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公开(公告)号：US6048522A
公开(公告)日：2000-04-11
申请号：US121380
申请日：1998-07-23
IPC分类号： A61K8/06 , A61K8/81 , A61K9/00 , A61K9/113 , A61K31/74 , A61K47/14 , A61K47/32 , A61K47/44 , A61Q17/04 , A61Q19/00 , C08F2/06 , C08F2/12 , C08F2/14 , C08F2/24 , C08F2/32 , C08F26/10 , C08F226/10 , C08G77/04 , A61K31/695 , A61K31/79
CPC分类号： A61K8/062 , A61K47/14 , A61K47/32 , A61K47/44 , A61K8/06 , A61K8/064 , A61K8/8141 , A61K9/0014 , A61Q17/04 , A61Q19/00 , C08F2/06 , C08F226/10 , A61K2800/57 , Y10T428/2987
摘要： A controlled-release, drug-delivery, emulsion composition for topical application comprising (a) the reaction product of the non-aqueous, heterogeneous polymerization of a reaction mixture of about 5-70%, preferably 10-30%, by weight, of a vinyl monomer in an oil as solvent, and a free radical initiator, optionally in the presence of a crosslinking agent and/or a surfactant, wherein the oil solvent is present in an amount sufficient to keep the resultant polymer in a stirrable state throughout the polymerization, (b) water, (c) a surfactant and (d) a pharmaceutical medicament.
摘要翻译： 一种用于局部施用的控释药物递送乳剂组合物，其包含（a）反应混合物的非水非均相聚合反应产物，其反应混合物的重量比为约5-70％，优选为10-30％ 任选在交联剂和/或表面活性剂存在下，油中的乙烯基单体和溶剂中的自由基引发剂，其中油溶剂的存在量足以使得到的聚合物在整个过程中保持在可搅拌状态 聚合，（b）水，（c）表面活性剂和（d）药物。
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2.发明授权Controlled release, drug-delivery tableted composition including a polymer of a vinyl amide, (meth)acrylic acid, a long chain alkyl (meth)acrylate and a lower alkyl (meth)acrylate 失效（甲基）丙烯酸，（甲基）丙烯酸长链烷基酯和（甲基）丙烯酸低级烷基酯的控释药物递送成片组合物
公开(公告)号：US5919484A
公开(公告)日：1999-07-06
申请号：US7409
申请日：1998-01-15
CPC分类号： A61K9/2027
摘要： A controlled release, drug-delivery tableted composition comprising, by weight, an uncrosslinked or crosslinked polymer of (a) about 5-40% of a vinyl amide, (b) about 10-70% of (meth)acrylic acid, (c) about 5-40% of a long chain alkyl (meth)acrylate or acrylamide, and (d) about 0-60% of a lower alkyl (meth)acrylate, and a pharmaceutical medicament.
摘要翻译： （a）约5-40％的乙烯基酰胺的未交联或交联的聚合物，（b）约10-70％的（甲基）丙烯酸，（c）的控释药物递送的成片组合物 ）约5-40％的长链烷基（甲基）丙烯酸酯或丙烯酰胺，和（d）约0-60％的（甲基）丙烯酸低级烷基酯和药物。
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公开(公告)号：US06620426B2
公开(公告)日：2003-09-16
申请号：US09875511
申请日：2001-06-05
IPC分类号： A61K4700
CPC分类号： A61K9/284 , A61K9/286 , A61K9/2866
摘要： A tablet coating composition including a mixture of (a) sodium alginate and (b) a polyvinylpyrrolidone-vinyl acetate copolymer, and, optionally, (c) hydroxypropylmethyl cellulose, and/or hydroxypropyl cellulose.
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公开(公告)号：US06524617B1
公开(公告)日：2003-02-25
申请号：US09915057
申请日：2001-07-25
IPC分类号： A61K920
CPC分类号： A61K9/2054 , A61K9/2027
摘要： A synergistic filler composition for making pharmaceutical tablets of sufficient tablet hardness at low compression force, and low friability, to preclude damage to the tablet upon further processing, and without requiring a substantial increase in the size of the tablet, comprising (a) a PVP-VA copolymer and (b) a microcrystalline cellulose.
摘要翻译： 一种协同的填充剂组合物，用于制备在低压力下具有足够的片剂硬度和低脆性的药物片剂，以防止在进一步加工时对片剂的损害，并且不需要片剂大小的显着增加，包括（a）PVP -VA共聚物和（b）微晶纤维素。
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5.发明授权Controlled-release, drug-delivery tableted composition including a complex between poly(maleic diacid-alkyl vinyl ether) and polyvinylpyrrolidone 有权控制释放，药物递送成片组合物，包括聚（马来酸二酸 - 烷基乙烯基醚）和聚乙烯吡咯烷酮
公开(公告)号：US6129931A
公开(公告)日：2000-10-10
申请号：US146422
申请日：1998-09-03
CPC分类号： A61K9/2027 , A61K9/2009
摘要： A pH-dependent, controlled-release, drug delivery composition is described herein which includes:(a) a complex between poly(maleic diacid-alkyl vinyl ether) and polyvinylpyrrolidone, or their equivalents, and(b) an effective amount of a pharmaceutical medicament.
摘要翻译： 本文描述了pH依赖性，控释药物递送组合物，其包括：（a）聚（马来酸二酸 - 烷基乙烯基醚）和聚乙烯吡咯烷酮或其等同物之间的复合物，和（b）有效量的药物 药物。
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