公开(公告)号：US06181319B2

公开(公告)日：2001-01-30

申请号：US09042664

申请日：1998-03-17

申请人： Kyozo Fujita ,  Kazuyuki Kanai ,  Shigehiro Numada

发明人： Kyozo Fujita ,  Kazuyuki Kanai ,  Shigehiro Numada

IPC分类号： G09G536

CPC分类号： G09G5/39 ,  G01N15/1429

摘要： A method of displaying a scattergram includes measuring a plurality of particles with a particle measuring apparatus and preparing distribution data representing a frequency distribution of the particles on a two-dimensional coordinate plane based on a pair of parameters obtained from each of the particles. Thereafter, a scattergram is displayed based on the distribution data on a color display device by allowing the coordinates of a particle to correspond to a pixel, each of the pixels being made of three fundamental color luminescent components. A luminance of each of the three fundamental color luminescent components corresponds to a frequency of the particles on the scattergram. As such, the frequencies of the particles are displayed in different colors.

摘要翻译： 显示散点图的方法包括使用粒子测量装置测量多个粒子，并且基于从每个粒子获得的一对参数来准备表示粒子在二维坐标平面上的频率分布的分布数据。 此后，通过使粒子的坐标与像素对应，基于彩色显示装置上的分布数据来显示散点图，每个像素由三个基色发光组件构成。 三个基色发光成分中的每一个的亮度对应于散点图上的粒子的频率。 因此，颗粒的频率以不同的颜色显示。

公开(公告)号：US6118522A

公开(公告)日：2000-09-12

申请号：US288503

申请日：1999-04-08

申请人： Kazuyuki Kanai ,  Masakazu Fukuda

发明人： Kazuyuki Kanai ,  Masakazu Fukuda

IPC分类号： G01N21/64 ,  G01N15/00 ,  G01N15/02 ,  G01N15/14 ,  G01N21/47 ,  G01N33/49 ,  G01N33/493

CPC分类号： G01N15/1429 ,  G01N33/493 ,  G01N15/1459 ,  G01N2015/0065 ,  G01N2015/1493

摘要： An apparatus for differentiating erythrocytes in urine includes: a sheath flow cell for forming a urine specimen flow by surrounding a urine specimen with a sheath liquid, the urine specimen containing particles; a light application device for applying light to the urine specimen flow; a light detector for detecting a light signal emitted by each particle in the urine specimen flow; an identification device for identifying erythrocytes from the particles in the urine specimen flow in accordance with the detected light signal; a particle size distribution preparing device for preparing a particle size distribution diagram of the identified erythrocytes; a determining device for determining an origin of the erythrocytes in accordance with an erythrocyte size value at which an accumulated frequency of erythrocytes as counted from a smallest size in the particle size distribution diagram agrees with a preset value larger than half of a total accumulated frequency in the particle size distribution diagram; and an output device for outputting a determination result.

摘要翻译： 用于分离尿液中的红细胞的装置包括：用鞘液包围尿液样本形成尿液样本流的鞘流池，含有颗粒的尿液样本; 用于向所述尿液样本流施加光的光施加装置; 光检测器，用于检测尿液样本流中每个颗粒发射的光信号; 根据检测到的光信号，从尿液样本中的颗粒中鉴定红细胞的识别装置; 用于制备鉴定的红细胞的粒度分布图的粒度分布制备装置; 用于根据红细胞大小值确定红细胞的来源的确定装置，其中在粒度分布图中从最小尺寸计数的红细胞的累积频率与大于总体累积频率的一半的预设值一致 粒度分布图; 以及输出装置，用于输出确定结果。

公开(公告)号：US06807531B1

公开(公告)日：2004-10-19

申请号：US09288504

申请日：1999-04-08

申请人： Kazuyuki Kanai

发明人： Kazuyuki Kanai

IPC分类号： G06F1760

CPC分类号： G06Q50/22 ,  G06F19/00 ,  G06Q10/10 ,  G16H50/70

摘要： A support system for making decisions on medical treatment plans or test plans includes using a decision tree having branches that represent actions to be selected in deciding the medical treatment plans or test plans for a person to be inspected and events that may possibly occur as a result of the selected actions, and calculating expectations of the actions to be selected in accordance with occurrence probabilities with which the respective events occur and utility values which reflect intentions of the person to be inspected on the events. The occurrence probabilities of the branches are renewable in accordance with attribute information of the person to be inspected.

摘要翻译： 用于对医疗计划或测试计划做出决定的支持系统包括使用具有分支的决策树来代表要被检查的人的医疗处理计划或测试计划以及可能发生的事件被选择的动作。 以及根据相应事件发生的发生概率来计算要选择的行动的期望值，以及反映对事件的被检查者的意图的效用值。 分支机构的发生概率可根据被检查人员的属性信息进行更新。

公开(公告)号：US5327792A

公开(公告)日：1994-07-12

申请号：US088569

申请日：1993-07-01

申请人： Kazuyuki Kanai

发明人： Kazuyuki Kanai

IPC分类号： G01N15/14 ,  G01N33/49 ,  G01N15/00 ,  G01N15/02

CPC分类号： G01N15/1456

摘要： In the case of forming a distribution diagram based upon measured data consisting of measured values of two or more characteristics of particles and counted values thereof which are obtained by analyzing a specimen intermixedly including plural kinds of particles with a particle analyzing device, by plotting the particles in a co-ordinate system of two or more dimensions having said characteristics as its parameters, a method of collecting the measured data over a specific length of measuring time and seeking a time-related change of the distribution diagram to visually display the same, in which a space defined by the co-ordinate system is partitioned into plural domains, in the measuring time is divided into plural time intervals and the number of the particles belonging to each domain is counted for each time interval, thereby displaying the particle distribution diagram partitioned into domains on a display screen and also displaying a time-related change of the number of particles with a folded-line diagram superposedly in each domain.

摘要翻译： 在基于通过用粒子分析装置分析包含多种粒子的试样的分析得到的粒子的两个以上特性的测定值和计数值的测定数据的形成分布图的情况下， 在具有所述特征作为其参数的两个或多个维度的坐标系统中，一种在特定测量时间长度上收集测量数据并寻求分布图的时间相关变化以在视觉上显示相同的方法 将由坐标系定义的空间划分为多个区域，将测量时间分为多个时间间隔，并且对于每个时间间隔对属于每个域的粒子的数量进行计数，从而显示分割的粒子分布图 在显示屏幕上的域中，并且还显示与颗粒数量的时间相关的变化 在每个域中叠加折叠图。

公开(公告)号：US5590665A

公开(公告)日：1997-01-07

申请号：US338826

申请日：1994-11-10

申请人： Kazuyuki Kanai

发明人： Kazuyuki Kanai

IPC分类号： A61B10/00 ,  A61B5/00 ,  G01N33/86 ,  G06F15/18 ,  G06F17/00 ,  G06N3/00 ,  G06N3/02 ,  G06N99/00 ,  A61B19/00

CPC分类号： A61B5/00 ,  A61B5/7267 ,  Y10S128/925

摘要： A novel method of diagnosing cerebral infarction using a neural network, wherein plural sets of data previously obtained from healthy and sick persons, each including an age, measured values of coagulo-fibrinolytic molecular markers ( e.g., D-dimer, TAT and PAP) , an index indicative of the state of cerebral infarction (e.g., 0 for healthy persons and 1 for sick persons) and the like, are repeatedly input into a neural network to let it learn the correlation of these characteristics and, thereafter, a set of data of a person to be diagnosed, including his age, measured values of the coagulo-fibrinolytic molecular markers and the like, are input in the neural network to obtain an index indicative of his state of cerebral infarction as a degree of dangerousness of cerebral infarction. This method is significantly higher in accuracy as compared with the prior art methods using the same data.

摘要翻译： 一种使用神经网络诊断脑梗死的新方法，其中先前从健康和病人获得的多组数据，每组包括年龄，凝血纤维蛋白溶解分子标记（例如D-二聚体，TAT和PAP）的测量值， 指示脑梗塞状态的指标（例如，健康人为0，病人为1）等被重复地输入到神经网络中，以使其学习这些特征的相关性，然后学习一组数据 要诊断的人，包括他的年龄，凝血 - 纤维蛋白溶解分子标记物的测量值等在神经网络中输入，以获得指示其脑梗死状态的指标作为脑梗死的危险程度。 与使用相同数据的现有技术方法相比，该方法的准确度显着更高。

公开(公告)号：US5359906A

公开(公告)日：1994-11-01

申请号：US823975

申请日：1992-01-23

申请人： Kazuyuki Kanai

发明人： Kazuyuki Kanai

IPC分类号： G01N15/02 ,  G01N15/14 ,  G01N33/49

CPC分类号： G01N15/02

摘要： A method of using a technique of fuzzy inference for partioning a particle size distribution diagram indicative of a relationship between particle size and its frequency of a mixture of several kinds of granular substances, such as white blood corpuscles including lymph corpuscles, monocytes and granulocytes, to define particle size regions for the respective substances. More particularly, some estimation points are selected on the abscissa of the particle size distribution diagram and some characteristic parameters are calculated at each estimation point with the corresponding frequency. A fuzzy production rule for each characteristic parameter is applied to seek an estimated value of the estimation point and the estimated values for all characteristic parameters at each estimation point are combined to obtain a composite estimated value. The estimation point corresponding to the greatest one of all resultant composite estimated values is appointed to an objective partition point.

摘要翻译： 一种使用模糊推理技术的方法，用于分离指示颗粒大小与几种粒状物质如白血球（包括淋巴细胞，单核细胞和粒细胞）的混合物的混合物的频率之间的关系的粒度分布图， 确定各物质的粒径区域。 更具体地，在粒度分布图的横坐标上选择一些估计点，并且在每个具有相应频率的估计点处计算一些特征参数。 应用每个特征参数的模糊生产规则来寻找估计点的估计值，并将每个估计点处的所有特征参数的估计值组合以获得复合估计值。 对应于所有合成估计值中最大的估计值的估计点被指定为目标分割点。

公开(公告)号：US6165740A

公开(公告)日：2000-12-26

申请号：US407286

申请日：1999-09-29

申请人： Masakazu Fukuda ,  Junya Inoue ,  Akito Terai ,  Kazuyuki Kanai ,  Kurayoshi Iseki ,  Mayumi Kamo

发明人： Masakazu Fukuda ,  Junya Inoue ,  Akito Terai ,  Kazuyuki Kanai ,  Kurayoshi Iseki ,  Mayumi Kamo

IPC分类号： C12Q1/04 ,  G01N15/14 ,  C12Q1/02 ,  C12Q1/14

CPC分类号： G01N15/14 ,  C12Q1/04 ,  G01N15/1459 ,  G01N2015/1402 ,  G01N2015/1497 ,  Y10S435/832 ,  Y10S435/833 ,  Y10S435/834 ,  Y10S435/835 ,  Y10S435/836 ,  Y10S435/837 ,  Y10S435/838 ,  Y10S435/839 ,  Y10S435/882 ,  Y10S435/885 ,  Y10S435/911

摘要： To reduce the effects of the contaminants in the measurement of microorganisms and the reduction of the time necessary for the measurement. Measurement is performed of the microorganism prior to and following culture, and the difference between the two is found. This prevents errors caused by the effect of contaminants contained in the specimens. Since the measurement of the microorganism is performed by means of a flow cytometer, the microorganisms can be measured even when the culture period is short. Moreover, the measurements are accurate, since the contaminants are not measured. Furthermore, the growth form of the microorganisms can be determined by measuring the changes in the intensity of the light emission over the duration of emission of the forward scattered light detected by means of a flow cytometer. Accordingly, based on differences in the particle-size distribution prior to and following culture, it is possible to formulate five major bacterial classifications: Bacilli, Staphylococci, Streptobacilli, Streptococci and yeast fungi.

摘要翻译： 减少污染物在微生物测量中的影响以及减少测量所需的时间。 培养前后培养微生物进行测定，发现两者之间的差异。 这样可以防止样品中含有污染物的影响引起的错误。 由于通过流式细胞仪进行微生物的测定，所以即使在培养期短的情况下也可以测定微生物。 此外，测量是准确的，因为不测量污染物。 此外，微生物的生长形式可以通过测量通过流式细胞仪检测的前向散射光的发射持续时间内的发光强度的变化来确定。 因此，根据培养之前和之后的粒度分布的差异，可以制定五种主要的细菌分类：芽孢杆菌，葡萄球菌，链球菌，链球菌和酵母真菌。

公开(公告)号：US5619990A

公开(公告)日：1997-04-15

申请号：US314008

申请日：1994-09-28

申请人： Kazuyuki Kanai

发明人： Kazuyuki Kanai

IPC分类号： G01N33/50 ,  G06F15/18 ,  G06N3/00 ,  A61B5/00

CPC分类号： G06F19/3431 ,  G06F19/345

摘要： An apparatus comprises a memory for storing a characteristic pattern for each of a plurality of groups, a discriminant function defining part for selecting at random every combination of two groups of the plurality of groups stored in the memory and defining for every selected combination of two groups a two-group linear discriminant function which provides an optimal borderline bisecting the combination of two groups, a two-group discrimination result calculation part for calculating a two-group discrimination result to which a given sample is attributed for every combination of two groups using the two-group linear discriminant function defined by the discriminant function defining part, a support degree determination part for determining a support degree of the two-group discrimination result obtained by the two-group discrimination result calculation part for every combination of two-groups, and an attribution degree calculation part for calculating attribution degrees indicating to what extent the test data is attributed to each of the plurality of groups based on the two-group discrimination result and support degree for every combination of two groups.

摘要翻译： 一种装置包括存储器，用于存储多个组中的每个组的特征模式，判别函数定义部分，用于随机选择存储在存储器中的多个组中的两组的每个组合，并为每组所选择的两组组合定义 提供将两组的组合平分的最佳边界线的两组线性判别函数，两组判别结果计算部分，用于计算给定样本归因于两组的每组合使用的两组判别结果 由判别函数定义部分定义的两组线性判别函数，用于确定由两组判别结果计算部分获得的两组判别结果计算部分对于两组的每个组合的支持度的支持度确定部分，以及 用于计算表示t的归因度的归属度计算部分 基于两组判别结果和两组的每个组合的支持度，测试数据被归因于多个组中的每个组的程度。