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    Methods and Reagents for Regulation of Cellular Responses in Biological Systems
    1.
    发明申请
    Methods and Reagents for Regulation of Cellular Responses in Biological Systems 审中-公开
    生物系统细胞响应调控方法与试剂

    公开(公告)号：US20070270351A1

    公开(公告)日：2007-11-22

    申请号：US11777455

    申请日：2007-07-13

    申请人： Laura Kiessling ,  Laura Strong ,  Jason Gestwicki

    发明人： Laura Kiessling ,  Laura Strong ,  Jason Gestwicki

    IPC分类号： A61K38/05 ,  A61K31/785

    CPC分类号： A61K31/74 ,  A61K31/70 ,  A61K31/785 ,  A61K38/178 ,  A61K39/385 ,  B82Y30/00 ,  G01N33/5005 ,  A61K2300/00

    摘要： This invention provides multivalent ligands which carry or display at least one recognition element (RE), and preferably a plurality of recognition elements, for binding directly or indirectly to cells or other biological particles or more generally by binding to any biological molecule. Provided are methods for inducing cellular chemotaxis by introducing a multivalent ligand having at least one N-formyl or N-acyl peptide as a signal recognition element. The signal recognition elements are bound to a molecular scaffold that is a ring-opening metathesis polymerization scaffold. In these scaffolds, the number, spacing, relative positioning and relative orientation of signal recognition elements can be controlled.

    摘要翻译： 本发明提供携带或显示至少一种识别元件（RE）的多价配体，并且优选多个识别元件，用于直接或间接地结合细胞或其他生物颗粒，或更一般地通过结合任何生物分子。 提供了通过引入具有至少一个N-甲酰基或N-酰基肽作为信号识别元件的多价配体来诱导细胞趋化性的方法。 信号识别元件与分子支架结合，分子支架是开环易位聚合支架。 在这些支架中，可以控制信号识别元件的数量，间距，相对定位和相对定向。

    Methods and Reagents for Regulation of Cellular Responses in Biological Systems
    10.
    发明申请
    Methods and Reagents for Regulation of Cellular Responses in Biological Systems 审中-公开
    生物系统细胞响应调控方法与试剂

    公开(公告)号：US20100104585A1

    公开(公告)日：2010-04-29

    申请号：US12571983

    申请日：2009-10-01

    申请人： Laura L. Kiessling ,  Byron R. Griffith ,  Jason E. Gestwicki ,  Laura Strong

    发明人： Laura L. Kiessling ,  Byron R. Griffith ,  Jason E. Gestwicki ,  Laura Strong

    IPC分类号： A61K39/395

    CPC分类号： A61K31/70 ,  A61K31/74 ,  A61K38/178 ,  B82Y30/00 ,  G01N33/5005

    摘要： Multivalent ligands which carry or display at least one recognition element (RE), and preferably a plurality of recognition elements, for binding directly or indirectly to cells or other biological particles or more generally by binding to any biological molecule. The multivalent ligands provided can function for binding or targeting to any biological particle or molecule and particularly to targeting of cells or cell types or viruses, for cell aggregation and for macromolecular assembly of biological macromolecules. The multivalent ligands of this invention are applicable for creating scaffolds (assemblies) of chemical or biological species, including without limitation, antigens, epitopes, ligand binding groups, ligands for cell receptors and various macromolecules. In these scaffolds, the number, spacing, relative positioning and relative orientation of recognition elements can be controlled. The invention also relates to methods for aggregating biological particles and macromolecules and for modulating biological response employing the multivalent ligands provided.

    摘要翻译： 携带或显示至少一种识别元件（RE）的多价配体，并且优选多个识别元件，用于直接或间接地结合细胞或其他生物颗粒，或更一般地通过结合任何生物分子。 所提供的多价配体可用于结合或靶向任何生物颗粒或分子，特别是靶向细胞或细胞类型或病毒，用于细胞聚集和生物大分子的大分子装配。 本发明的多价配体适用于生成化学或生物物种的支架（组件），包括但不限于抗原，表位，配体结合基团，细胞受体配体和各种大分子。 在这些支架中，可以控制识别元件的数量，间距，相对定位和相对定向。 本发明还涉及聚集生物颗粒和大分子的方法以及使用所提供的多价配体来调节生物反应的方法。