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    Agonists and antagonists of ryzn for the treatment of metabolic disorders
    2.
    发明申请
    Agonists and antagonists of ryzn for the treatment of metabolic disorders 审中-公开
    激动剂和ryzn的拮抗剂用于治疗代谢紊乱

    公开(公告)号：US20060089311A1

    公开(公告)日：2006-04-27

    申请号：US10496758

    申请日：2002-10-03

    申请人： Deno Dialvnas ,  Aaron Scalia ,  John Lucas ,  Kristen Briggs

    发明人： Deno Dialvnas ,  Aaron Scalia ,  John Lucas ,  Kristen Briggs

    IPC分类号： A61K38/06

    CPC分类号： A61K38/177 ,  G01N33/566 ,  G01N33/6893 ,  G01N2333/70575 ,  G01N2333/70578 ,  G01N2500/00 ,  G01N2800/042

    摘要： The present invention relates to the field of metabolic research, in particular the discovery of compounds effective for reducing body mass and useful for treating obesity-related diseases and disorders. The obesity-related diseases or disorders envisioned to be treated by the methods of the invention include, but are not limited to, hyperlipidemia, atherosclerosis, insulin resistance, diabetes, and hypertension. In particular, the invention provides for methods of identifying and using AGONISTS and ANTAGONISTS of RYZN activity, wherein said activity is selected from the group consisting of lipid partitioning, lipid metabolism, and insulin-like activity.

    摘要翻译： 本发明涉及代谢研究领域，特别涉及有效减少体重并可用于治疗与肥胖有关的疾病和病症的化合物的发现。 预期通过本发明的方法治疗的肥胖相关疾病或病症包括但不限于高脂血症，动脉粥样硬化，胰岛素抵抗，糖尿病和高血压。 特别地，本发明提供了鉴定和使用RYZN活性的AGONISTS和ANTAGONISTS的方法，其中所述活性选自脂质分配，脂质代谢和胰岛素样活性。

    Xcrf polynucleotides and polypeptides and uses thereof
    4.
    发明申请
    Xcrf polynucleotides and polypeptides and uses thereof 审中-公开
    Xcrf多核苷酸和多肽及其用途

    公开(公告)号：US20060258567A1

    公开(公告)日：2006-11-16

    申请号：US10510002

    申请日：2003-03-26

    申请人： Kristen Briggs ,  Deno Dialynas ,  John Lucas ,  Aaron Scalia

    发明人： Kristen Briggs ,  Deno Dialynas ,  John Lucas ,  Aaron Scalia

    IPC分类号： A61K48/00 ,  A61K38/17

    CPC分类号： A61K48/00 ,  A61K9/0019 ,  A61K38/00 ,  C07K14/47

    摘要： The present invention relates to the field of metabolic research. Metabolic disorders, such as obesity, are a public health problem that is serious and widespread. XCRF polypeptides have been identified that are beneficial in the treatment of metabolic disorders. These compounds should be effective for reducing body mass and for treating metabolic-related diseases and disorders. These metabolic-related diseases and disorders include hyperlipidemias, atherosclerosis, diabetes, and hypertension.

    摘要翻译： 本发明涉及代谢研究领域。 代谢紊乱，如肥胖，是一个严重而广泛的公共卫生问题。 已经鉴定出有利于治疗代谢紊乱的XCRF多肽。 这些化合物应该有效减少体重和治疗与代谢有关的疾病和病症。 这些代谢相关的疾病和病症包括高脂血症，动脉粥样硬化，糖尿病和高血压。

    Gmg-2 polynucleotides and polypeptides and uses thereof
    5.
    发明申请
    Gmg-2 polynucleotides and polypeptides and uses thereof 审中-公开
    Gmg-2多核苷酸和多肽及其用途

    公开(公告)号：US20060293225A1

    公开(公告)日：2006-12-28

    申请号：US10484707

    申请日：2002-07-25

    申请人： Deno Dialynas ,  John Lucas ,  Aaron Scalia ,  Hiroaki Tanaka

    发明人： Deno Dialynas ,  John Lucas ,  Aaron Scalia ,  Hiroaki Tanaka

    IPC分类号： A61K38/17

    CPC分类号： A61K38/1709 ,  C07K14/435 ,  C07K2319/00

    摘要： The present invention relates to the field of obesity research. Obesity is a public health problem that is serious and widespread. A compound, homotrimer of GMG-2 polypeptide fragment comprising globular domain and all or part of GMG-2 collagen-like region, has been identified that has utility for reducing body mass, for maintaining weight loss, and for treating obesity-related diseases and disorders. These obesity-related diseases and disorders include hyperlipidemias, atherosclerosis, diabetes, and hypertension.

    摘要翻译： 本发明涉及肥胖研究领域。 肥胖是一个严重而广泛的公共卫生问题。 已经鉴定了包含球状结构域和全部或部分GMG-2胶原样区域的GMG-2多肽片段的同三聚物，其具有用于减少体重，用于维持体重减轻和用于治疗与肥胖有关的疾病和 疾病 这些肥胖相关的疾病和病症包括高脂血症，动脉粥样硬化，糖尿病和高血压。