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101 条记录 (耗时 0.028 秒)

    Complex consisted of a polysaccharide and an HBP
    5.
    发明申请
    Complex consisted of a polysaccharide and an HBP 有权
    复合物由多糖和HBP组成

    公开(公告)号：US20100184965A1

    公开(公告)日：2010-07-22

    申请号：US12585886

    申请日：2009-09-28

    申请人： Olivier Soula ,  Remi Soula ,  Martin Gaudier ,  Gerard Soula

    发明人： Olivier Soula ,  Remi Soula ,  Martin Gaudier ,  Gerard Soula

    IPC分类号： A61K47/48 ,  C08B37/04 ,  C08B15/06 ,  C08B37/00

    CPC分类号： A61K9/0019 ,  A61K9/19 ,  A61K38/1825 ,  A61K38/185 ,  A61K38/1866 ,  A61K38/27 ,  A61K38/29 ,  A61K47/42 ,  A61K47/61

    摘要： The invention relates to a complex consisted of a polysaccharide and an HBP, said polysaccharide being consisted from glycoside bonds of (1,6) and/or (1,4) and/or (1,3) and/or (1,2) type and functionalized with at least one salifiable or salified tryptophan derivative. The invention also relates to a pharmaceutical composition comprising a complex according to the invention and to the use of a polysaccharide consisted of glycoside bonds of (1,6) and/or (1,4) and/or (1,3) and/or (1,2) type and functionalized with at least one salifiable or salified tryptophan derivative, for the preparation of a pharmaceutical formulation of stable HBPs.

    摘要翻译： 本发明涉及由多糖和HBP组成的复合物，所述多糖由（1,6）和/或（1,4）和/或（1,3）和/或（1,2）的糖苷键组成 ）类型并用至少一种可成盐或盐化的色氨酸衍生物官能化。 本发明还涉及包含根据本发明的复合物和由（1,6）和/或（1,4）和/或（1,3）和/或（1,3）的糖苷键组成的多糖和/ 或（1,2）型，并用至少一种可成盐或盐化的色氨酸衍生物官能化，用于制备稳定HBP的药物制剂。

    Angiogenic composition
    7.
    发明申请
    Angiogenic composition 审中-公开
    血管生成成分

    公开(公告)号：US20080293635A1

    公开(公告)日：2008-11-27

    申请号：US12078443

    申请日：2008-03-31

    申请人： Olivier Soula ,  Gerard Soula ,  Remi Soula ,  Rosy Eloy

    发明人： Olivier Soula ,  Gerard Soula ,  Remi Soula ,  Rosy Eloy

    IPC分类号： A61K38/16 ,  A61P9/00

    CPC分类号： A61K9/0014 ,  A61K38/1858 ,  A61K47/61

    摘要： The present invention relates to a amphiphilic polymer in the preparation of a therapeutic composition for promoting angiogenesis at its site of administration, comprising a complex between a polymer and a PDGF, wherein the polymer is amphiphilic.In an embodiment, the PDGF is selected from the group of the PDGFs (platelet-derived growth factors) and the amphiphilic polymer is selected from the group: The invention relates also to the therapeutic composition is in the form of a gel, a cream, a solution, a spray, a paste or a patch or a dressing.

    摘要翻译： 本发明涉及制备用于在其施用部位促进血管发生的治疗组合物的两亲性聚合物，其包含聚合物和PDGF之间的复合物，其中所述聚合物是两亲性的。 在一个实施方案中，PDGF选自PDGF（血小板衍生生长因子）组，两亲性聚合物选自：本发明还涉及治疗组合物，其形式为凝胶，霜剂， 溶液，喷雾剂，糊剂或贴剂或敷料。

    Administration form of osteogenic protein complexes
    8.
    发明授权
    Administration form of osteogenic protein complexes 有权

    公开(公告)号：US08497253B2

    公开(公告)日：2013-07-30

    申请号：US12591442

    申请日：2009-11-19

    申请人： Olivier Soula ,  Remi Soula ,  Gerard Soula

    发明人： Olivier Soula ,  Remi Soula ,  Gerard Soula

    IPC分类号： A61K31/721 ,  C08B37/02

    摘要： Osteogenic compositions composed of a coprecipitate that contains at least one insoluble calcium salt and at least one complex between an osteogenic protein and a polysaccharide, the coprecipitate being in divided form, are described. Kits are also described, as are a process for preparing the coprecipitate in divided form, containing at least one insoluble calcium salt and at least one complex between an osteogenic protein and a polysaccharide.

    Complexes between an amphiphilic polymer and an osteogenic protein belonging to the family of BMPs
    10.
    发明申请
    Complexes between an amphiphilic polymer and an osteogenic protein belonging to the family of BMPs 有权
    两亲性聚合物与属于BMP家族的成骨蛋白质之间的复合物

    公开(公告)号：US20090048412A1

    公开(公告)日：2009-02-19

    申请号：US12219679

    申请日：2008-07-25

    申请人： Gerard Soula ,  Olivier Soula ,  Remi Soula

    发明人： Gerard Soula ,  Olivier Soula ,  Remi Soula

    IPC分类号： A61K31/765 ,  C08F251/00 ,  A61P19/00

    CPC分类号： A61K9/0019 ,  A61K38/1875 ,  A61K47/36 ,  A61K47/61 ,  C08B11/12 ,  C08B15/00 ,  C08B37/0021 ,  C08B37/003 ,  C08B37/0045 ,  C08B37/0069 ,  C08B37/0072 ,  C08B37/0084

    摘要： The invention relates to an amphiphilic-BMP polymer complex which is physically and chemically stable and soluble in water, characterised in that: the amphiphilic polymers comprise a hydrophilic polysaccharide skeleton functionalised with hydrophobic substituents and hydrophilic groups the BMP is selected from the group of therapeutically active BMPs (Bone morphogenetic Proteins), the polymer/BMP mass ratio is lower than or equal to 700. The invention also relates to the process for preparing the amphiphilic-BMP polymer complex in an aqueous medium and in the absence of organic solvents likely to denature the protein.The invention also relates to therapeutic compositions of an amphiphilic-BMP polymer complex according to the invention.

    摘要翻译： 本发明涉及在物理和化学上稳定和可溶于水的两亲性-MPB聚合物复合物，其特征在于：两亲性聚合物包含用疏水取代基和亲水基团官能化的亲水性多糖骨架，所述BMP选自治疗活性 BMP（骨形态发生蛋白），聚合物/ BMP质量比低于或等于700.本发明还涉及在水性介质中制备两亲性-MPB聚合物复合物的方法，并且在不存在可能变性的有机溶剂的情况下 蛋白质。 本发明还涉及根据本发明的两亲性-MPB聚合物复合物的治疗组合物。