公开(公告)号：US20180231532A1

公开(公告)日：2018-08-16

申请号：US15949965

申请日：2018-04-10

申请人： LEUKODX LTD.

发明人： Harvey Lee Kasdan ,  Julien Meissonnier ,  Yoav Zuta ,  Bruce Davis ,  Micha Rosen ,  Yael Himmel ,  Yehoshua Broder

IPC分类号： G01N33/53 ,  B01L3/00 ,  G01N33/68 ,  G01N33/50 ,  G01N33/543 ,  G01N33/58 ,  G01N33/569

CPC分类号： G01N33/5302 ,  B01L3/502 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/025 ,  B01L2200/10 ,  B01L2300/041 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0877 ,  B01L2300/0883 ,  B01L2300/123 ,  B01L2300/18 ,  B01L2400/0406 ,  B01L2400/0481 ,  G01N33/5091 ,  G01N33/54386 ,  G01N33/569 ,  G01N33/56972 ,  G01N33/582 ,  G01N33/68 ,  G01N33/6872 ,  G01N2333/70535 ,  G01N2333/70596 ,  G01N2800/26

摘要： The present invention provides kits, apparatus and methods for determining a biological condition in a mammalian subject, the method includes incubating a specimen from a patient with at least one composition in a kit for a predetermined period of time to form at least one reaction product, when the subject has said biological condition, and receiving an indication of the at least one reaction product responsive to at least one reporter element in the kit thereby providing the indication of the biological condition in the subject.

公开(公告)号：US10024855B2

公开(公告)日：2018-07-17

申请号：US15670560

申请日：2017-08-07

申请人： LEUKODX LTD.

发明人： Harvey Lee Kasdan ,  Julien Meissonnier ,  Yoav Zuta ,  Micha Rosen ,  Yael Himmel ,  Yehoshua Broder ,  Bruce Davis ,  Bruce Goldman ,  Boaz Giron ,  Zion Botesazan ,  Ellezer Blasberg ,  Ilan Semmel ,  Jacques Aschkenasy

IPC分类号： G01N33/569 ,  B01L3/00

CPC分类号： G01N33/56972 ,  B01L3/5027 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0883 ,  B01L2400/0481 ,  B01L2400/0487 ,  G01N33/68 ,  G01N2333/70535 ,  G01N2333/70596

摘要： The present invention provides self-contained systems for performing an assay for determining a chemical state, the system including a stationary cartridge for performing the assay therein, at least one reagent adapted to react with a sample; and at least one reporter functionality adapted to report a reaction of the at least one reagent with said sample to report a result of the assay, wherein the at least one reagent, the sample and the at least one reporter functionality are contained within the cartridge.

公开(公告)号：US09759722B2

公开(公告)日：2017-09-12

申请号：US14646395

申请日：2013-12-17

申请人： LEUKODX LTD.

发明人： Harvey Lee Kasdan ,  Julien Meissonnier ,  Yoav Zuta ,  Micha Rosen ,  Yael Himmel ,  Yehoshua Broder ,  Bruce Davis ,  Bruce Goldman ,  Boaz Giron ,  Zion Botesazan ,  Ellezer Blasberg ,  Ilan Semmel ,  Jacques Aschkenasy

IPC分类号： G01N33/569 ,  B01L3/00

CPC分类号： G01N33/56972 ,  B01L3/5027 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0883 ,  B01L2400/0481 ,  B01L2400/0487 ,  G01N33/68 ,  G01N2333/70535 ,  G01N2333/70596

摘要： The present invention provides self-contained systems for performing an assay for determining a chemical state, the system including a stationary cartridge for performing the assay therein, at least one reagent adapted to react with a sample; and at least one reporter functionality adapted to report a reaction of the at least one reagent with said sample to report a result of the assay, wherein the at least one reagent, the sample and the at least one reporter functionality are contained within the cartridge.

公开(公告)号：US20140287435A1

公开(公告)日：2014-09-25

申请号：US14296317

申请日：2014-06-04

申请人： LEUKODX LTD.

发明人： Harvey Lee Kasdan ,  Julien Meissonnier ,  Yoav Zuta ,  Bruce Davis ,  Micha Rosen ,  Yael Himmel ,  Yehoshua Broder

IPC分类号： G01N33/569

CPC分类号： G01N33/5302 ,  B01L3/502 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/025 ,  B01L2200/10 ,  B01L2300/041 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0877 ,  B01L2300/0883 ,  B01L2300/123 ,  B01L2300/18 ,  B01L2400/0406 ,  B01L2400/0481 ,  G01N33/5091 ,  G01N33/54386 ,  G01N33/569 ,  G01N33/56972 ,  G01N33/582 ,  G01N33/68 ,  G01N33/6872 ,  G01N2333/70535 ,  G01N2333/70596 ,  G01N2800/26

摘要： The present invention provides kits, apparatus and methods for determining a biological condition in a mammalian subject, the method includes incubating a specimen from a patient with at least one composition in a kit for a predetermined period of time to form at least one reaction product, when the subject has said biological condition, and receiving an indication of the at least one reaction product responsive to at least one reporter element in the kit thereby providing the indication of the biological condition in the subject.

摘要翻译： 本发明提供用于确定哺乳动物受试者的生物学状况的试剂盒，装置和方法，所述方法包括用试剂盒中的至少一种组合物将来自患者的样品温育预定时间以形成至少一种反应产物， 当所述受试者具有所述生物学条件并且接受对所述试剂盒中的至少一种报道元件的响应的所述至少一种反应产物的指示，从而提供所述受试者中生物学条件的指示。

公开(公告)号：US20150330971A1

公开(公告)日：2015-11-19

申请号：US14718990

申请日：2015-05-21

申请人： LEUKODX LTD.

发明人： Harvey Lee Kasdan ,  Julien Meissonnier ,  Yoav Zuta ,  Micha Rosen ,  Yael Himmel ,  Yehoshua Broder ,  Bruce Davis ,  Bruce Goldman ,  Boaz Giron ,  Zion Botesazan ,  Ellezer Blasberg ,  Ilan Semmel ,  Jacques Aschkenasy

IPC分类号： G01N33/50 ,  G01N33/543 ,  G01N33/68 ,  B01L3/00

CPC分类号： G01N33/5302 ,  B01L3/502 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/025 ,  B01L2200/10 ,  B01L2300/041 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0877 ,  B01L2300/0883 ,  B01L2300/123 ,  B01L2300/18 ,  B01L2400/0406 ,  B01L2400/0481 ,  G01N33/5091 ,  G01N33/54386 ,  G01N33/569 ,  G01N33/56972 ,  G01N33/582 ,  G01N33/68 ,  G01N33/6872 ,  G01N2333/70535 ,  G01N2333/70596 ,  G01N2800/26

摘要： The present invention provides self-contained systems, apparatus and methods for determining a chemical state, the system includes a stationary cartridge for performing the assay therein, the cartridge adapted to house at least one reagent adapted to react with a sample; and at least one reporter functionality adapted to report a reaction of the at least one reagent with the sample to report a result of the assay, a mechanical controller including a first urging means adapted to apply a force externally onto the cartridge to release the at least one reagent; and at least one second urging means adapted to apply a removable force to induce fluidic movement in a first direction in the cartridge and upon removal of the force causing fluidic movement in an opposite direction to the first direction, an optical reader adapted to detect the reaction and a processor adapted to receive data from the optical reader and to process the data to determine said chemical state.

公开(公告)号：US20150293095A1

公开(公告)日：2015-10-15

申请号：US14646603

申请日：2013-12-17

申请人： LEUKODX, LTD.

发明人： Harvey Lee Kasdan ,  Julien Meissonnier ,  Yoav Zuta ,  Micha Rosen ,  Yael Himmel ,  Yehoshua Broder ,  Bruce Davis ,  Bruce Goldman ,  Boaz Giron ,  Zion Botesazan ,  Ellezer Blasberg ,  Ilan Semmel ,  Jacques Aschkenasy

IPC分类号： G01N33/569

CPC分类号： G01N33/5302 ,  B01L3/502 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/025 ,  B01L2200/10 ,  B01L2300/041 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0877 ,  B01L2300/0883 ,  B01L2300/123 ,  B01L2300/18 ,  B01L2400/0406 ,  B01L2400/0481 ,  G01N33/5091 ,  G01N33/54386 ,  G01N33/569 ,  G01N33/56972 ,  G01N33/582 ,  G01N33/68 ,  G01N33/6872 ,  G01N2333/70535 ,  G01N2333/70596 ,  G01N2800/26

摘要： The present invention provides self-contained systems, apparatus and methods for determining a chemical state, the system includes a stationary cartridge for performing the assay therein, the cartridge adapted to house at least one reagent adapted to react with a sample; and at least one reporter functionality adapted to report a reaction of the at least one reagent with the sample to report a result of the assay, a mechanical controller including a first urging means adapted to apply a force externally onto the cartridge to release the at least one reagent; and at least one second urging means adapted to apply a removable force to induce fluidic movement in a first direction in the cartridge and upon removal of the force causing fluidic movement in an opposite direction to the first direction, an optical reader adapted to detect the reaction and a processor adapted to receive data from the optical reader and to process the data to determine said chemical state.

摘要翻译： 本发明提供用于确定化学状态的独立系统，装置和方法，所述系统包括用于在其中进行测定的固定盒，所述盒适于容纳至少一种适于与样品反应的试剂; 以及适于报告所述至少一种试剂与所述样品的反应以报告所述测定结果的至少一个报道官功能;机械控制器，包括适于将力外部施加到所述盒上的第一施力装置，以释放所述至少 一种试剂; 以及至少一个第二推动装置，其适于施加可移除的力以在所述盒中的第一方向上引起流体运动，并且在去除引起与所述第一方向相反的方向的流体运动的力时，适于检测所述反应的光学读取器 以及适于从光学读取器接收数据并处理数据以确定所述化学状态的处理器。

公开(公告)号：US20150132776A1

公开(公告)日：2015-05-14

申请号：US14571906

申请日：2014-12-16

申请人： LeukoDx Ltd.

发明人： Harvey Lee Kasdan ,  Julien Meissonnier ,  Yoav Zuta ,  Bruce Davis ,  Micha Rosen ,  Yael Himmel ,  Yehoshua Broder

IPC分类号： G01N33/569 ,  B01L3/00

CPC分类号： G01N33/5302 ,  B01L3/502 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/025 ,  B01L2200/10 ,  B01L2300/041 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0877 ,  B01L2300/0883 ,  B01L2300/123 ,  B01L2300/18 ,  B01L2400/0406 ,  B01L2400/0481 ,  G01N33/5091 ,  G01N33/54386 ,  G01N33/569 ,  G01N33/56972 ,  G01N33/582 ,  G01N33/68 ,  G01N33/6872 ,  G01N2333/70535 ,  G01N2333/70596 ,  G01N2800/26

摘要： The present invention provides kits, apparatus and methods for determining a biological condition in a mammalian subject, the method includes incubating a specimen from a patient with at least one composition in a kit for a predetermined period of time to form at least one reaction product, when the subject has said biological condition, and receiving an indication of the at least one reaction product responsive to at least one reporter element in the kit thereby providing the indication of the biological condition in the subject.

摘要翻译： 本发明提供用于确定哺乳动物受试者的生物学状况的试剂盒，装置和方法，所述方法包括用试剂盒中的至少一种组合物将来自患者的样品温育预定时间以形成至少一种反应产物， 当所述受试者具有所述生物学条件并且接受对所述试剂盒中的至少一种报道元件的响应的所述至少一种反应产物的指示，从而提供所述受试者中生物学条件的指示。

公开(公告)号：US20170370914A1

公开(公告)日：2017-12-28

申请号：US15646111

申请日：2017-07-11

申请人： LEUKODX LTD.

发明人： Harvey Lee Kasdan ,  Julien Meissonnier ,  Yoav Zuta ,  Micha Rosen ,  Yael Himmel ,  Yehoshua Broder ,  Bruce Davis ,  Bruce Goldman ,  Boaz Giron ,  Zion Botesazan ,  Ellezer Blasberg ,  Ilan Semmel ,  Jacques Aschkenasy

IPC分类号： G01N33/53 ,  G01N33/58 ,  G01N33/543 ,  G01N33/569 ,  G01N33/50 ,  B01L3/00 ,  G01N33/68

CPC分类号： G01N33/56972 ,  B01L3/502 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502761 ,  B01L2200/025 ,  B01L2200/10 ,  B01L2300/041 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0877 ,  B01L2300/0883 ,  B01L2300/123 ,  B01L2300/18 ,  B01L2400/0406 ,  B01L2400/0481 ,  B01L2400/0487 ,  G01N15/1459 ,  G01N15/1484 ,  G01N21/03 ,  G01N21/6428 ,  G01N21/75 ,  G01N33/5091 ,  G01N33/5302 ,  G01N33/54386 ,  G01N33/569 ,  G01N33/582 ,  G01N33/68 ,  G01N33/6872 ,  G01N2015/1006 ,  G01N2021/0328 ,  G01N2021/6439 ,  G01N2021/6482 ,  G01N2035/00158 ,  G01N2333/70535 ,  G01N2333/70596 ,  G01N2800/26

摘要： The present invention provides self-contained systems, apparatus and methods for determining a chemical state, the system includes a stationary cartridge for performing the assay therein, the cartridge adapted to house at least one reagent adapted to react with a sample; and at least one reporter functionality adapted to report a reaction of the at least one reagent with the sample to report a result of the assay, a mechanical controller including a first urging means adapted to apply a force externally onto the cartridge to release the at least one reagent; and at least one second urging means adapted to apply a removable force to induce fluidic movement in a first direction in the cartridge and upon removal of the force causing fluidic movement in an opposite direction to the first direction, an optical reader adapted to detect the reaction and a processor adapted to receive data from the optical reader and to process the data to determine said chemical state.

公开(公告)号：US09746462B2

公开(公告)日：2017-08-29

申请号：US14646603

申请日：2013-12-17

申请人： LEUKODX LTD.

发明人： Harvey Lee Kasdan ,  Julien Meissonnier ,  Yoav Zuta ,  Micha Rosen ,  Yael Himmel ,  Yehoshua Broder ,  Bruce Davis ,  Bruce Goldman ,  Boaz Giron ,  Zion Botesazan ,  Ellezer Blasberg ,  Ilan Semmel ,  Jacques Aschkenasy

IPC分类号： G01N33/53 ,  G01N33/68 ,  G01N33/50 ,  B01L3/00 ,  G01N33/543 ,  G01N33/569 ,  G01N33/58

CPC分类号： G01N33/5302 ,  B01L3/502 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/025 ,  B01L2200/10 ,  B01L2300/041 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0877 ,  B01L2300/0883 ,  B01L2300/123 ,  B01L2300/18 ,  B01L2400/0406 ,  B01L2400/0481 ,  G01N33/5091 ,  G01N33/54386 ,  G01N33/569 ,  G01N33/56972 ,  G01N33/582 ,  G01N33/68 ,  G01N33/6872 ,  G01N2333/70535 ,  G01N2333/70596 ,  G01N2800/26

摘要： The present invention provides self-contained systems, apparatus and methods for determining a chemical state, the system includes a stationary cartridge for performing the assay therein, the cartridge adapted to house at least one reagent adapted to react with a sample; and at least one reporter functionality adapted to report a reaction of the at least one reagent with the sample to report a result of the assay, a mechanical controller including a first urging means adapted to apply a force externally onto the cartridge to release the at least one reagent; and at least one second urging means adapted to apply a removable force to induce fluidic movement in a first direction in the cartridge and upon removal of the force causing fluidic movement in an opposite direction to the first direction, an optical reader adapted to detect the reaction and a processor adapted to receive data from the optical reader and to process the data to determine said chemical state.

公开(公告)号：US09989523B2

公开(公告)日：2018-06-05

申请号：US14942921

申请日：2015-11-16

申请人： LEUKODX LTD.

发明人： Harvey Lee Kasdan ,  Julien Meissonnier ,  Yoav Zuta ,  Bruce Davis ,  Micha Rosen ,  Yael Himmel ,  Yehoshua Broder

IPC分类号： G01N33/53 ,  G01N33/68 ,  G01N33/50 ,  B01L3/00 ,  G01N33/543 ,  G01N33/569 ,  G01N33/58

CPC分类号： G01N33/5302 ,  B01L3/502 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/025 ,  B01L2200/10 ,  B01L2300/041 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0877 ,  B01L2300/0883 ,  B01L2300/123 ,  B01L2300/18 ,  B01L2400/0406 ,  B01L2400/0481 ,  G01N33/5091 ,  G01N33/54386 ,  G01N33/569 ,  G01N33/56972 ,  G01N33/582 ,  G01N33/68 ,  G01N33/6872 ,  G01N2333/70535 ,  G01N2333/70596 ,  G01N2800/26

摘要： The present invention provides kits, apparatus and methods for determining a biological condition in a mammalian subject, the method includes incubating a specimen from a patient with at least one composition in a kit for a predetermined period of time to form at least one reaction product, when the subject has said biological condition, and receiving an indication of the at least one reaction product responsive to at least one reporter element in the kit thereby providing the indication of the biological condition in the subject.