公开(公告)号：US20110137235A1

公开(公告)日：2011-06-09

申请号：US13057858

申请日：2009-08-07

申请人： Koki Kanehira ,  Shuji Sonezaki ,  Yumi Ogami ,  Toshiaki Banzai ,  Tomomi Nakamura

发明人： Koki Kanehira ,  Shuji Sonezaki ,  Yumi Ogami ,  Toshiaki Banzai ,  Tomomi Nakamura

IPC分类号： A61M37/00 ,  C07F7/28 ,  C07F19/00 ,  C12N13/00 ,  A61K31/28 ,  A61P35/00

CPC分类号： A61K41/0033 ,  A61K31/28 ,  A61K47/6923 ,  Y10T428/2982

摘要： Provided is an ultrasonic cancer therapy accelerator comprising titanium oxide-metal complex particles showing a long-lasting antitumor effect imparted thereto while sustaining the dispersibility and catalytic activity thereof which are obtained by dispersing titanium oxide-metal complex particles in an aqueous solvent with the use of a water-soluble polymer and modifying the same with molecules containing a low-valent transition metal via linker molecules having been bound thereto without denaturing the water-soluble polymer. To the titanium oxide surface of titanium oxide-metal complex particles which have been dispersed in an aqueous solvent with the use of a water-soluble polymer, linker molecules are bound via at least one functional group selected from the group consisting of carboxyl, amino, diol, salicylate and phosphate groups followed by the modification with low-valent transition metal-containing molecules via the linker molecules. Thus, an ultrasonic cancer therapy accelerator, which comprises titanium oxide-metal complex particles showing a long-lasting antitumor effect imparted thereto while sustaining the dispersibility and catalytic activity thereof, can be provided. This ultrasonic cancer therapy accelerator, which accumulates in an affected area, can be used as a drug for therapy combined with ultrasonic irradiation.

摘要翻译： 本发明提供一种包含氧化钛 - 金属络合物颗粒的超声波治疗促进剂，其表现出赋予其持久的抗肿瘤效果，同时维持其分散性和催化活性，其通过将氧化钛 - 金属络合物颗粒分散在水性溶剂中而获得， 水溶性聚合物，并通过已经结合到其上的连接分子将其与含有低价过渡金属的分子进行改性而不变性水溶性聚合物。 通过使用水溶性聚合物分散在水性溶剂中的氧化钛 - 金属络合物颗粒的氧化钛表面，通过至少一种选自羧基，氨基， 二醇，水杨酸酯和磷酸酯基，然后通过连接分子用低价含过渡金属的分子进行修饰。 因此，可以提供包含表现出持久的抗肿瘤作用的氧化钛 - 金属络合物颗粒，同时维持其分散性和催化活性的超声波癌症治疗促进剂。 积聚在受影响区域的超声波治疗加速器可以用作与超声波照射联合治疗的药物。

公开(公告)号：US20090297620A1

公开(公告)日：2009-12-03

申请号：US12384664

申请日：2009-04-07

申请人： Koki Kanehira ,  Shuji Sonezaki ,  Yumi Ogami ,  Tomomi Nakamura ,  Toshiaki Banzai

发明人： Koki Kanehira ,  Shuji Sonezaki ,  Yumi Ogami ,  Tomomi Nakamura ,  Toshiaki Banzai

IPC分类号： A61K9/14 ,  C07K16/00 ,  A61K39/395

CPC分类号： B82Y5/00 ,  A61K47/58 ,  A61K47/60 ,  A61K47/6843 ,  A61K47/6923

摘要： Titanium oxide-antibody conjugated particles are disclosed, which are provided with selective binding ability without loss of dispersibility and catalytic activity by modifying titanium oxide conjugated particles, dispersed in a water-based solvent by a water-soluble polymer, with an antibody via a linker molecule bound without changing the nature of the water-soluble polymer. The present invention is an antitumor agent, comprising titanium oxide-antibody conjugated particles, wherein a linker molecule is bound to the titanium oxide surface of the titanium oxide conjugated particles, dispersed in a water-based solvent by a water-soluble polymer, via at least one functional group selected from a group consisting of a carboxyl group, an amino group, a diol group, a salicylic acid group, and a phosphoric acid group, and wherein the titanium oxide conjugated particles are further modified with an antibody via the linker molecule. This antitumor agent is concentrated in the affected area and can be utilized as an agent for diagnosis or for treatment in combination with ultrasonic irradiation.

摘要翻译： 公开了氧化钛 - 抗体共轭颗粒，其具有选择性结合能力，而不丧失分散性和催化活性，通过经由接头将抗体通过用水溶性聚合物改性分散在水基溶剂中的氧化钛共轭颗粒 分子结合而不改变水溶性聚合物的性质。 本发明是一种抗氧化剂 - 抗体共轭颗粒的抗肿瘤剂，其中连接分子通过水溶性聚合物通过水溶性聚合物与氧化钛共轭颗粒的氧化钛表面结合，分散在水基溶剂中 至少一个选自羧基，氨基，二醇基，水杨酸基和磷酸基的官能团，并且其中所述氧化钛共轭颗粒通过所述连接分子被抗体进一步修饰 。 该抗肿瘤药物集中在受影响的区域，可用于诊断或与超声波照射相结合的治疗剂。

公开(公告)号：US20090130050A1

公开(公告)日：2009-05-21

申请号：US11883249

申请日：2007-03-22

申请人： Koki Kanehira ,  Shuji Sonezaki ,  Yumi Ogami ,  Tomomi Nakamura

发明人： Koki Kanehira ,  Shuji Sonezaki ,  Yumi Ogami ,  Tomomi Nakamura

IPC分类号： A61K47/34 ,  C08G65/331 ,  C08F8/42 ,  B32B5/16

CPC分类号： A61N5/062 ,  A61K9/0009 ,  A61K9/167 ,  A61K33/24 ,  A61K41/0014 ,  A61K41/0019 ,  A61K41/0033 ,  A61K41/0057 ,  A61K47/54 ,  A61K47/542 ,  A61K47/548 ,  A61K47/58 ,  A61K47/59 ,  A61K47/595 ,  A61K47/60 ,  A61K47/6923 ,  A61K51/1244 ,  A61N7/00 ,  A61N2005/0661 ,  B82Y5/00 ,  C01G23/047 ,  C09C1/3676 ,  Y10T428/2982

摘要： Disclosed are titanium oxide composite particles and a dispersion of the titanium oxide composite particles, which can improve retentivity in blood and accumulation in cancer cells while satisfactorily developing the catalytic activity of titanium oxide particles to be excited upon exposure to ultrasonic waves or ultraviolet light. The titanium oxide composite particles comprise titanium oxide particles; and a nonionic hydrophilic polymer bound to the surface of the titanium oxide particles through at least one functional group selected from carboxyl-group, amino group, diol group, salicylic acid group, and phosphoric acid group. The composite particles can be rendered cytotoxic upon ultrasonic or ultraviolet irradiation to efficiently kill cells to be killed, such as cancer cells.

摘要翻译： 本发明公开了氧化钛复合粒子和氧化钛复合粒子的分散体，能够提高血液中的保持性和癌细胞中的积聚，同时令人满意地显现出在暴露于超声波或紫外线时被激发的氧化钛粒子的催化活性。 氧化钛复合颗粒包含氧化钛颗粒; 和通过选自羧基，氨基，二醇基，水杨酸基和磷酸基中的至少一个官能团与氧化钛颗粒的表面结合的非离子亲水性聚合物。 复合颗粒在超声波或紫外线照射下可以呈现细胞毒性，以有效杀死被杀死的细胞，如癌细胞。

公开(公告)号：US06472114B2

公开(公告)日：2002-10-29

申请号：US09944386

申请日：2001-09-04

申请人： Tatsuhiro Morita ,  Tomomi Nakamura ,  Rikiya Matsuo ,  Akihiko Kawahara ,  Koichi Toriyama ,  Mikio Kakui

发明人： Tatsuhiro Morita ,  Tomomi Nakamura ,  Rikiya Matsuo ,  Akihiko Kawahara ,  Koichi Toriyama ,  Mikio Kakui

IPC分类号： G03G505

CPC分类号： G03G5/0507 ,  G03G5/05 ,  G03G5/0514 ,  G03G5/0517 ,  G03G5/0525 ,  G03G5/0542 ,  G03G5/0696

摘要： An organic electrophotographic receptor comprising at least an undercoating layer, an electric charge generating layer, and an electric charge transferring layer which are laminated in said order, wherein a coating fluid 5 for forming said electric charge generating layer comprising an electric charge generating material, a binding resin, a silicon oil having a surface tension of 22 mN/m or less, and an organic solvent is stored inside a tank 4, and a photosensitive base 1 supported by a chucking device 8 is dipped into said coating tank 4 so as to form said electric charge generating layer.

摘要翻译： 一种有机电子照相受体，其至少包含底涂层，电荷产生层和电荷转移层，其按顺序层叠，其中用于形成所述电荷产生层的涂布液5包括电荷产生材料， 粘合树脂，表面张力为22mN / m以下的硅油和有机溶剂储存在罐4内，并且将由夹紧装置8支撑的感光基底1浸入所述涂布槽4中，以便 形成所述电荷产生层。

公开(公告)号：US06447965B1

公开(公告)日：2002-09-10

申请号：US09653252

申请日：2000-08-31

申请人： Tomomi Nakamura ,  Masato Miyauchi

发明人： Tomomi Nakamura ,  Masato Miyauchi

IPC分类号： G03G5047

CPC分类号： C09B67/0003 ,  C09B67/0002 ,  G03G5/0696

摘要： An electrophotographic photoreceptor highly sensitive to laser light, which is capable of forming an image without forming an interference fringe and a coating liquid for a charge generating layer for forming the same are provided, and the photoreceptor is produced with excellent coating properties and high electric characteristics at a low cost. The electrophotographic photoreceptor comprises an electroconductive support and a photosensitive layer thereon having a charge generating layer containing TiOPc as a charge generating material and having a Y value by a color measuring apparatus of 37 or less, and particularly 35 or less, and a charge transporting layer, accumulated thereon, containing a charge transporting material. In an X-ray diffraction spectrum, the TiOPc has major diffraction peaks at Bragg angles (2&thgr;±0.2°) of 7.3°, 9.4°, 9.6°, 11.6°, 13.3°, 17.9°, 24.1° and 27.2°, and in particular, the diffraction peaks at the Bragg angles (2&thgr;±0.2°) of 9.4° and 9.6° overlap each other and form a bundle of peaks, which is a maximum intensity of diffraction, and the peak at the Bragg angle (2&thgr;±0.2°of 27.2° is a second maximum intensity of diffraction. The charge generating layer is produced by using a coating liquid containing TiOPc and having a turbidity of 180 or more, particularly 200 to 350.

摘要翻译： 提供对激光器高度敏感的电子照相感光体，其能够形成图像而不形成干涉条纹，并且提供用于形成其的电荷产生层的涂布液，并且制造具有优异的涂布性能和高电特性的感光体 以低成本。 电子照相感光体包括导电载体和感光层，其上具有电荷产生层，该电荷产生层含有TiOPc作为电荷产生材料，并且通过颜色测量装置具有37以下，特别是35以下的Y值，电荷输送层 ，其上积累有电荷输送材料。 在X射线衍射光谱中，TiOPc在7.3°，9.4°，9.6°，11.6°，13.3°，17.9°，24.1°和27.2°的布拉格角（2θ±0.2°）处具有主要衍射峰， 特别地，在9.4°和9.6°的布拉格角（2θ±0.2°）处的衍射峰彼此重叠，并形成一束峰，其是最大的衍射强度，并且在布拉格角处的峰值（2θ±0.2° 27.2°的°是第二最大衍射强度，电荷产生层是通过使用含有TiOPc并且浊度为180以上，特别是200〜350的涂布液来制造的。

公开(公告)号：US20120114091A1

公开(公告)日：2012-05-10

申请号：US13291277

申请日：2011-11-08

申请人： Ryo ISHIBASHI ,  Masahisa Inagaki ,  Hideo Soneda ,  Naoya Okizaki ,  Tomomi Nakamura ,  Yoshikazu Todaka ,  Hiroaki Azuma ,  Nozomu Adachi ,  Minoru Umemoto

发明人： Ryo ISHIBASHI ,  Masahisa Inagaki ,  Hideo Soneda ,  Naoya Okizaki ,  Tomomi Nakamura ,  Yoshikazu Todaka ,  Hiroaki Azuma ,  Nozomu Adachi ,  Minoru Umemoto

IPC分类号： G21C3/07 ,  C22F1/18 ,  B21D31/00 ,  G21C3/34 ,  C23F1/00 ,  C22C16/00 ,  G21C3/336

CPC分类号： G21C3/07 ,  C21D7/08 ,  C21D2221/10 ,  C22C16/00 ,  C22F1/186 ,  G21C3/324 ,  G21C3/34 ,  Y02E30/40

摘要： Disclosed is a zirconium alloy material having high corrosion resistance regardless of thermal history during its manufacturing process. The zirconium alloy material is obtained by providing a zirconium alloy containing on the mass basis: 0.001% to 1.9% of Sn, 0.01% to 0.3% of Fe, 0.01% to 0.3% of Cr, 0.001% to 0.3% of Ni, 0.001% to 3.0% of Nb, 0.027% or less of C, 0.025% or less of N, 4.5% or less of Hf and 0.16% or less of O with the remainder being inevitable impurities and zirconium, being formed of a bulk alloy and a surface layer, in which the surface layer has a plastic strain of 3 or more or a Vickers hardness of 260 HV or more and an arithmetic mean surface roughness Ra of 0.2 μm or less.

摘要翻译： 公开了一种具有高耐腐蚀性的锆合金材料，而与制造过程中的热历史无关。 通过提供以质量计的锆合金，可以得到锆合金材料：Sn：0.001〜1.9％，Fe：0.01〜0.3％，Cr：0.01〜0.3％，Ni：0.001〜0.3％ Nb：3.0％以下，C：0.027％以下，N：0.025％以下，Hf：4.5％以下，O：0.16％以下，剩余部分是不可避免的杂质，锆由本体合金形成， 表面层的塑性应变为3以上，维氏硬度为260HV以上，算术平均表面粗糙度Ra为0.2μm以下。

公开(公告)号：US20070261764A1

公开(公告)日：2007-11-15

申请号：US11797383

申请日：2007-05-03

申请人： Tomomi Nakamura

发明人： Tomomi Nakamura

IPC分类号： H01F1/03

CPC分类号： H01F13/003 ,  H02K1/17 ,  H02K7/1166 ,  H02K15/03 ,  Y10T29/49009 ,  Y10T29/49012 ,  Y10T29/49075 ,  Y10T29/49119 ,  Y10T29/53143

摘要： A magnetization apparatus for magnetizing a magnetic material provided inside a yoke housing of a motor, which has a connector portion radially outward of the yoke housing, includes at least one pair of magnetization cores and a plurality of magnetization coils. The at least one pair of magnetization cores are provided to oppose to each other, wherein the at least one pair of magnetization cores have corresponding magnetization surfaces, which oppose to each other. The plurality of magnetization coils generate a magnetic field at the at least one pair of magnetization cores, wherein the plurality of magnetization coils magnetize the magnetic material in a state, where the yoke housing is provided between the magnetization surfaces. The at least one pair of magnetization cores defines a receiving recess therein for receiving the connector portion of the motor in the state, where the yoke housing is provided between the magnetization surfaces.

摘要翻译： 用于磁化磁性材料的磁化装置包括至少一对磁化铁芯和多个磁化线圈，该磁化装置用于磁化设置在电动机的轭架内部的磁性材料，该磁体材料具有位于磁轭外壳的径向外侧的连接器部分。 所述至少一对磁化铁芯被设置为彼此相对，其中所述至少一对磁化铁芯具有彼此相对的相应的磁化表面。 多个磁化线圈在至少一对磁化铁芯处产生磁场，其中多个磁化线圈在磁轭壳体设置在磁化表面之间的状态下磁化磁性材料。 所述至少一对磁化铁芯在其中限定了用于在所述磁轭壳体设置在所述磁化表面之间的状态下容纳所述电动机的所述连接器部分的容纳凹部。

公开(公告)号：US08815451B2

公开(公告)日：2014-08-26

申请号：US13535166

申请日：2012-06-27

申请人： Satoshi Wada ,  Isao Mugima ,  Tomomi Nakamura ,  Masaru Kihara ,  Toshiki Sato

发明人： Satoshi Wada ,  Isao Mugima ,  Tomomi Nakamura ,  Masaru Kihara ,  Toshiki Sato

IPC分类号： H01M4/02 ,  H01M10/04 ,  H01M10/12 ,  H01M2/02 ,  H01M10/42 ,  H01M10/28 ,  H01M10/0587

CPC分类号： H01M10/0422 ,  H01M2/022 ,  H01M10/0431 ,  H01M10/0587 ,  H01M10/123 ,  H01M10/125 ,  H01M10/286 ,  H01M2004/021 ,  H01M2010/4292 ,  Y02E60/12

摘要： A negative-electrode plate 22 for use in a cylindrical cell, intended to be laid over a positive-electrode plate 21 with a separator 23 interposed between and rolled to form a cylindrical electrode body 20, with the positive-electrode plate 21 inside, the electrode body being arranged in a bottomed cylindrical outer can 10 to form the cylindrical cell, comprises a first negative-electrode part 22a which is to face the positive-electrode plate 21 on either side, with the separator 23 between, when formed into the electrode body 20, and a second negative-electrode part 22b which is to form the innermost circumference of the electrode body 20 and face the positive-electrode plate 21 only on one side, with the separator 23 between, when formed into the electrode body 20, the second negative-electrode part 22b being lower in negative-electrode active material density than the first negative-electrode part 22a.

摘要翻译： 用于圆柱形电池的负电极板22，用于放置在正极板21之间，隔板23插入并卷成以形成圆柱形电极体20，其中正极板21在其内， 电极体设置在有底的圆筒形外罐10中以形成圆柱形电池，包括第一负电极部件22a，其在隔离件23形成于电极之间时在任一侧面对正极板21 主体20和第二负极部分22b，其形成电极体20的最内周并仅在一侧面对正极板21，隔板23在形成电极体20时， 第二负极部分22b的负极活性物质密度低于第一负极部分22a。

公开(公告)号：US07489413B2

公开(公告)日：2009-02-10

申请号：US10883817

申请日：2004-07-06

申请人： Yutaka Nakatsu ,  Shin Iima ,  Kayoko Ohyoshi ,  Tomomi Nakamura

发明人： Yutaka Nakatsu ,  Shin Iima ,  Kayoko Ohyoshi ,  Tomomi Nakamura

IPC分类号： G06F15/00 ,  G06K1/00

CPC分类号： H04N1/46

摘要： A video printer (1) comprises a video printer housing portion (2), and a video camera station (3) disposed on a rear upper portion of the video printer housing portion (2) and having a signal input and output connection terminal (4). A video camera (6) with a liquid-crystal display monitor (7) is electrically connected to the connection terminal (4), and attached to the video printer (1) at its video camera station (3) so that, when the video printer (1) is in use, a user can operate the video camera (6) and the video printer (1) by operating systems (8), (9) disposed on the video printer (1) while visually confirming a picture displayed on a picture screen of the liquid-crystal display monitor (7).

摘要翻译： 视频打印机（1）包括视频打印机外壳部分（2）和设置在视频打印机外壳部分（2）的后部上部并且具有信号输入和输出连接端子（4）的视频相机站（3） ）。 具有液晶显示监视器（7）的摄像机（6）电连接到连接端子（4），并在其摄像机站（3）附接到视频打印机（1），使得当视频 打印机（1）正在使用中，用户可以通过在视频打印机（1）上设置的操作系统（8），（9）来操作摄像机（6）和视频打印机（1），同时在视觉上确认显示在 液晶显示监视器（7）的画面。

公开(公告)号：US08989339B2

公开(公告)日：2015-03-24

申请号：US13291277

申请日：2011-11-08

申请人： Ryo Ishibashi ,  Masahisa Inagaki ,  Hideo Soneda ,  Naoya Okizaki ,  Tomomi Nakamura ,  Yoshikazu Todaka ,  Hiroaki Azuma ,  Nozomu Adachi ,  Minoru Umemoto

发明人： Ryo Ishibashi ,  Masahisa Inagaki ,  Hideo Soneda ,  Naoya Okizaki ,  Tomomi Nakamura ,  Yoshikazu Todaka ,  Hiroaki Azuma ,  Nozomu Adachi ,  Minoru Umemoto

IPC分类号： C22C16/00 ,  G21C3/06 ,  G21C3/32 ,  G21C3/336 ,  G21C3/07 ,  C22F1/18 ,  G21C3/324 ,  G21C3/34 ,  G21C21/00 ,  C21D7/08

CPC分类号： G21C3/07 ,  C21D7/08 ,  C21D2221/10 ,  C22C16/00 ,  C22F1/186 ,  G21C3/324 ,  G21C3/34 ,  Y02E30/40

摘要： Disclosed is a zirconium alloy material having high corrosion resistance regardless of thermal history during its manufacturing process. The zirconium alloy material is obtained by providing a zirconium alloy containing on the mass basis: 0.001% to 1.9% of Sn, 0.01% to 0.3% of Fe, 0.01% to 0.3% of Cr, 0.001% to 0.3% of Ni, 0.001% to 3.0% of Nb, 0.027% or less of C, 0.025% or less of N, 4.5% or less of Hf and 0.16% or less of O with the remainder being inevitable impurities and zirconium, being formed of a bulk alloy and a surface layer, in which the surface layer has a plastic strain of 3 or more or a Vickers hardness of 260 HV or more and an arithmetic mean surface roughness Ra of 0.2 μm or less.

摘要翻译： 公开了一种具有高耐腐蚀性的锆合金材料，而与制造过程中的热历史无关。 通过提供以质量计的锆合金，可以得到锆合金材料：Sn：0.001〜1.9％，Fe：0.01〜0.3％，Cr：0.01〜0.3％，Ni：0.001〜0.3％ Nb：3.0％以下，C：0.027％以下，N：0.025％以下，Hf：4.5％以下，O：0.16％以下，剩余部分是不可避免的杂质，锆由本体合金形成， 表面层的塑性应变为3以上，维氏硬度为260HV以上，算术平均表面粗糙度Ra为0.2μm以下。