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    Sugar chain array
    3.
    发明授权
    Sugar chain array 有权
    糖链阵列

    公开(公告)号：US09310358B2

    公开(公告)日：2016-04-12

    申请号：US13812787

    申请日：2011-07-29

    申请人： Shin-Ichiro Nishimura ,  Takahiko Matsushita ,  Hideyuki Shimaoka ,  Wataru Takada ,  Kohta Igarashi ,  Midori Abe ,  Hiroki Abe ,  Masao Fukushima

    发明人： Shin-Ichiro Nishimura ,  Takahiko Matsushita ,  Hideyuki Shimaoka ,  Wataru Takada ,  Kohta Igarashi ,  Midori Abe ,  Hiroki Abe ,  Masao Fukushima

    IPC分类号： G01N33/53 ,  G01N33/543 ,  G01N33/66

    CPC分类号： G01N33/5308 ,  G01N33/54393 ,  G01N33/569 ,  G01N33/66 ,  G01N2333/42

    摘要： A sugar chain array containing a sugar chain immobilized thereon for detecting binding between an analyte and a sugar chain, and a sugar chain array having the sugar chain immobilized thereon that is capable of inhibiting non-specific adsorption and binding of an analyte without having to coat the array with an adsorption inhibitor. A specific sugar chain is immobilized on the array, and is useful for detecting binding between the sugar chain and an analyte, such as a pathogen of an infectious disease or an excretion thereof. In addition, in the array, when a base material is coated with a polymeric compound having a unit having a primary amino group, a unit for maintaining hydrophilicity, and a unit having a hydrophobic group, the sugar chain is immobilized efficiently and non-specific adsorption and binding of the analyte can be effectively inhibited.

    摘要翻译： 含有固定在其上用于检测分析物和糖链之间的结合的糖链的糖链阵列和其上固定有糖链的糖链阵列，其能够抑制分析物的非特异性吸附和结合而不必涂覆 该阵列带有吸附抑制剂。 特定的糖链固定在阵列上，并且可用于检测糖链和分析物之间的结合，例如感染性疾病的病原体或其排泄物。 此外，在阵列中，当用具有伯氨基单元的聚合化合物，保持亲水性的单元和具有疏水基团的单元涂覆基材时，糖链被有效且非特异性地固定 可以有效地抑制分析物的吸附和结合。

    SUGAR CHAIN ARRAY
    4.
    发明申请
    SUGAR CHAIN ARRAY 有权
    糖链阵列

    公开(公告)号：US20130196881A1

    公开(公告)日：2013-08-01

    申请号：US13812787

    申请日：2011-07-29

    申请人： Shin-Ichiro Nishimura ,  Takahiko Matsushita ,  Hideyuki Shimaoka ,  Wataru Takada ,  Kohta Igarashi ,  Midori Abe ,  Hiroki Abe ,  Masao Fukushima

    发明人： Shin-Ichiro Nishimura ,  Takahiko Matsushita ,  Hideyuki Shimaoka ,  Wataru Takada ,  Kohta Igarashi ,  Midori Abe ,  Hiroki Abe ,  Masao Fukushima

    IPC分类号： G01N33/53

    CPC分类号： G01N33/5308 ,  G01N33/54393 ,  G01N33/569 ,  G01N33/66 ,  G01N2333/42

    摘要： A sugar chain array containing a sugar chain immobilized thereon for detecting binding between an analyte and a sugar chain, and a sugar chain array having the sugar chain immobilized thereon that is capable of inhibiting non-specific adsorption and binding of an analyte without having to coat the array with an adsorption inhibitor. A specific sugar chain is immobilized on the array, and is useful for detecting binding between the sugar chain and an analyte, such as a pathogen of an infectious disease or an excretion thereof. In addition, in the array, when a base material is coated with a polymeric compound having a unit having a primary amino group, a unit for maintaining hydrophilicity, and a unit having a hydrophobic group, the sugar chain is immobilized efficiently and non-specific adsorption and binding of the analyte can be effectively inhibited.

    摘要翻译： 含有固定在其上用于检测分析物和糖链之间的结合的糖链的糖链阵列和其上固定有糖链的糖链阵列，其能够抑制分析物的非特异性吸附和结合而不必涂覆 该阵列带有吸附抑制剂。 特定的糖链固定在阵列上，并且可用于检测糖链和分析物之间的结合，例如感染性疾病的病原体或其排泄物。 此外，在阵列中，当用具有伯氨基单元的聚合化合物，保持亲水性的单元和具有疏水基团的单元涂覆基材时，糖链被有效且非特异性地固定 可以有效地抑制分析物的吸附和结合。

    GLYCOPEPTIDE ARRAY
    5.
    发明申请
    GLYCOPEPTIDE ARRAY 审中-公开
    糖蛋白阵列

    公开(公告)号：US20130316932A1

    公开(公告)日：2013-11-28

    申请号：US13989023

    申请日：2011-11-22

    申请人： Shin-Ichiro Nishimura ,  Takahiko Matsushita ,  Hideyuki Shimaoka ,  Wataru Takada ,  Kohta Igarashi ,  Midori Abe ,  Hiroki Abe ,  Masao Fukushima

    发明人： Shin-Ichiro Nishimura ,  Takahiko Matsushita ,  Hideyuki Shimaoka ,  Wataru Takada ,  Kohta Igarashi ,  Midori Abe ,  Hiroki Abe ,  Masao Fukushima

    IPC分类号： G01N33/68

    CPC分类号： G01N33/6845 ,  G01N33/54353 ,  G01N33/54393 ,  G01N33/6842

    摘要： The present invention provides: a glycopeptide array which is useful for the detection of the binding between a substance to be detected and a glycopeptide; and an array which can inhibit the non-specific adsorption or binding of a substance to be detected without the need of coating any adsorption-inhibiting agent and which has the glycopeptide immobilized thereon. In the present invention, it was found that a glycopeptide that has a molecule having a carbonyl group bound to a peptide moiety thereof can be immobilized on a substrate that is coated with a polymer compound containing a unit having a primary amino group with high efficiency through the carbonyl group. Particularly, it was found by the present inventors that a glycopeptide can be immobilized on a substrate with high efficiency and the non-specific adsorption or binding of a substance to be detected can be inhibited effectively when a substrate that is coated with a polymer compound containing a unit having a primary amino group, a unit for retaining hydrophilicity and a unit having a hydrophobic group is used as the substrate for the glycopeptide.

    摘要翻译： 本发明提供：糖肽阵列，其可用于检测待检测物质与糖肽之间的结合; 以及可以抑制待检测物质的非特异性吸附或结合而不需要涂覆任何吸附抑制剂并且其上固定有糖肽的阵列。 在本发明中，发现具有与其肽部分结合的具有羰基的分子的糖肽可以固定在具有高分子量的高分子化合物的基材上，所述高分子化合物通过 羰基。 特别是本发明人发现，可以高效率地将糖肽固定在基材上，并且当涂布有含高分子化合物的基材时，能够有效地抑制待检测物质的非特异性吸附或结合 使用具有伯氨基的单元，用于保持亲水性的单元和具有疏水基团的单元作为糖肽的底物。