公开(公告)号：US06620962B2

公开(公告)日：2003-09-16

申请号：US10239678

申请日：2002-09-24

申请人： Lars Rodefeld ,  Thomas Höpfner ,  Alexander Klausener ,  Horst Behre

发明人： Lars Rodefeld ,  Thomas Höpfner ,  Alexander Klausener ,  Horst Behre

IPC分类号： C07C22702

CPC分类号： C07C233/15 ,  C07C231/12 ,  C07C233/54

摘要： According to the invention, N-butyryl-4-amino-3-methyl-methyl benzoate is obtained in a particularly advantageous manner by, initially, reacting o-toluidine with butyric acid chloride, by brominating the reaction product and by reacting the bromide obtained therefrom with carbon monoxide and methanol in the presence of a palladium catalyst. The invention also relates to the important novel chemical compound N-(4-bromine-2-methylphenyl)-butanamide.

摘要翻译： 根据本发明，以特别有利的方式，通过使邻甲苯胺与丁酰氯反应，通过溴化反应产物并使所得到的溴化物反应，得到N-丁酰基-4-氨基-3-甲基 - 甲基苯甲酸酯 与一氧化碳和甲醇在钯催化剂存在下反应。 本发明还涉及重要的新化合物N-（4-溴-2-甲基苯基） - 丁酰胺。

公开(公告)号：US06465678B1

公开(公告)日：2002-10-15

申请号：US09889813

申请日：2001-07-20

申请人： Lars Rodefeld ,  Horst Behre ,  Alexander Klausener ,  Robert Söllner

发明人： Lars Rodefeld ,  Horst Behre ,  Alexander Klausener ,  Robert Söllner

IPC分类号： C07C22900

CPC分类号： C07C281/02

摘要： Methyl carbazate which is particularly pure and has a particularly low tendency toward discoloration is obtained from hydrazine and dimethyl carbonate if the two reactants are metered simultaneously into an initially introduced first solvent at from −20 to +30° C., the solvent and low-boiling components are then distilled off under reduced pressure, and then either a second solvent is added to the crude methyl carbazate present and this solvent is distilled off under reduced pressure or an inert gas is passed through the crude methyl carbazate present.

摘要翻译： 如果两个反应物在-20至+ 30℃下同时计量到初始引入的第一溶剂中，则可从肼和碳酸二甲酯得到特别纯的具有特别低的变色趋势的肼基甲酸甲酯， 然后在减压下蒸馏沸腾的组分，然后将第二溶剂加入到存在的粗甲基肼基甲酸酯中，并在减压下蒸馏掉该溶剂，或使惰性气体通过存在的粗甲基肼基甲酸酯。

公开(公告)号：US06204413B1

公开(公告)日：2001-03-20

申请号：US09547310

申请日：2000-04-11

申请人： Lars Rodefeld ,  Alexander Klausener ,  Horst Behre

发明人： Lars Rodefeld ,  Alexander Klausener ,  Horst Behre

IPC分类号： C07C20900

CPC分类号： C07C213/10 ,  C07C213/02 ,  C07C215/80

摘要： The invention relates to a process for the preparation of specific salts of 1-substituted 2,4-diaminobenzenes by catalytic hydrogenation of 1-substituted 2,4-dinitrobenzenes and addition of the reaction product obtained after the hydrogenation and separated from the catalyst to an aqueous solution of an acid.

摘要翻译： 本发明涉及通过1-取代的2,4-二硝基苯的催化氢化制备1-取代的2,4-二氨基苯的特定盐的方法，加入氢化后得到的反应产物并从催化剂中分离成 酸的水溶液。

公开(公告)号：US06610893B2

公开(公告)日：2003-08-26

申请号：US10240966

申请日：2002-10-07

申请人： Horst Behre ,  Michael Dockner ,  Alexander Klausener

发明人： Horst Behre ,  Michael Dockner ,  Alexander Klausener

IPC分类号： C07C20500

CPC分类号： C07C201/08 ,  C07C205/22

摘要： A process is provided for preparing 4-hydroxy-3-nitrobiphenyl from 4-hydroxy-biphenyl by nitrating in the position adjacent to the phenolic hydroxyl group in high selectivity and yield, and the nitric acid used as the nitrating reagent is metered into the reaction system in a specific manner.

公开(公告)号：US6133480A

公开(公告)日：2000-10-17

申请号：US209401

申请日：1998-12-10

申请人： Horst Behre ,  Helmut Fiege ,  Wolfgang Eymann ,  Frank Arndt ,  Rudolf Wiemers ,  Alexander Klausener

发明人： Horst Behre ,  Helmut Fiege ,  Wolfgang Eymann ,  Frank Arndt ,  Rudolf Wiemers ,  Alexander Klausener

IPC分类号： B01J27/24 ,  B01J31/26 ,  C07B61/00 ,  C07C209/60 ,  C07C209/64 ,  C07C211/58 ,  C07C211/00

CPC分类号： C07C209/64 ,  Y02P20/582

摘要： N-Phenyl-1-naphthylamine can be prepared by reaction of aniline and 1-naphthylamine in the liquid phase at 100-400.degree. C. under normal pressure, a catalyst mixture comprising boron and fluorine being employed. Such catalyst mixtures can be obtained, for example, by reaction of hydrogen fluoride, boric acid and aniline and/or 1-naphthylamine. The catalyst is recovered and can be employed again. The reaction can be carried out discontinuously or continuously.

摘要翻译： N-苯基-1-萘胺可以通过在常压下在100-400℃下在液相中使苯胺和1-萘胺反应来制备，使用包含硼和氟的催化剂混合物。 这样的催化剂混合物可以通过例如氟化氢，硼酸和苯胺和/或1-萘胺的反应获得。 催化剂被回收并可再次使用。 反应可以不连续或连续进行。

公开(公告)号：US4450297A

公开(公告)日：1984-05-22

申请号：US476093

申请日：1983-03-17

申请人： Michael Preiss ,  Wolfgang Gau ,  Horst Behre

发明人： Michael Preiss ,  Wolfgang Gau ,  Horst Behre

IPC分类号： C07C201/16 ,  C07C20060101 ,  C07C45/78 ,  C07C67/00 ,  C07C201/00 ,  C07C205/44 ,  C07C76/06 ,  C07C79/36

CPC分类号： C07C201/12 ,  C07C201/16

摘要： A process for the preparation of o-nitrobenzaldehyde, comprising converting to the corresponding acetals a mixture of nitrated benzaldehyde which contains about 10 to 30% of o-nitrobenzaldehyde and about 70 to 90% of m-nitrobenzaldehyde, removing the o-nitrobenzaldehyde acetal by distillation, and then converting the o-nitrobenzaldehyde acetal to o-nitrobenzaldehyde.

摘要翻译： 一种制备邻硝基苯甲醛的方法，包括将相应的缩醛转化成含有约10-30％邻硝基苯甲醛的硝化苯甲醛和约70-90％间硝基苯甲醛的混合物，通过以下步骤除去邻硝基苯甲醛缩醛 蒸馏，然后将邻硝基苯甲醛缩醛转化为邻硝基苯甲醛。

公开(公告)号：US4348334A

公开(公告)日：1982-09-07

申请号：US113412

申请日：1980-01-18

申请人： Bernhard Albrecht ,  Hans Frey ,  Vinzenz Habermacher ,  Horst Behre ,  Lutz Kienitz ,  Wolfgang Schenk ,  Guido Steffan ,  Axel Vogel

发明人： Bernhard Albrecht ,  Hans Frey ,  Vinzenz Habermacher ,  Horst Behre ,  Lutz Kienitz ,  Wolfgang Schenk ,  Guido Steffan ,  Axel Vogel

IPC分类号： C07C309/40 ,  C07C67/00 ,  C07C301/00 ,  C07C303/06 ,  C07C303/22 ,  C07C303/32 ,  C07C143/55

CPC分类号： C07C309/00

摘要： A process for producing the magnesium salt of 3-nitro-naphthalene-1,5-disulfonic acid by sulfonating naphthalene, nitrating the sulfonation product, and separating the pure magnesium salt of 3-nitronaphthalene-1,5-disulfonic acid, which process comprises:(a) sulfonating naphthalene with liquid SO.sub.3 in the presence of an inert organic solvent at temperatures between -40.degree. and +20.degree. C.;(b) adding to the reaction mixture obtained a mixture consisting of about equal parts of 100% sulfuric acid and fully reacted crude nitration mixture from nitration of a previous nitration charge, separating from the resulting two-phase system the upper organic solvent phase by decanting, and removing from the Armstrong's acid anhydride acid slurry the remainder of organic solvent by distillation, or removing it during or after subsequent nitration, subsequently adding to the residue the amount of nitric acid required for nitration, and then nitrating;(c) adding then firstly water and afterwards, in the absence of the inert organic solvent, at 90.degree. to 120.degree. C., a compound releasing magnesium ions, the amount being such that, per mol of 3-nitronaphthalene-1,5-disulfonic acid, 1.1 to 1.3 mols of magnesium ions are added, and a sulfuric acid concentration of between 40 and 60 percent by weight (relative to the sulfuric acid and water) is maintained; and(d) separating the crystallized magnesium salt of 3-nitronaphthalene-1,5-disulfonic acid at a temperature of between 20.degree. and 70.degree. C., and subsequently optionally washing it with a maximum of 60 percent by weight of sulfuric acid and/or water, and optionally drying the product.

摘要翻译： 通过磺化萘，硝化磺化产物和分离3-硝基萘-1,5-二磺酸的纯镁盐来生产3-硝基 - 萘-1,5-二磺酸的镁盐的方法，该方法包括 ：（a）在-40℃〜+ 20℃的温度下，在惰性有机溶剂的存在下，用液态SO 3磺化萘。 （b）向反应混合物中加入由约等量的100％硫酸组成的混合物和来自先前硝化装置的硝化的完全反应的粗硝化混合物，通过倾析从所得两相体系中分离出上部有机溶剂相 ，并通过蒸馏从阿姆斯壮的酸酐酸浆中除去剩余的有机溶剂，或者在后续硝化过程中或之后将其除去，随后向残余物中加入硝化所需的硝酸量，然后硝化; （c）然后首先加入水，然后在不存在惰性有机溶剂的情况下，在90〜120℃下，加入释放镁离子的化合物，其用量为每摩尔3-硝基萘-1,5 二磺酸，加入1.1〜1.3摩尔的镁离子，硫酸浓度保持在40〜60重量％之间（相对于硫酸和水）; 和（d）在20℃至70℃的温度下分离3-硝基萘-1,5-二磺酸的结晶镁盐，随后任选地用最多60重量％的硫酸洗涤， /或水，并任选地干燥产品。

公开(公告)号：US4163752A

公开(公告)日：1979-08-07

申请号：US868558

申请日：1978-01-11

申请人： Otto Barth ,  Hans-Joachim Becker ,  Horst Behre ,  Reinhard Kaiser ,  Guido Steffan ,  Jurgen Zander

发明人： Otto Barth ,  Hans-Joachim Becker ,  Horst Behre ,  Reinhard Kaiser ,  Guido Steffan ,  Jurgen Zander

IPC分类号： C07C309/47 ,  C07C67/00 ,  C07C301/00 ,  C07C303/22 ,  C07C303/32 ,  C07C143/56

摘要： A process has been invented for the preparation of aminonaphthalenesulphonic acids by the catalytic hydrogenation of salts of nitronaphthalenesulphonic acids with hydrogen in the presence of Raney nickel catalysts at elevated temperature and pressure, said catalysts comprising a combination of fresh Raney nickel catalyst and Raney nickel catalyst which has already been used in prior hydrogenation or hydrogenations.

摘要翻译： 已经发明了一种通过在高温和高压下在阮内镍催化剂存在下通过硝基萘磺酸的盐催化氢化制备氨基萘磺酸的方法，所述催化剂包含新鲜的阮内镍催化剂和阮内镍催化剂的组合， 已经用于以前的氢化或氢化。

公开(公告)号：US06891060B2

公开(公告)日：2005-05-10

申请号：US10458093

申请日：2003-06-10

申请人： Johannes Scherer ,  Horst Behre ,  Friedrich Müller-Hauck

发明人： Johannes Scherer ,  Horst Behre ,  Friedrich Müller-Hauck

IPC分类号： C07C51/00 ,  C07C67/08 ,  C07C69/00

CPC分类号： C07C51/00 ,  C07C67/08 ,  C07C67/287 ,  C07C65/03 ,  C07C69/157 ,  C07C69/63

摘要： The invention relates to an improved process for preparing 3-acyloxy-2-methylbenzoic acids by heating substituted naphthalenes in the presence of alkali metal hydroxides and subsequently acylating.

摘要翻译： 本发明涉及通过在碱金属氢氧化物存在下加热取代萘并随后进行酰化来制备3-酰氧基-2-甲基苯甲酸的改进方法。

公开(公告)号：US5847217A

公开(公告)日：1998-12-08

申请号：US982360

申请日：1997-12-02

申请人： Horst Behre ,  Guido Steffan

发明人： Horst Behre ,  Guido Steffan

IPC分类号： C07C213/00 ,  C07C215/76 ,  G03C7/34 ,  C07C209/68

CPC分类号： G03C7/346 ,  C07C213/00

摘要： 2-Amino-5-alkyl-phenols, which are suitable as intermediates in the production of crop-protection agents or photographic couplers, can be prepared by subjecting 2-amino-5-alkyl-benzenesulphonic acids or their salts to alkaline hydrolysis.

摘要翻译： 2-氨基-5-烷基苯酚，其适用作为农作物保护剂或照相成色剂生产中的中间体，可通过使2-氨基-5-烷基 - 苯磺酸或其盐进行碱水解来制备。