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1.发明申请公开(公告)号：US20130331343A1
公开(公告)日：2013-12-12
申请号：US13883005
申请日：2011-11-08
申请人： Lan Cao , Kamal H. Bouhadir , David J. Mooney
发明人： Lan Cao , Kamal H. Bouhadir , David J. Mooney
IPC分类号： A61K38/10
CPC分类号： A61K38/10 , A61K38/1709 , A61K47/61 , A61K47/64
摘要： The invention provides a solution to the problem of delivering molecules in a physiologically relevant manner to direct cell fate. For example, a Notch ligand molecule is presented in a microenvironment that mimics the environment encountered in vivo. Accordingly, the invention features a cell delivery vehicle comprising a biocompatible hydrogel or polymer and a composition that binds to a Notch receptor and methods of directing cell fate, e.g., stem cell differentiation, using such compositions.
摘要翻译： 本发明提供了以生理相关方式递送分子以引导细胞命运的问题的解决方案。 例如，Notch配体分子呈现在模拟体内遇到的环境的微环境中。 因此，本发明的特征在于包含生物相容性水凝胶或聚合物的细胞递送载体以及结合Notch受体的组合物和使用这种组合物引导细胞命运（例如干细胞分化）的方法。
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公开(公告)号：US09603894B2
公开(公告)日：2017-03-28
申请号：US13883005
申请日：2011-11-08
申请人： Lan Cao , Kamal H. Bouhadir , David J. Mooney
发明人： Lan Cao , Kamal H. Bouhadir , David J. Mooney
CPC分类号： A61K38/10 , A61K38/1709 , A61K47/61 , A61K47/64
摘要： The invention provides a solution to the problem of delivering molecules in a physiologically relevant manner to direct cell fate. For example, a Notch ligand molecule is presented in a microenvironment that mimics the environment encountered in vivo. Accordingly, the invention features a cell delivery vehicle comprising a biocompatible hydrogel or polymer and a composition that binds to a Notch receptor and methods of directing cell fate, e.g., stem cell differentiation, using such compositions.
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公开(公告)号：US20130195764A1
公开(公告)日：2013-08-01
申请号：US13641971
申请日：2011-04-20
申请人： Jaeyun Kim , Lan Cao , David J. Mooney
发明人： Jaeyun Kim , Lan Cao , David J. Mooney
CPC分类号： A61K49/005 , A61K38/1866 , A61K47/6923 , A61K49/0002 , A61K49/0032 , A61K49/0065 , A61K49/0093 , A61K2300/00
摘要： The invention provides compositions and methods that provide a solution to the difficulties in diagnosing ischemia, e.g., identifying specific affected anatomical areas, and treating ischemic tissue so as to minimize damage and promote healing of damaged tissue in a subject such as a human or other animal.
摘要翻译： 本发明提供组合物和方法，其提供诊断缺血的困难的解决方案，例如鉴定特定的受影响的解剖区域，以及治疗缺血组织，以便最小化受试者（例如人或其他动物）中受损组织的损伤和促进愈合。 。
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4.发明授权Controlled release of growth factors and signaling molecules for promoting angiogenesis 有权控制释放促进血管发生的生长因子和信号分子公开(公告)号：US09012399B2
公开(公告)日：2015-04-21
申请号：US12992617
申请日：2009-06-01
申请人： Lan Cao , David J. Mooney
发明人： Lan Cao , David J. Mooney
CPC分类号： A61K38/1866 , A61K9/0019 , A61K9/06 , A61K38/05 , A61K38/1858 , A61K45/06 , A61K47/6903 , A61L27/54 , A61L2300/412 , A61L2300/414 , A61L2300/426 , A61L2300/432 , A61L2300/45 , A61L2300/602
摘要： The present invention comprises compositions, methods, and devices for delivering angiogenic factors and signaling molecules to a target tissue, and controlling the release of these factors and signaling molecules to spatially and temporally restrict their release and dissemination, for the purpose of promoting angiogenesis in target tissues.
摘要翻译： 本发明包括用于将血管生成因子和信号分子递送至靶组织的组合物，方法和装置，以及控制这些因子和信号分子的释放以空间和时间限制其释放和扩散，目的是促进目标中的血管生成 组织。
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5.发明申请Controlled Release of Growth Factors and Signaling Molecules for Promoting Angiogenesis 有权控制释放生长因子和信号分子促进血管发生公开(公告)号：US20110117170A1
公开(公告)日：2011-05-19
申请号：US12992617
申请日：2009-06-01
申请人： Lan Cao , David J. Mooney
发明人： Lan Cao , David J. Mooney
IPC分类号： A61K9/00 , A61K38/18 , A61K38/22 , A61K38/43 , A61K38/46 , A61K38/44 , A61K38/48 , A61K38/20 , A61K33/00 , A61K38/30 , A61K38/28 , A61K39/395 , A61P9/00
CPC分类号： A61K38/1866 , A61K9/0019 , A61K9/06 , A61K38/05 , A61K38/1858 , A61K45/06 , A61K47/6903 , A61L27/54 , A61L2300/412 , A61L2300/414 , A61L2300/426 , A61L2300/432 , A61L2300/45 , A61L2300/602
摘要： The present invention comprises compositions, methods, and devices for delivering angiogenic factors and signaling molecules to a target tissue, and controlling the release of these factors and signaling molecules to spatially and temporally restrict their release and dissemination, for the purposed promoting angiogenesis in target tissues.
摘要翻译： 本发明包括用于将血管生成因子和信号分子递送至靶组织的组合物，方法和装置，以及控制这些因子和信号分子的释放以空间和时间限制其释放和扩散，用于靶组织中的促进血管生成 。
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公开(公告)号：US07551346B2
公开(公告)日：2009-06-23
申请号：US11768395
申请日：2007-06-26
CPC分类号： C08G18/765 , C08G18/0804 , C08G18/4825 , C09J175/08 , G02F1/167 , G02F2202/28 , Y10T428/14 , Y10T428/1476 , Y10T428/24 , Y10T428/28 , Y10T428/2891
摘要： An electro-optic display comprises a layer of solid electro-optic material; a backplane comprising at least one electrode; and an adhesive layer disposed between the layer of electro-optic material and the backplane and adhesively securing the layer of electro-optic material to the backplane, the adhesive layer comprising a thermally-activated cross-linking agent comprising an epoxidized vegetable oil fatty acid or an epoxidized ester of such a fatty acid. The cross-linking agent reduces void growth when the display is subjected to temperature changes.
摘要翻译： 电光显示器包括一层固体电光材料; 包括至少一个电极的背板; 以及粘合剂层，其设置在所述电光材料层和所述背板之间并将所述电光材料层粘附到所述背板上，所述粘合剂层包含热活化交联剂，所述热活化交联剂包含环氧化植物油脂肪酸或 这种脂肪酸的环氧化酯。 当显示器经受温度变化时，交联剂减少空隙生长。
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公开(公告)号：US20050179642A1
公开(公告)日：2005-08-18
申请号：US10904707
申请日：2004-11-24
申请人： Russell Wilcox , Thomas Whitesides , Karl Amundson , Guy Danner , Richard Webber , Charles Honeyman , Lan Cao , Richard Paolini , Rajesh Chebiyam
发明人： Russell Wilcox , Thomas Whitesides , Karl Amundson , Guy Danner , Richard Webber , Charles Honeyman , Lan Cao , Richard Paolini , Rajesh Chebiyam
IPC分类号： G09G3/34
CPC分类号： G09G3/344 , G02B26/00 , G02B26/026 , G02F1/0018 , G02F1/13306 , G02F1/167 , G02F2001/1678 , G09G3/34 , G09G3/36 , G09G3/3629 , G09G2320/0257 , G09G2340/16
摘要： The invention provides materials and methods (including driving methods) for reducing the effects of remnant voltages in electro-optic displays.
摘要翻译： 本发明提供了用于减少电光显示器中剩余电压的影响的材料和方法（包括驱动方法）。
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8.发明申请公开(公告)号：US20110293667A1
公开(公告)日：2011-12-01
申请号：US13007250
申请日：2011-01-14
申请人： Dolores Baksh , Xianyan Wang , Matthew Q. Wong , Lan Cao , Parid Sava , Thomas Bollenbach , Esin Yesilalan
发明人： Dolores Baksh , Xianyan Wang , Matthew Q. Wong , Lan Cao , Parid Sava , Thomas Bollenbach , Esin Yesilalan
IPC分类号： A61K35/12 , A61K35/44 , A61K35/50 , A61K35/34 , C12P21/00 , A61K9/00 , A61P19/04 , A61P19/08 , A61P21/00 , A61K35/28 , A61K35/32
CPC分类号： C12N5/0663 , A61K2035/124 , A61L27/3633 , A61L27/3804 , A61L27/3834 , A61L27/3886 , A61L27/3891 , C12N5/0667 , C12N5/0668 , C12N2500/25 , C12N2500/38 , C12N2500/90 , C12N2501/02 , C12N2501/11 , C12N2501/115 , C12N2501/148 , C12N2501/39 , C12N2533/90
摘要： Bioengineered constructs are formed from cultured cells induced to synthesize and secrete endogenously produced extracellular matrix components without the requirement of exogenous matrix components or network support or scaffold members. The bioengineered constructs of the invention can be produced with multiple cell types that can all contribute to producing the extracellular matrix. Additionally or alternatively, one of the multiple cell types can be delivered to a site in the body via the endogenously produced extracellular matrix components to achieve various therapeutic benefits.
摘要翻译： 生物工程化构建体由诱导合成和分泌内源性产生的细胞外基质组分的培养细胞形成，而不需要外源基质组分或网络支持物或支架构件。 本发明的生物工程化构建体可以用多种可以有助于产生细胞外基质的细胞类型产生。 另外或替代地，多种细胞类型中的一种可以通过内源产生的细胞外基质组分递送到体内的位点，以实现各种治疗益处。
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公开(公告)号：US20090237773A1
公开(公告)日：2009-09-24
申请号：US12351880
申请日：2009-01-12
申请人： Lan Cao , David D. Miller , Richard M. Webber , Shafiq N. Fazel
发明人： Lan Cao , David D. Miller , Richard M. Webber , Shafiq N. Fazel
CPC分类号： C08G18/0823 , C08G18/10 , C08G18/12 , C08G18/348 , C08G18/4018 , C08G18/4277 , C08G18/4825 , C08G18/6659 , C08G18/758 , G02F1/167 , G02F2202/28 , Y10T156/1052 , Y10T156/1064 , C08G18/3228
摘要： A polyurethane formed from an isocyanate, a polyether diol and a polyester diol, the polyester diol having a molecular weight less than about 2000, or comprising two polyester diol segments connected by a steric hindrance group, each of the polyester diol segments having a molecular weight less than about 2000, the molar ratio of polyether diol to polyester diol being in the range of from about 1:9 to about 9:1. The polyurethane is useful as a lamination adhesive in electro-optic displays, and in components used to form such displays.
摘要翻译： 由异氰酸酯，聚醚二醇和聚酯二醇形成的聚氨酯，分子量小于约2000的聚酯二醇或由空间位阻基团连接的两个聚酯二醇片段，每个聚酯二醇片段具有分子量 小于约2000，聚醚二醇与聚酯二醇的摩尔比在约1:9至约9:1的范围内。 聚氨酯可用作电光显示器中的层压粘合剂，以及用于形成这种显示器的部件。
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公开(公告)号：US20070286975A1
公开(公告)日：2007-12-13
申请号：US11768395
申请日：2007-06-26
申请人： Shafiq Fazel , Guy Danner , Lan Cao , David Miller , Eric Klingenberg
发明人： Shafiq Fazel , Guy Danner , Lan Cao , David Miller , Eric Klingenberg
CPC分类号： C08G18/765 , C08G18/0804 , C08G18/4825 , C09J175/08 , G02F1/167 , G02F2202/28 , Y10T428/14 , Y10T428/1476 , Y10T428/24 , Y10T428/28 , Y10T428/2891
摘要： An electro-optic display comprises a layer of solid electro-optic material; a backplane comprising at least one electrode; and an adhesive layer disposed between the layer of electro-optic material and the backplane and adhesively securing the layer of electro-optic material to the backplane, the adhesive layer comprising a thermally-activated cross-linking agent comprising an epoxidized vegetable oil fatty acid or an epoxidized ester of such a fatty acid. The cross-linking agent reduces void growth when the display is subjected to temperature changes.
摘要翻译： 电光显示器包括一层固体电光材料; 包括至少一个电极的背板; 以及粘合剂层，其设置在所述电光材料层和所述背板之间并将所述电光材料层粘附到所述背板上，所述粘合剂层包含热活化交联剂，所述热活化交联剂包含环氧化植物油脂肪酸或 这种脂肪酸的环氧化酯。 当显示器经受温度变化时，交联剂减少空隙生长。
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