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1.发明申请公开(公告)号：US20220298459A1
公开(公告)日：2022-09-22
申请号：US17659403
申请日：2022-04-15
发明人： Xiaoyu Zheng , Joshua R. Deotte
摘要： A functionally graded material is formed by pipetting individual micro-or-nano-litter droplets with a variety of materials including multi-nanostructured material (nanowires, carbon nanotubes, enzymes, multi-element and/or multi-color, multi-biomolecules) and UV polymerization of the flat hydrogel meniscus surface formed at the carrier fluid interface. After step-by-step droplet pipetting and subsequent layer-by-layer UV polymerization via a digital mask, the complete fabricated part without supporting layers is taken out of the carrier fluid while the un-cured micro-litter residue is conveniently suctioned out of the carrier fluid.
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公开(公告)号：US20220064625A1
公开(公告)日：2022-03-03
申请号：US17522726
申请日：2021-11-09
发明人： Fang Qian , Sarah E. Baker , Joshua R. Deotte , Eric B. Duoss , Nathan C. Ellebracht , Jennifer Marie Knipe , Samantha Ruelas , Hawi Bacha Gemeda , Michael Guarnieri
IPC分类号： C12N11/089 , C12M1/00 , C12N11/04
摘要： A method for forming a product from a gas includes flowing a gas through a bioreactor for contacting the gas with polymer-immobilized whole cells and collecting the product from the bioreactor. The bioreactor includes a plurality of printed three-dimensional structures, each printed three-dimensional structure having at least one sidewall being a lattice, and the polymer-immobilized whole cells being present in the lattice.
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3.发明授权公开(公告)号：US11345879B2
公开(公告)日：2022-05-31
申请号：US14943873
申请日：2015-11-17
发明人： Xiaoyu Zheng , Joshua R. Deotte
IPC分类号： B33Y10/00 , C12M3/00 , C12N5/00 , C12M1/42 , B29C64/135 , C12M1/12 , C12N5/071 , B29C64/20 , B33Y30/00 , B33Y50/02 , B29C35/08 , B29K105/00 , B29L31/34 , B29L31/00 , B29C64/386
摘要： A functionally graded material is formed by pipetting individual micro-or-nano-litter droplets with a variety of materials including multi-nanostructured material (nanowires, carbon nanotubes, enzymes, multi-element and/or multi-color, multi-biomolecules) and UV polymerization of the flat hydrogel meniscus surface formed at the carrier fluid interface. After step-by-step droplet pipetting and subsequent layer-by-layer UV polymerization via a digital mask, the complete fabricated part without supporting layers is taken out of the carrier fluid while the un-cured micro-litter residue is conveniently suctioned out of the carrier fluid.
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公开(公告)号：US10118338B2
公开(公告)日：2018-11-06
申请号：US14919441
申请日：2015-10-21
发明人： Joshua R. Deotte , Xiaoyu Zheng
IPC分类号： B29C64/20 , B33Y10/00 , B33Y30/00 , B33Y50/02 , B29C64/129 , B29C64/386
摘要： An additive manufacturing system utilizing an oxygen-permeable membrane to facilitate low-volume printing and high-speed resin change in a stereolithography-based 3D printer. The membrane is used to constrain the fluid surface at the focal plane of the stereolithography printer and a carrier fluid is used to hold the fluid against the membrane. The small amount of resin is quickly switched using integrated microfluidic channels.
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公开(公告)号：US20240271118A1
公开(公告)日：2024-08-15
申请号：US18593547
申请日：2024-03-01
发明人： Jennifer M. Knipe , Sarah Baker , Joshua R. Deotte , Fang Qian
IPC分类号： C12N11/089 , B33Y10/00 , B33Y80/00 , C12M1/00 , C12N11/04
摘要： According to one inventive concept, a method for forming a bioreactor includes: forming a three-dimensional structure using an additive manufacturing technique; infilling the at least one side of the three-dimensional structure with a mixture for forming a polymer-encapsulated whole cells; and curing the infilled three-dimensional structure.
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公开(公告)号：US20190210276A1
公开(公告)日：2019-07-11
申请号：US16352451
申请日：2019-03-13
发明人： Joshua R. Deotte
IPC分类号： B29C64/135 , B29C64/112 , B29C64/124
CPC分类号： B29C64/135 , B29C64/112 , B29C64/124 , B33Y10/00 , B33Y30/00 , B33Y50/02 , B33Y70/00
摘要： A system for building a structure. The system includes a reservoir; an immiscible fluid in the reservoir; a membrane operatively connected to the reservoir; channels and delivery ports in the membrane; a microliter amount of curable resin; a delivery system for delivering the microliter amount of curable resin to channels and delivery ports in the membrane and to the reservoir in contact with the immiscible fluid in the reservoir; and an energy source adapted to deliver energy to the reservoir onto the microliter amount of curable resin for building the structure.
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公开(公告)号：US20170113417A1
公开(公告)日：2017-04-27
申请号：US14919408
申请日：2015-10-21
发明人： Joshua R. Deotte
CPC分类号： B29C64/135 , B33Y10/00 , B33Y30/00 , B33Y50/02 , B33Y70/00
摘要： A system for building a structure. The system includes a reservoir; an immiscible fluid in the reservoir; a membrane operatively connected to the reservoir; channels and delivery ports in the membrane; a microliter amount of curable resin; a delivery system for delivering the microliter amount of curable resin to channels and delivery ports in the membrane and to the reservoir in contact with the immiscible fluid in the reservoir; and an energy source adapted to deliver energy to the reservoir onto the microliter amount of curable resin for building the structure.
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公开(公告)号：US11688596B2
公开(公告)日：2023-06-27
申请号：US17175302
申请日：2021-02-12
CPC分类号： H01J49/0409 , B33Y80/00
摘要： The present disclosure relates to a lattice substrate adapted for use in direct ionization mass spectrometry. The substrate may have a plurality of tessellated unit cells forming an integral structure. Each tessellated unit cell may have a dimension of no more than about 1.5 mm and may include a plurality of pores arranged in an ordered pattern. The substrate may further include a form factor suitable for use with a direct ionization mass spectrometry system.
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公开(公告)号：US11130131B2
公开(公告)日：2021-09-28
申请号：US16584460
申请日：2019-09-26
发明人： Joshua R. Deotte , Sarah Baker , Eric Duoss , Jennifer Marie Knipe , Fang Qian , Samantha Ruelas
摘要： An engineered unit cell is disclosed for flowing a fluid therethrough in three dimensions. The unit cell may have a substrate with a plurality of flow channels around and between struts formed within the substrate. The struts may each be formed with a desired shape and orientation within the substrate to achieve a desired degree of fluid flow through the flow channels, in each of one of three dimensions, through the unit cell.
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公开(公告)号：US10946580B2
公开(公告)日：2021-03-16
申请号：US16352451
申请日：2019-03-13
发明人： Joshua R. Deotte
IPC分类号： B29C64/135 , B29C64/124 , B29C64/112 , B29C64/386 , B33Y10/00 , B33Y30/00 , B33Y50/02 , B33Y70/00
摘要： A system for building a structure. The system includes a reservoir; an immiscible fluid in the reservoir; a membrane operatively connected to the reservoir; channels and delivery ports in the membrane; a microliter amount of curable resin; a delivery system for delivering the microliter amount of curable resin to channels and delivery ports in the membrane and to the reservoir in contact with the immiscible fluid in the reservoir; and an energy source adapted to deliver energy to the reservoir onto the microliter amount of curable resin for building the structure.
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