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1.发明申请Nucleic acid molecules, polypeptides and uses therefor, including diagnosis and treatment of Alzheimer's disease 审中-公开核酸分子，多肽及其用途，包括阿尔茨海默病的诊断和治疗公开(公告)号：US20050163789A9
公开(公告)日：2005-07-28
申请号：US10264309
申请日：2002-10-03
申请人： L. Durham , David Friedman , Herath Mudiyanselage Herath , Lida Kimmel , Rajesh Parekh , David Potter , Christian Rohlff , B. Silber , Peter Snyder , Holly Soares , Thomas Stiger , P. Sunderland , Robert Townsend , W. White , Stephen Williams
发明人： L. Durham , David Friedman , Herath Mudiyanselage Herath , Lida Kimmel , Rajesh Parekh , David Potter , Christian Rohlff , B. Silber , Peter Snyder , Holly Soares , Thomas Stiger , P. Sunderland , Robert Townsend , W. White , Stephen Williams
CPC分类号： G01N33/6896 , G01N2333/4709 , G01N2550/00 , G01N2800/2821 , G01N2800/52
摘要： The present invention provides methods and compositions for screening, diagnosis and prognosis of Alzheimer's disease, for monitoring the effectiveness of Alzheimer's disease treatment, and for drug development. Alzheimer's Disease-Associated Features (AFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Alzheimer's Disease-Associated Protein Isoforms (APIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated APIs, antibodies immunospecific for APIs, pharmaceutical compositions, diagnostic and therapeutic methods, and kits comprising or based on the same.
摘要翻译： 本发明提供了用于阿尔茨海默病筛选，诊断和预后的方法和组合物，用于监测阿尔茨海默病治疗的有效性和用于药物开发。 描述了通过脑脊液，血清或血浆的二维电泳可检测的阿尔茨海默氏病相关特征（AF）。 本发明还提供在脑脊液，血清或血浆中可检测的阿尔茨海默氏病相关蛋白质异构体（API），包含分离的API的制剂，针对API免疫特异性的抗体，药物组合物，诊断和治疗方法，以及包含或基于其的试剂盒。
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2.发明申请Nucleic acid molecules, polypeptides and uses therefor, including diagnosis and treatment of Alzheimer's disease 审中-公开核酸分子，多肽及其用途，包括阿尔茨海默病的诊断和治疗公开(公告)号：US20070015217A1
公开(公告)日：2007-01-18
申请号：US11078000
申请日：2005-03-11
申请人： L. Durham , David Friedman , Herath Mudiyanselage Chandrasiri Herath , Lida Kimmel , Rajesh Parekh , David Potter , Christian Rohlff , B. Silber , Thomas Stiger , P. Sunderland , Robert Townsend , W. White , Stephen Williams
发明人： L. Durham , David Friedman , Herath Mudiyanselage Chandrasiri Herath , Lida Kimmel , Rajesh Parekh , David Potter , Christian Rohlff , B. Silber , Thomas Stiger , P. Sunderland , Robert Townsend , W. White , Stephen Williams
IPC分类号： G01N33/567 , G01N33/53
CPC分类号： G01N33/6896 , G01N2800/2821
摘要： The present invention provides methods and compositions for screening, diagnosis and prognosis of Alzheimer's disease, for monitoring the effectiveness of Alzheimer's disease treatment, and for drug development. Alzheimer's Disease-Associated Features (AFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Alzheimer's Disease-Associated Protein Isoforms (APIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated APIs, antibodies, pharmaceutical compositions, diagnostic and therapeutic methods, and kits comprising or based on the same.
摘要翻译： 本发明提供了用于阿尔茨海默病筛选，诊断和预后的方法和组合物，用于监测阿尔茨海默病治疗的有效性和用于药物开发。 描述了通过脑脊液，血清或血浆的二维电泳可检测的阿尔茨海默氏病相关特征（AF）。 本发明进一步提供可在脑脊液，血清或血浆中检测的阿尔茨海默氏病相关蛋白质异构体（API），包含分离的API，抗体，药物组合物，诊断和治疗方法以及包含或基于其的试剂盒。
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公开(公告)号：US08156304B2
公开(公告)日：2012-04-10
申请号：US12631737
申请日：2009-12-04
IPC分类号： G06F12/00
CPC分类号： G06F3/0644 , G06F3/0613 , G06F3/0676
摘要： Embodiments of the present invention enable dynamic repartitioning of data storage in response to one or more triggers. In embodiments, a trigger may be a user-initiated action, a system-generated action, and/or an inference based on storage usage parameters. Applications of the present invention are its use in embodiments of a storage management system comprising a file system manager and a volume manager, where the placement of data into a partition (data storage region) may be specified by matching one or more disk region placement data attributes assigned to data with corresponding disk region attributes. In embodiments, dynamic repartitioning comprises adjustment of the location of the boundary between adjacent disk partitions and, if necessary, rebalancing of the data stored within the partitions by identifying mismatched data and relocating it to the partition with which it is associated.
摘要翻译： 本发明的实施例能够响应于一个或多个触发而动态地重新分配数据存储器。 在实施例中，触发器可以是基于存储使用参数的用户发起的动作，系统生成的动作和/或推断。 本发明的应用是在包括文件系统管理器和卷管理器的存储管理系统的实施例中的用途，其中可以通过匹配一个或多个盘区域放置数据来指定将数据放置到分区（数据存储区域）中 分配给具有相应磁盘区域属性的数据的属性。 在实施例中，动态重新分配包括调整相邻磁盘分区之间的边界的位置，并且如果需要，通过识别不匹配的数据并将其重定位到与其相关联的分区，来重新平衡存储在分区内的数据。
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公开(公告)号：US20090290141A1
公开(公告)日：2009-11-26
申请号：US12454058
申请日：2009-05-12
申请人： David Friedman
发明人： David Friedman
摘要： A system is provided for certifying two or more gemstones as being a matched pair. The system includes measuring values for at least four physical properties of a multiplicity of gemstones, identifying a first gemstone, a second gemstone, and optionally still further gemstones all being within match tolerances of the respective measured values, and certifying in a single certificate that based on the match tolerances, the gemstones constitute a matched set. Also disclosed is jewelry and a process for creating jewelry based on the certification system.
摘要翻译： 提供了一种用于将两个或多个宝石认证为匹配对的系统。 该系统包括测量多个宝石的至少四个物理性质的值，识别第一宝石，第二宝石以及可能还有更多的宝石，其全部在相应测量值的匹配容限内，并且在单个证书中证明基于 在匹配公差上，宝石构成了匹配的集合。 还披露了珠宝和基于认证系统创建珠宝的过程。
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公开(公告)号：US20080084919A1
公开(公告)日：2008-04-10
申请号：US11606448
申请日：2006-11-30
IPC分类号： H04B1/00
摘要： In a wireless transmission method, an input data signal corresponding to a serial combination of a first transmit data signal and a second transmit data signal is received. The first and second transmit data signals are phase-modulated with different first and second spreading code signals to produce first and second DSSS transmit signals, which are serially output as a baseband transmit signal that is up-converted to a selected wireless transmission frequency range. The first and second phase-modulated signals are serially output as a baseband transmit signal. In a wireless reception method, an input receive signal is down-converted to a baseband receive signal corresponding to a serial combination of first and second time-interleaved DSSS receive signals in a baseband frequency range. The first and second DSSS receive signals are phase-demodulated with different first and second de-spreading code signals to produce first and second receive data signals.
摘要翻译： 在无线发送方法中，接收对应于第一发送数据信号和第二发送数据信号的串行组合的输入数据信号。 第一和第二发射数据信号用不同的第一和第二扩展码信号进行相位调制，以产生第一和第二DSSS发射信号，其被串行地输出为上变频到所选无线传输频率范围的基带发射信号。 串行输出第一和第二相位调制信号作为基带发送信号。 在无线接收方法中，将输入接收信号下变频为与基带频率范围内的第一和第二时间交织的DSSS接收信号的串行组合相对应的基带接收信号。 第一和第二DSSS接收信号用不同的第一和第二去扩展码信号进行相位解调，以产生第一和第二接收数据信号。
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6.发明申请WIRELESS COMMUNICATIONS BETWEEN A PERIPHERAL AND A MOBILE UNIT IN A WIRELESS NETWORK ENVIRONMENT 审中-公开无线网络环境中的外围设备和移动设备之间的无线通信公开(公告)号：US20080062939A1
公开(公告)日：2008-03-13
申请号：US11754943
申请日：2007-05-29
申请人： Peter Van Horn , David Friedman
发明人： Peter Van Horn , David Friedman
IPC分类号： H04Q7/24
CPC分类号： H04W74/06
摘要： Systems and methods of wireless communications between a peripheral and a mobile unit in a wireless network environment are described. In one aspect, a trigger frame is wirelessly transmitted in accordance with a wireless local area network (LAN) communications protocol in response to a determination to acquire data wirelessly from a target peripheral. The trigger frame reserves a wireless channel for a duration sufficient to meet a time needed by the target peripheral to transmit local data. The target peripheral awaits receipt of a trigger frame from a target mobile unit before wirelessly transmitting local data. In response to receipt of the trigger frame, the target peripheral transmits the local data to the target mobile unit over the wireless channel during the reserved duration in accordance with a wireless local area network (LAN) communications protocol.
摘要翻译： 描述无线网络环境中的外围设备和移动单元之间的无线通信的系统和方法。 在一个方面，响应于从目标外围设备无线地获取数据的确定，根据无线局域网（LAN）通信协议无线地发送触发帧。 触发帧保留无线信道足够长的时间以满足目标外设传输本地数据所需的时间。 在无线发送本地数据之前，目标外设等待从目标移动单元接收触发帧。 响应于触发帧的接收，目标外围设备根据无线局域网（LAN）通信协议在保留的持续时间期间通过无线信道将本地数据发送到目标移动单元。
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公开(公告)号：US20060021990A1
公开(公告)日：2006-02-02
申请号：US10959838
申请日：2004-10-06
申请人： David Friedman
发明人： David Friedman
IPC分类号： A47G19/22
CPC分类号： A47G19/22
摘要： The present invention includes a food immersing apparatus adapted to be retrofit onto an open beverage container having walls continuously connected to a substantially horizontal base. The apparatus includes a holder defining an area adapted to hold food that fits within the container. An elongated member couples a handle to the holder. The elongated member extends out of the container, over its walls and down at least a portion of an exterior part of its walls. The handle can be attached to the elongated member at the top of the container or along the part that extends downward. The holder may include a basket defining drainage holes to allow liquid to drain from the basket upon removal from the container. A restraint or lid member may be added atop the food holder to secure the food during immersion in the liquid.
摘要翻译： 本发明包括一种食品浸渍设备，其适于改装到具有连续连接到基本上水平的基部的壁的敞开的饮料容器上。 该装置包括限定适于容纳适合于容器内的食物的区域的保持器。 细长构件将把手连接到保持器。 细长构件从容器的外壁延伸出其壁的外部部分的至少一部分。 手柄可以在容器的顶部或沿着向下延伸的部分附接到细长构件。 保持器可以包括限定排水孔的篮子，以允许液体从容器中取出时从篮子排出。 可以在食物保持器顶部添加约束或盖构件，以在浸入液体中时固定食物。
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公开(公告)号：US4177829A
公开(公告)日：1979-12-11
申请号：US787297
申请日：1977-04-13
申请人： David Friedman
发明人： David Friedman
CPC分类号： F16K31/20 , Y10T137/7413 , Y10T137/7468 , Y10T137/7478
摘要： A float controlled valve including a first body having a passage passing through it, the outlet end of the passage defining a valve seat, a co-operating second body having a closure member, the first body and second body being telescopically movable relative to each other while being in sealing contact to define a chamber including the valve seat and the closure member, and an outlet from said chamber, means being provided for moving the second body with closure member axially relative to the first body with valve seat to cause closing of the valve. A stop valve is built into the passage upstream of the valve seat to isolate the valve seat from supply pressure. The float has a short lever arm and the means for moving the second body comprises a pivotally mounted member supporting eccentrically of the pivot a transverse float arm having one end projecting from the pivotally mounted member and located for engagement with the second body to urge it towards a closed condition as the pivotally mounted member is rotated by a rising float associated with the float arm and means for adjusting axially the degree to which the said end projects from the pivotally mounted member. A loose closure element is free to be moved onto the valve seat when there is a reverse pressure gradient in the water in the valve, to provide a non return function.
摘要翻译： 一种浮子控制阀，包括具有通过其的通道的第一主体，通道的出口端限定阀座，具有闭合构件的协作的第二主体，第一主体和第二主体相对于彼此可伸缩地移动 同时处于密封接触以限定包括阀座和封闭构件的室以及来自所述室的出口，所述装置被设置成用于使具有闭合构件的第二主体相对于具有阀座的第一主体轴向移动，以使闭合 阀。 在阀座上游的通道内置有止回阀，以将阀座与供应压力隔离开。 浮子具有短的杠杆臂，并且用于移动第二主体的装置包括枢转地安装的构件，该构件支撑枢轴，横向浮动臂具有从枢转安装的构件突出的一端，并且定位成与第二主体接合以将其向 当枢转安装的构件通过与浮动臂相关联的上升的浮子旋转时的闭合状态以及用于沿轴向调节所述端部从枢转安装构件突出的程度的装置。 当在阀中的水中存在反向压力梯度时，松动的封闭元件可自由地移动到阀座上，以提供不返回功能。
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公开(公告)号：US4091316A
公开(公告)日：1978-05-23
申请号：US620125
申请日：1975-09-30
申请人： David Friedman
发明人： David Friedman
CPC分类号： H02P8/32
摘要： A method and apparatus for damping stepper motors are disclosed. A tachometer feedback is used to modulate the phase angle of the stepper motor command currents to achieve damping.
摘要翻译： 公开了一种用于阻尼步进电动机的方法和装置。 转速计反馈用于调节步进电机指令电流的相位角以实现阻尼。
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公开(公告)号：US20210362905A1
公开(公告)日：2021-11-25
申请号：US17324700
申请日：2021-05-19
摘要： A pallet comprises an upper load supporting surface having a peripheral edge, and a lower surface having a peripheral edge. The lower surface has substantially the same dimensions as the upper load supporting surface. A plurality of peripheral supports are provided at or near the peripheral edge of the lower surface and extend upwardly therefrom to the upper load supporting surface so that the upper load supporting surface and the lower surface are spaced from each other and define sides of the pallet. Each side of the pallet has a first opening and a second opening which are defined by the upper load supporting surface, the lower surface, and a pair of peripheral supports. Inclined surfaces are provided on the lower surface.
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