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1.发明授权公开(公告)号：US10532092B2
公开(公告)日：2020-01-14
申请号：US16027289
申请日：2018-07-04
申请人： Lanzhou Veterinary Research Institute Chinese Academy of Agricultural Sciences , Zhejiang University
发明人： Huichen Guo , Shiqi Sun , Ping Du , Zhidong Teng , Ruikang Tang , Ruibo Zhao , Jiaxi Ru , Yanquan Wei , Yun Zhang , Yuan Gao , Junwu Ma , Xiangtao Liu , Hong Yin
摘要： Foot-and-mouth disease virus like particles, the particles including a structural protein VP0, a structural protein VP1 including a mineralization peptide, a structural protein VP3, and a calcium phosphate coat. The structural protein VP1 including a mineralization peptide is encoded by a gene sequence represented by SEQ ID NO. 7, SEQ ID NO. 8 or SEQ ID NO. 9. The structural protein VP0 is encoded by a gene sequence represented by SEQ ID NO. 2. The structural protein VP3 is encoded by a gene sequence represented by SEQ ID NO. 3. The calcium phosphate coat covers the structural protein VP0, the structural protein VP1 including a mineralization peptide, and the structural protein VP3.
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公开(公告)号：US10532077B2
公开(公告)日：2020-01-14
申请号：US16413598
申请日：2019-05-15
发明人： Huichen Guo , Shiqi Sun , Shichong Han , Hu Dong , Xiaoran Guo , Hong Yin , Jianxun Luo
IPC分类号： C07K14/005 , C07K16/10 , C12N7/00 , A61K39/00 , A61K39/12 , A61K35/76 , C12N15/86 , A61P31/14 , A61K39/39
摘要： A virus-like particle of Senecavirus A, the particle including a structural protein VP0, a structural protein VP1 and a structural protein VP3. The structural protein VP0 is encoded by a gene sequence represented by SEQ ID NO: 1. The structural protein VP1 is encoded by a gene sequence represented by SEQ ID NO: 2. The structural protein VP3 is encoded by a gene sequence represented by SEQ ID NO: 3.
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公开(公告)号：US10829741B2
公开(公告)日：2020-11-10
申请号：US15993637
申请日：2018-05-31
发明人： Shiqi Sun , Huichen Guo , Yun Zhang , Yanyan Chang , Yanquan Wei , Jiaxi Ru , Xiaoying Zhi , Ping Du , Xiangtao Liu , Hong Yin , Jianxun Luo
IPC分类号： C12N7/04 , C12N7/00 , G01N33/569
摘要： A method for preparing serotype O foot-and-mouth disease virus-like particles, the method including: construction of small ubiquitin-like modifier fusion expression vector, construction of recombinant expression vectors, construction of recombinant co-expression vector, expression and purification of proteins, and in-vitro assembly of serotype O foot-and-mouth disease virus-like particles. The disclosure also provides a test strip for detecting serotype O foot-and-mouth disease including a bottom board, and a detection layer disposed on the top of the bottom board. A detection line and a control line are disposed on the detection layer. An absorbent layer is disposed at one end of the detection layer close to the control line, and an immuno-gold pad is disposed at the other side of the detection layer close to the detection line. A sample pad is disposed on the top of the immuno-gold pad.
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4.发明授权公开(公告)号：US11407698B2
公开(公告)日：2022-08-09
申请号：US16759931
申请日：2018-10-10
发明人： Hong Yin , Zhirong Chen , Xinrong Wang , Weisong Wang , Yuanrong Yu , Shengli Wang , Yuefen Wang , Zhenqiang Ma , Xingjun Zhao , Jianfang Qian
IPC分类号： C07C17/10 , C07C21/067 , B01J19/24 , B01J12/00 , B01J19/00
摘要： The present invention relates to a synthesis method and synthesis reactor of high-selectivity 2-methylallyl chloride by taking isobutylene and chlorine gas as raw materials and performing a gas-phase chlorination reaction in a microchannel reactor with a cooling surface. The isobutylene and the chlorine gas are reacted in a T-shaped microchannel reactor, and the mixing speed is extremely fast. Meanwhile, the huge heat exchange area per unit volume can ensure that the reaction proceeds stably at a substantially constant temperature and has good controllability. Therefore, side reactions caused by excessive local temperature can be effectively suppressed, the reaction selectivity is high, and no coking phenomenon occurs.
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5.发明申请公开(公告)号：US20210147350A1
公开(公告)日：2021-05-20
申请号：US17263362
申请日：2019-08-27
发明人： Zhirong Chen , Hong Yin , Baishan Hu , Zhengjiang Wang , Zhixuan Wang , Cong Chen , Guisheng Qiu , Qichuan Li , Qingai Shi
IPC分类号： C07C319/20 , C07C319/28 , C07C323/52 , B01J19/24
摘要： Provided by the present disclosure are a method and a device for preparing 2-hydroxy-4-methylthiobutyric acid and intermediates thereof; the intermediates for preparing 2-hydroxy-4-methylthiobutyric acid comprise 3-methylthiopropionaldehyde and 2-hydroxy-4-methylthiobutyronitrile. The method for preparing 2-hydroxy-4-methylthiobutyric acid provided by the present disclosure comprises: step (1), a step of reacting acrolein with methyl mercaptan to prepare 3-methylthiopropionaldehyde; step (2), a step of reacting 3-methylthiopropionaldehyde with hydrocyanic acid to prepare 2-hydroxy-4-methylthiobutyronitrile; and step (3), a step of hydrating 2-hydroxy-4-methylthiobutyronitrile by using sulfuric acid and then hydrolyzing to prepare 2-hydroxy-4-methylthiobutyric acid; wherein in steps (1), (2) and (3), the reaction status of the materials is detected online, and the proportions of the materials are controlled according to the detection results such that reactions are performed completely
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公开(公告)号：US11632970B2
公开(公告)日：2023-04-25
申请号：US16067528
申请日：2016-12-08
发明人： Jiandong Li , Zhirong Chen , Hong Yin , Xiaoyong Zhu , Dan Qiu , Lifang Shi , Dongming Shi , Yong Qi
IPC分类号： A23K20/174 , A23K40/30 , A23P10/30 , A23L33/15 , A61K9/14 , A61K31/015
摘要： The present invention discloses a method for preparation of vitamin and carotenoid powder; the vitamin and carotenoid powder comprises vitamin, carotenoid microcapsule and physical gel protection film covered on the surface of the vitamin and carotenoid microcapsule; the physical gel protection film is made from super-molecular system; the super-molecular system comprises the following constituents of parts in weight: vegetable oil: 6-30 parts; gel: 0.5-3 parts and antioxidant: 0.5-3 parts. The hot super-molecular solution is sprayed on the surface of cold vitamin and carotenoid microcapsule during preparation to form a specific 3D network structure that is used to bind the liquefied vegetable oil to form a physical gel protection film; the physical gel protection film has improved product storage stability as well as the its stability for application in feedstuff, food and health care products.
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公开(公告)号：US09567440B2
公开(公告)日：2017-02-14
申请号：US14655326
申请日：2013-10-29
申请人： ZHEJIANG NHU SPECIAL MATERIALS CO., LTD. , ZHEJIANG UNIVERSITY , SHANGYU NHU BIOLOGICAL CHEMICAL CO., LTD. , ZHEJIANG NHU COMPANY LTD.
发明人： Zhirong Chen , Woyuan Li , Haoran Li , Ming Lian , Hong Yin , Guiyang Zhou , Xinfeng Zheng
摘要： The present invention discloses a fiber-grade polyphenylene sulfide resin synthesis method, taking sodium bisulfide and p-dichlorobenzene as raw materials, N-methyl pyrrolidone as the solvent and C5-C6 fatty acid salt formed through dehydration to C5-C6 fatty acid and sodium hydroxide as the polymerization additive for synthesis through polymerization. White polyphenylene sulfide resin is obtained through acidification and washing of reaction slurry. In view of the fact that MFR is below 125 g/10 min, weight-average molecular weight as measured by GPC is over 4.2×104, and whiteness is over 90, it can satisfy requirements for fiber polyphenylene sulfide resin. C5-C6 fatty acid salt according to the method of the present invention has a higher solubility in NMP, which can better promote polymerization. It is to be fully diverted into the filtrate after filter prior to conversion into free fatty acid again through acidification with hydrochloric acid. C5-C6 fatty acid is available for azeotropy with water, which has a limited solubility in water. Therefore, it is applicable to recycle C5-C6 fatty acid from the filtrate through azeotropy with water, and thereby solve the problem with separation of additive and sodium chloride that are soluble in water.
摘要翻译： 本发明公开了以二硫化二钠和对二氯苯为原料的纤维级聚苯硫醚树脂的合成方法，将N-甲基吡咯烷酮作为溶剂和通过脱水形成C5-C6脂肪酸和 氢氧化物作为通过聚合合成的聚合添加剂。 白色聚苯硫醚树脂通过反应浆液的酸化和洗涤得到。 鉴于MFR低于125g / 10min，通过GPC测得的重均分子量超过4.2×104，白度超过90，可以满足纤维聚苯硫醚树脂的要求。 根据本发明方法的C5-C6脂肪酸盐在NMP中的溶解度较高，可以更好地促进聚合。 过滤后将其全部转入滤液，然后再用盐酸酸化再转化成游离脂肪酸。 C5-C6脂肪酸可与水共沸，其在水中的溶解度有限。 因此，适用于通过与水共沸从滤液中回收C5-C6脂肪酸，从而解决了可溶于水的添加剂和氯化钠的分离问题。
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公开(公告)号：US20240336560A1
公开(公告)日：2024-10-10
申请号：US17800452
申请日：2022-06-21
申请人： ZHEJIANG UNIVERSITY , ZHEJIANG NHU CO., LTD. , ZHEJIANG NHU SPECIAL MATERIALS CO., LTD. , ZHEJIANG NHU NYLON MATERIALS CO., LTD.
发明人： Zhirong Chen , Wenbin Wu , Hong Yin , Zengshi Zha , Keyan Wang , Li Ma , Guodong Huang , Guiyang Zhou , Yong Xu
IPC分类号： C07C253/10 , B01J31/18 , B01J37/04 , C07F9/06 , C07F9/6571
CPC分类号： C07C253/10 , B01J31/185 , B01J37/04 , C07F9/062 , C07F9/6571 , B01J2231/322 , B01J2231/52 , B01J2531/004 , B01J2531/847
摘要： A multidentate phosphite ligand is used in the catalytic synthesis of adiponitrile. The ligand is represented by the following general formula (I). The method of catalytic synthesis of adiponitrile comprises primary hydrocyanation, isomerization, and secondary hydrocyanation reactions, wherein the catalyst adopted each comprises a phosphite ligand-nickel complex composed of a nickel precursor and a multidentate phosphite ligand. The ligand molecule has a higher electron cloud density, and the phosphorus content capable of participating in coordination in the ligand molecule per unit mass is higher, so that the catalytic activity of the catalyst is improved, and the amount of the catalyst is reduced.
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公开(公告)号：US20220025120A1
公开(公告)日：2022-01-27
申请号：US17416587
申请日：2019-11-20
发明人： Zhirong Chen , Hong Yin , Hangjun Deng , Guiyang Zhou , Danqi Zhu , Xiaoxiao Wu , Wengang Hong , Guisheng Qiu , Qichuan Li
摘要： The present disclosure discloses a semi-aromatic polyamide and a preparation method therefor. The semi-aromatic polyamide is obtained by polymerization reaction using a diamine, a dibasic acid and a monoacid as main raw materials while adding a special end-capping agent. The semi-aromatic polyamide prepared according to the present disclosure has good thermal stability, a yellowness index of less than 20, a glass transition temperature of 90° C. or above, and a melting point of 300° C. or above, and can be applied to spare parts for fuel pipelines in automobiles, and electronic and electrical industries such as LED panels.
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10.发明申请公开(公告)号：US20230094350A1
公开(公告)日：2023-03-30
申请号：US17795838
申请日：2021-09-16
申请人： ZHEJIANG UNIVERSITY , ZHEJIANG NHU CO., LTD. , SHANDONG NHU AMINO ACID CO., LTD. , ZHEJIANG NHU SPECIAL MATERIALS CO., LTD.
发明人： Zhirong Chen , Wenbin Wu , Hong Yin , Yaqing Liu , Zengshi Zha , Zhichao Feng , Tinglan Zhang , Guodong Huang
IPC分类号： B01J31/06 , C08F30/02 , C08J9/14 , B01J23/755 , B01J31/28 , B01J35/10 , B01J35/00 , C07C253/10
摘要： A porous polymer has a pore volume of 0.3 to 2.5 cm3/g and comprises a pore having a first pore diameter and a pore having a second pore diameter. A ratio of pore volume of the pore having a first pore diameter to pore volume of the pore having a second pore diameter is 1 to 10:1. The porous polymer is obtained by self-polymerization or copolymerization of at least one of the phosphorus ligands, and phosphorous content of the porous polymer is 1 to 5 mmol/g. The porous polymer-nickel catalyst made of the porous polymer has a significant increase in water resistance, which may reduce the consumption of phosphorus ligands, eliminating the steps of removing water from raw materials and reaction system water control, which greatly saves process equipment investment. When used in the preparation of adiponitrile from butadiene, it has high catalytic activity, high reaction selectivity, and high linearity.
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