-
公开(公告)号：US20230407222A1
公开(公告)日：2023-12-21
申请号：US18247406
申请日：2021-10-07
Applicant: OCTANE BIOTECH INC. , LONZA WALKERSVILLE, INC.
Inventor： Paul GARDIN , Raelyn DANIELS , Talib ALI , Guy ORAM , Matthew HEWITT , Eytan ABRAHAM
Abstract: The present disclosure provides devices and associated methods for temperature monitoring and control in automated biological material engineering systems, including cell engineering systems. The devices and methods utilize measurement of internal temperatures in an automated system to map temperatures during the various processes carried out in the systems.
-
公开(公告)号：US20200208121A1
公开(公告)日：2020-07-02
申请号：US16720227
申请日：2019-12-19
Applicant: LONZA WALKERSVILLE, INC.
Inventor： Matthew HEWITT , Young SHIN , Bingnan GU , Caitlin M. GUENTHER , Anandita SETH
Abstract: The present disclosure provides an automated method of producing viral vectors, utilizing engineered viral vector-producing cell lines within a fully-enclosed cell engineering system. Exemplary viral vectors that can be produced include lentivirus vectors, adeno-associated virus vectors, baculovirus vectors and retrovirus vectors.
-
公开(公告)号：US20230018373A1
公开(公告)日：2023-01-19
申请号：US17757345
申请日：2020-12-18
Applicant: LONZA WALKERSVILLE, INC. , LONZA SALES AG
Inventor： Evlampia DIMITRIADOU , Matthew HEWITT , Andrew RACHER
Abstract: The present disclosure provides an automated method of producing viral vectors, utilizing engineered viral vector-producing cell lines, or packaging cells, within a fully-enclosed cell engineering system. Exemplary viral vectors that can be produced include lentivirus vectors, adeno-associated virus vectors, baculovirus vectors and retrovirus vectors.
-
公开(公告)号：US20210123008A1
公开(公告)日：2021-04-29
申请号：US17077447
申请日：2020-10-22
Applicant: OCTANE BIOTECH INC. , LONZA WALKERSVILLE, INC.
Inventor： Nuala TRAINOR , Eytan ABRAHAM , Timothy SMITH , Matthew HEWITT , Yaling SHI , Kelly PURPURA , Chase MCROBIE
IPC: C12M1/12 , C12M1/04 , C12M1/00 , C12N5/00 , G01N35/10 , C12M1/02 , C12M3/00 , C12M1/34 , C12M1/36
Abstract: The present disclosure provides cell culture chambers for use in automated cell engineering systems, and in particular, cell culture chambers that include improved cell-contacting surfaces. Improved cell-contacting surfaces can include a surface coating that promotes cell growth, adherence, differentiation, maintenance of phenotype, and/or improves transduction; a cell-contacting surface comprising a non-porous, gas-permeable material; as well as other modifications to the cell-contacting surfaces. Cassettes comprising the cell culture chambers are also provided.
-
Patent Agency Ranking
公开(公告)号：US20240026306A1
公开(公告)日：2024-01-25
申请号：US18337734
申请日：2023-06-20
Applicant: LONZA WALKERSVILLE, INC.
Inventor： Matthew HEWITT , Young SHIN , Bingnan GU , Caitlin M. GUENTHER , Anandita SETH
CPC classification number: C12N7/00 , C12N15/86 , C12N15/90 , A61K35/76 , A61K9/007 , A61K9/0019 , C12N2740/15051 , C12N2750/14143 , C12N2750/14151 , C12N2740/15043
Abstract: The present disclosure provides an automated method of producing viral vectors, utilizing engineered viral vector-producing cell lines within a fully-enclosed cell engineering system. Exemplary viral vectors that can be produced include lentivirus vectors, adeno-associated virus vectors, baculovirus vectors and retrovirus vectors.
-
公开(公告)号：US20250066744A1
公开(公告)日：2025-02-27
申请号：US18941394
申请日：2024-11-08
Applicant: LONZA WALKERSVILLE, INC.
Inventor： Matthew HEWITT , Young SHIN , Bingnan GU , Caitlin M. GUENTHER , Anandita SETH
Abstract: The present disclosure provides an automated method of producing viral vectors, utilizing engineered viral vector-producing cell lines within a fully-enclosed cell engineering system. Exemplary viral vectors that can be produced include lentivirus vectors, adeno-associated virus vectors, baculovirus vectors and retrovirus vectors.
-
公开(公告)号：US20240009400A1
公开(公告)日：2024-01-11
申请号：US18247552
申请日：2021-10-08
Applicant: OCTANE BIOTECH INC. , LONZA WALKERSVILLE, INC.
Inventor： Chase MCROBIE , Raelyn DANIELS , Matthew HEWITT
IPC: A61M5/315
CPC classification number: A61M5/31513
Abstract: Devices and methods for sterile sampling from automated cell engineering systems are provided. Sterile sampling devices are configured to maintain sterility of a sample reservoir during intake and expulsion of fluids or other material to the sterile sampling devices. Methods provided herein employ sterile sampling devices to achieve the sterile withdrawal and sterile injection of materials and fluids to and from an automated cell engineering system.
-
公开(公告)号：US20250066810A1
公开(公告)日：2025-02-27
申请号：US18938929
申请日：2024-11-06
Applicant: LONZA WALKERSVILLE, INC.
Inventor： Matthew HEWITT , Eytan ABRAHAM , Nicholas OSTROUT
IPC: C12N15/85 , A61K39/00 , C12N5/0783
Abstract: The present disclosure provides methods for assessing and optimizing cellular quality of a cell-based therapy that is being produced in an automated cell engineering system. The methods suitably include monitoring molecular characteristics of the cells before, during, and after the automated process to provide feedback to the process parameters. In embodiments, the cells being produced are Chimeric Antigen Receptor (CAR) T-cells.
-
公开(公告)号：US20210148895A1
公开(公告)日：2021-05-20
申请号：US17093943
申请日：2020-11-10
Applicant: LONZA WALKERSVILLE, INC.
Inventor： Matthew HEWITT , Eytan ABRAHAM , Nicholas OSTROUT
IPC: G01N33/50 , C12N15/85 , C12N5/0783
Abstract: The present disclosure provides methods for assessing and optimizing cellular quality of a cell-based therapy that is being produced in an automated cell engineering system. The methods suitably include monitoring molecular characteristics of the cells before, during, and after the automated process to provide feedback to the process parameters. In embodiments, the cells being produced are Chimeric Antigen Receptor (CAR) T-cells.
-
-
-
-
-
-
-
-
Search Results
9
records
(took 0.014 seconds)
