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公开(公告)号：US06649611B2
公开(公告)日：2003-11-18
申请号：US09821322
申请日：2001-03-29
申请人： Laura C. Blumberg , Matthew F. Brown , Ronald P. Gladue , Molly A. McGlynn , Christopher S. Poss
发明人： Laura C. Blumberg , Matthew F. Brown , Ronald P. Gladue , Molly A. McGlynn , Christopher S. Poss
IPC分类号： A61K31495
CPC分类号： C07D213/40 , C07D207/16 , C07D213/38 , C07D213/56 , C07D233/64 , C07D295/185 , C07D295/192 , C07D295/215 , C07D295/30 , C07D307/14 , C07D307/20 , C07D307/24 , C07D307/52 , C07D307/68 , C07D521/00
摘要： A compound of the formula or the pharmaceutically acceptable salt thereof; wherein a, b, c, d, e, j, R1, R2, R3, and R4 are as defined herein and are useful to treat inflammation and other immune disorders.
摘要翻译： 式的化合物或其药学上可接受的盐; 其中a，b，c，d，e，j，R 1，R 2，R 3和R 4如本文所定义，并且可用于治疗炎症和其它免疫疾病。
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公开(公告)号：US07098212B2
公开(公告)日：2006-08-29
申请号：US10273658
申请日：2002-10-18
申请人： Laura C. Blumberg , Matthew F. Brown , Matthew M. Hayward , Gregory D. Lundquist , Christopher S. Poss , Andrei Shavnya
发明人： Laura C. Blumberg , Matthew F. Brown , Matthew M. Hayward , Gregory D. Lundquist , Christopher S. Poss , Andrei Shavnya
IPC分类号： A61K31/506 , A61K31/495 , A61K31/496 , C07D295/00 , C07D403/12
CPC分类号： C07D213/74 , C07D207/16 , C07D213/63 , C07D213/64 , C07D213/75 , C07D213/76 , C07D213/79 , C07D213/80 , C07D213/82 , C07D239/34 , C07D239/60 , C07D257/04 , C07D277/56 , C07D295/185 , C07D307/33 , C07D307/68 , C07D333/38
摘要： The present invention relates to compounds of the formula I and the pharmaceutically acceptable forms thereof; wherein X, Y, a, b, c, d, R1, R2, R3, R4 and R5 are as defined herein. Moreover, the present invention is also directed at pharmaceutical compositions comprising a compound of the formula I and a pharmaceutically acceptable carrier. Furthermore, the present invention is directed at methods of using the herein described compounds and compositions for treating or preventing a disorder or condition that can be treated or prevented by antagonizing the CCR1 receptor in a mammal.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的形式; 其中X，Y，a，b，c，d，R 1，R 2，R 3，R 4， SUP＆gt;和R 5＆gt;如本文所定义。 此外，本发明还涉及包含式I化合物和药学上可接受的载体的药物组合物。 此外，本发明涉及使用本文所述的化合物和组合物治疗或预防可通过拮抗哺乳动物CCR1受体来治疗或预防的病症或病症的方法。
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公开(公告)号：US06689886B2
公开(公告)日：2004-02-10
申请号：US10360059
申请日：2003-02-06
IPC分类号： C07D2444
CPC分类号： C07D401/12 , C07D215/54 , C07D241/44 , C07D403/12 , C07D413/12
摘要： A compound of the formula XXXI or the pharmaceutically acceptable salt thereof; wherein R1, R2, and R3 are as defined herein and the compound is useful in the preparation or use of compounds that treat inflammation and other immune disorders.
摘要翻译： 式XXXI的化合物或其药学上可接受的盐; 其中R 1，R 2和R 3如本文所定义，并且该化合物可用于制备或使用治疗炎症和其他免疫疾病的化合物。
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公开(公告)号：US06548671B2
公开(公告)日：2003-04-15
申请号：US09774871
申请日：2001-01-31
IPC分类号： C07D24144
CPC分类号： C07D401/12 , C07D215/54 , C07D241/44 , C07D403/12 , C07D413/12
摘要： A compound of the formula or the pharmaceutically acceptable salt thereof; wherein R1, R2, R3 and R4 are as defined above useful to treat inflammation and other immune disorders.
摘要翻译： 式的化合物或其药学上可接受的盐; 其中R1，R2，R3和R4如上所定义，可用于治疗炎症和其他免疫疾病。
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公开(公告)号：US5009808A
公开(公告)日：1991-04-23
申请号：US462922
申请日：1990-01-11
IPC分类号： C09K11/61
CPC分类号： C09K11/612
摘要： A phosphor composition consisting essentially of particles of zinc sulfide electroluminescent phosphor activated with from about 0.7% by weight of about 1.3% by weight of manganese, based upon the total weight of the phosphor composition, wherein the electroluminescent emission of the phosphor has an x color coordinate value of from about 0.522 to about 0.532 and a y color coordinate value of from about 0.460 to about 0.470 and an efficiency of greater than about 5.6 lumens per watt at 115V/400 Hz. A solid state process for producing the foregoing phosphor comprises a multiple firing in order to incorporate manganese, chloride and copper ions into the zinc sulfide lattice. Controlled levels of manganese yield highly efficient electroluminescent phosphors.
摘要翻译： 基于荧光体组合物的总重量，基本上由基于硫化金属电致发光荧光体的颗粒组成的磷光体组合物，其以约0.7重量％的约1.3重量％的锰为基准，其中荧光体的电致发光发射具有x颜色 约0.522至约0.532的坐标值和约0.460至约0.470的ay色坐标值，以及在115V / 400Hz下大于约5.6流明/瓦特的效率。 用于制造上述荧光体的固态方法包括多次烧制以将锰，氯化物和铜离子掺入硫化锌晶格中。 锰的控制水平产生高效的电致发光荧光体。
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6.发明授权
公开(公告)号：US5516921A
公开(公告)日：1996-05-14
申请号：US308184
申请日：1994-09-19
IPC分类号： C07D225/04 , C07D313/00 , A61K31/335
CPC分类号： C07D225/04 , C07D313/00
摘要： Novel compounds related structurally to Brefeldin A useful as antiviral, antifungal, antiproliferative, immunosuppresive and detoxifying agents as well as pharmaceutical compositions and methods based thereon are disclosed.
摘要翻译： 涉及结构上与布雷菲德菌素A有关的新型化合物可用作抗病毒，抗真菌，抗增殖，免疫抑制和解毒剂以及基于其的药物组合物和方法。
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