公开(公告)号：US20070003707A1

公开(公告)日：2007-01-04

申请号：US11423503

申请日：2006-06-12

Applicant: Patrick Guire ,  Kristin Taton ,  Jie Wen

Inventor： Patrick Guire ,  Kristin Taton ,  Jie Wen

IPC: C08F2/48 ,  C07D239/02

CPC classification number: C07D251/30 ,  C07C275/10 ,  C07D251/34 ,  C09D139/08

Abstract: The invention describes novel crosslinking compounds that include photoactivatable moieties. Several families of compounds are disclosed that can include one or more hydrophilic moieties that help to solubilize the compounds in aqueous environments.

Abstract translation: 本发明描述了包含可光活化部分的新型交联化合物。 公开了几种化合物家族，其可以包括一种或多种有助于将化合物溶解在水性环境中的亲水部分。

公开(公告)号：US07989619B2

公开(公告)日：2011-08-02

申请号：US11457170

申请日：2006-07-13

Applicant: Patrick Guire ,  Kristin Taton ,  Jie Wen ,  Laurie R. Lawin

Inventor： Patrick Guire ,  Kristin Taton ,  Jie Wen ,  Laurie R. Lawin

IPC: C07D251/32 ,  C07D251/34 ,  C08K5/3492 ,  C09K11/06

CPC classification number: C09D7/1233 ,  C08K5/0025 ,  C09D7/63 ,  Y10T428/31507 ,  Y10T428/31511 ,  Y10T428/31551 ,  Y10T428/31678 ,  Y10T428/31721 ,  Y10T428/31725 ,  Y10T428/31855 ,  Y10T428/31989 ,  Y10T428/31993

Abstract: The invention describes novel compositions that include a cross linking compound, a polymer and a 1 nm to about a 25 micron sized particle optionally with an oxide layer. In particular, the particle is a silica and one which has been pretreated with a silane.

Abstract translation: 本发明描述了包含交联化合物，聚合物和任选具有氧化物层的1nm至约25微米尺寸的颗粒的新型组合物。 特别地，颗粒是二氧化硅和已经用硅烷预处理的颗粒。

公开(公告)号：US07772393B2

公开(公告)日：2010-08-10

申请号：US11423503

申请日：2006-06-12

Applicant: Patrick Guire ,  Kristin Taton ,  Jie Wen

Inventor： Patrick Guire ,  Kristin Taton ,  Jie Wen

IPC: C07D251/32 ,  C07D251/34 ,  C08K5/3492 ,  C09K11/06

CPC classification number: C07D251/30 ,  C07C275/10 ,  C07D251/34 ,  C09D139/08

Abstract: The invention describes novel crosslinking compounds that include photoactivatable moieties. Several families of compounds are disclosed that can include one or more hydrophilic moieties that help to solubilize the compounds in aqueous environments.

Abstract translation: 本发明描述了包含可光活化部分的新型交联化合物。 公开了几种化合物家族，其可以包括一种或多种有助于将化合物溶解在水性环境中的亲水部分。

公开(公告)号：US20060024350A1

公开(公告)日：2006-02-02

申请号：US11165884

申请日：2005-06-24

Applicant: Signe Varner ,  Patrick Guire ,  Kristin Taton ,  Jie Wen ,  Nathan Beeley ,  Laurie Lawin ,  Robert Hergenrother ,  Ralph Chappa ,  Aron Anderson

Inventor： Signe Varner ,  Patrick Guire ,  Kristin Taton ,  Jie Wen ,  Nathan Beeley ,  Laurie Lawin ,  Robert Hergenrother ,  Ralph Chappa ,  Aron Anderson

IPC: A61F2/00

CPC classification number: A61K9/0051 ,  A61F9/0017 ,  A61F2210/0004 ,  A61L31/06 ,  C08L67/025

Abstract: The invention provides implantable medical devices that are fabricated of biodegradable materials for delivery of bioactive agent to limited access regions of a patient's body, such as the eye. The invention further provides methods of treatment utilizing the devices.

Abstract translation: 本发明提供了由可生物降解材料制成的植入式医疗装置，用于将生物活性剂递送到患者身体如眼睛的有限进入区域。 本发明还提供了利用这些装置的治疗方法。

公开(公告)号：US20060018948A1

公开(公告)日：2006-01-26

申请号：US11165993

申请日：2005-06-24

Applicant: Patrick Guire ,  Kristin Taton ,  Jie Wen ,  David DeWitt ,  Robert Hergenrother ,  Aron Anderson

Inventor： Patrick Guire ,  Kristin Taton ,  Jie Wen ,  David DeWitt ,  Robert Hergenrother ,  Aron Anderson

IPC: A61F2/00

CPC classification number: A61L31/06 ,  A61L31/148 ,  C08L67/025 ,  C08L71/02

Abstract: The invention provides implantable intraluminal medical devices that are fabricated of biodegradable materials. The invention further provides methods of treatment utilizing the devices.

Abstract translation: 本发明提供了由可生物降解材料制成的可植入管腔内医疗装置。 本发明还提供了利用这些装置的治疗方法。

公开(公告)号：US20100081750A1

公开(公告)日：2010-04-01

申请号：US11457170

申请日：2006-07-13

Applicant: Patrick Guire ,  Kristin Taton ,  Jie Wen ,  Laurie R. Lawin

Inventor： Patrick Guire ,  Kristin Taton ,  Jie Wen ,  Laurie R. Lawin

IPC: C09D5/00

CPC classification number: C09D7/1233 ,  C08K5/0025 ,  C09D7/63 ,  Y10T428/31507 ,  Y10T428/31511 ,  Y10T428/31551 ,  Y10T428/31678 ,  Y10T428/31721 ,  Y10T428/31725 ,  Y10T428/31855 ,  Y10T428/31989 ,  Y10T428/31993

Abstract: The invention describes novel compositions that include a cross linking compound, a polymer and a 1 nm to about a 25 micron sized particle optionally with an oxide layer. In particular, the particle is a silica and one which has been pretreated with a silane.

Abstract translation: 本发明描述了包含交联化合物，聚合物和任选具有氧化物层的1nm至约25微米尺寸的颗粒的新型组合物。 特别地，颗粒是二氧化硅和已经用硅烷预处理的颗粒。

公开(公告)号：US20080039343A1

公开(公告)日：2008-02-14

申请号：US11682526

申请日：2007-03-06

Applicant: Patrick Guire ,  Kristin Taton ,  John Wall

Inventor： Patrick Guire ,  Kristin Taton ,  John Wall

IPC: C40B40/14 ,  C40B40/06 ,  C40B40/10 ,  C40B40/12

CPC classification number: B82Y30/00 ,  B01J19/0046 ,  B01J2219/00466 ,  B01J2219/005 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00637 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00725 ,  B82Y5/00 ,  B82Y10/00 ,  C12Q1/6837 ,  G01N33/54366 ,  Y10S530/81 ,  Y10S530/811 ,  Y10S530/815 ,  Y10S530/816 ,  C12Q2563/149

Abstract: Arrays including microparticles having probe and marker moieties are used for the detection of a target in a sample. Microparticles are randomly immobilized on at least a portion of a substrate. A detection scheme is performed to detect the marker associated with the microparticle and the identity of the probe, and any target bound to the probe.

Abstract translation: 包括具有探针和标记物部分的微粒的阵列用于检测样品中的靶。 微粒随机固定在底物的至少一部分上。 执行检测方案以检测与微粒相关的标记和探针的身份以及与探针结合的任何靶标。

公开(公告)号：US07943234B2

公开(公告)日：2011-05-17

申请号：US12037520

申请日：2008-02-26

Applicant: Laurie R. Lawin ,  Patrick Guire ,  Jie Wen ,  Kristin Taton

Inventor： Laurie R. Lawin ,  Patrick Guire ,  Jie Wen ,  Kristin Taton

IPC: B32B5/16

CPC classification number: C09D125/10 ,  C08K3/08 ,  C08K3/22 ,  C08K5/1525 ,  C08K9/06 ,  C09D5/00 ,  C09D7/62 ,  C09D7/67 ,  C09D7/68 ,  C09D7/69 ,  C09D125/06 ,  Y10T428/25 ,  Y10T428/254 ,  Y10T428/31551 ,  Y10T428/31569

Abstract: The invention describes compositions that include a polymer having a water contact angle of between about 120° and about 150° or greater adhered to a 1 nm to about a 25 micron diameter sized particle optionally with an oxide layer. In particular, the particle is a silica and one which has been pretreated with a silane.

Abstract translation: 本发明描述了包含具有大约120°至大约150°或更大的水接触角的聚合物的组合物，其粘附到任选地具有氧化物层的1nm至约25微米直径的颗粒。 特别地，颗粒是二氧化硅和已经用硅烷预处理的颗粒。

公开(公告)号：US20100274012A1

公开(公告)日：2010-10-28

申请号：US12831673

申请日：2010-07-07

Applicant: Patrick Guire ,  Kristin Taton ,  Jie Wen

Inventor： Patrick Guire ,  Kristin Taton ,  Jie Wen

IPC: C07D251/06

CPC classification number: C07D251/30 ,  C07C275/10 ,  C07D251/34 ,  C09D139/08

Abstract: The invention describes novel crosslinking compounds that include photoactivatable moieties. Several families of compounds are disclosed that can include one or more hydrophilic moieties that help to solubilize the compounds in aqueous environments.

Abstract translation: 本发明描述了包含可光活化部分的新型交联化合物。 公开了几种化合物家族，其可以包括一种或多种有助于将化合物溶解在水性环境中的亲水部分。

公开(公告)号：US20060030669A1

公开(公告)日：2006-02-09

申请号：US10944384

申请日：2004-09-17

Applicant: Kristin Taton ,  Patrick Guire

Inventor： Kristin Taton ,  Patrick Guire

IPC: C08F297/02

CPC classification number: A61L31/14 ,  A61L31/10 ,  C08F220/54 ,  C08F220/60 ,  C08F226/10 ,  C08L2312/00 ,  C09D133/26 ,  C08L77/10

Abstract: A thermally-reactive polymer that forms a polymer-coupled reactive species upon heating is described and useful for forming coated surfaces. The polymer-coated surface has improved lubricity and passivity. A thermally-reactive quaternary amine-containing polymer was produced that provides passivity and anti-microbial activity.

Abstract translation: 描述了在加热时形成聚合物偶联反应性物质的热反应性聚合物，并且可用于形成涂覆表面。 聚合物涂覆的表面具有改善的润滑性和被动性。 制备了一种提供无源和抗微生物活性的热反应性含季胺的聚合物。