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公开(公告)号：US07155930B2
公开(公告)日：2007-01-02
申请号：US11165528
申请日：2005-06-23
申请人： Kuniaki Kawamura , Akito Machida , Masamitsu Ikeuchi , Kazuhiro Hattori , Kouichi Matsuo , Hideharu Yanagi
发明人： Kuniaki Kawamura , Akito Machida , Masamitsu Ikeuchi , Kazuhiro Hattori , Kouichi Matsuo , Hideharu Yanagi
CPC分类号： F25J1/0015 , F25C1/00 , F25D3/10 , F25J1/0221 , F25J1/0251 , F25J1/0276 , F25J2205/20 , F25J2205/30 , F25J2205/90 , F25J2210/42 , F25J2240/60
摘要： Liquid nitrogen is filled in a low temperature vessel; an ejector that sucks liquid nitrogen by blowing a cooling agent (liquid or gas) such as low temperature helium gas or liquid helium of pressure higher than in the space within the vessel is disposed in the vessel; the liquid nitrogen blown with the cooling agent is cooled by the cooling agent to become fine particles of solid nitrogen which fall down; and gas in a space of the vessel is discharged out of the vessel so as to maintain the pressure of the space higher than the atmospheric pressure.A gaseous phase of liquid nitrogen in an adiabatic vessel is depressurized to vaporize nitrogen in a liquid phase so that a temperature of the nitrogen is reached to the triple point of nitrogen by lowering temperature thereby and solid nitrogen is produced by keeping at the triple point, and that the produced solid nitrogen is transformed into slush by stirring the content of the adiabatic vessel.In a method for cooling a super conductive body in which a material showing a state of super conductance in the vicinity of the temperature of liquid nitrogen or of the temperature liquid nitrogen and solid nitrogen coexist is used, a method for cooling a super conductive body characterized in that the super conductive body is immersed in slush nitrogen held in an adiabatic vessel, and that the body is contacted with slush nitrogen to cool.
摘要翻译： 液氮填充在低温容器中; 喷射器通过吹送诸如低温氦气或低于容器内的空间的压力的液氦的冷却剂（液体或气体）而吸入液氮; 用冷却剂吹入的液氮被冷却剂冷却，成为脱落的固体氮的细小颗粒; 并且将容器的空间中的气体排出容器，以保持空间的压力高于大气压力。 将绝热容器中的氮气气相减压以使液相中的氮气蒸发，由此通过降低温度将氮气的温度达到氮的三分之一，由此通过保持三相点产生固体氮， 并且通过搅拌绝热容器的内容物将所产生的固体氮转变成泥浆。 在使用在液氮温度或液氮附近存在超导状态的材料和固体氮共存的超导电体的冷却方法中，使用超导电体的冷却方法， 因为超导体被浸入保持在绝热容器中的冰冷的氮气中，并且使主体与冷却氮气接触以冷却。
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公开(公告)号：US07370481B2
公开(公告)日：2008-05-13
申请号：US11532527
申请日：2006-09-16
申请人： Kuniaki Kawamura , Akito Machida , Masamitsu Ikeuchi , Kazuhiro Hattori , Kouichi Matsuo , Hideharu Yanagi
发明人： Kuniaki Kawamura , Akito Machida , Masamitsu Ikeuchi , Kazuhiro Hattori , Kouichi Matsuo , Hideharu Yanagi
CPC分类号： F25J1/0015 , F25C1/00 , F25D3/10 , F25J1/0221 , F25J1/0251 , F25J1/0276 , F25J2205/20 , F25J2205/30 , F25J2205/90 , F25J2210/42 , F25J2240/60
摘要： Liquid nitrogen is filled in a low temperature vessel; an ejector that sucks liquid nitrogen by blowing a cooling agent (liquid or gas) such as low temperature helium gas or liquid helium of pressure higher than in the space within the vessel is disposed in the vessel; the liquid nitrogen blown with the cooling agent is cooled by the cooling agent to become fine particles of solid nitrogen which fall down; and gas in a space of the vessel is discharged out of the vessel so as to maintain the pressure of the space higher than the atmospheric pressure. A gaseous phase of liquid nitrogen in an adiabatic vessel is depressurized to vaporize nitrogen in a liquid phase so that the temperature of the nitrogen reaches the triple point of nitrogen by lowering the temperature to thereby produce solid nitrogen by keeping the temperature at the triple point, and that the produced solid nitrogen is transformed into slush by stirring the content of the adiabatic vessel. A super conductive body formed of a material exhibiting a state of super conductance in the vicinity of the temperature of liquid nitrogen or of the temperature where liquid nitrogen and solid nitrogen coexist can be cooled by immersing the body in slush nitrogen held in an adiabatic vessel or flowing in an adiabatic pipe.
摘要翻译： 液氮填充在低温容器中; 喷射器通过吹送诸如低温氦气或低于容器内的空间的压力的液氦的冷却剂（液体或气体）而吸入液氮; 用冷却剂吹入的液氮被冷却剂冷却，成为脱落的固体氮的细小颗粒; 并且将容器的空间中的气体排出容器，以保持空间的压力高于大气压力。 将绝热容器中的氮气气相减压以使液相中的氮气蒸发，使得氮气的温度通过降低温度而达到氮的三重点，从而通过将温度保持在三重点来产生固体氮， 并且通过搅拌绝热容器的内容物将所产生的固体氮转变成泥浆。 在液氮温度附近或液氮和固态氮共存的温度下表现出超导状态的材料形成的超导体可以通过将本体浸入保持在绝热容器中的冰冷氮气中来冷却，或 在绝热管中流动。
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公开(公告)号：US20060000222A1
公开(公告)日：2006-01-05
申请号：US11165528
申请日：2005-06-23
申请人： Kuniaki Kawamura , Akito Machida , Masamitsu Ikeuchi , Kazuhiro Hattori , Kouichi Matsuo , Hideharu Yanagi
发明人： Kuniaki Kawamura , Akito Machida , Masamitsu Ikeuchi , Kazuhiro Hattori , Kouichi Matsuo , Hideharu Yanagi
CPC分类号： F25J1/0015 , F25C1/00 , F25D3/10 , F25J1/0221 , F25J1/0251 , F25J1/0276 , F25J2205/20 , F25J2205/30 , F25J2205/90 , F25J2210/42 , F25J2240/60
摘要： Liquid nitrogen is filled in a low temperature vessel; an ejector that sucks liquid nitrogen by blowing a cooling agent (liquid or gas) such as low temperature helium gas or liquid helium of pressure higher than in the space within the vessel is disposed in the vessel; the liquid nitrogen blown with the cooling agent is cooled by the cooling agent to become fine particles of solid nitrogen which fall down; and gas in a space of the vessel is discharged out of the vessel so as to maintain the pressure of the space higher than the atmospheric pressure. A gaseous phase of liquid nitrogen in an adiabatic vessel is depressurized to vaporize nitrogen in a liquid phase so that a temperature of the nitrogen is reached to the triple point of nitrogen by lowering temperature thereby and solid nitrogen is produced by keeping at the triple point, and that the produced solid nitrogen is transformed into slush by stirring the content of the adiabatic vessel. In a method for cooling a super conductive body in which a material showing a state of super conductance in the vicinity of the temperature of liquid nitrogen or of the temperature liquid nitrogen and solid nitrogen coexist is used, a method for cooling a super conductive body characterized in that the super conductive body is immersed in slush nitrogen held in an adiabatic vessel, and that the body is contacted with slush nitrogen to cool.
摘要翻译： 液氮填充在低温容器中; 喷射器通过吹送诸如低温氦气或低于容器内的空间的压力的液氦的冷却剂（液体或气体）而吸入液氮; 用冷却剂吹入的液氮被冷却剂冷却，成为脱落的固体氮的细小颗粒; 并且将容器的空间中的气体排出容器，以保持空间的压力高于大气压力。 将绝热容器中的氮气的气相减压以使液相中的氮气蒸发，由此通过降低温度将氮气的温度达到氮的三重点，从而通过保持三相点产生固体氮， 并且通过搅拌绝热容器的内容物将所产生的固体氮转变成泥浆。 在使用在液氮温度或液氮附近存在超导状态的材料和固体氮共存的超导电体的冷却方法中，使用超导电体的冷却方法， 因为超导体被浸入保持在绝热容器中的冰冷的氮气中，并且使主体与冷却氮气接触以冷却。
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公开(公告)号：US07602085B2
公开(公告)日：2009-10-13
申请号：US11195853
申请日：2005-08-03
IPC分类号： G05F3/06
摘要： A system for utilizing coal energy includes a thermal power generator near a coal field area that converts coal energy of the coal field area located remotely from a demand end to electric energy. It also includes an alternating current load at a demand end side, an alternating current power distribution network, and an electric power transmission mechanism that transmit electric energy from the thermal power generator to the power distribution network. The electric power transmission mechanism is a combination of super conductive power transmitting system that transmit direct current electricity with small transmission loss utilizing super conductive power transmitting cables and a conventional power distribution network operating at ambient temperatures.
摘要翻译： 利用煤能的系统包括靠近煤田区域的火力发电机，其将远离需求端的煤田区域的煤能转化为电能。 它还包括在需求端侧的交流负载，交流配电网络和将电能从火力发电机传输到配电网络的电力传输机构。 电力传输机构是超导电功率传输系统的组合，其使用超导电输电电缆和常规的在环境温度下工作的配电网络传输直流电和小传输损耗。
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公开(公告)号：US20060056120A1
公开(公告)日：2006-03-16
申请号：US11195853
申请日：2005-08-03
IPC分类号： H02H7/00
摘要： A system for utilizing coal energy includes a thermal power generator near a coal field area that converts coal energy of the coal field area located remotely from a demand end to electric energy. It also includes an alternating current load at a demand end side, an alternating current power distribution network, and an electric power transmission mechanism that transmit electric energy from the thermal power generator to the power distribution network. The electric power transmission mechanism is a combination of super conductive power transmitting system that transmit direct current electricity with small transmission loss utilizing super conductive power transmitting cables and a conventional power distribution network operating at ambient temperatures. Electricity is transmitted to the demand end through the alternating current power distribution network by converting alternating current at a feeding point of the power distribution network where the current is fed with an alternating current converting mechanism provided at the connecting end.
摘要翻译： 利用煤能的系统包括靠近煤田区域的火力发电机，其将远离需求端的煤田区域的煤能转化为电能。 它还包括在需求端侧的交流负载，交流配电网络和将电能从火力发电机传输到配电网络的电力传输机构。 电力传输机构是超导电功率传输系统的组合，其使用超导电输电电缆和常规的在环境温度下工作的配电网络传输直流电和小传输损耗。 通过交流配电网络将电流传送到需求端，通过在配电网的馈电点处转换交流电，其中电流被馈送在设置在连接端的交流电转换机构。
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公开(公告)号：US07652025B2
公开(公告)日：2010-01-26
申请号：US10477062
申请日：2002-05-08
CPC分类号： A61K31/40 , A61K31/485 , A61K38/00 , C07D489/08 , C07K5/1016
摘要： A therapeutic agent for sepsis and various symptoms accompanying sepsis (such as septic shock, disseminated intravascular coagulation syndrome, adult respiratory distress syndrome and multiple organ dysfunction) is disclosed. The therapeutic agent for sepsis according to the present invention comprises as an effective ingredient an opioid κ receptor agonist compound such as (−)-17-(cyclopropylmethyl)-3,14β-dihydroxy-4,5α-epoxy-6β[N-methyl-trans-3-(3-furyl)acrylamide] oxide derivative. The opioid κ receptor agonist compound may be administered as it is or in the form of a pharmaceutical composition prepared by mixing the compound with a known pharmaceutically acceptable acid, carrier or vehicle orally or parenterally.
摘要翻译： 公开了脓毒症和伴随脓毒症的各种症状的治疗剂（例如脓毒性休克，弥散性血管内凝血综合征，成人呼吸窘迫综合征和多器官功能障碍）。 根据本发明的败血症治疗剂包括作为有效成分的阿片样物质κ受体激动剂化合物，例如（ - ） - 17-（环丙基甲基）-3,14β-二羟基-4,5α-环氧-6β-[N-甲基 （3-呋喃基）丙烯酰胺]氧化物衍生物。 阿片样物质κ受体激动剂化合物可以原样或以通过将化合物与已知的药学上可接受的酸，载体或载体口服或胃肠外混合制备的药物组合物的形式进行给药。
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公开(公告)号：US06583151B2
公开(公告)日：2003-06-24
申请号：US09297364
申请日：1999-07-12
申请人： Hiroshi Nagase , Takashi Endoh , Tsutomu Suzuki , Kuniaki Kawamura , Koji Oshima , Hideaki Inada
发明人： Hiroshi Nagase , Takashi Endoh , Tsutomu Suzuki , Kuniaki Kawamura , Koji Oshima , Hideaki Inada
IPC分类号： A61K314748
CPC分类号： A61K31/485 , C07D489/08
摘要： A method for treating drug dependence comprising administering, as the active ingredient, an opioid &kgr; receptor agonist of a compound represented by the following formula, is disclosed wherein A and the R terms are herein defined.
摘要翻译： 一种治疗药物依赖性的方法，包括给予作为活性成分的由下式表示的化合物的阿片样物质κ受体激动剂，其中A和R术语在本文中定义。
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公开(公告)号：US06277859B1
公开(公告)日：2001-08-21
申请号：US09541793
申请日：2000-03-31
申请人： Hiroshi Nagase , Koji Kawai , Kuniaki Kawamura , Jun Hayakawa , Takashi Endoh
发明人： Hiroshi Nagase , Koji Kawai , Kuniaki Kawamura , Jun Hayakawa , Takashi Endoh
IPC分类号： C07D48900
CPC分类号： C07D405/12 , C07D409/12 , C07D413/12 , C07D489/08
摘要： A morphinan derivative or its pharmacologically allowed acid addition salt represented with compound I, an analgesic and diuretic having its derivative or its salt as the active ingredient, and its production process are described. The compound of the present invention possesses strong analgesic activity and diuretic action as a highly selective &kgr;-opioid agonist, allowing it to be used as a useful analgesic and diuretic.
摘要翻译： 描述了以化合物I表示的吗啡喃衍生物或其药理学允许的酸加成盐，其衍生物或其盐作为活性成分的止痛剂和利尿剂及其制备方法。 本发明化合物作为高度选择性的κ-阿片样物质激动剂具有强的止痛活性和利尿作用，可用作有用的镇痛和利尿剂。
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公开(公告)号：US06174891B1
公开(公告)日：2001-01-16
申请号：US09117052
申请日：1998-08-24
申请人： Hiroshi Nagase , Jun Utsumi , Takashi Endoh , Toshiaki Tanaka , Junzo Kamei , Kuniaki Kawamura
发明人： Hiroshi Nagase , Jun Utsumi , Takashi Endoh , Toshiaki Tanaka , Junzo Kamei , Kuniaki Kawamura
IPC分类号： A61K31485
CPC分类号： A61K31/541 , A61K31/40 , A61K31/4025 , A61K31/435 , A61K31/485 , A61K31/5377 , C07D489/00 , C07D489/08
摘要： This invention provides an antipruritic comprising an opiate &kgr; receptor agonist as an effective component, a new morphinan quaternary ammonium salt derivative and a new morphinan-N-oxide derivative which are useful in treating pruritus complicated with some diseases.
摘要翻译： 本发明提供了含有鸦片类κ受体激动剂作为有效成分的止痒剂，新的吗啡喃季铵盐衍生物和新的吗啡喃-N-氧化物衍生物，其可用于治疗与某些疾病并发的瘙痒。
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10.发明申请公开(公告)号：US20060040970A1
公开(公告)日：2006-02-23
申请号：US10530664
申请日：2003-10-08
IPC分类号： A61K31/473
CPC分类号： C07D489/08
摘要： The invention provides a morphinan derivative of the Formula (I): (wherein R1 is methyl, cyclopropylmethyl or the like; R2 and R3 are hydroxy, methoxy, acetoxy or the like; both Y and Z are valence bonds, —C(═O)— or the like; X is C2-C5 carbon chain (one of the carbon atoms may be substituted by oxygen, sulfur or nitrogen) constituting a part of the ring structure, or the like; (R4)k is substituted or non-substituted benzene fused ring, carbonyl group or the like; R9 is hydrogen or the like; R10 and R11 are bound to represent —O—, or the like, and R6 is hydrogen or the like) or a pharmaceutically acceptable acid addition salt thereof. The invention also provides a therapeutic or prophylactic agent for urinary frequency or urinary incontinence, comprising as an effective ingredient the morphinan derivative or the pharmaceutically acceptable acid addition salt thereof; a method for therapy or prophylaxis of the diseases.
摘要翻译： 本发明提供式（I）的吗啡喃衍生物：其中R 1是甲基，环丙基甲基等; R 2和R 3 O >是羟基，甲氧基，乙酰氧基等; Y和Z都是价键，-C（-O） - 等; X是C 2 -C 5 构成环结构的一部分的碳链（其中一个碳原子可以被氧，硫或氮取代）等;（R 4） 是取代或未取代的苯稠环，羰基等; R 9是氢等; R 10和R 11， 必须代表-O-等，R 6是氢等）或其药学上可接受的酸加成盐。 本发明还提供了用于尿频或尿失禁的治疗或预防剂，其包含吗啡喃衍生物或其药学上可接受的酸加成盐作为有效成分; 一种治疗或预防疾病的方法。
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