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1.发明申请Nucleic acid molecules, polypeptides and uses therefor, including diagnosis and treatment of Alzheimer's disease 审中-公开核酸分子，多肽及其用途，包括阿尔茨海默病的诊断和治疗公开(公告)号：US20050163789A9
公开(公告)日：2005-07-28
申请号：US10264309
申请日：2002-10-03
申请人： L. Durham , David Friedman , Herath Mudiyanselage Herath , Lida Kimmel , Rajesh Parekh , David Potter , Christian Rohlff , B. Silber , Peter Snyder , Holly Soares , Thomas Stiger , P. Sunderland , Robert Townsend , W. White , Stephen Williams
发明人： L. Durham , David Friedman , Herath Mudiyanselage Herath , Lida Kimmel , Rajesh Parekh , David Potter , Christian Rohlff , B. Silber , Peter Snyder , Holly Soares , Thomas Stiger , P. Sunderland , Robert Townsend , W. White , Stephen Williams
CPC分类号： G01N33/6896 , G01N2333/4709 , G01N2550/00 , G01N2800/2821 , G01N2800/52
摘要： The present invention provides methods and compositions for screening, diagnosis and prognosis of Alzheimer's disease, for monitoring the effectiveness of Alzheimer's disease treatment, and for drug development. Alzheimer's Disease-Associated Features (AFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Alzheimer's Disease-Associated Protein Isoforms (APIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated APIs, antibodies immunospecific for APIs, pharmaceutical compositions, diagnostic and therapeutic methods, and kits comprising or based on the same.
摘要翻译： 本发明提供了用于阿尔茨海默病筛选，诊断和预后的方法和组合物，用于监测阿尔茨海默病治疗的有效性和用于药物开发。 描述了通过脑脊液，血清或血浆的二维电泳可检测的阿尔茨海默氏病相关特征（AF）。 本发明还提供在脑脊液，血清或血浆中可检测的阿尔茨海默氏病相关蛋白质异构体（API），包含分离的API的制剂，针对API免疫特异性的抗体，药物组合物，诊断和治疗方法，以及包含或基于其的试剂盒。
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2.发明申请Nucleic acid molecules, polypeptides and uses therefor, including diagnosis and treatment of Alzheimer's disease 审中-公开核酸分子，多肽及其用途，包括阿尔茨海默病的诊断和治疗公开(公告)号：US20070015217A1
公开(公告)日：2007-01-18
申请号：US11078000
申请日：2005-03-11
申请人： L. Durham , David Friedman , Herath Mudiyanselage Chandrasiri Herath , Lida Kimmel , Rajesh Parekh , David Potter , Christian Rohlff , B. Silber , Thomas Stiger , P. Sunderland , Robert Townsend , W. White , Stephen Williams
发明人： L. Durham , David Friedman , Herath Mudiyanselage Chandrasiri Herath , Lida Kimmel , Rajesh Parekh , David Potter , Christian Rohlff , B. Silber , Thomas Stiger , P. Sunderland , Robert Townsend , W. White , Stephen Williams
IPC分类号： G01N33/567 , G01N33/53
CPC分类号： G01N33/6896 , G01N2800/2821
摘要： The present invention provides methods and compositions for screening, diagnosis and prognosis of Alzheimer's disease, for monitoring the effectiveness of Alzheimer's disease treatment, and for drug development. Alzheimer's Disease-Associated Features (AFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Alzheimer's Disease-Associated Protein Isoforms (APIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated APIs, antibodies, pharmaceutical compositions, diagnostic and therapeutic methods, and kits comprising or based on the same.
摘要翻译： 本发明提供了用于阿尔茨海默病筛选，诊断和预后的方法和组合物，用于监测阿尔茨海默病治疗的有效性和用于药物开发。 描述了通过脑脊液，血清或血浆的二维电泳可检测的阿尔茨海默氏病相关特征（AF）。 本发明进一步提供可在脑脊液，血清或血浆中检测的阿尔茨海默氏病相关蛋白质异构体（API），包含分离的API，抗体，药物组合物，诊断和治疗方法以及包含或基于其的试剂盒。
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公开(公告)号：US08555002B2
公开(公告)日：2013-10-08
申请号：US13443086
申请日：2012-04-10
IPC分类号： G06F13/00
CPC分类号： G06F12/1009 , G06F3/0604 , G06F3/0628 , G06F3/0638 , G06F3/064 , G06F3/0646 , G06F3/0647 , G06F3/068 , G06F3/0685 , G06F9/5016 , G06F12/0207 , G06F12/0223 , G06F12/0292 , G06F12/08 , G06F12/10 , G06F12/121 , G06F12/1475 , G06F13/1657 , G06F13/1694 , G06F2212/205 , G06F2212/657 , Y02D10/13 , Y02D10/14 , Y02D10/22
摘要： Main memory is managed by receiving a command from an application to read data associated with a virtual address that is mapped to the main memory. A memory controller determines that the virtual address is mapped to one of the symmetric memory components of the main memory, and accesses memory use characteristics indicating how the data associated with the virtual address has been accessed, The memory controller determines that the data associated with the virtual address has access characteristics suited to an asymmetric memory component of the main memory and loads the data associated with the virtual address to the asymmetric memory component of the main memory. After the loading and using the memory management unit, a command is received from the application to read the data associated with the virtual address, and the data associated with the virtual address is retrieved from the asymmetric memory component.
摘要翻译： 通过接收来自应用程序的命令来读取与映射到主存储器的虚拟地址相关联的数据来管理主存储器。 存储器控制器确定虚拟地址被映射到主存储器的对称存储器组件中的一个，并且访问指示如何与虚拟地址相关联的数据被访问的存储器使用特性。存储器控制器确定与 虚拟地址具有适合于主存储器的非对称存储器组件的访问特征，并将与虚拟地址相关联的数据加载到主存储器的非对称存储器组件。 在加载和使用存储器管理单元之后，从应用程序接收到用于读取与虚拟地址相关联的数据的命令，并且从非对称存储器组件检索与虚拟地址相关联的数据。
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4.发明申请APPARATUS WITH A MEMORY CONTROLLER CONFIGURED TO CONTROL ACCESS TO RANDOMLY ACCESSIBLE NON-VOLATILE MEMORY 有权配有记忆控制器的设备，用于控制访问随机访问的非易失性存储器公开(公告)号：US20130138872A1
公开(公告)日：2013-05-30
申请号：US13747455
申请日：2013-01-22
IPC分类号： G06F12/02
CPC分类号： G06F12/0246 , G06F12/0638 , G06F13/12 , G06F13/1657 , G06F13/1694 , G06F2212/25 , G06F2212/7203 , G11C7/1006 , G11C7/1072 , Y02D10/14
摘要： An apparatus includes a printed circuit board with a plurality of printed circuit board traces, a memory controller mounted on the printed circuit board coupled to one or more of the plurality of printed circuit board traces, a plurality of non-volatile type of memory integrated circuits coupled to the printed circuit board, and a plurality of support integrated circuits coupled between the memory controller and the plurality of non-volatile type of memory integrated circuits.
摘要翻译： 一种装置包括具有多个印刷电路板迹线的印刷电路板，安装在与多个印刷电路板迹线中的一个或多个印刷电路板迹线耦合的印刷电路板上的存储器控制器，多个非易失型存储器集成电路 耦合到印刷电路板，以及耦合在存储器控制器和多个非易失性类型的存储器集成电路之间的多个支持集成电路。
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5.发明授权Methods of assembly of a computer system with randomly accessible non-volatile memory 有权具有随机访问的非易失性存储器的计算机系统的组装方法公开(公告)号：US08370548B2
公开(公告)日：2013-02-05
申请号：US12832921
申请日：2010-07-08
IPC分类号： G06F13/12
CPC分类号： G06F13/1657 , Y02D10/14
摘要： An apparatus includes a printed circuit board with a plurality of printed circuit board traces, a memory controller mounted on the printed circuit board coupled to one or more of the plurality of printed circuit board traces, a plurality of non-volatile type of memory integrated circuits coupled to the printed circuit board, and a plurality of support integrated circuits coupled between the memory controller and the plurality of non-volatile type of memory integrated circuits.
摘要翻译： 一种装置包括具有多个印刷电路板迹线的印刷电路板，安装在与多个印刷电路板迹线中的一个或多个印刷电路板迹线耦合的印刷电路板上的存储器控制器，多个非易失型存储器集成电路 耦合到印刷电路板，以及耦合在存储器控制器和多个非易失性类型的存储器集成电路之间的多个支持集成电路。
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公开(公告)号：US08205061B2
公开(公告)日：2012-06-19
申请号：US13048012
申请日：2011-03-15
IPC分类号： G06F13/00
CPC分类号： G06F12/1009 , G06F3/0604 , G06F3/0628 , G06F3/0638 , G06F3/064 , G06F3/0646 , G06F3/0647 , G06F3/068 , G06F3/0685 , G06F9/5016 , G06F12/0207 , G06F12/0223 , G06F12/0292 , G06F12/08 , G06F12/10 , G06F12/121 , G06F12/1475 , G06F13/1657 , G06F13/1694 , G06F2212/205 , G06F2212/657 , Y02D10/13 , Y02D10/14 , Y02D10/22
摘要： A command from an application is received to access a data structure associated with one or more virtual addresses mapped to main memory. A first subset of the virtual addresses for the data structure having constituent addresses that are mapped to the symmetric memory components and a second subset of the virtual addresses for the data structure having constituent addresses that are mapped to the asymmetric memory components are identified. Data associated with the virtual address from the first physical addresses and data associated with the virtual addresses from the second physical addresses are accessed. The data associated with the symmetric and asymmetric memory components is accessed by the application without providing the application with an indication of whether the data is accessed within the symmetric memory component or the asymmetric memory component.
摘要翻译： 接收来自应用程序的命令以访问与映射到主存储器的一个或多个虚拟地址相关联的数据结构。 识别具有映射到对称存储器组件的组成地址的数据结构的虚拟地址的第一子集以及具有映射到非对称存储器组件的组成地址的数据结构的虚拟地址的第二子集。 访问与来自第一物理地址的虚拟地址相关联的数据和与来自第二物理地址的虚拟地址相关联的数据。 与对称和非对称存储器组件相关联的数据被应用程序访问，而不向应用程序提供在对称存储器组件或非对称存储器组件内是否访问数据的指示。
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公开(公告)号：US20110173371A1
公开(公告)日：2011-07-14
申请号：US13053371
申请日：2011-03-22
CPC分类号： G06F12/1009 , G06F3/0604 , G06F3/0628 , G06F3/0638 , G06F3/064 , G06F3/0646 , G06F3/0647 , G06F3/068 , G06F3/0685 , G06F9/5016 , G06F12/0207 , G06F12/0223 , G06F12/0292 , G06F12/08 , G06F12/10 , G06F12/121 , G06F12/1475 , G06F13/1657 , G06F13/1694 , G06F2212/205 , G06F2212/657 , Y02D10/13 , Y02D10/14 , Y02D10/22
摘要： A memory controller writes to a virtual address associated with data residing within an asymmetric memory component of main memory that is within a computer system and that has a symmetric memory component, while preserving proximate other data residing within the asymmetric memory component. The symmetric memory component within the main memory of the computer system is configured to enable random access write operations in which an address within a block of the symmetric memory component is written without affecting the availability of other addresses within the block of the symmetric memory component during the writing of that address. The asymmetric memory component is configured to enable block write operations in which writing to an address within a region of the asymmetric memory component affects the availability of other addresses within the region of the asymmetric memory component during the block write operations involving the address.
摘要翻译： 存储器控制器写入与驻留在计算机系统内的主存储器的非对称存储器组件内的数据相关联的虚拟地址，并且具有对称存储器组件，同时保留驻留在非对称存储器组件内的邻近其他数据。 计算机系统的主存储器内的对称存储器组件被配置为实现随机存取写入操作，其中写入对称存储器组件的块内的地址而不影响对称存储器组件的块内的其他地址的可用性 写这个地址。 非对称存储器组件被配置为启用块写入操作，其中对非对称存储器组件的区域内的地址的写入在涉及地址的块写入操作期间影响非对称存储器组件的区域内的其他地址的可用性。
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8.发明申请公开(公告)号：US20110035273A1
公开(公告)日：2011-02-10
申请号：US12536334
申请日：2009-08-05
CPC分类号： G06Q30/02 , G06Q30/0243
摘要： A method for recommending improvements to advertisement campaign performance includes receiving a seed campaign insertion order (IO) having one or more campaign IO lines; computing a plurality of neighbor ad campaigns based on comparison of the seed campaign IO with a dataset of advertiser ad campaign IO lines; generating campaign IO recommendations by executing an algorithm to recommend profiles to add to the seed campaign IO from booking lines corresponding to the profiles based on performance of such use by the neighbor ad campaigns being generally above average when compared with campaigns that did not use the recommended profiles; filtering the profile recommendations based on a plurality of performance-enhancing criteria of the seed campaign IO and the neighbor ad campaigns with respect to each potential profile recommendation; ranking the profile recommendations based on at least one performance metric; and displaying the ranked profile recommendations to the advertiser for selection.
摘要翻译： 一种用于推荐改进广告活动性能的方法包括：接收具有一个或多个活动IO线的种子活动插入订单（IO）; 基于种子活动IO与广告主广告活动IO行的数据集的比较来计算多个邻居广告活动; 通过执行一种算法，通过执行一种算法来推荐配置文件，以推荐配置文件，以根据与配置文件相对应的预定行添加种子广告系列IO，这些配置文件基于相邻广告系列的使用效果，通常高于平均水平，与未使用推荐的广告系列相比 档案; 基于关于每个潜在简档建议的种子活动IO和邻居广告活动的多个绩效增强标准来过滤简档建议; 根据至少一个绩效指标对简档建议进行排名; 并向广告商显示排名的配置文件推荐以进行选择。
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公开(公告)号：US20100325383A1
公开(公告)日：2010-12-23
申请号：US12853135
申请日：2010-08-09
CPC分类号： G06F12/1009 , G06F3/0604 , G06F3/0628 , G06F3/0638 , G06F3/064 , G06F3/0646 , G06F3/0647 , G06F3/068 , G06F3/0685 , G06F9/5016 , G06F12/0207 , G06F12/0223 , G06F12/0292 , G06F12/08 , G06F12/10 , G06F12/121 , G06F12/1475 , G06F13/1657 , G06F13/1694 , G06F2212/205 , G06F2212/657 , Y02D10/13 , Y02D10/14 , Y02D10/22
摘要： Main memory is managed by receiving a command from an application to read data associated with a virtual address that is mapped to the main memory. A memory controller determines that the virtual address is mapped to one of the symmetric memory components of the main memory, and accesses memory use characteristics indicating how the data associated with the virtual address has been accessed, The memory controller determines that the data associated with the virtual address has access characteristics suited to an asymmetric memory component of the main memory and loads the data associated with the virtual address to the asymmetric memory component of the main memory. After the loading and using the memory management unit, a command is received from the application to read the data associated with the virtual address, and the data associated with the virtual address is retrieved from the asymmetric memory component.
摘要翻译： 通过接收来自应用程序的命令来读取与映射到主存储器的虚拟地址相关联的数据来管理主存储器。 存储器控制器确定虚拟地址被映射到主存储器的对称存储器组件中的一个，并且访问指示如何与虚拟地址相关联的数据被访问的存储器使用特性。存储器控制器确定与 虚拟地址具有适合于主存储器的非对称存储器组件的访问特征，并将与虚拟地址相关联的数据加载到主存储器的非对称存储器组件。 在加载和使用存储器管理单元之后，从应用程序接收到用于读取与虚拟地址相关联的数据的命令，并且从非对称存储器组件检索与虚拟地址相关联的数据。
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公开(公告)号：US07774556B2
公开(公告)日：2010-08-10
申请号：US11935224
申请日：2007-11-05
IPC分类号： G06F12/00
CPC分类号： G06F12/1009 , G06F3/0604 , G06F3/0628 , G06F3/0638 , G06F3/064 , G06F3/0646 , G06F3/0647 , G06F3/068 , G06F3/0685 , G06F9/5016 , G06F12/0207 , G06F12/0223 , G06F12/0292 , G06F12/08 , G06F12/10 , G06F12/121 , G06F12/1475 , G06F13/1657 , G06F13/1694 , G06F2212/205 , G06F2212/657 , Y02D10/13 , Y02D10/14 , Y02D10/22
摘要： Main memory is managed by receiving a command from an application to read data associated with a virtual address that is mapped to the main memory. A memory controller determines that the virtual address is mapped to one of the symmetric memory components of the main memory, and accesses memory use characteristics indicating how the data associated with the virtual address has been accessed, The memory controller determines that the data associated with the virtual address has access characteristics suited to an asymmetric memory component of the main memory and loads the data associated with the virtual address to the asymmetric memory component of the main memory. After the loading and using the memory management unit, a command is received from the application to read the data associated with the virtual address, and the data associated with the virtual address is retrieved from the asymmetric memory component.
摘要翻译： 通过接收来自应用程序的命令来读取与映射到主存储器的虚拟地址相关联的数据来管理主存储器。 存储器控制器确定虚拟地址被映射到主存储器的对称存储器组件中的一个，并且访问指示如何与虚拟地址相关联的数据被访问的存储器使用特性。存储器控制器确定与 虚拟地址具有适合于主存储器的非对称存储器组件的访问特征，并将与虚拟地址相关联的数据加载到主存储器的非对称存储器组件。 在加载和使用存储器管理单元之后，从应用程序接收到用于读取与虚拟地址相关联的数据的命令，并且从非对称存储器组件检索与虚拟地址相关联的数据。
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