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1.发明申请公开(公告)号：US20110293667A1
公开(公告)日：2011-12-01
申请号：US13007250
申请日：2011-01-14
申请人： Dolores Baksh , Xianyan Wang , Matthew Q. Wong , Lan Cao , Parid Sava , Thomas Bollenbach , Esin Yesilalan
发明人： Dolores Baksh , Xianyan Wang , Matthew Q. Wong , Lan Cao , Parid Sava , Thomas Bollenbach , Esin Yesilalan
IPC分类号： A61K35/12 , A61K35/44 , A61K35/50 , A61K35/34 , C12P21/00 , A61K9/00 , A61P19/04 , A61P19/08 , A61P21/00 , A61K35/28 , A61K35/32
CPC分类号： C12N5/0663 , A61K2035/124 , A61L27/3633 , A61L27/3804 , A61L27/3834 , A61L27/3886 , A61L27/3891 , C12N5/0667 , C12N5/0668 , C12N2500/25 , C12N2500/38 , C12N2500/90 , C12N2501/02 , C12N2501/11 , C12N2501/115 , C12N2501/148 , C12N2501/39 , C12N2533/90
摘要： Bioengineered constructs are formed from cultured cells induced to synthesize and secrete endogenously produced extracellular matrix components without the requirement of exogenous matrix components or network support or scaffold members. The bioengineered constructs of the invention can be produced with multiple cell types that can all contribute to producing the extracellular matrix. Additionally or alternatively, one of the multiple cell types can be delivered to a site in the body via the endogenously produced extracellular matrix components to achieve various therapeutic benefits.
摘要翻译： 生物工程化构建体由诱导合成和分泌内源性产生的细胞外基质组分的培养细胞形成，而不需要外源基质组分或网络支持物或支架构件。 本发明的生物工程化构建体可以用多种可以有助于产生细胞外基质的细胞类型产生。 另外或替代地，多种细胞类型中的一种可以通过内源产生的细胞外基质组分递送到体内的位点，以实现各种治疗益处。
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公开(公告)号：US20120123519A1
公开(公告)日：2012-05-17
申请号：US12672521
申请日：2008-08-11
申请人： Michael L. Lovett , Xianyan Wang , Christopher M. Cannizzaro , Gordana Vunjak-Novakovic , David L. Kaplan
发明人： Michael L. Lovett , Xianyan Wang , Christopher M. Cannizzaro , Gordana Vunjak-Novakovic , David L. Kaplan
CPC分类号： A61L27/227 , A61F2/07 , A61F2/08 , A61F2/82 , A61L27/26 , A61L27/3604 , D10B2211/22 , Y10T428/13 , C08L89/00
摘要： Described are tubular silk fibroin compositions and methods for their manufacture and use. Tubular compositions as described herein can be produced in a range of high burst strengths, can easily be made in a range of inner diameters, can be derivatized with functional moieties, and can be produced in a range of permeabilities suitable for particularized uses. In one aspect, the tubular compositions can be used in the repair or replacement of damaged or diseased blood vessels, including, but not limited to vessels smaller than about 6 mm.
摘要翻译： 描述的是管状丝素蛋白组合物及其制造和使用的方法。 如本文所述的管状组合物可以在高爆裂强度的范围内制备，可以容易地在内径范围内制备，可以用官能部分衍生化，并且可以在适合于特定用途的渗透性范围内制备。 在一个方面，管状组合物可用于修复或更换受损或患病的血管，包括但不限于小于约6mm的血管。
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公开(公告)号：US08354501B2
公开(公告)日：2013-01-15
申请号：US11997193
申请日：2006-07-28
申请人： David L. Kaplan , Xianyan Wang
发明人： David L. Kaplan , Xianyan Wang
CPC分类号： A61L31/10 , A61J3/00 , A61L15/32 , A61L15/44 , A61L27/3604 , A61L27/50 , A61L31/16 , A61L2300/416 , A61L2300/43 , A61L2400/12 , A61L2400/18 , C09D189/00 , Y10T428/31768
摘要： The invention provides a method for the controlled assembly of layered silk fibroin coatings using aqueous silk fibroin material. The methods described herein can be used to coat substrates of any material, shape, or size. Importantly, the described methods enable control of the biomaterial surface chemistry, thickness, morphology and structure using layered thin film coatings, or bulk coatings. Furthermore, the methods can be performed in all water and do not require intensive chemical processing enabling controlled entrapment of labile molecules such as, drugs, cytokines, and even cells or viruses to generate functional coatings that can be used in a variety of applications.
摘要翻译： 本发明提供了一种使用水性丝素蛋白材料控制组合层状丝素蛋白涂层的方法。 本文所述的方法可用于涂覆任何材料，形状或尺寸的基材。 重要的是，所描述的方法使得能够使用分层薄膜涂层或散装涂层来控制生物材料表面化学，厚度，形态和结构。 此外，所述方法可以在所有的水中进行，并且不需要强化的化学处理，从而能够控制不稳定的分子例如药物，细胞因子甚至细胞或病毒的捕获，以产生可用于各种应用的功能性涂层。
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公开(公告)号：US20090142836A1
公开(公告)日：2009-06-04
申请号：US12324367
申请日：2008-11-26
申请人： Xianyan Wang , Katherine C. Faria
发明人： Xianyan Wang , Katherine C. Faria
IPC分类号： C12N5/06
CPC分类号： C12N5/0068 , A61L27/3633 , A61L27/3683 , A61L27/3804 , C12N5/0698 , C12N2500/25 , C12N2500/36 , C12N2500/38 , C12N2500/40 , C12N2500/50 , C12N2500/90 , C12N2500/92 , C12N2501/11 , C12N2501/148 , C12N2501/395 , C12N2502/094 , C12N2502/1323 , C12N2533/50 , C12N2533/92
摘要： Bioengineered constructs are formed from cultured cells induced to synthesize and secrete endogenously produced extracellular matrix components without the requirement of exogenous matrix components or network support or scaffold members. The bioengineered constructs of the invention can be treated in various ways such that the cells of the bioengineered constructs can be devitalized and/or removed without compromising the structural integrity of the constructs. Moreover, the bioengineered constructs of the invention can be used in conjunction with biocompatible/bioremodelable solutions that allow for various geometric configurations of the constructs.
摘要翻译： 生物工程化构建体由诱导合成和分泌内源性产生的细胞外基质组分的培养细胞形成，而不需要外源基质组分或网络支持物或支架构件。 可以以各种方式处理本发明的生物工程化构建体，使得生物工程化构建体的细胞可以在不影响构建体的结构完整性的情况下失活和/或去除。 此外，本发明的生物工程化构建体可以与允许构建体的各种几何构型的生物相容/生物可重构溶液结合使用。
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公开(公告)号：US09808557B2
公开(公告)日：2017-11-07
申请号：US12672521
申请日：2008-08-11
申请人： Michael L. Lovett , Xianyan Wang , Christopher M. Cannizzaro , Gordana Vunjak-Novakovic , David L. Kaplan
发明人： Michael L. Lovett , Xianyan Wang , Christopher M. Cannizzaro , Gordana Vunjak-Novakovic , David L. Kaplan
CPC分类号： A61L27/227 , A61F2/07 , A61F2/08 , A61F2/82 , A61L27/26 , A61L27/3604 , D10B2211/22 , Y10T428/13 , C08L89/00
摘要： Described are tubular silk fibroin compositions and methods for their manufacture and use. Tubular compositions as described herein can be produced in a range of high burst strengths, can easily be made in a range of inner diameters, can be derivatized with functional moieties, and can be produced in a range of permeabilities suitable for particularized uses. In one aspect, the tubular compositions can be used in the repair or replacement of damaged or diseased blood vessels, including, but not limited to vessels smaller than about 6 mm.
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公开(公告)号：US20090202614A1
公开(公告)日：2009-08-13
申请号：US11997193
申请日：2006-07-28
申请人： David L. Kaplan , Xianyan Wang
发明人： David L. Kaplan , Xianyan Wang
CPC分类号： A61L31/10 , A61J3/00 , A61L15/32 , A61L15/44 , A61L27/3604 , A61L27/50 , A61L31/16 , A61L2300/416 , A61L2300/43 , A61L2400/12 , A61L2400/18 , C09D189/00 , Y10T428/31768
摘要： The invention provides a method for the controlled assembly of layered silk fibroin coatings using aqueous silk fibroin material. The methods described herein can be used to coat substrates of any material, shape, or size. Importantly, the described methods enable control of the biomaterial surface chemistry, thickness, morphology and structure using layered thin film coatings, or bulk coatings. Furthermore, the methods can be performed in all water and do not require intensive chemical processing enabling controlled entrapment of labile molecules such as, drugs, cytokines, and even cells or viruses to generate functional coatings that can be used in a variety of applications.
摘要翻译： 本发明提供了一种使用水性丝素蛋白材料控制组合层状丝素蛋白涂层的方法。 本文所述的方法可用于涂覆任何材料，形状或尺寸的基材。 重要的是，所描述的方法使得能够使用分层薄膜涂层或散装涂层来控制生物材料表面化学，厚度，形态和结构。 此外，所述方法可以在所有的水中进行，并且不需要强化的化学处理，从而能够控制不稳定的分子例如药物，细胞因子甚至细胞或病毒的捕获，以产生可用于各种应用的功能性涂层。
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公开(公告)号：US20110293666A1
公开(公告)日：2011-12-01
申请号：US13007201
申请日：2011-01-14
申请人： Xianyan Wang , Katherine C. Faria
发明人： Xianyan Wang , Katherine C. Faria
IPC分类号： A61K9/00 , A61K35/12 , A61K35/36 , A61K35/44 , A61K35/42 , A61K35/22 , A61K35/38 , C12N5/071 , A61K35/32
CPC分类号： A61L27/3633 , A61L27/3683 , A61L27/3804 , C12N5/0068 , C12N5/0698 , C12N2500/25 , C12N2500/36 , C12N2500/38 , C12N2500/40 , C12N2500/50 , C12N2500/90 , C12N2501/11 , C12N2501/148 , C12N2501/395 , C12N2502/094 , C12N2502/1323 , C12N2533/50 , C12N2533/92
摘要： Bioengineered constructs are formed from cultured cells induced to synthesize and secrete endogenously produced extracellular matrix components, e.g., without the requirement of exogenous matrix components or network support or scaffold members. The bioengineered constructs of the invention can be treated in various ways such that the cells of the bioengineered constructs can be devitalized and/or removed without compromising the structural integrity of the constructs. Moreover, the bioengineered constructs of the invention can be used in conjunction with biocompatible/bioremodelable solutions that allow for various geometric configurations of the constructs.
摘要翻译： 生物工程化构建体由诱导合成和分泌内源产生的细胞外基质组分的培养细胞形成，例如不需要外源基质组分或网络支持物或支架构件。 可以以各种方式处理本发明的生物工程化构建体，使得生物工程化构建体的细胞可以在不影响构建体的结构完整性的情况下失活和/或去除。 此外，本发明的生物工程化构建体可以与允许构建体的各种几何构型的生物相容/生物可重构溶液结合使用。
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