摘要:
The present invention relates to an alcohol extract of ogalpi, erectile dysfunction improving health food and a treating agent containing the same, more precisely, an alcohol extract of ogalpi having an effect of improving erectile dysfunction, erectile dysfunction improving health food and an erectile dysfunction treating agent containing the same. The alcohol extract of ogalpi of the present invention has a promoting effect of penile erectility, so that it can be effectively used for the improvement of erectile dysfunction.
摘要:
Disclosed herein are an HIF-1 inhibitor, a method for the preparation thereof, and a pharmaceutical composition comprising the same as an active ingredient. The HIF-1 inhibitor shows anticancer activity thanks to the inhibition activity against HIF-1, a transcription factor which plays an important role in the growth and metastasis of cancer, but not to general cytotoxicity. Thus, the HIF-inhibitor and a pharmaceutically acceptable salt thereof can be used as a therapeutic for various cancers such as liver cancer; stomach cancer and breast cancer. Also, the compound having inhibition activity against HIF-1 is useful in the treatment of diabetic retinopathy and arthritis, which are aggravated by HIF-1-mediated VEGF expression.
摘要:
Disclosed is a composition for the prevention and treatment of metabolic diseases, which comprises a benzazole derivative as an active ingredient. The benzazole derivative has inhibitory activity against DGAT (diacylglycerol acyltransferase), which causes metabolic diseases such as obesity and diabetes in the process of lipid metabolism. With the ability to effectively control lipid metabolism and energy metabolism, thus, the composition is useful in the prevention and treatment of metabolic diseases, such as obesity and diabetes.
摘要:
The disclosure concerns an extract of Acanthopanax koreanum and its use. More particularly, it concerns the extract of Acanthopanax koreanum comprising 1) the extract of Acanthopanax koreanum extracted from water, 2) among the water extract, the extract of Acanthopanax koreanum only containing ethanol insoluble part obtained by precipitating ethanol, 3) among the ethanol insoluble part, the extract of Acanthopanax koreanum containing polysaccaride with a molecular weight larger than range of 12,000˜14,000, or 4) among the ethanol insoluble part, the extract of Acanthopanax koreanum containing polysaccaride with a molecular weight larger than 100,000, which is respectively obtained from the root or stem of Acanthopanax koreanum. The extract of the present invention shows a high inhibitory activity against hepatitis and protects the liver, and thus, can be used for the treatment or prevention of hepatitis, or as a liver protective drug.
摘要:
Disclosed herein are an HIF-1 inhibitor, a method for the preparation thereof, and a pharmaceutical composition comprising the same as an active ingredient. The HIF-1 inhibitor shows anticancer activity thanks to the inhibition activity against HIF-1, a transcription factor which plays an important role in the growth and metastasis of cancer, but not to general cytotoxicity. Thus, the HIF-inhibitor and a pharmaceutically acceptable salt thereof can be used as a therapeutic for various cancers such as liver cancer; stomach cancer and breast cancer. Also, the compound having inhibition activity against HIF-1 is useful in the treatment of diabetic retinopathy and arthritis, which are aggravated by HIF-1-mediated VEGF expression.
摘要:
The present invention relates to geldanamycin derivatives, benzoquinone ansamycin biosynthesized by gene manipulation of Streptomyces hygroscopicus subsp. duamyceticus and the method producing them, more particularly to a geldanamycin O-carbamoyl transferase gene(gel8)-inactive mutant, the method producing it and geldanamycin derivatives, 4,5-dihydro-7-O-descarbamoyl-7-hydroxy geldanamycin and 4,5-dihydro-7-O-descarbamoyl-7-hydroxy-17-O-demethyl geldanamycin. Since geldanamycin derivatives of the present invention suppress Hsp90 like geldanamycin, they can effectively be used for antibiotic, antifungal, antiviral, anti-inflammatory and antitumor agents and an immune suppressant.
摘要:
This invention relates to an inside structure of a male underpants for kinematically moving a penis. The inside structure of the underpants comprises comprises a waistband 110, a penis cord 120 for lifting a lower muscle of the penis positioned between the penis and a scrotum, penis supporting cords 130a, 130b, connected to either side of the penis cord 120, and penis exercising cords 140a, 140b positioned between the penis supporting cords 130a, 130b. The invention has a simple constitution, and thus may be easily manufactured. The invention provides healthful underpants having a pleasant wearing feeling by giving a pleasant stimulation to the lower muscle of the penis and kinematically moving the penis.
摘要:
The disclosure concerns novel use of diterpene compound as a therapeutic agent of inlfammation, immune disease or cancer. More particularly, the present invention relates to novel use of diterpene compound that include kamebanin, kamebacetal A, kamebakaurin, and exisanin A, which would be effective for the treatment inflammation, immune disease or cancer by inhibiting the production of nitric oxide, prostaglandin, and TNF-a1 through the suppression of NF-k B activity.
摘要:
Disclosed are a novel compound represented by the following chemical formula (1), useful for the prophylaxis and treatment of angiogenic diseases, its production, and a novel microorganism producing the same. Aspergillus sp. Y80118 isolated from soil was found to produce 7,8-dihydro-1,7-dihydroxy-3-hydroxymethyl-xanthenone-8-carboxylic acid methylester which inhibits VEGF-induced proliferation of HUVEC, angiogenesis in CAM assay, and tumor growth. The novel compound can be effectively used for the medical treatment of anigiogenic diseases, including cancers, rheumatoid arthritis, and diabetic retinopathy.