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    Shaped chitin body
    1.
    发明授权
    Shaped chitin body 失效
    形状的几丁质体

    公开(公告)号：US4699135A

    公开(公告)日：1987-10-13

    申请号：US761260

    申请日：1985-08-01

    申请人： Kenzo Motosugi ,  Koji Kifune ,  Yasuhiko Yamaguchi ,  Yasuo Nobe ,  Hiroyuki Tanae

    发明人： Kenzo Motosugi ,  Koji Kifune ,  Yasuhiko Yamaguchi ,  Yasuo Nobe ,  Hiroyuki Tanae

    IPC分类号： A61L15/28 ,  C08L5/08 ,  D01F9/00 ,  A61F15/00

    CPC分类号： D01F9/00 ,  A61L15/28 ,  C08L5/08

    摘要： A shaped chitin body prepared by treating a shaped body of chitin with an alkali solution, such that within a dilute aqueous solution of acetic acid, the volume of said shaped chitin body will increase by a factor of at least about 10 while substantially retaining its shape. This shaped chitin body has versatile capabilities comparable to those of chitosan. A nonwoven fabric made of a fibrous chitin body is particularly effective as a wound dressing.

    摘要翻译： 通过用碱溶液处理几丁质成形体制备的成形甲壳质体，使得在乙酸的稀水溶液中，所述成形甲壳质体的体积将增加至少约10倍，同时基本保持其形状 。 这种形状的几丁质体具有与壳聚糖相当的通用能力。 由纤维状几丁质体制成的非织造织物作为伤口敷料是特别有效的。

    Method for preparation of a shaped chitin body containing a physiologically active substance
    3.
    发明授权
    Method for preparation of a shaped chitin body containing a physiologically active substance 失效
    含有生理活性物质的成形甲壳素的制备方法

    公开(公告)号：US5290752A

    公开(公告)日：1994-03-01

    申请号：US963256

    申请日：1992-10-19

    申请人： Koji Kifune ,  Kenzo Motosugi ,  Hiroyuki Tanae

    发明人： Koji Kifune ,  Kenzo Motosugi ,  Hiroyuki Tanae

    IPC分类号： A01N25/10 ,  A61K9/20 ,  C08L5/08

    CPC分类号： A61K9/205 ,  A01N25/10 ,  C08L5/08

    摘要： A shaped chitin body containing a high content of a physiologically active substance, such as a drug to be used for the cure or prevention of disease, is prepared by incorporating said physiologically active substance into a dope comprising (a) a water-insoluble chitin, (b) lithium chloride, and (c) N-methylpyrrolidone and/or dimethylacetamide, with the amount of said physiologically active substance incorporated being 0.5 wt. % or more with respect to the amount of the chitin contained in said dope, and thereafter coagulating the resulting mixture with a coagulant to obtain a shaped body.The high content of the physiologically active substance thus incorporated in the shaped chitin can be slowly released therefrom over a long period of time. The shaped-chitin of the present invention is characterized by long duration of the physiological activity of the active substance contained therein.

    摘要翻译： 通过将所述生理活性物质掺入到包含（a）不溶于水的几丁质中，制备含有高含量生理活性物质（例如用于治愈或预防疾病的药物）的成形甲壳质， （b）氯化锂，和（c）N-甲基吡咯烷酮和/或二甲基乙酰胺，其中加入的所述生理活性物质的量为0.5wt。 相对于所述涂料中所含的几丁质的量，然后用凝结剂使所得混合物凝结，得到成形体。 因此，结合在成形甲壳质中的生理活性物质的高含量可以长时间缓慢释放。 本发明的成形几丁质的特征在于其中含有活性物质的生理活性持续时间长。

    Method for producing a thermostable lipoprotein lipase from streptomyces
    5.
    发明授权
    Method for producing a thermostable lipoprotein lipase from streptomyces 失效
    从链霉菌制备热稳定性脂蛋白脂肪酶的方法

    公开(公告)号：US5232846A

    公开(公告)日：1993-08-03

    申请号：US929744

    申请日：1992-09-03

    申请人： Akira Takeda ,  Tomoko Kamei ,  Masao Kageyama ,  Kenzo Motosugi

    发明人： Akira Takeda ,  Tomoko Kamei ,  Masao Kageyama ,  Kenzo Motosugi

    IPC分类号： C12N9/20 ,  C12Q1/44

    CPC分类号： C12Q1/44 ,  C12N9/20 ,  Y10S435/906

    摘要： The present invention is directed toward a thermostable lipoprotein lipase capable of hydrolyzing triglycerides in lipoproteins to glycerol and fatty acids, a process for producing the thermostable lipoprotein lipase, and a blood triglyceride determining reagent containing the thermostable lipoprotein lipase. The thermostable lipoprotein lipase exhibits about 100% retention of the hydrolyzing activity when treated in a buffer having a pH of from bout 4 to 7 at about 60.degree. C. for about 15 minutes and a glycerol forming activity/fatty acid forming activity ratio of at least about 15%. The process comprises cultivating a thermophilic actinomycetes, particularly Streptomyces 7825 (FERM P-9983, FERM BP-2489 is cultivated to produce a thermostable lipoprotein lipase.

    摘要翻译： 本发明涉及能够将脂蛋白中的甘油三酯水解成甘油和脂肪酸的热稳定性脂蛋白脂肪酶，产生热稳定性脂蛋白脂肪酶的方法和含有热稳定性脂蛋白脂肪酶的血液甘油三酯测定试剂。 热稳定性脂蛋白脂肪酶在约60℃左右pH4〜7的缓冲液中处理约15分钟，甘油形成活性/脂肪酸形成活性比为 至少约15％。 该方法包括培养嗜热放线菌，特别是Streptomyces 7825（FERM P-9983，培养FERM BP-2489以产生热稳定性脂蛋白脂肪酶）。

    Bacillus stearothermophilus strain UK 788 and process for producing a useful enzyme
    9.
    发明授权
    Bacillus stearothermophilus strain UK 788 and process for producing a useful enzyme 失效
    嗜热脂肪芽孢杆菌菌株UK 788和生产有用酶的方法

    公开(公告)号：US4331762A

    公开(公告)日：1982-05-25

    申请号：US209097

    申请日：1980-11-21

    申请人： Hiroshi Nakajima ,  Kazuhiko Nagata ,  Masao Kageyama ,  Toyohiko Suga ,  Tadao Suzuki ,  Kenzo Motosugi

    发明人： Hiroshi Nakajima ,  Kazuhiko Nagata ,  Masao Kageyama ,  Toyohiko Suga ,  Tadao Suzuki ,  Kenzo Motosugi

    IPC分类号： C12N9/00 ,  C12N9/04 ,  C12N9/12 ,  C12N1/20

    CPC分类号： C12N9/0006 ,  C12N9/00 ,  C12N9/1258 ,  C12R1/07 ,  Y10S435/832

    摘要： Strain UK 788 (FERM-P No. 5141) that belongs to Bacillus stearothermophilus, the cell of which is longer than about 10 microns and which permits easier release of intracellular components than a type culture Bacillus stearothermophilus, IAM 11001 is disclosed. Also, a process for producing a useful enzyme selected from the group consisting of a heat-resistant polynucleotide phosphorylase, heat-resistant maleate dehydrogenase, heat-resistant glucokinase, heat-resistant glucose-6-phosphate dehydrogenase and heat-resistant pyruvate kinase by culturing such UK 788 and recovering the desired enzyme from the culture is disclosed. Since the cell of the strain UK 788 is easy to settle and its membrane is also easy to break, the useful enzymes mentioned above can be efficiently produced on an industrial scale.

    摘要翻译： 属于嗜热脂肪芽孢杆菌的菌株UK788（FERM-P编号5141），其细胞长于约10微米，并且允许比类型培养的嗜热脂肪芽孢杆菌IAM 11001更容易释放细胞内组分。 此外，通过培养生产选自耐热多核苷酸磷酸化酶，耐热马来酸脱氢酶，耐热葡萄糖激酶，耐热葡萄糖-6-磷酸脱氢酶和耐热丙酮酸激酶的有用酶的方法 公开了这样的英国788并从培养物中回收所需的酶。 由于菌株UK 788的细胞容易沉降并且其膜也易于破裂，所以上述有用的酶可以在工业规模上有效地生产。