公开(公告)号：US20190307794A1

公开(公告)日：2019-10-10

申请号：US16379523

申请日：2019-04-09

申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Yeon-Sun HONG ,  Hyo Suk Kim ,  Yoo Soo Yang ,  Sun Hwa Kim ,  In-San Kim ,  Ick Chan Kwon

IPC分类号： A61K35/15 ,  C12N5/0786 ,  C12N5/0784 ,  C12N5/0775 ,  A61K9/127 ,  C12N5/00

摘要： The present invention relates to a method of inducing trans-differentiating a first type of immune cell into a second type of immune cell comprising: isolating exosomes from the second type of immune cell that has undergone differentiation, and treating the first type of immune cell or a cell population including the first type of immune cell with the isolated exosomes in vitro.

公开(公告)号：US10130254B2

公开(公告)日：2018-11-20

申请号：US15472439

申请日：2017-03-29

申请人： Korea Institute of Science and Technology

发明人： Jae Hun Kim ,  Seok Hwan Kim ,  Ju Yeong Oh ,  Byeong Ho Park ,  Hyo Suk Kim ,  Min Ah Seo ,  Chul Ki Kim ,  Taik Jin Lee ,  Deok Ha Woo ,  Seok Lee ,  Young Min Jhon

IPC分类号： A61B3/12 ,  A61B3/10 ,  G02B27/00 ,  G02B27/28 ,  G02B26/06 ,  G02B5/30

摘要： Provided is a cell-level retinal disease detection apparatus including a light imaging means configured to emit light to an eyeball and a light processing means which receives light reflected by the eyeball and processes and compensates light for an astigmatism aberration thereof which occurs at the eyeball to compensate. Here, the light processing means includes a wavefront sensor which senses the astigmatism aberration of the reflected light which occurs due to the eyeball and a light compensation mirror which compensates the light based on the sensed astigmatism aberration, and compensates for a difference in the astigmatism aberration to detect a disease of a retina of the eyeball.