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    Hypoglycaemically and hypolipidaemically active derivatives of phenyl-alkane-carboxylic acids
    1.
    发明授权
    Hypoglycaemically and hypolipidaemically active derivatives of phenyl-alkane-carboxylic acids 失效
    苯基 - 烷烃 - 羧酸的低血糖和降血糖活性衍生物

    公开(公告)号：US4238506A

    公开(公告)日：1980-12-09

    申请号：US920508

    申请日：1978-06-29

    申请人： Kurt Stach, deceased ,  Elmar Bosies ,  Ruth Heerdt ,  Hans-Frieder Kuhnle ,  Felix H. Schmidt

    发明人： Kurt Stach, deceased ,  Elmar Bosies ,  Ruth Heerdt ,  Hans-Frieder Kuhnle ,  Felix H. Schmidt

    IPC分类号： C07D213/82 ,  C07D241/24 ,  C07D307/79 ,  C07D311/66 ,  C07D333/38 ,  C07C101/42

    CPC分类号： C07D213/82 ,  C07D241/24 ,  C07D307/79 ,  C07D311/66 ,  C07D333/38 ,  C07C2103/18

    摘要： Phenyl-alkane-carboxylic acids of the formula ##STR1## wherein A is an aryl, aralkyl or arylvinyl radical optionally substituted by hydroxy, halogen, trifluoromethyl, alkyl, alkylthio, alkoxy, alkenyloxy, alkoxyalkoxy, alkyl-substituted amino, aryloxy or alkoxy-substituted aryloxy, or is an aryloxyalkyl or arylthioalkyl radical, or a heterocyclic ring system optionally substituted by halogen, alkyl or alkoxy,Y is a valency bond or an unbranched or branched lower alkylene radical containing up to 3 carbon atoms,X is a straight or branched, saturated or unsaturated divalent aliphatic hydrocarbon radical containing 2 to 8 carbon atoms, there being at least 2 carbon atoms between the benzene ring and the carboxyl group, andR is a hydrogen atom or a lower alkyl radical, as well as physiologically compatible salts, esters and amides thereof, exhibit hypoglycaemic and hypolipidaemic activity.

    摘要翻译： 式（I）的苯基 - 烷烃 - 羧酸其中A是任选被羟基，卤素，三氟甲基，烷基，烷硫基，烷氧基，烯氧基，烷氧基烷氧基，烷基取代的氨基，芳氧基 或烷氧基取代的芳氧基，或是芳氧基烷基或芳硫基烷基，或任选被卤素，烷基或烷氧基取代的杂环体系，Y是价态键或含有至多3个碳原子的无支链或支链低级亚烷基，X是 含有2至8个碳原子的直链或支链，饱和或不饱和的二价脂族烃基，苯环和羧基之间至少有2个碳原子，R是氢原子或低级烷基，以及 其生理上相容的盐，酯和酰胺显示出低血糖和降血脂活性。