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21 条记录 (耗时 0.023 秒)

    Diaryl piperidine containing esters of 1,4-dihydropyridines and coronary therapeutic use
    2.
    发明授权
    Diaryl piperidine containing esters of 1,4-dihydropyridines and coronary therapeutic use 失效
    二芳基哌啶含有1,4-二氢吡啶的酯和冠状动脉治疗用途

    公开(公告)号：US4707486A

    公开(公告)日：1987-11-17

    申请号：US781808

    申请日：1985-09-30

    申请人： Dieter Flockerzi ,  Kurt Klemm ,  Wolf-Rudiger Ulrich

    发明人： Dieter Flockerzi ,  Kurt Klemm ,  Wolf-Rudiger Ulrich

    IPC分类号： C07D401/12 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/455 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07D211/14 ,  C07D211/22 ,  C07D211/90 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

    CPC分类号： C07D401/14 ,  C07D211/14 ,  C07D211/22 ,  C07D211/90 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

    摘要： Diaryl compounds of formula I ##STR1## wherein Ar represents a ring of the formula ##STR2## in which Y denotes oxygen (O), sulfur (S), vinylene (--CH.dbd.CH--), azomethine (--CH.dbd.N--) or a group of the formula ##STR3## R1, R2 and R3 are identical or different and denote hydrogen, C.sub.1 -C.sub.6 -alkyl, C.sub.3 -C.sub.7 -alkoxyalkyl, aryl, aryl-C.sub.1 -C.sub.6 -alkyl or aryloxy-C.sub.1 -C.sub.6 -alkyl,R4 and R5 are identical or different and denote hydrogen, hydroxyl, halogen, nitro, cyano, trifluoromethyl, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -alkoxy which is completely or partly substituted by fluorine, C.sub.1 -C.sub.4 -alkoxycarbonyl, C.sub.2 -C.sub.5 -acyl, amino or mono- or di-C.sub.1 -C.sub.4 -alkylamino,R6, R7, R8 and R9 are identical or different and denote hydrogen, hydroxyl, halogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, amino, mono- or di-C.sub.1 -C.sub.4 -alkylamino, or C.sub.1 -C.sub.4 -alkoxy which is completely or partly substituted by fluorine, andA denotes straight-chain or branched C.sub.2 -C.sub.5 -alkylene, which can be substituted by C.sub.1 -C.sub.4 -alkoxy or aryl,and their salts are new compounds for the treatment and prophylaxis of diseases of circulatory origin.

    摘要翻译： 式I的二芳基化合物其中Ar表示下式的环：其中Y表示氧（O），硫（S），亚乙烯基（-CH = CH-），偶氮甲碱（-CH = N-）或下式的基团R 1，R 2和R 3相同或不同，表示氢，C 1 -C 6 - 烷基，C 3 -C 7 - 烷氧基烷基，芳基，芳基-C 1 -C 6 - 烷基或芳氧基-C 1 C 1-6 - 烷基，R 4和R 5相同或不同，表示氢，羟基，卤素，硝基，氰基，三氟甲基，C 1 -C 4 - 烷基，C 1 -C 4 - 烷氧基，被C 1 -C 4 - 烷氧基完全或部分被 氟，C 1 -C 4 - 烷氧基羰基，C 2 -C 5酰基，氨基或单或二-C 1 -C 4烷基氨基，R 6，R 7，R 8和R 9相同或不同，表示氢，羟基，卤素， 烷基，C 1 -C 4 - 烷氧基，氨基，单或二-C 1 -C 4烷基氨基或被氟完全或部分取代的C 1 -C 4 - 烷氧基，A表示直链或支链C 2 -C 5亚烷基， 其可以被C 1 -C 4 - 烷氧基或芳基取代，并且它们的盐是tre的新化合物 治疗和预防循环系统疾病。

    4(1H)-pyrimidinones
    4.
    发明授权
    4(1H)-pyrimidinones 失效
    4（1H） - 嘧啶酮

    公开(公告)号：US4034093A

    公开(公告)日：1977-07-05

    申请号：US393814

    申请日：1973-09-04

    申请人： Kurt Klemm ,  Erhard Langenscheid

    发明人： Kurt Klemm ,  Erhard Langenscheid

    IPC分类号： A01N37/52 ,  A61K31/275 ,  C07D239/36 ,  C07D295/14 ,  C07D239/22 ,  A61K31/535

    CPC分类号： C07D239/36 ,  A01N37/52 ,  A61K31/275 ,  C07C251/72 ,  Y10S514/821

    摘要： Therapeutically-active and pharmacologically-acceptable 1-amido-5-cyano-4(1H)-pyrimidinones and their pharmaceutically-acceptable acid addition salts inhibit xanthineoxidase and are useful as the active ingredient in medicaments for the treatment of gout. Such pyrimidinones are prepared by treating 2-(acyl) hydrazonomethyl-3-chloro or hydroxy-4-aza-2,4-pentadienenitriles with acid.

    摘要翻译： 治疗活性和药理学上可接受的1-酰氨基-5-氰基-4（1H） - 嘧啶酮及其药学上可接受的酸加成盐抑制黄嘌呤氧化酶，并且可用作用于治疗痛风的药物中的活性成分。 通过用酸处理2-（酰基）亚肼基甲基-3-氯或羟基-4-氮杂-2,4-戊二烯基腈制备此类嘧啶酮。

    Anterior support device
    5.
    发明授权
    Anterior support device 有权
    前支撑装置

    公开(公告)号：US07422016B2

    公开(公告)日：2008-09-09

    申请号：US10427108

    申请日：2003-04-30

    申请人： Kurt Klemm

    发明人： Kurt Klemm

    IPC分类号： A61G15/00

    CPC分类号： A61B90/60 ,  A61G15/08

    摘要： The present invention is directed to a device which supports a user's spine while the user is in a forward bent position. The device includes a padded rest on which the user can lean while working in a forward bent position, and support structure enabling at least three of lateral adjustment of the rest along the projected perimeter of the work area, adjustment of the rest across the projected perimeter, height adjustment of the rest, and angular orientation of the rest. Since the user leans against the rest, the stresses otherwise normally experienced in the lower, middle and upper back are substantially attenuated. Attenuating such stress attenuates the pain experienced by the user as well as potentially extending his or her productive life.

    摘要翻译： 本发明涉及一种在使用者处于向前弯曲位置时支撑用户脊椎的装置。 该装置包括填充的休息部分，使用者可在其上朝向弯曲的位置工作时倾斜，以及支撑结构，使得能够沿着工作区域的突出周边对其余部分进行至少三个横向调整，其余部分跨越投影周边的调整 ，其余部分的高度调节和其余部分的角度定向。 由于用户倾斜于其余部分，所以在下，中，上背部通常经历的应力基本上是衰减的。 减轻这种压力会减轻用户所遭受的痛苦，并延长他或她的生产生活。

    Deck and pier accessories and mounting assemblies
    7.
    发明申请
    Deck and pier accessories and mounting assemblies 有权
    甲板和码头附件和安装组件

    公开(公告)号：US20070256612A1

    公开(公告)日：2007-11-08

    申请号：US11799995

    申请日：2007-05-03

    申请人： Kurt Klemm ,  Gregory Books ,  Greg Macheel

    发明人： Kurt Klemm ,  Gregory Books ,  Greg Macheel

    IPC分类号： A47B11/00

    CPC分类号： A47B97/00

    摘要： A recreational accessory and corresponding mounting assembly is disclosed which is adapted and configured for use in combination with a substrate, such as a pier, dock, deck, porch, staircase, etc. The mounting assembly is secured to the substrate and the recreational accessory is removably attached to the mounting assembly. In the complete assemblage, the mounting assembly is optionally cantilevered outwardly beyond the perimeter of the substrate. Accordingly, the recreational accessory does not occupy any surface area of the substrate.

    摘要翻译： 公开了一种娱乐附件和相应的安装组件，其适配和配置用于与诸如码头，码头，甲板，门廊，楼梯等的基底组合使用。安装组件固定到基底上，娱乐附件是 可拆卸地连接到安装组件。 在完整的组合中，安装组件可选地向外悬伸超过衬底的周边。 因此，娱乐附件不占用基板的任何表面积。

    Anterior support device
    8.
    发明授权
    Anterior support device 失效
    前支撑装置

    公开(公告)号：US06435186B1

    公开(公告)日：2002-08-20

    申请号：US09932041

    申请日：2001-08-17

    申请人： Kurt Klemm

    发明人： Kurt Klemm

    IPC分类号： A61G1500

    CPC分类号： A61B90/60 ,  A61G15/08

    摘要： The present invention is directed to a device that supports an individual's spine while the individual is in a forward bent position. The device includes a padded rest on which an individual could lean while working in a forward bent position and brackets for adjusting the angle, height, and position of the device. Since the individual leans against the rest, the stresses experienced in the lower, middle and upper back are substantially decreased. Reducing such stress decreases the pain experienced by the individual as well as extends his or her productive life.

    摘要翻译： 本发明涉及一种在个体处于向前弯曲位置时支撑个人脊椎的装置。 该装置包括一个填充的休息部分，一个人可在其上倾斜，同时在向前弯曲的位置工作，并且用于调节装置的角度，高度和位置的支架。 由于个人倾斜于其余部分，所以下，中，上背部的压力大大减少。 减少这种压力会减轻个人所遭受的痛苦，延长他或她的生产生活。