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    Fluorous capping reagents and methods for peptide purification
    1.
    发明授权
    Fluorous capping reagents and methods for peptide purification 有权
    氟封端试剂和肽纯化方法

    公开(公告)号：US07612166B2

    公开(公告)日：2009-11-03

    申请号：US11597067

    申请日：2005-05-18

    申请人： Krishna Kumar ,  Vittorio Montanari

    发明人： Krishna Kumar ,  Vittorio Montanari

    IPC分类号： A61K38/00 ,  C07K1/00

    CPC分类号： C07K7/06 ,  C07C229/36 ,  C07C311/48 ,  C07K1/04 ,  C07K1/10 ,  C07K5/06113 ,  C07K5/1016 ,  C07K7/08

    摘要： Aspects of the present invention relate to compounds for preparing fluorocarbon compounds, methods for preparing fluorocarbon compounds, and methods for purifying a mixture of compounds. One aspect of the present invention relates to a trivalent iodonium fluorocarbon. The trivalent iodonium fluorocarbon compound of the invention is useful for attaching a fluorocarbon group to a compound that has a nucleophilic functional group. Another aspect of the present invention relates to a method of preparing a trivalent iodonium fluorocarbon. Another aspect of the present invention relates to a method of preparing a fluorocarbon by treating a compound bearing a nucleophilic functional group with a trivalent iodonium fluorocarbon compound. Another aspect of the present invention relates to a method or purifying a mixture comprising a first and a second compound by treating the mixture with a trivalent iodonium fluorocarbon to attach a fluorocarbon group to the second compound leaving the first compound unchanged, and purifying the mixture by fluorous-phase purification.

    摘要翻译： 本发明的方面涉及制备碳氟化合物的化合物，制备碳氟化合物的方法，以及化合物的混合物的纯化方法。 本发明的一个方面涉及三价碘代氟碳化合物。 本发明的三价碘氟碳化合物可用于将氟碳基团连接到具有亲核官能团的化合物上。 本发明的另一方面涉及制备三价碘代氟碳化合物的方法。 本发明的另一方面涉及通过用三价碘氟碳化合物处理带有亲核官能团的化合物来制备碳氟化合物的方法。 本发明的另一方面涉及一种方法或纯化包含第一和第二化合物的混合物，通过用三价碘代氟碳处理该混合物以将氟碳基团连接到第二化合物上，使第一化合物保持不变，并通过 氟相纯化。

    Fluorous Capping Reagents and Methods for Peptide Purification
    2.
    发明申请
    Fluorous Capping Reagents and Methods for Peptide Purification 有权
    氟封端试剂和肽纯化方法

    公开(公告)号：US20080275216A1

    公开(公告)日：2008-11-06

    申请号：US11597067

    申请日：2005-05-18

    申请人： Krishna Kumar ,  Vittorio Montanari

    发明人： Krishna Kumar ,  Vittorio Montanari

    IPC分类号： C07K1/14 ,  C07C313/04 ,  C07H1/06 ,  C07C17/00

    CPC分类号： C07K7/06 ,  C07C229/36 ,  C07C311/48 ,  C07K1/04 ,  C07K1/10 ,  C07K5/06113 ,  C07K5/1016 ,  C07K7/08

    摘要： Aspects of the present invention relate to compounds for preparing fluorocarbon compounds, methods for preparing fluorocarbon compounds, and methods for purifying a mixture of compounds. One aspect of the present invention relates to a trivalent iodonium fluorocarbon. The trivalent iodonium fluorocarbon compound of the invention is useful for attaching a fluorocarbon group to a compound that has a nucleophilic functional group. Another aspect of the present invention relates to a method of preparing a trivalent iodonium fluorocarbon. Another aspect of the present invention relates to a method of preparing a fluorocarbon by treating a compound bearing a nucleophilic functional group with a trivalent iodonium fluorocarbon compound. Another aspect of the present invention relates to a method or purifying a mixture comprising a first and a second compound by treating the mixture with a trivalent iodonium fluorocarbon to attach a fluorocarbon group to the second compound leaving the first compound unchanged, and purifying the mixture by fluorous-phase purification.

    摘要翻译： 本发明的方面涉及制备碳氟化合物的化合物，制备碳氟化合物的方法，以及化合物的混合物的纯化方法。 本发明的一个方面涉及三价碘代氟碳化合物。 本发明的三价碘氟碳化合物可用于将氟碳基团连接到具有亲核官能团的化合物上。 本发明的另一方面涉及制备三价碘代氟碳化合物的方法。 本发明的另一方面涉及通过用三价碘氟碳化合物处理带有亲核官能团的化合物来制备碳氟化合物的方法。 本发明的另一方面涉及一种方法或纯化包含第一和第二化合物的混合物，通过用三价碘代氟碳处理该混合物以将氟碳基团连接到第二化合物上，使第一化合物保持不变，并通过 氟相纯化。

    Perfluoroalkyl compounds and their methods of use and manufacture
    3.
    发明授权
    Perfluoroalkyl compounds and their methods of use and manufacture 失效
    全氟烷基化合物及其使用和制造方法

    公开(公告)号：US06794492B2

    公开(公告)日：2004-09-21

    申请号：US09817507

    申请日：2001-03-26

    申请人： Darryl DesMarteau ,  Vittorio Montanari

    发明人： Darryl DesMarteau ,  Vittorio Montanari

    IPC分类号： C07K508

    CPC分类号： C07D317/58 ,  C07B2200/07 ,  C07C229/36 ,  C07C237/20 ,  C07K5/06191 ,  C07K5/1027 ,  C07K14/001

    摘要： Fluorinated alkyl compounds may be used as reaction intermediates or reaction products in polymerizing amino acid structures into peptides. Fluorinated methyl groups have been found to be particularly useful. A compound having a fluorinated methyl group such as that set forth below: wherein R is selected from the group consisting of: alkyls, hydrogen, aryls, aromatic compounds, amines, sulfur-containing alkyl groups, sulfur-containing aryl groups, and heterocyclic compounds may be utilized alone, or reacted in combination with other amino acids, to form a dipeptide, or polypeptide.

    摘要翻译： 氟化烷基化合物可以用作将氨基酸结构聚合成肽的反应中间体或反应产物。 已经发现氟化甲基是特别有用的。 具有如下所示的氟化甲基的化合物：其中R选自：烷基，氢，芳基，芳族化合物，胺，含硫烷基，含硫芳基和杂环化合物 可单独使用或与其它氨基酸组合反应以形成二肽或多肽。

    Halogenated 1,3-dioxolanes
    4.
    发明授权
    Halogenated 1,3-dioxolanes 失效
    卤化1,3-二氧戊环

    公开(公告)号：US5235074A

    公开(公告)日：1993-08-10

    申请号：US847138

    申请日：1992-03-06

    申请人： Walter Navarrini ,  Simonetta Fontana ,  Vittorio Montanari

    发明人： Walter Navarrini ,  Simonetta Fontana ,  Vittorio Montanari

    IPC分类号： C07D317/42

    CPC分类号： C07D317/42

    摘要： This invention process for preparing 1,3-dioxolanes of formula: ##STR1## wherein; X.sub.1, X.sub.2, X.sub.3 and X.sub.4, like or different from one another, represent F, Cl, Br, I, CF.sub.2 OSO.sub.2 F, SO.sub.2 F, C(O)F, H, perhaloalkyl or oxyperhaloalkyl radicals containing from 1 to 5 carbon atoms,X.sub.5 and X.sub.6, like or different from each other, represent F or CF.sub.3. Said process is characterized in that a bis(fluoroxy)perfluoroalkane is reacted, at a temperature ranging from -140.degree. C. to +60.degree. C., with a halogenated olefin.This invention also relates to new 1,3-dioxolanes of formula (I) belonging to the class defined hereinbefore.

    摘要翻译： 本发明的制备下式的1,3-二氧戊环的方法：其中： X1，X2，X3和X4彼此相同或不同，表示含有1至5个碳原子的F，Cl，Br，I，CF 2 OSO 2 F，SO 2 F，C（O）F，H，全卤代烷基或氧全氟烷基，X 5和 X6彼此相同或不同，表示F或CF 3。 所述方法的特征在于，在-140℃至+60℃的温度下，使双卤代烯烃与双（氟氧基）全氟烷烃反应。 本发明还涉及属于上文定义的类别的式（I）的新的1,3-二氧戊环。

    Process for preparing halogenated 1,3-dioxolanes
    6.
    发明授权
    Process for preparing halogenated 1,3-dioxolanes 失效
    制备恶唑烷-1,3-二氧杂环己烷的方法

    公开(公告)号：US5225576A

    公开(公告)日：1993-07-06

    申请号：US711775

    申请日：1991-06-07

    申请人： Walter Navarrini ,  Simonetta Fontana ,  Vittorio Montanari

    发明人： Walter Navarrini ,  Simonetta Fontana ,  Vittorio Montanari

    IPC分类号： C07D317/16 ,  C07D317/42

    CPC分类号： C07D317/42

    摘要： This invention relates to a process for preparing 1,3-dioxolanes of formula: ##STR1## wherein; X.sub.1, X.sub.2, X.sub.3 and X.sub.4, like or different from one another, represent F, Cl, Br, I, CF.sub.2 OSO.sub.2 F, SO.sub.2 F, C(O)F, H, perhaloalkyl or oxyperhaloalkyl radicals containing from 1 to 5 carbon atoms,X.sub.5 and X.sub.6, like or different from each other, represent F or CF.sub.3. Said process is characterized in that a bis(fluoroxy)perfluoroalkane is reacted, at a temperature ranging from -140.degree. C. to +60.degree. C., with a halogenated olefin.This invention also relates to new 1,3-dioxolanes of formula (I) belonging to the class defined hereinbefore.