公开(公告)号：US11859169B2

公开(公告)日：2024-01-02

申请号：US17186723

申请日：2021-02-26

Applicant: Korea University Research and Business Foundation

Inventor： Hee-Min Kang ,  Chandra Khatua ,  Gun-Hyu Bae ,  Hyo-Jun Choi ,  Sun-Hong Min

IPC: C12N5/0786 ,  A61K9/51 ,  C12N13/00

CPC classification number: C12N5/0645 ,  A61K9/5115 ,  A61K9/5169 ,  C12N13/00 ,  C12N2501/998 ,  C12N2529/00

Abstract: The present invention relates to a nano-ligand for promoting cell adhesion and regeneration of macrophages and a method of promoting cell adhesion and regeneration of macrophages by using the nano-ligand. The method of promoting cell adhesion and regeneration of macrophages according to the present invention applies a magnetic field to a substrate including the nano-ligand, so that it is possible to reversely control the sliding of the nano-ligand, as well as temporally and spatially control the sliding of the nano-ligand, and efficiently control cell adhesion and phenotypic polarization of macrophages in vivo or ex vivo through the magnetic field-based spatiotemporal control.

公开(公告)号：US11828719B2

公开(公告)日：2023-11-28

申请号：US17186675

申请日：2021-02-26

Applicant: Korea University Research and Business Foundation

Inventor： Hee-Min Kang ,  Chandra Khatua ,  Gun-Hyu Bae ,  Hyo-Jun Choi ,  Sun-Hong Min

IPC: C12N5/071 ,  C12N11/14 ,  G01N27/327 ,  C07K14/705 ,  C12N5/00

CPC classification number: G01N27/3278 ,  C07K14/70546 ,  C12N5/0075 ,  C12N11/14 ,  C12N2501/40 ,  C12N2533/50 ,  G01N2203/0635

Abstract: The present invention relates to a nano-ligand for promoting cell adhesion and differentiation of stem cells and a method of promoting cell adhesion and differentiation of stem cells by using the nano-ligand, and the method of promoting cell adhesion and differentiation of stem cells according to the present invention may temporally and spatially, and reversibly control nano-ligand sliding by applying a magnetic field to a substrate including the nano-ligands, and efficiently control stem cell adhesion and differentiation ex vivo or in vivo through the magnetic-field based on spatiotemporal control.

公开(公告)号：US20230324326A1

公开(公告)日：2023-10-12

申请号：US18339108

申请日：2023-06-21

Applicant: Korea University Research and Business Foundation

Inventor： Hee-Min KANG ,  Chandra Khatua ,  Gun-Hyu Bae ,  Hyo-Jun Choi ,  Sun-Hong Min

IPC: G01N27/327 ,  C07K14/705 ,  C12N5/00 ,  C12N11/14

CPC classification number: G01N27/3278 ,  C07K14/70546 ,  C12N5/0075 ,  C12N11/14 ,  G01N2203/0635 ,  C12N2501/40 ,  C12N2533/50

Abstract: The present invention relates to a nano-ligand for promoting cell adhesion and differentiation of stem cells and a method of promoting cell adhesion and differentiation of stem cells by using the nano-ligand, and the method of promoting cell adhesion and differentiation of stem cells according to the present invention may temporally and spatially, and reversibly control nano-ligand sliding by applying a magnetic field to a substrate including the nano-ligands, and efficiently control stem cell adhesion and differentiation ex vivo or in vivo through the magnetic-field based on spatiotemporal control.