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    TARGETED BINDING AGENTS DIRECTED TO UPAR AND USES THEREOF
    5.
    发明申请
    TARGETED BINDING AGENTS DIRECTED TO UPAR AND USES THEREOF 审中-公开
    指定的绑定代理指令及其使用

    公开(公告)号：US20120108797A1

    公开(公告)日：2012-05-03

    申请号：US13193167

    申请日：2011-07-28

    申请人： Paul Elvin ,  Stephen Charles Emery ,  Qing Zhou

    发明人： Paul Elvin ,  Stephen Charles Emery ,  Qing Zhou

    IPC分类号： C07K16/28

    CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

    摘要： Targeted binding agents directed to the antigen uPAR and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the antigen uPAR. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementary determine regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.

    摘要翻译： 描述了针对抗原uPAR的靶向结合剂和这些抗体的用途。 特别是针对抗原uPAR的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 。 表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。

    Targeted binding agents directed to uPAR and uses thereof
    6.
    发明授权
    Targeted binding agents directed to uPAR and uses thereof 失效
    针对uPAR的靶向结合剂及其用途

    公开(公告)号：US08026344B2

    公开(公告)日：2011-09-27

    申请号：US11733157

    申请日：2007-04-09

    申请人： Qing Zhou ,  Stephen Charles Emery ,  Paul Elvin

    发明人： Qing Zhou ,  Stephen Charles Emery ,  Paul Elvin

    IPC分类号： C07K16/00 ,  C07K16/46 ,  C07K16/24 ,  A61K39/395

    CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

    摘要： Targeted binding agents directed to the antigen uPAR and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the antigen uPAR. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.

    摘要翻译： 描述了针对抗原uPAR的靶向结合剂和这些抗体的用途。 特别是针对抗原uPAR的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 。 表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。

    TARGETED BINDING AGENTS DIRECTED TO UPAR AND USES THEREOF
    7.
    发明申请
    TARGETED BINDING AGENTS DIRECTED TO UPAR AND USES THEREOF 审中-公开
    指定的绑定代理指令及其使用

    公开(公告)号：US20090123476A1

    公开(公告)日：2009-05-14

    申请号：US12296593

    申请日：2007-04-09

    申请人： Paul Elvin ,  Stephen Charles Emery ,  Qing Zhou

    发明人： Paul Elvin ,  Stephen Charles Emery ,  Qing Zhou

    IPC分类号： A61K39/395 ,  C07K16/18 ,  C07K14/00 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  C12P21/04

    CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

    摘要： Targeted binding agents directed to the antigen uPAR and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the antigen uPAR. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.

    摘要翻译： 描述了针对抗原uPAR的靶向结合剂和这些抗体的用途。 特别是针对抗原uPAR的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 。 表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。

    TARGETED BINDING AGENTS DIRECTED TO uPAR AND USES THEREOF
    8.
    发明申请
    TARGETED BINDING AGENTS DIRECTED TO uPAR AND USES THEREOF 失效
    指定的绑定代理人及其用途

    公开(公告)号：US20080152587A1

    公开(公告)日：2008-06-26

    申请号：US11733157

    申请日：2007-04-09

    申请人： Qing Zhou ,  Stephen Charles Emery ,  Paul Elvin

    发明人： Qing Zhou ,  Stephen Charles Emery ,  Paul Elvin

    IPC分类号： A61K51/00 ,  C07K16/00 ,  C07H21/02 ,  C12N15/66 ,  A61P35/00 ,  A61K39/00

    CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

    摘要： Targeted binding agents directed to the antigen uPAR and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the antigen uPAR. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.

    摘要翻译： 描述了针对抗原uPAR的靶向结合剂和这些抗体的用途。 特别是针对抗原uPAR的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 。 表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。

    ANTI-HUMAN RANKL ANTIBODY, HUMANIZED ANTIBODY OF THE SAME, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF
    9.
    发明申请
    ANTI-HUMAN RANKL ANTIBODY, HUMANIZED ANTIBODY OF THE SAME, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF 有权
    抗人RANKL抗体，其人类抗体及药物组合物及其用途

    公开(公告)号：US20160333101A1

    公开(公告)日：2016-11-17

    申请号：US14757970

    申请日：2015-12-23

    申请人： Qing Zhou ,  Xiao Feng ,  Weihong Nian ,  Lingyun Li

    发明人： Qing Zhou ,  Xiao Feng ,  Weihong Nian ,  Lingyun Li

    IPC分类号： C07K16/28

    CPC分类号： C07K16/2875 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30

    摘要： An anti-human RANKL antibody, a humanized antibody for the anti-human RANKL antibody, a pharmaceutical composition and a use thereof are provided. The anti-human RANKL antibody is capable of bonding specifically with an amino acid sequence of SEQ ID NO.1, a heavy chain of the anti-human RANKL antibody includes a variable region in one of amino acid sequences of SEQ ID NO.2-9, and a light chain of the anti-human RANKL antibody includes a variable region in one of amino acid sequences of SEQ ID NO.10-17. The humanized antibody is capable of bonding specifically with human RANKL, a variable region in a heavy chain of the humanized antibody is selected from amino acid sequences of SEQ ID NO.6, NO.23, NO.25, NO.27 or NO.29, and a variable region in a light chain of the humanized antibody is selected from amino acid sequences of SEQ ID NO.14, NO.31, NO.33, NO.35, NO.37 or NO.39.

    摘要翻译： 提供抗人RANKL抗体，抗人RANKL抗体的人源化抗体，药物组合物及其用途。 抗人RANKL抗体能够与SEQ ID NO.1的氨基酸序列特异性结合，抗人RANKL抗体的重链包含SEQ ID NO.2-1的氨基酸序列之一的可变区， 9，抗人RANKL抗体的轻链包含SEQ ID NO.10-17的氨基酸序列之一的可变区。 人源化抗体能够与人RANKL特异性结合，人源化抗体重链中的可变区选自SEQ ID NO.6，NO.23，NO.25，NO.27或NO的氨基酸序列。 29，并且人源化抗体的轻链中的可变区选自SEQ ID NO.14，NO.31，NO.33，NO.35，NO37或NO.39的氨基酸序列。

    Graphics processing using two-dimensional scissor regions
    10.
    发明授权
    Graphics processing using two-dimensional scissor regions 有权
    使用二维剪刀区域的图形处理

    公开(公告)号：US09064343B2

    公开(公告)日：2015-06-23

    申请号：US12861890

    申请日：2010-08-24

    申请人： Ruiduo Yang ,  Linda Ip ,  Michael D. Street ,  Qing Zhou

    发明人： Ruiduo Yang ,  Linda Ip ,  Michael D. Street ,  Qing Zhou

    IPC分类号： G06T15/10 ,  G06T15/00 ,  G06T1/20 ,  G06T15/30

    CPC分类号： G06T15/30

    摘要： Aspects of this disclosure are directed to techniques to store values indicative of one or more scissor regions in a scissor buffer. In aspects of this disclosure, a processor may receive two dimensional (2-D) coordinates of a scissor region. The processor may transform the 2-D coordinates into coordinates that include more than two dimensions. The processor may store a value indicative of the scissor region in one or more storage units of the scissor buffer based on the coordinates that include more than two dimensions.

    摘要翻译： 本公开的方面涉及将指示剪刀缓冲器中的一个或多个剪刀区域的值存储的技术。 在本公开的方面，处理器可以接收剪刀区域的二维（2-D）坐标。 处理器可以将二维坐标变换为包括二维以上的坐标。 处理器可以基于包括多于两维的坐标将指示剪刀区域的值存储在剪刀缓冲器的一个或多个存储单元中。