公开(公告)号：US20070015217A1

公开(公告)日：2007-01-18

申请号：US11078000

申请日：2005-03-11

申请人： L. Durham ,  David Friedman ,  Herath Mudiyanselage Chandrasiri Herath ,  Lida Kimmel ,  Rajesh Parekh ,  David Potter ,  Christian Rohlff ,  B. Silber ,  Thomas Stiger ,  P. Sunderland ,  Robert Townsend ,  W. White ,  Stephen Williams

发明人： L. Durham ,  David Friedman ,  Herath Mudiyanselage Chandrasiri Herath ,  Lida Kimmel ,  Rajesh Parekh ,  David Potter ,  Christian Rohlff ,  B. Silber ,  Thomas Stiger ,  P. Sunderland ,  Robert Townsend ,  W. White ,  Stephen Williams

IPC分类号： G01N33/567 ,  G01N33/53

CPC分类号： G01N33/6896 ,  G01N2800/2821

摘要： The present invention provides methods and compositions for screening, diagnosis and prognosis of Alzheimer's disease, for monitoring the effectiveness of Alzheimer's disease treatment, and for drug development. Alzheimer's Disease-Associated Features (AFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Alzheimer's Disease-Associated Protein Isoforms (APIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated APIs, antibodies, pharmaceutical compositions, diagnostic and therapeutic methods, and kits comprising or based on the same.

摘要翻译： 本发明提供了用于阿尔茨海默病筛选，诊断和预后的方法和组合物，用于监测阿尔茨海默病治疗的有效性和用于药物开发。 描述了通过脑脊液，血清或血浆的二维电泳可检测的阿尔茨海默氏病相关特征（AF）。 本发明进一步提供可在脑脊液，血清或血浆中检测的阿尔茨海默氏病相关蛋白质异构体（API），包含分离的API，抗体，药物组合物，诊断和治疗方法以及包含或基于其的试剂盒。

公开(公告)号：US20050163789A9

公开(公告)日：2005-07-28

申请号：US10264309

申请日：2002-10-03

申请人： L. Durham ,  David Friedman ,  Herath Mudiyanselage Herath ,  Lida Kimmel ,  Rajesh Parekh ,  David Potter ,  Christian Rohlff ,  B. Silber ,  Peter Snyder ,  Holly Soares ,  Thomas Stiger ,  P. Sunderland ,  Robert Townsend ,  W. White ,  Stephen Williams

发明人： L. Durham ,  David Friedman ,  Herath Mudiyanselage Herath ,  Lida Kimmel ,  Rajesh Parekh ,  David Potter ,  Christian Rohlff ,  B. Silber ,  Peter Snyder ,  Holly Soares ,  Thomas Stiger ,  P. Sunderland ,  Robert Townsend ,  W. White ,  Stephen Williams

IPC分类号： G01N33/68 ,  A61K48/00 ,  A61K39/00 ,  C07K16/40 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/542

CPC分类号： G01N33/6896 ,  G01N2333/4709 ,  G01N2550/00 ,  G01N2800/2821 ,  G01N2800/52

摘要： The present invention provides methods and compositions for screening, diagnosis and prognosis of Alzheimer's disease, for monitoring the effectiveness of Alzheimer's disease treatment, and for drug development. Alzheimer's Disease-Associated Features (AFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Alzheimer's Disease-Associated Protein Isoforms (APIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated APIs, antibodies immunospecific for APIs, pharmaceutical compositions, diagnostic and therapeutic methods, and kits comprising or based on the same.

摘要翻译： 本发明提供了用于阿尔茨海默病筛选，诊断和预后的方法和组合物，用于监测阿尔茨海默病治疗的有效性和用于药物开发。 描述了通过脑脊液，血清或血浆的二维电泳可检测的阿尔茨海默氏病相关特征（AF）。 本发明还提供在脑脊液，血清或血浆中可检测的阿尔茨海默氏病相关蛋白质异构体（API），包含分离的API的制剂，针对API免疫特异性的抗体，药物组合物，诊断和治疗方法，以及包含或基于其的试剂盒。

公开(公告)号：US10958074B2

公开(公告)日：2021-03-23

申请号：US14374833

申请日：2012-02-01

申请人： Donald S. Berkowitz ,  David Porter ,  Terrence Bellei ,  James W. Sember ,  Stephen Williams

发明人： Donald S. Berkowitz ,  David Porter ,  Terrence Bellei ,  James W. Sember ,  Stephen Williams

IPC分类号： H02J3/32 ,  G05B15/02

摘要： This patent describes embodiments of systems, apparatus and methods to provide improved control and coordination of a multiplicity of electric distribution grid-connected, energy storage units deployed over a geographically-dispersed area.

公开(公告)号：US08523111B2

公开(公告)日：2013-09-03

申请号：US12737549

申请日：2009-07-20

申请人： Stephen Williams

发明人： Stephen Williams

IPC分类号： B64C1/00

CPC分类号： B64C3/187 ,  B64F5/10 ,  Y10T29/49622

摘要： A method of stiffening a rib (19, 20) during the assembly of an aircraft wing is described. A stiffener panel (40, 41) is attached to a face of the rib (19, 20). The rib is aligned with one or more wing components with the stiffener panel (40, 41) attached. An assembly operation such as drilling (16) is performed with the rib aligned and the stiffener panel attached. The stiffener panel (40, 41) is removed from the rib after the assembly operation. The stiffener panel has a resilient external sealing ring which is mounted on a face of the panel and forms an external perimeter of a vacuum cavity; and at least one resilient internal sealing ring which is mounted on the panel (20, 21) within the perimeter defined by the external sealing ring and forms an internal perimeter of the vacuum cavity. The stiffener can be attached to the rib by a vacuum clamping force, the vacuum being sealed by the external and internal sealing rings. The internal sealing ring(s) seal any holes which are present in the rib. The stiffener (40, 41) can support the rib (20, 21) during alignment to give it the required flatness.

摘要翻译： 描述了在飞行器机翼的组装期间加强肋（19,20）的方法。 加强板（40,41）附接到肋（19,20）的表面。 肋与一个或多个机翼部件对准，并且加强板（40,41）连接在一起。 执行诸如钻孔（16）的组装操作，其中肋对准并且加强板连接。 在组装操作之后，加强板（40,41）从肋上移除。 加强板具有弹性的外部密封环，其安装在面板的表面上并形成真空腔的外周; 以及至少一个弹性内部密封环，其安装在由外部密封环限定的周边内的面板（20,21）上并形成真空腔的内部周边。 加强件可以通过真空夹紧力连接到肋上，真空由外部和内部密封环密封。 内密封环密封肋中存在的任何孔。 加强件（40,41）可以在对准期间支撑肋（20,21），以使其成为所需的平整度。

公开(公告)号：US08146376B1

公开(公告)日：2012-04-03

申请号：US12353852

申请日：2009-01-14

申请人： Stephen Williams ,  Marwan E. Estiban ,  Jameson P. Gavin

发明人： Stephen Williams ,  Marwan E. Estiban ,  Jameson P. Gavin

IPC分类号： F25D17/00 ,  F24F7/00

CPC分类号： F24F1/00 ,  F24F3/1603 ,  F24F11/30 ,  F24F11/62 ,  F24F11/65 ,  F24F2110/00

摘要： An active air cleaning controller is connected to a forced air heating, ventilation and air conditioning (HVAC) system. The active air cleaning controller uses call signals from a thermostat to the HVAC system and/or sensor signals to determine when, and for how long, the blower of the HVAC system has been active and whether to independently activate the blower. The active air cleaning controller uses at least the collected information regarding the blower run time to determine when to activate the blower, in addition to its use within the HVAC system, to cycle and thus clean the air in a living environment independently of call signals used to activate heating and/or cooling functions of the HVAC system.

摘要翻译： 主动空气净化控制器连接到强制空气加热，通风和空调（HVAC）系统。 主动空气净化控制器使用来自恒温器的呼叫信号到HVAC系统和/或传感器信号，以确定HVAC系统的鼓风机何时以及多长时间已经起作用以及是否独立启动鼓风机。 主动空气净化控制器至少使用收集的有关鼓风机运行时间的信息来确定何时启动鼓风机，除了在HVAC系统中使用之外，还可以独立于使用的呼叫信号循环并因此清洁生活环境中的空气 以激活HVAC系统的加热和/或冷却功能。

公开(公告)号：US20090209129A1

公开(公告)日：2009-08-20

申请号：US12293461

申请日：2007-03-21

申请人： Stephen Williams

发明人： Stephen Williams

IPC分类号： H01R13/66

CPC分类号： H01R13/73 ,  H01R13/533 ,  H02G3/22

摘要： An aircraft wiring installation connecting a set of fuel side wires in an aircraft fuel tank to a set of airside wires outside the fuel tank, the installation comprising: a connector box having a fuel side wall (22) and an airside wall (21); one or more connectors (40, 43) carried by the fuel side wall (22) which connect the fuel side wires to the airside wires; a fairing (6) partially covering the airside wall (21); and one or more holes (30) in the airside wall through which the airside wires pass from the connector box into the fairing (6).

摘要翻译： 一种将飞机燃料箱中的一组燃料侧电线连接到燃料箱外部的一组空气侧电线的飞行器接线装置，该装置包括：具有燃料侧壁（22）和空气侧壁（21）的连接器盒; 一个或多个由燃料侧壁（22）承载的连接器（40,43），其将燃料侧电线连接到空气侧电线; 部分覆盖空气侧壁（21）的整流罩（6）; 和空气侧壁中的一个或多个孔（30），空气侧线通过该孔从连接器盒穿过整流罩（6）。

公开(公告)号：US20070269435A1

公开(公告)日：2007-11-22

申请号：US11716878

申请日：2007-03-12

申请人： Stephen Gillies ,  Francis Carr ,  Jones Tim ,  Graham Carter ,  Anila Hamilton ,  Stephen Williams ,  Marian Hanlon ,  John Watkins ,  Matthew Baker ,  Jeffrey Way

发明人： Stephen Gillies ,  Francis Carr ,  Jones Tim ,  Graham Carter ,  Anila Hamilton ,  Stephen Williams ,  Marian Hanlon ,  John Watkins ,  Matthew Baker ,  Jeffrey Way

IPC分类号： A61K39/395 ,  A61P35/00 ,  C07H21/00 ,  C12P21/08

CPC分类号： C07K16/30 ,  C07K16/28 ,  C07K16/2863 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2319/00 ,  C07K2319/30

摘要： The invention relates to artificial modified proteins, preferably fusion proteins, having a reduced immunogenicity compared to the parent non-modified molecule when exposed to a species in vivo. The invention relates, above all, to novel immunoglobulin fusion proteins which essentially consist of an immunoglobulin molecule or a fragment thereof covalently fused via its C-terminus to the N-terminus of a biologically active non-immunoglobulin molecule, preferably a polypeptide or protein or a biologically active fragment thereof. In a specific embodiment, the invention relates to fusion proteins consisting of an Fc portion of an antibody which is fused as mentioned to the non-immunological target molecule which elicits biological or pharmacological efficacy. The molecules of the invention have amino acid sequences which are altered in one or more amino acid residue positions but have in principal the same biological activity as compared with the non-altered molecules. The changes are made in regions of the molecules which are identified as T-cell epitopes, which contribute to an immune reaction in a living host. Thus, the invention also relates to a novel method of making such fusion proteins by identifying said epitopes comprising calculation of T-cell epitope values for MHC Class II molecule binding sites in a peptide by computer-aided methods.

摘要翻译： 本发明涉及人体修饰蛋白，优选融合蛋白，当与体内物种暴露时，与亲本非修饰分子相比具有降低的免疫原性。 本发明首先涉及新的免疫球蛋白融合蛋白，其基本上由通过其C-末端与生物活性非免疫球蛋白分子（优选多肽或蛋白质）的N末端共价融合的免疫球蛋白分子或其片段组成，或 其生物活性片段。 在一个具体的实施方案中，本发明涉及由抗体的Fc部分组成的融合蛋白，所述Fc部分如提及的非免疫靶标分子融合而引起生物学或药理学功效。 本发明的分子具有氨基酸序列，其在一个或多个氨基酸残基位置被改变，但与未改变的分子相比具有相同的生物学活性。 在被鉴定为T细胞表位的分子的区域中进行改变，其有助于在宿主中的免疫反应。 因此，本发明还涉及通过鉴定所述表位来制备此类融合蛋白的新方法，包括通过计算机辅助方法计算肽中MHC II类分子结合位点的T细胞表位值。

公开(公告)号：US07155683B1

公开(公告)日：2006-12-26

申请号：US09507945

申请日：2000-02-22

申请人： Stephen Williams

发明人： Stephen Williams

IPC分类号： G06F3/00

CPC分类号： G06F3/0237 ,  H04M1/274558 ,  H04M1/72552 ,  H04M2001/274541 ,  H04M2250/70

摘要： A communication terminal having a display; a keypad having a plurality of keys associated with several letters each; a processor for controlling the display in accordance with the operation of the keypad; a selectable predictive editor program for generating an output containing words matching a received string of ambiguous key strokes, the predictive editor program has a number of associated vocabularies including at least one language dependent dictionary and at least one dictionary receiving user defined inputs. An editor application is controlled by the processor which communicates with said predictive editor programs for generating matching words based on an ambiguous string of key strokes. A second memory of the communication terminal for storing user inputted data. The processor automatically searches the second memory for words and copies these words into the dictionary for receiving user defined inputs associated with said predictive editor program.

摘要翻译： 具有显示器的通信终端; 键盘，其具有与多个字母相关联的多个键; 处理器，用于根据键盘的操作来控制显示; 一种可选择的预测编辑器程序，用于生成包含与所接收的不明确的关键笔划串匹配的单词的输出，所述预测编辑器程序具有包括至少一个取决于语言的字典和至少一个接收用户定义的输入的字典的相关词汇的数量。 编辑器应用程序由处理器控制，该处理器与所述预测编辑器程序进行通信，用于基于不确定的键击串来产生匹配词。 用于存储用户输入数据的通信终端的第二存储器。 处理器自动搜索第二存储器中的字，并将这些字复制到字典中，以接收与所述预测编辑器程序相关联的用户定义的输入。

公开(公告)号：US20060249885A1

公开(公告)日：2006-11-09

申请号：US10539286

申请日：2003-12-18

申请人： Paul Stacey ,  Stephen Williams

发明人： Paul Stacey ,  Stephen Williams

IPC分类号： G01B15/00

CPC分类号： B29C35/0227 ,  B29C35/0288

摘要： An apparatus and method for controlling the curing process during the manufacture of composite laminates and components. The apparatus including a temperature controlled vessel such as an autoclave in which the material is placed during curing and an infra-red temperature measuring device such as a camera located remotely from the component to measure the temperature of at least part of the material during curing.

摘要翻译： 一种用于在制造复合层压板和部件期间控制固化过程的装置和方法。 该装置包括诸如高温灭菌器的温度控制容器，其中材料在固化期间放置，以及红外温度测量装置，例如远离组件的照相机，以在固化期间测量至少部分材料的温度。

公开(公告)号：US06892074B2

公开(公告)日：2005-05-10

申请号：US09138218

申请日：1998-08-21

申请人： Mika Tarkiainen ,  Stephen Williams ,  Ari Riekki

发明人： Mika Tarkiainen ,  Stephen Williams ,  Ari Riekki

IPC分类号： H04W4/08 ,  H04W4/12 ,  H04W4/16 ,  H04Q7/20

CPC分类号： H04W4/12 ,  H04W4/08 ,  H04W4/16

摘要： The invention relates to a method for the transmission of messages by using a message service to a recipient who uses at least a primary mobile station (3), in which there is at least the possibility to receive calls and messages, and at least one secondary mobile station (4, 4′), in which there is at least the possibility to receive messages. The messages addressed to the primary mobile station (3) can be directed to any of the secondary mobile stations (4, 4′) of the recipient, irrespective of calls.

摘要翻译： 本发明涉及一种通过使用至少使用主移动台（3）的接收者的消息服务来发送消息的方法，其中至少有可能接收呼叫和消息，以及至少一个次要 移动台（4,4'），其中至少有可能接收消息。 寻址到主移动台（3）的消息可以被定向到接收者的任何次要移动台（4,4'），而不管呼叫如何。