摘要:
The present invention addresses an ongoing need in the art to improve the stability of immunogenic compositions such as polysaccharide-protein conjugates and protein immunogens. The invention broadly relates to novel formulations which stabilize and inhibit precipitation of immunogenic compositions. More particularly, the invention described hereinafter, addresses a need in the art for formulations which stabilize and inhibit particulate formation (e.g., aggregation, precipitation) of immunogenic compositions which are processed, developed, formulated, manufactured and/or stored in container means such as fermentors, bioreactors, vials, flasks, bags, syringes, rubber stoppers, tubing and the like.
摘要:
The present invention addresses an ongoing need in the art to improve the stability of immunogenic compositions such as polysaccharide-protein conjugates and protein immunogens. The invention broadly relates to novel formulations which stabilize and inhibit precipitation of immunogenic compositions. More particularly, the invention described hereinafter, addresses a need in the art for formulations which stabilize and inhibit particulate formation (e.g., aggregation, precipitation) of immunogenic compositions which are processed, developed, formulated, manufactured and/or stored in container means such as fermentors, bioreactors, vials, flasks, bags, syringes, rubber stoppers, tubing and the like.
摘要:
The present invention addresses an ongoing need in the art to improve the stability of immunogenic compositions such as polysaccharide-protein conjugates and protein immunogens. The invention broadly relates to novel formulations which stabilize and inhibit precipitation of immunogenic compositions. More particularly, the invention described hereinafter, addresses a need in the art for formulations which stabilize and inhibit particulate formation (e.g., aggregation, precipitation) of immunogenic compositions which are processed, developed, formulated, manufactured and/or stored in container means such as fermentors, bioreactors, vials, flasks, bags, syringes, rubber stoppers, tubing and the like.
摘要:
A method, apparatus and computer-readable medium for determining deformation of a plurality of coupled members. A distributed strain sensor string on a first member is coupled to a distributed strain sensor string on a second member. Signals are obtained from the sensor strings. A subset of strain data relating to sensor strain on the first member and the second member is created. A virtual sensor string is created having a plurality of virtual sensors placed on the first and second members including a joint therebetween. Strain data of sensors in the distributed stain sensor strings is mapped to sensors in the virtual sensor string. The deformation of the plurality of coupled members is determined using the strain data of the virtual sensors.
摘要:
A method, apparatus and computer-readable medium for determining a deformation strain distribution of a member corresponding to a selected deformation mode is disclosed. Strain measurements are obtained at a plurality of sensors, wherein each strain measurement is related to a strain at a location of the member. A component of the strain related to a selected deformation mode for the obtained strain measurements is determined and a principal strain component and a secondary strain component for each of the determined components of the strain is determined. The determined principal strain component and secondary strain component are mapped to a surface of the member to determine the deformation strain distribution.
摘要:
A method, apparatus and computer-readable medium for filtering a signal from a plurality of distributed sensors is disclosed. The signal is obtained from the plurality of distributed strain sensors. A first subspace of a measurement space of the obtained signal is selected, wherein the first subspace is characterized by a step having a selected step size. An error for a filter corresponding to the first subspace is estimated and the step size when the estimated error meets a selected criterion. A second subspace characterized by a step having the adjusted step size is selected and the signal is filtered by applying a filter corresponding to the second subspace.
摘要:
Since structural portions of a device made of a plurality of materials are different from one another in mechanical hardness, it is very difficult to uniformly lap the structural portions. This is attributable to generation of machining recessions due to differences in lapped amount when large fixed abrasive grains are used, and generation of lapping marks caused by that the dropped abrasive grains rotate. Accordingly, in order to cope with the disadvantage, it is essential to surely grip abrasive grains of small size to a surface of a surface plate.[Solving Means]Abrasive grains are fixedly forced into a surface of a lapping tool with mechanical pressure and then the surface of the lapping tool including the abrasive grains is subjected to plasma processing, whereby an improvement in adhesion between the abrasive grains and a surface plate and reduction in the number of loose abrasive grains, which are dropped from the surface of the lapping tool, can be achieved, so that it is possible to realize lapping, in which a surface of a device made of a plurality of materials is made very plane.
摘要:
A method, apparatus and computer-readable medium for determining a strain component for a deformation mode of a member is disclosed. A plurality of measurements is obtained, wherein each of the plurality of measurements relates to a strain at a location of the member. A deformation mode is selected and an adjustable filter is applied to the plurality of strain measurements to determine the strain component for the selected deformation mode.
摘要:
A method, apparatus and computer-readable medium for determining deformation of a plurality of coupled members. A distributed strain sensor string on a first member is coupled to a distributed strain sensor string on a second member. Signals are obtained from the sensor strings. A subset of strain data relating to sensor strain on the first member and the second member is created. A virtual sensor string is created having a plurality of virtual sensors placed on the first and second members including a joint therebetween. Strain data of sensors in the distributed stain sensor strings is mapped to sensors in the virtual sensor string. The deformation of the plurality of coupled members is determined using the strain data of the virtual sensors.
摘要:
A system, method and computer-readable medium for providing an image of a deformation of a member is disclosed. Strain measurements are obtained at a plurality of sensors located at the member. Components of the obtained strain measurements corresponding to a bending deformation are obtained. From the obtained components, components are obtained that corresponding to at least one cross-sectional deformation of the member and a bending parameter is determined from the components corresponding to the bending deformation. A cross-sectional deformation parameter is determined from the components corresponding to the at least one of the cross-sectional deformations. The image of the deformation of the member is provided using the determined bending parameter and the determined cross-sectional deformation parameter.