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    THERAPEUTIC AGENT FOR CANCER, INFLAMMATION, AND AUTO-IMMUNE DISEASE CONTAINING INHIBITOR OF ZINC FINGER PROTEIN 91
    7.
    发明申请
    THERAPEUTIC AGENT FOR CANCER, INFLAMMATION, AND AUTO-IMMUNE DISEASE CONTAINING INHIBITOR OF ZINC FINGER PROTEIN 91 审中-公开
    含有锌指蛋白91的抑制剂的癌症，炎症和自身免疫疾病的治疗剂

    公开(公告)号：US20080248024A1

    公开(公告)日：2008-10-09

    申请号：US12039640

    申请日：2008-02-28

    申请人： Jung Joon Lee ,  Jeong-Hyung Lee ,  Kyeong Lee ,  Young-Soo Hong ,  Xuejun Jin

    发明人： Jung Joon Lee ,  Jeong-Hyung Lee ,  Kyeong Lee ,  Young-Soo Hong ,  Xuejun Jin

    IPC分类号： A61K39/395 ,  A61P35/00 ,  A61K31/70 ,  G01N33/53 ,  A61P9/00 ,  A61P29/00 ,  C12Q1/68 ,  A61K38/02

    CPC分类号： C07K16/18 ,  A61K38/1709 ,  C12N15/113 ,  C12N2310/14 ,  G01N33/57415 ,  G01N33/57434 ,  G01N33/57438 ,  G01N33/57446 ,  G01N33/6872 ,  G01N2333/4703 ,  G01N2510/00 ,  G01N2800/00

    摘要： The present invention relates to a use of ZFP91 based on the functions of ZFP91 (Zinc Finger Protein 91) and the interaction of ZFP91 with NF-κB (Nuclear factor kappa B) signal transduction pathway proteins, more precisely a method to inhibit the activation of NF-κB alternative pathway by regulating ZFP91 activation, to inhibit tumor growth by inhibiting the transcription factor HIF-1 (hypoxia inducible factor-1) activation, to inhibit cancer malignancy by inhibiting angiogenesis, or reversely a method to increase the activation of NF-κB alternative pathway or to increase angiogenesis by increasing activation of HIF-1. The method of regulating ZFP91 activation of the present invention can increase or reduce HIF-1α stability by increasing or reducing the activation of NF-κB alternative pathway, so that it can be effectively used for the development of an anticancer agent, a therapeutic agent for arthritis, a therapeutic agent for ulcerative colitis, an anti-inflammatory agent and an angiogenesis inducer.

    摘要翻译： 本发明涉及基于ZFP91（锌指蛋白91）的功能和ZFP91与NF-κB（核因子κB）信号转导途径蛋白的相互作用的ZFP91的应用，更准确地说是抑制活化的方法 NF-κB通过调节ZFP91激活，通过抑制转录因子HIF-1（缺氧诱导因子-1）激活抑制肿瘤生长，通过抑制血管生成来抑制癌症恶性，或反向增加NF- kappaB替代途径或通过增加HIF-1的活化来增加血管生成。 调节本发明ZFP91活化的方法可以通过增加或减少NF-κB替代途径的活化来增加或降低HIF-1α的稳定性，从而可以有效地用于开发抗癌剂，治疗剂 关节炎，溃疡性结肠炎的治疗剂，抗炎剂和血管发生诱导剂。

    Extract of Acanthopanax koreanum for the treatment or prevention of hepatitis or the liver protective drug
    9.
    发明授权
    Extract of Acanthopanax koreanum for the treatment or prevention of hepatitis or the liver protective drug 失效
    刺五加提取物用于治疗或预防肝炎或肝脏保护性药物

    公开(公告)号：US07309504B2

    公开(公告)日：2007-12-18

    申请号：US10502140

    申请日：2003-01-24

    申请人： Jung Joon Lee ,  Jeong-Hyung Lee ,  Young Soo Hong ,  Young Ho Kim ,  Jeong Bum Nam ,  Dong Hwan Shon ,  Hang Sub Kim

    发明人： Jung Joon Lee ,  Jeong-Hyung Lee ,  Young Soo Hong ,  Young Ho Kim ,  Jeong Bum Nam ,  Dong Hwan Shon ,  Hang Sub Kim

    IPC分类号： A61K36/25 ,  A61K36/00

    CPC分类号： A61K36/254

    摘要： The disclosure concerns an extract of Acanthopanax koreanum and its use. More particularly, it concerns the extract of Acanthopanax koreanum comprising 1) the extract of Acanthopanax koreanum extracted from water, 2) among the water extract, the extract of Acanthopanax koreanum only containing ethanol insoluble part obtained by precipitating ethanol, 3) among the ethanol insoluble part, the extract of Acanthopanax koreanum containing polysaccaride with a molecular weight larger than range of 12,000˜14,000, or 4) among the ethanol insoluble part, the extract of Acanthopanax koreanum containing polysaccaride with a molecular weight larger than 100,000, which is respectively obtained from the root or stem of Acanthopanax koreanum. The extract of the present invention shows a high inhibitory activity against hepatitis and protects the liver, and thus, can be used for the treatment or prevention of hepatitis, or as a liver protective drug.

    摘要翻译： 本公开涉及刺五加的提取物及其用途。 更具体地说，涉及刺五加提取物，其包括1）从水中提取的刺五加提取物，2）在水提取物中，仅含有通过沉淀乙醇获得的乙醇不溶部分的刺五加的提取物，3）乙醇不溶性 一部分含有分子量大于12,000〜14,000范围的多糖的刺五加提取物，或4）在乙醇不溶部分中，含有分子量大于100,000的多糖的刺五加提取物分别从 刺五加的根或茎。 本发明的提取物显示出对肝炎的高抑制活性并保护肝脏，因此可用于治疗或预防肝炎，或用作肝保护药物。