公开(公告)号：US10221138B2

公开(公告)日：2019-03-05

申请号：US14894928

申请日：2014-06-26

申请人： LG CHEM, LTD.

发明人： Young Kwan Kim ,  Sang Yun Park ,  Hyun Woo Joo ,  Eun Sil Choi

IPC分类号： C07C59/68 ,  C07C59/72 ,  C07C217/80 ,  C07C323/52 ,  C07C323/53 ,  C07D213/30 ,  C07D213/64 ,  C07D213/65 ,  C07D213/70 ,  C07D213/74 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D213/643

摘要： The present invention relates to biaryl derivatives of Formula 1, a method for preparing the same, a pharmaceutical composition comprising the same and use thereof. The biaryl derivatives of Formula 1 according to the present invention promote GLP-1 formation in the gastrointestinal tract and improve insulin resistance in the liver or in muscle due to anti-inflammatory action in macrophages, lipocytes, etc., and can accordingly be effectively used for preventing or treating diabetes, complications of diabetes, obesity, non-alcoholic fatty liver, steatohepatitis, osteoporosis or inflammation.

公开(公告)号：US20220135574A1

公开(公告)日：2022-05-05

申请号：US17577139

申请日：2022-01-17

申请人： LG CHEM, LTD.

发明人： Young Kwan Kim ,  Sang Yun Park ,  Hyun Woo Joo ,  Eun Sil Choi ,  Seung Yup Paek ,  Seung Wan Kang ,  Byung Gyu Kim ,  Chang Seok Lee ,  Sung Wook Kim ,  Sang Dae Lee

IPC分类号： C07D487/04 ,  C07D401/04 ,  A61K31/4725 ,  C07C59/31 ,  C07C229/42 ,  C07C229/44 ,  C07C317/22 ,  C07D207/06 ,  C07D209/08 ,  C07D211/34 ,  C07D213/30 ,  C07D213/64 ,  C07D213/70 ,  C07D231/56 ,  C07D235/16 ,  C07D239/34 ,  C07D241/18 ,  C07D261/08 ,  C07D277/34 ,  C07D307/42 ,  C07D307/80 ,  C07D311/58 ,  C07D317/46 ,  C07D317/72 ,  C07D333/16 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D407/04 ,  C07D409/04 ,  C07D409/10 ,  C07D409/14 ,  C07D413/10 ,  C07D413/12 ,  C07D417/10

摘要： The present invention relates to a biaryl derivative expressed by the chemical formula 1, a method for producing the biaryl derivative, a pharmaceutical composition comprising same, and use of same, the biaryl derivative expressed by the chemical formula 1, as a GPR120 agonist, promoting GLP-1 generation in the gastro-intestinal tract, reducing insulin resistance in the liver, muscles and the like from anti-inflammatory activity in the macrophage, pancreatic cells and the like, and allowing effective use in prevention or treatment of inflammation or metabolic diseases such as diabetes, complications from diabetes, obesity, non-alcoholic fatty liver disease, fatty liver disease, and osteoporosis.

公开(公告)号：US11261186B2

公开(公告)日：2022-03-01

申请号：US15539310

申请日：2015-12-23

申请人： LG CHEM, LTD.

发明人： Young Kwan Kim ,  Sang Yun Park ,  Hyun Woo Joo ,  Eun Sil Choi ,  Seung Yup Paek ,  Seung Wan Kang ,  Byung Gyu Kim ,  Chang Seok Lee ,  Sung Wook Kim ,  Sang Dae Lee

IPC分类号： C07D239/34 ,  C07D401/10 ,  C07D403/10 ,  C07D471/04 ,  C07D487/04 ,  C07D401/04 ,  A61K31/4725 ,  C07C59/31 ,  C07C229/42 ,  C07C229/44 ,  C07C317/22 ,  C07D207/06 ,  C07D209/08 ,  C07D211/34 ,  C07D213/30 ,  C07D213/64 ,  C07D213/70 ,  C07D231/56 ,  C07D235/16 ,  C07D241/18 ,  C07D261/08 ,  C07D277/34 ,  C07D307/42 ,  C07D307/80 ,  C07D311/58 ,  C07D317/46 ,  C07D317/72 ,  C07D333/16 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D407/04 ,  C07D409/04 ,  C07D409/10 ,  C07D409/14 ,  C07D413/10 ,  C07D413/12 ,  C07D417/10

摘要： Compounds having the chemical formula 1, a method for producing the compounds of chemical formula 1, a pharmaceutical composition comprising same, and use thereof as a GPR120 agonist for prevention or treatment of inflammation or metabolic diseases such as diabetes, complications from diabetes, obesity, non-alcoholic fatty liver disease, fatty liver disease, and osteoporosis.