公开(公告)号：US20200263231A1

公开(公告)日：2020-08-20

申请号：US16340373

申请日：2017-11-01

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Kyle GEE ,  Jongtae YANG

IPC: C12Q1/6806 ,  C12Q1/6818 ,  C12Q1/02 ,  C09B62/44 ,  C09K11/07 ,  C07D417/06

Abstract: The present disclosure is directed to unsymmetrical cyanine dyes comprising a substituted benzazolium ring system linked by a methine bridge to a quinolinium ring that contains a heteroatom. Compounds of formula (I) are provided herein. The compounds can be useful for fluorescent detection or quantification of nucleic acids. Related methods, uses, and kits are disclosed.

公开(公告)号：US20160010145A1

公开(公告)日：2016-01-14

申请号：US14649370

申请日：2013-12-06

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Jason DALLWIG ,  Kyle GEE ,  Nancy AHNERT ,  Hee Chol KANG ,  Jongtae YANG

IPC: C12Q1/68 ,  C09B23/00

CPC classification number: C12Q1/6825 ,  C09B23/00 ,  C09B23/04 ,  C09B23/06 ,  C09B23/083 ,  C09B23/086 ,  C12Q1/6816 ,  C12Q1/6837 ,  C12Q2525/207 ,  C12Q2563/107 ,  C12Q2563/173

Abstract: Substituted unsymmetrical cyanine dyes are provided herein, including kits, assays systems and methods for their use in the detection of RNA compounds (e.g., miRNA).

Abstract translation: 本文提供取代的不对称花青染料，包括用于检测RNA化合物（例如miRNA）的试剂盒，测定系统和方法。

公开(公告)号：US20210324198A1

公开(公告)日：2021-10-21

申请号：US17150247

申请日：2019-08-08

Applicant: Life Technologies Corporation

Inventor： Jongtae YANG ,  Xin WANG ,  Yi-Zhen HU ,  Kyle GEE ,  Aimei CHEN ,  Scott BENSON ,  Brian EVANS ,  Aleksey RUKAVISHNIKOV

IPC: C09B11/28 ,  C07F7/08 ,  C07F9/6561 ,  C12Q1/6816 ,  C12Q1/6869 ,  G01N33/58

Abstract: Silicon-substituted rhodamine compounds are disclosed herein. Also described herein are SiR dyes comprising at least one vinyl group attached to the Si atom (10 position) of the SiR dye. Derivatives, functionalized versions, conjugates, kits, related synthetic methods and uses of SiR compounds also are provided. Silicon-rhodamine (SiR) dyes can provide bright fluorescence at far red wavelengths and exhibit good photostability. The compounds described herein can be useful for fluorescent labeling and detection of biological samples.