includes a first working electrode that a biocatalyst, which has a property that reacts on a specified ground substance, is disposed, a second working electrode that the biocatalyst, which the property is lost, is disposed, and at least one counter electrode for respectively applying a voltage to the first working electrode and the second working electrode.

公开(公告)号：US20110174638A1

公开(公告)日：2011-07-21

申请号：US13009295

申请日：2011-01-19

申请人： Koji Katsuki

发明人： Koji Katsuki

IPC分类号： G01N27/28 ,  G01N33/48

CPC分类号： A61B5/1495 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1491 ,  A61B5/6849 ,  A61B2560/0252 ,  A61B2562/0271

摘要： A monitoring device which measures numerical value information on a subject substance in a body fluid has an electrochemical sensor including a sensor unit for detecting the subject substance which is used in the way of being embedded subcutaneously and generating an electric signal correlating to the numerical value information on the subject substance, and a temperature control unit which adjusts the detected ambient temperature as a temperature ambient to a sensor unit when detecting the subject substance so as to reach a target setting temperature when measuring the subject substance.

摘要翻译： 测量体液中的被检物质的数值信息的监视装置具有电化学传感器，其包括用于检测以皮下埋入的方式使用的被检物体的传感器单元，并产生与数值信息相关的电信号 以及温度控制单元，其在检测被检物体时将检测到的环境温度调节为传感器单元的温度环境，以便在测量被检物体时达到目标设定温度。

公开(公告)号：US20060042361A1

公开(公告)日：2006-03-02

申请号：US10533602

申请日：2003-10-30

申请人： Hideaki Yamaoka ,  Koji Katsuki

发明人： Hideaki Yamaoka ,  Koji Katsuki

IPC分类号： G01N1/40

CPC分类号： C12Q1/006 ,  C12Q1/001 ,  C12Q1/005 ,  G01N27/3272

摘要： The present invention relates to a measuring instrument (1) comprising a channel (60) for moving a sample liquid (BL) containing a solid component (B1) and providing a liquid reaction field and first and second electrodes (31, 32) which are used to apply voltage to the liquid reaction field. The first electrode (31) has an electron transfer interface (31a) for transferring electrons between it and the liquid reaction field when voltage is applied to the liquid reaction field via the first and second electrodes (31, 32). The measuring instrument (1) comprises concentrating means (51) for increasing the concentration of solid components at portions thereof which contact the electron transfer interface (31a) in the liquid reaction field. The concentrating means (51) preferably comprises a water-absorbing layer containing an absorbent polymer material.

摘要翻译： 本发明涉及一种测量仪器（1），其包括用于移动含有固体组分（B 1）并提供液体反应场的样品液体（BL）的通道（60）和第一和第二电极（31,32），所述第一和第二电极 用于向液体反应场施加电压。 当电压通过第一和第二电极（31,32）施加到液体反应场时，第一电极（31）具有用于在其与液体反应场之间转移电子的电子转移界面（31a）。 测量仪器（1）包括浓缩装置（51），用于增加在液体反应场中接触电子传递界面（31a）的部分处的固体组分的浓度。 浓缩装置（51）优选包括含有吸收性聚合物材料的吸水层。

公开(公告)号：US08784624B2

公开(公告)日：2014-07-22

申请号：US12309222

申请日：2007-07-11

申请人： Koji Katsuki ,  Konomu Hirao ,  Kenji Nagakawa ,  Masashi Okamoto ,  Yoshiaki Fujinawa

发明人： Koji Katsuki ,  Konomu Hirao ,  Kenji Nagakawa ,  Masashi Okamoto ,  Yoshiaki Fujinawa

IPC分类号： G01N27/327

CPC分类号： C12Q1/001

摘要： The present invention relates to an enzyme electrode including: a carbon particle; a metal particle held on the carbon particle, the metal particle having a catalytic activity against a redox reaction; a redox enzyme. The enzyme electrode of the present invention further includes a high-resistance particle enhancing an electrical resistance, the high-resistance particle being chemically stable. The high-resistance particle contains an inorganic substance, for example. The inorganic substance is aluminum oxide or smectite, for example.

摘要翻译： 本发明涉及一种酶电极，包括：碳粒子; 保持在碳粒子上的金属粒子，具有对氧化还原反应的催化活性的金属粒子; 一种氧化还原酶。 本发明的酶电极还包括提高电阻的高电阻粒子，高电阻粒子化学稳定。 高电阻粒子例如含有无机物质。 无机物质例如是氧化铝或绿土。

公开(公告)号：US07879211B2

公开(公告)日：2011-02-01

申请号：US10483443

申请日：2002-07-11

申请人： Koji Katsuki ,  Tetsuya Sakata ,  Yasuhide Kusaka

发明人： Koji Katsuki ,  Tetsuya Sakata ,  Yasuhide Kusaka

IPC分类号： B01J19/12 ,  C25D17/00 ,  C12M1/00 ,  C12N9/00 ,  C12N11/00 ,  C25B9/00 ,  C25B11/00 ,  C25B13/00 ,  A61B5/00 ,  A61B17/14 ,  A61B17/32 ,  B65D81/00 ,  G01N1/00 ,  G01N27/26 ,  G01N31/00 ,  G01N33/487

CPC分类号： A61B5/1486 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150213 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/1519 ,  A61B5/15194 ,  A61B5/157 ,  A61B2562/0295 ,  G01N27/3271

摘要： The present invention relates to an analyzing instrument (1A) which includes a capillary (31), a fluid feed port (20) for introducing a sample liquid to the capillary (31), and a fluid feed promoter (6) for promoting the introduction of the sample liquid into the feed port (20). The capillary (31) of the analyzer (1A) may be formed on a substrate (2) for example. The fluid feed promoter (6) may include at lease one of a water-absorbing layer having a higher water-absorbing capacity than the substrate (2) and an adhesive layer having a greater adhesion to the skin than the substrate (2).

摘要翻译： 本发明涉及一种分析仪器（1A），其包括毛细管（31），用于将样品液体引入毛细管（31）的流体供给口（20）和用于促进引入的流体促进剂（6） 的样品液体进入进料口（20）。 分析器（1A）的毛细管（31）例如可以形成在基板（2）上。 流体进料促进剂（6）可以包括至少一个具有比基材（2）更高的吸水能力的吸水层和与基材（2）相比具有更大粘合力的粘合剂层。

公开(公告)号：US20100187107A1

公开(公告)日：2010-07-29

申请号：US12309222

申请日：2007-07-11

申请人： Koji Katsuki ,  Konomu Hirao ,  Kenji Nagakawa ,  Masashi Okamoto ,  Yoshiaki Fujinawa

发明人： Koji Katsuki ,  Konomu Hirao ,  Kenji Nagakawa ,  Masashi Okamoto ,  Yoshiaki Fujinawa

IPC分类号： G01N27/26

CPC分类号： C12Q1/001

摘要： The present invention relates to an enzyme electrode including: a carbon particle; a metal particle held on the carbon particle, the metal particle having a catalytic activity against a redox reaction; a redox enzyme. The enzyme electrode of the present invention further includes a high-resistance particle enhancing an electrical resistance, the high-resistance particle being chemically stable. The high-resistance particle contains an inorganic substance, for example. The inorganic substance is aluminum oxide or smectite, for example.

摘要翻译： 本发明涉及一种酶电极，包括：碳粒子; 保持在碳粒子上的金属粒子，具有对氧化还原反应的催化活性的金属粒子; 一种氧化还原酶。 本发明的酶电极还包括提高电阻的高电阻粒子，高电阻粒子化学稳定。 高电阻粒子例如含有无机物质。 无机物质例如是氧化铝或绿土。

公开(公告)号：US07537684B2

公开(公告)日：2009-05-26

申请号：US10522394

申请日：2003-07-23

申请人： Yoshiharu Sato ,  Koji Katsuki

发明人： Yoshiharu Sato ,  Koji Katsuki

IPC分类号： G01N27/327

CPC分类号： G01N27/3274

摘要： This invention relates to a technique for analyzing a sample. A sample analyzer (1) provided by the invention includes: a voltage applier (12) for applying a voltage to a reaction field which includes a sample; a response measurer (13) for measurement of a response to the voltage applied to the reaction field; a selector (11) for selecting a first voltage application state for measurement of a first response for use in calculation necessary for analyzing the sample or a second voltage application state for measurement of a second response for use in determining whether or not the reaction field has been supplied with a target amount of the sample; an arithmetic operator (17) for calculation necessary for analyzing the sample based on the first response; a determiner (17) for determination, based on the second response, on whether or not the reaction field has been supplied with the target amount of sample; and a controller (15) which makes the selector select the second voltage application state after making the selector select the first voltage application state.

摘要翻译： 本发明涉及一种用于分析样品的技术。 本发明提供的样品分析仪（1）包括：用于对包括样品的反应场施加电压的电压施加器（12）; 响应测量器（13），用于测量对施加到反应场的电压的响应; 选择器（11），用于选择用于测量用于分析样本所需的计算的第一响应的第一电压施加状态或用于确定反应场是否具有的第二响应的第二电压施加状态 已提供样品的目标量; 用于基于第一响应分析样本所需的计算的算术运算器（17）; 基于第二响应确定反应场是否已经提供了目标量的样品的确定器（17）; 以及在使选择器选择第一电压施加状态之后使选择器选择第二电压施加状态的控制器（15）。