专利检索 ap:("Kristen L. Arienti" OR "James G. Breitenbucher" OR "Daniel J. Buzard" OR "James P. Edwards" OR "Michael D. Hack" OR "Alice Lee-Dutra" OR "Haripada Khatuya") AND inv:"Alice Lee-Dutra" 第 1 页

1.

发明申请
Benzoimidazole compounds 审中-公开

公开(公告)号：US20090281307A1

公开(公告)日：2009-11-12

申请号：US12229891

申请日：2008-08-26

申请人： Kristen L. Arienti , James G. Breitenbucher , Daniel J. Buzard , James P. Edwards , Michael D. Hack , Alice Lee-Dutra , Haripada Khatuya

发明人： Kristen L. Arienti , James G. Breitenbucher , Daniel J. Buzard , James P. Edwards , Michael D. Hack , Alice Lee-Dutra , Haripada Khatuya

IPC分类号： C07D403/12 , C07D401/12 , C07D401/14

CPC分类号： C07D235/18 , C04B35/632 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07K16/00 , C07K2317/50 , C07K2317/53 , C07K2318/10

摘要： Benzoimidazole compounds, compositions, and methods of using them in leukocyte recruitment inhibition, in modulating H4 receptor, and in treating conditions such as inflammation, H4 receptor-mediated conditions, and related conditions.

2.

发明授权
Benzoimidazole compounds 有权

公开(公告)号：US07723527B2

公开(公告)日：2010-05-25

申请号：US12229886

申请日：2008-08-26

申请人： Kristen L. Arienti , James G. Breitenbucher , Daniel J. Buzard , James P. Edwards , Michael D. Hack , Alice Lee-Dutra

发明人： Kristen L. Arienti , James G. Breitenbucher , Daniel J. Buzard , James P. Edwards , Michael D. Hack , Alice Lee-Dutra

IPC分类号： C07D401/00

CPC分类号： C07D235/18 , C04B35/632 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07K16/00 , C07K2317/50 , C07K2317/53 , C07K2318/10

摘要： Benzoimidazole compounds, compositions, and methods of using them in leukocyte recruitment inhibition, in modulating H4 receptor, and in treating conditions such as inflammation, H4 receptor-mediated conditions, and related conditions.

3.

发明申请
Benzoimidazole compounds 有权
标题翻译：苯并咪唑化合物

公开(公告)号：US20090264647A1

公开(公告)日：2009-10-22

申请号：US12229886

申请日：2008-08-26

申请人： Kristen L. Arienti , James G. Breitenbucher , Daniel J. Buzard , James P. Edwards , Michael D. Hack , Alice Lee-Dutra

发明人： Kristen L. Arienti , James G. Breitenbucher , Daniel J. Buzard , James P. Edwards , Michael D. Hack , Alice Lee-Dutra

IPC分类号： C07D401/14 , C07D401/12 , C07D403/14

CPC分类号： C07D235/18 , C04B35/632 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07K16/00 , C07K2317/50 , C07K2317/53 , C07K2318/10

摘要： Benzoimidazole compounds, compositions, and methods of using them in leukocyte recruitment inhibition, in modulating H4 receptor, and in treating conditions such as inflammation, H4 receptor-mediated conditions, and related conditions.

摘要翻译： 苯并咪唑化合物，组合物及其在白细胞募集抑制中的用途，调节H4受体以及治疗诸如炎症，H4受体介导的病症和相关病症的病症的方法。

4.

发明申请
TETRAHYDRO-PYRAZOLO-PYRIDINE THIOETHER MODULATORS OF CATHEPSIN S 审中-公开
标题翻译：四氢吡喃类吡嗪类三氯乙烯调节剂

公开(公告)号：US20090099157A1

公开(公告)日：2009-04-16

申请号：US12031551

申请日：2008-02-14

申请人： Michael K. Ameriks , Kristen L. Arienti , James P. Edwards , Cheryl A. Grice , Todd K. Jones , Alice Lee-Dutra , Jing Liu , Neelakandha S. Mani , Danielle K. Neff , Alvah T. Wickboldt , John J.M. Wiener

发明人： Michael K. Ameriks , Kristen L. Arienti , James P. Edwards , Cheryl A. Grice , Todd K. Jones , Alice Lee-Dutra , Jing Liu , Neelakandha S. Mani , Danielle K. Neff , Alvah T. Wickboldt , John J.M. Wiener

IPC分类号： A61K31/551 , C07D471/04 , A61K31/5377 , A61P9/10 , A61P37/08 , A61K31/437

CPC分类号： C07D471/04

摘要： Tetrahydro-pyrazolo-pyridine thioether compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.

摘要翻译： 描述了四氢吡唑并吡啶硫醚化合物，其可用作组织蛋白酶S调节剂。这些化合物可用于治疗由组织蛋白酶S活性介导的疾病状态，病症和病症的药物组合物和方法，例如银屑病，疼痛，多发性硬化，动脉粥样硬化和类风湿性关节炎。

5.

发明授权
Aryl-substituted bridged or fused diamines as modulators of leukotriene A4 hydrolase 有权

公开(公告)号：US08367719B2

公开(公告)日：2013-02-05

申请号：US13091772

申请日：2011-04-21

申请人： Genesis M. Bacani , Scott D. Bembenek , Wendy Eccles , James P. Edwards , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Kelly J. McClure , Taraneh Mirzadegan , Alejandro Santillán, Jr.

发明人： Genesis M. Bacani , Scott D. Bembenek , Wendy Eccles , James P. Edwards , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Kelly J. McClure , Taraneh Mirzadegan , Alejandro Santillán, Jr.

IPC分类号： A61K31/34

CPC分类号： C07D487/08 , C07D417/12 , C07D451/04 , C07D471/04 , C07D471/08 , C07D487/04

摘要： Aryl-substituted bridged or fused diamine compounds, pharmaceutical compositions containing them, and methods of using the compounds and the pharmaceutical compositions for leukotriene A4 hydrolase (LTA4H or LTA4H) modulation and for the treatment of disease states, disorders, and conditions mediated by LTA4H activity, such as allergy, asthma, autoimmune diseases, pruritis, inflammatory bowel disease, ulcerative colitis, and cardiovascular disease, including atherosclerosis and prevention of myocardial infarction.

6.

发明授权
Aryl-substituted bridged or fused diamines as modulators of leukotriene A ydrolase 有权
标题翻译：芳基取代的桥连或稠合二胺作为白三烯A型调质剂

公开(公告)号：US08344008B2

公开(公告)日：2013-01-01

申请号：US13091498

申请日：2011-04-21

申请人： Genesis M. Bacani , Scott D. Bembenek , Wendy Eccles , James P. Edwards , Matthew T. Epperson , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Kelly J. McClure , Taraneh Mirzadegan , Alexandro Santillán, Jr.

发明人： Genesis M. Bacani , Scott D. Bembenek , Wendy Eccles , James P. Edwards , Matthew T. Epperson , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Kelly J. McClure , Taraneh Mirzadegan , Alexandro Santillán, Jr.

IPC分类号： A61K31/425

CPC分类号： C07D487/08 , C07D417/12 , C07D451/04 , C07D471/04 , C07D471/08 , C07D487/04

摘要： Aryl-substituted bridged or fused diamine compounds, pharmaceutical compositions containing them, and methods of using the compounds and the pharmaceutical compositions for leukotriene A4 hydrolase (LTA4H or LTA4H) modulation and for the treatment of disease states, disorders, and conditions mediated by LTA4H activity, such as allergy, asthma, autoimmune diseases, pruritis, inflammatory bowel disease, ulcerative colitis, and cardiovascular disease, including atherosclerosis and prevention of myocardial infarction.

摘要翻译： 芳基取代的桥连或稠合二胺化合物，含有它们的药物组合物，以及使用该化合物和药物组合物用于白三烯A4水解酶（LTA4H或LTA4H）调节和治疗由LTA4H活性介导的疾病状态，障碍和病症的方法，例如过敏，哮喘，自身免疫性疾病，瘙痒炎，炎性肠病，溃疡性结肠炎和心血管疾病，包括动脉粥样硬化和预防心肌梗死。

7.

发明申请
Aryl-substituted bridged or fused diamines as modulators of leukotriene A4 hydrolase 有权
标题翻译：芳基取代的桥连或稠合二胺作为白三烯A4水解酶的调节剂

公开(公告)号：US20110263639A1

公开(公告)日：2011-10-27

申请号：US13091772

申请日：2011-04-21

申请人： Genesis M. Bacani , Scott D. Bembenek , Wendy Eccles , James P. Edwards , Matthew T. Epperson , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Kelly J. McClure , Taraneh Mirzadegan , Alejandro Santillán, JR.

发明人： Genesis M. Bacani , Scott D. Bembenek , Wendy Eccles , James P. Edwards , Matthew T. Epperson , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Kelly J. McClure , Taraneh Mirzadegan , Alejandro Santillán, JR.

IPC分类号： A61K31/46 , C12N9/99 , A61P29/00 , C07D451/04

CPC分类号： C07D487/08 , C07D417/12 , C07D451/04 , C07D471/04 , C07D471/08 , C07D487/04

摘要： Aryl-substituted bridged or fused diamine compounds, pharmaceutical compositions containing them, and methods of using the compounds and the pharmaceutical compositions for leukotriene A4 hydrolase (LTA4H or LTA4H) modulation and for the treatment of disease states, disorders, and conditions mediated by LTA4H activity, such as allergy, asthma, autoimmune diseases, pruritis, inflammatory bowel disease, ulcerative colitis, and cardiovascular disease, including atherosclerosis and prevention of myocardial infarction.

摘要翻译： 芳基取代的桥连或稠合二胺化合物，含有它们的药物组合物，以及使用该化合物和药物组合物用于白三烯A4水解酶（LTA4H或LTA4H）调节和治疗由LTA4H活性介导的疾病状态，障碍和病症的方法，例如过敏，哮喘，自身免疫性疾病，瘙痒炎，炎性肠病，溃疡性结肠炎和心血管疾病，包括动脉粥样硬化和预防心肌梗死。

8.

发明申请
Aryl-substituted bridged or fused diamines as modulators of leukotriene A4 hydrolase 有权

公开(公告)号：US20110257153A1

公开(公告)日：2011-10-20

申请号：US13091498

申请日：2011-04-21

申请人： Genesis M. Bacani , Scott D. Bembenek , Wendy Eccles , James P. Edwards , Matthew T. Epperson , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Kelly J. Mcclure , Taraneh Mirzadegan , Alexandro Santillan, JR.

发明人： Genesis M. Bacani , Scott D. Bembenek , Wendy Eccles , James P. Edwards , Matthew T. Epperson , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Kelly J. Mcclure , Taraneh Mirzadegan , Alexandro Santillan, JR.

IPC分类号： A61K31/428 , C12N9/99 , C07D451/02 , A61K31/46 , A61K31/4995 , C07D487/04 , C07D471/04 , A61K31/437 , A61K31/4375 , A61K31/5377 , A61P29/00 , A61P17/00 , A61P11/06 , A61P1/00 , A61P9/10 , A61P17/02 , C07D487/08

CPC分类号： C07D487/08 , C07D417/12 , C07D451/04 , C07D471/04 , C07D471/08 , C07D487/04

摘要： Aryl-substituted bridged or fused diamine compounds, pharmaceutical compositions containing them, and methods of using the compounds and the pharmaceutical compositions for leukotriene A4 hydrolase (LTA4H or LTA4H) modulation and for the treatment of disease states, disorders, and conditions mediated by LTA4H activity, such as allergy, asthma, autoimmune diseases, pruritis, inflammatory bowel disease, ulcerative colitis, and cardiovascular disease, including atherosclerosis and prevention of myocardial infarction.

9.

发明申请
Aryl-substituted bridged or fused diamines as modulators of leukotriene A4 hydrolase 有权
标题翻译：芳基取代的桥连或稠合二胺作为白三烯A4水解酶的调节剂

公开(公告)号：US20090111794A1

公开(公告)日：2009-04-30

申请号：US12291018

申请日：2008-10-30

申请人： Genesis M. Bacani , Scott D. Bembenek , Wendy Eccles , James P. Edwards , Matthew T. Epperson , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Kelly J. McClure , Taraneh Mirzadegan , Alejandro Santillan, JR.

发明人： Genesis M. Bacani , Scott D. Bembenek , Wendy Eccles , James P. Edwards , Matthew T. Epperson , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Kelly J. McClure , Taraneh Mirzadegan , Alejandro Santillan, JR.

IPC分类号： A61K31/55 , C07D277/68 , C07D263/54 , C07D487/08 , A61K31/423 , A61K31/4439 , A61P37/02 , A61K31/497 , A61K31/428 , C07D401/14 , C07D417/14

CPC分类号： C07D487/08 , C07D417/12 , C07D451/04 , C07D471/04 , C07D471/08 , C07D487/04

摘要： Aryl-substituted bridged or fused diamine compounds, pharmaceutical compositions containing them, and methods of using the compounds and the pharmaceutical compositions for leukotriene A4 hydrolase (LTA4H or LTA4H) modulation and for the treatment of disease states, disorders, and conditions mediated by LTA4H activity, such as allergy, asthma, autoimmune diseases, pruritis, inflammatory bowel disease, ulcerative colitis, and cardiovascular disease, including atherosclerosis and prevention of myocardial infarction.

摘要翻译： 芳基取代的桥连或稠合二胺化合物，含有它们的药物组合物，以及使用该化合物和药物组合物用于白三烯A4水解酶（LTA4H或LTA4H）调节和治疗由LTA4H活性介导的疾病状态，障碍和病症的方法，例如过敏，哮喘，自身免疫性疾病，瘙痒炎，炎性肠病，溃疡性结肠炎和心血管疾病，包括动脉粥样硬化和预防心肌梗死。