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公开(公告)号：US07220573B2
公开(公告)日：2007-05-22
申请号：US10177358
申请日：2002-06-21
CPC分类号： B01L9/52 , B01J19/0046 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00722 , B01J2219/00725 , B01L3/502 , B01L2300/043 , B01L2300/0636 , B01L2300/0822 , B01L2300/0877 , C40B40/06 , C40B40/10 , G01N33/54366
摘要： Array assay devices and methods for using the same in array based assays are provided. The subject devices are characterized by having a base dimensioned to hold a substrate having at least one array, a cover dimensioned to cover the substrate and a snap-fit for holding the cover and the base together to enclose a space between the base and the cover. The subject invention also includes methods for performing an array assay. In the subject methods, a subject device is provided and a substrate having at least one array is positioned on the base. The snap-fit is engaged to hold the cover and the base together to enclose a space between the base and the cover. Next, a sample is contacted with the at least one array and an array assay is performed. The subject invention also includes kits which include the subject devices.
摘要翻译： 提供了阵列测定装置及其在基于阵列的测定中的使用方法。 主题装置的特征在于具有尺寸适于保持具有至少一个阵列的基板的基座，尺寸适于覆盖基板的盖子和用于将盖子和基座保持在一起以将基部和盖子之间的空间封闭的卡扣配合 。 本发明还包括用于进行阵列测定的方法。 在本发明的方法中，提供了一种主体装置，并且具有至少一个阵列的基板位于基座上。 卡扣配合被接合以将盖和基座保持在一起以封闭基座和盖之间的空间。 接下来，使样品与至少一个阵列接触并进行阵列测定。 本发明还包括包括本发明装置的试剂盒。
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公开(公告)号：US08579819B2
公开(公告)日：2013-11-12
申请号：US13296023
申请日：2011-11-14
申请人： Shih-Ping Wang , Jiayu Chen , Douglas G. Summers
发明人： Shih-Ping Wang , Jiayu Chen , Douglas G. Summers
IPC分类号： A61B8/00
CPC分类号： A61B8/0825 , A61B8/4218 , A61B8/4281 , A61B8/44 , A61B8/4405 , A61B8/4444 , A61B8/462 , A61B8/483 , A61B8/54
摘要： Apparatus and related methods for facilitating volumetric ultrasonic scanning of a breast are described. In one preferred embodiment, a generally cone-shaped radial scanning template having a vertex and a wide opening angle is provided, the radial scanning template having a slot-like opening extending outward from the vertex through which an ultrasound transducer scans the breast as the radial scanning template is rotated. In another preferred embodiment, a flexible membrane for compressing a skin surface of the breast is provided, the flexible membrane being mounted on a mechanical assembly such as a roller assembly to form a slot-like opening through which an ultrasound transducer directly contacts the skin surface, the flexible membrane rising and falling relative to the skin surface but not moving laterally as the slot-like opening and ultrasound transducer move laterally across the compressed breast, whereby stabilization of the breast and direct transducer-skin contact are concurrently achieved.
摘要翻译： 描述了用于促进乳房体积超声扫描的装置和相关方法。 在一个优选实施例中，提供了具有顶点和宽开口角度的大致锥形的径向扫描模板，该径向扫描模板具有从顶点向外延伸的狭缝状开口，超声波换能器通过该顶点径向扫描模具 扫描模板旋转。 在另一个优选实施例中，提供了用于压缩乳房皮肤表面的柔性膜，柔性膜被安装在诸如辊组件的机械组件上以形成狭缝状开口，超声波换能器通过该槽开口直接接触皮肤表面 ，柔性膜相对于皮肤表面上升和下降，但是当狭缝状开口和超声换能器横向压缩的乳房移动时横向移动，从而同时实现乳房的稳定和直接的换能器 - 皮肤接触。
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公开(公告)号：US20170095225A1
公开(公告)日：2017-04-06
申请号：US15244950
申请日：2016-08-23
申请人： Shih-Ping WANG , Jiayu Chen , Douglas G. Summers
发明人： Shih-Ping WANG , Jiayu Chen , Douglas G. Summers
CPC分类号： A61B8/0825 , A61B8/14 , A61B8/145 , A61B8/4209 , A61B8/4218 , A61B8/4281 , A61B8/4405 , A61B8/4455 , A61B8/4461 , A61B8/4494 , A61B8/463 , A61B8/483 , A61B8/54
摘要： An apparatus and a method are disclosed for obtaining ultrasound images of a patient's breast that is chestwardly compressed with a template that is essentially planar and rotates relative to the breast while one or more ultrasound transducers moving with the template take 2D images of the breast through one or more respective radially oriented slots in the template, preferably through a membrane that is porous to a gel. The 2D images are processed into slice images representing breast slices of desired thicknesses and orientation that are displayed alone or with some of the 2D images, preferably pairs of orthogonally disposed 2D images.
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公开(公告)号：US20100174185A1
公开(公告)日：2010-07-08
申请号：US12299275
申请日：2007-05-02
CPC分类号： A61B8/0825 , A61B8/0833 , A61B8/0841 , A61B8/14 , A61B8/4218 , A61B8/4455 , A61B8/4461 , A61B8/4472 , A61B8/4483 , A61B8/54 , G01S15/8934
摘要： An apparatus and related methods for ultrasonically scanning a tissue sample are described, the apparatus comprising an ultrasound transducer and a membranous sheet, the membranous sheet compressing the tissue sample, the ultrasound transducer contacting the membranous sheet and ultrasonically scanning the tissue sample therethrough, wherein the membranous sheet has a generally arcuate shape and the ultrasound transducer is movable in a generally arcuate trajectory therealong during the ultrasonic scan. Also described is an apparatus for facilitating a medical procedure, comprising a membranous sheet compressing a tissue sample, an ultrasound transducer contacting the membranous sheet to ultrasonically scan the tissue sample therethrough, and a biopsy guide operably coupled to the ultrasound transducer for maintaining a biopsy instrument in a scan plane of the ultrasound transducer to facilitate a percutaneous biopsy of a lesion located in the scan plane.
摘要翻译： 描述了用于超声波扫描组织样品的装置和相关方法，所述装置包括超声换能器和膜片，所述膜片压缩所述组织样本，所述超声波换能器接触所述膜片并且超声扫描所述组织样本，其中， 膜片具有大致弓形的形状，并且超声波换能器在超声波扫描期间沿着大致弧形的轨迹移动。 还描述了一种用于促进医疗过程的装置，包括压缩组织样本的膜片，接触膜片的超声波换能器以超声扫描组织样本，以及可操作地耦合到超声换能器的活检导管，用于维持活检器械 在超声换能器的扫描平面中，以便于位于扫描平面中的病变的经皮活检。
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公开(公告)号：US20140323866A1
公开(公告)日：2014-10-30
申请号：US14077050
申请日：2013-11-11
申请人： Shih-Ping WANG , Jiayu CHEN , Douglas G. Summers
发明人： Shih-Ping WANG , Jiayu CHEN , Douglas G. Summers
CPC分类号： A61B8/0825 , A61B8/4218 , A61B8/4281 , A61B8/44 , A61B8/4405 , A61B8/4444 , A61B8/462 , A61B8/483 , A61B8/54
摘要： Apparatus and related methods for facilitating volumetric ultrasonic scanning of a breast are described. In one preferred embodiment, a generally cone-shaped radial scanning template having a vertex and a wide opening angle is provided, the radial scanning template having a slot-like opening extending outward from the vertex through which an ultrasound transducer scans the breast as the radial scanning template is rotated. In another preferred embodiment, a flexible membrane for compressing a skin surface of the breast is provided, the flexible membrane being mounted on a mechanical assembly such as a roller assembly to form a slot-like opening through which an ultrasound transducer directly contacts the skin surface, the flexible membrane rising and falling relative to the skin surface but not moving laterally as the slot-like opening and ultrasound transducer move laterally across the compressed breast, whereby stabilization of the breast and direct transducer-skin contact are concurrently achieved.
摘要翻译： 描述了用于促进乳房体积超声扫描的装置和相关方法。 在一个优选实施例中，提供了具有顶点和宽开口角度的大致锥形的径向扫描模板，该径向扫描模板具有从顶点向外延伸的狭缝状开口，超声波换能器通过该顶点径向扫描模具 扫描模板旋转。 在另一个优选实施例中，提供了用于压缩乳房皮肤表面的柔性膜，柔性膜被安装在诸如辊组件的机械组件上以形成狭缝状开口，超声波换能器通过该槽开口直接接触皮肤表面 ，柔性膜相对于皮肤表面上升和下降，但是当狭缝状开口和超声换能器横向压缩的乳房移动时横向移动，从而同时实现乳房的稳定和直接的换能器 - 皮肤接触。
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公开(公告)号：US20120089026A1
公开(公告)日：2012-04-12
申请号：US13296023
申请日：2011-11-14
申请人： Shih-Ping Wang , Jiayu Chen , Douglas G. Summers
发明人： Shih-Ping Wang , Jiayu Chen , Douglas G. Summers
IPC分类号： A61B8/14
CPC分类号： A61B8/0825 , A61B8/4218 , A61B8/4281 , A61B8/44 , A61B8/4405 , A61B8/4444 , A61B8/462 , A61B8/483 , A61B8/54
摘要： Apparatus and related methods for facilitating volumetric ultrasonic scanning of a breast are described. In one preferred embodiment, a generally cone-shaped radial scanning template having a vertex and a wide opening angle is provided, the radial scanning template having a slot-like opening extending outward from the vertex through which an ultrasound transducer scans the breast as the radial scanning template is rotated. In another preferred embodiment, a flexible membrane for compressing a skin surface of the breast is provided, the flexible membrane being mounted on a mechanical assembly such as a roller assembly to form a slot-like opening through which an ultrasound transducer directly contacts the skin surface, the flexible membrane rising and falling relative to the skin surface but not moving laterally as the slot-like opening and ultrasound transducer move laterally across the compressed breast, whereby stabilization of the breast and direct transducer-skin contact are concurrently achieved.
摘要翻译： 描述了用于促进乳房体积超声扫描的装置和相关方法。 在一个优选实施例中，提供了具有顶点和宽开口角度的大致锥形的径向扫描模板，该径向扫描模板具有从顶点向外延伸的狭缝状开口，超声波换能器通过该顶点径向扫描模具 扫描模板旋转。 在另一个优选实施例中，提供了用于压缩乳房皮肤表面的柔性膜，柔性膜被安装在诸如辊组件的机械组件上以形成狭缝状开口，超声波换能器通过该槽开口直接接触皮肤表面 ，柔性膜相对于皮肤表面上升和下降，但是当狭缝状开口和超声换能器横向压缩的乳房移动时横向移动，从而同时实现乳房的稳定和直接的换能器 - 皮肤接触。
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公开(公告)号：US08128568B2
公开(公告)日：2012-03-06
申请号：US12238091
申请日：2008-09-25
IPC分类号： A61B8/00
CPC分类号： A61B10/0233 , A61B8/4427 , A61B8/4455 , A61B8/4461 , A61B8/483 , A61B90/11 , A61B2090/378
摘要： An apparatus and related methods for ultrasonically scanning a tissue volume are described, the apparatus being particularly advantageous in the context of freehand ultrasound assisted biopsy of the breast although readily applied to non-biopsy contexts and other body parts. The apparatus comprises a casing configured and dimensioned for single-handed manipulation relative to a surface of the tissue, and a texturably couplant-porous material sheet extending across an opening of the casing. The texturably couplant-porous material sheet has an outer side and an inner side relative to the casing, the outer side for compressively contacting the tissue surface. The apparatus further comprises an ultrasound transducer positioned against the inner side of the texturably couplant-porous material sheet and being mechanically translatable thereacross for volumetrically scanning the tissue volume therethrough.
摘要翻译： 描述了用于超声扫描组织体积的装置和相关方法，该装置在乳房的手写超声辅助活检的上下文中特别有利，尽管容易地应用于非活检上下文和其他身体部位。 该装置包括一个外壳，其被配置和尺寸设计成相对于该组织的表面进行单手操作，以及一个横跨该外壳的开口延伸的可变形的耦合剂 - 多孔材料片。 可变形的联合多孔材料片具有相对于外壳的外侧和内侧，用于压缩地接触组织表面的外侧。 该装置还包括一个超声波换能器，该超声波换能器抵靠着可柔软的耦合剂 - 多孔材料片的内侧，并可在其上机械平移，用于体积扫描组织体积。
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公开(公告)号：US20090024039A1
公开(公告)日：2009-01-22
申请号：US12238091
申请日：2008-09-25
IPC分类号： A61B8/14
CPC分类号： A61B10/0233 , A61B8/4427 , A61B8/4455 , A61B8/4461 , A61B8/483 , A61B90/11 , A61B2090/378
摘要： An apparatus and related methods for ultrasonically scanning a tissue volume are described, the apparatus being particularly advantageous in the context of freehand ultrasound assisted biopsy of the breast although readily applied to non-biopsy contexts and other body parts. The apparatus comprises a casing configured and dimensioned for single-handed manipulation relative to a surface of the tissue, and a texturably couplant-porous material sheet extending across an opening of the casing. The texturably couplant-porous material sheet has an outer side and an inner side relative to the casing, the outer side for compressively contacting the tissue surface. The apparatus further comprises an ultrasound transducer positioned against the inner side of the texturably couplant-porous material sheet and being mechanically translatable thereacross for volumetrically scanning the tissue volume therethrough.
摘要翻译： 描述了用于超声扫描组织体积的装置和相关方法，该装置在乳房的手写超声辅助活检的上下文中特别有利，尽管容易地应用于非活检上下文和其他身体部位。 该装置包括一个外壳，其被配置和尺寸设计成相对于该组织的表面进行单手操作，以及一个横跨该外壳的开口延伸的可变形的耦合剂 - 多孔材料片。 可变形的联合多孔材料片具有相对于外壳的外侧和内侧，用于压缩地接触组织表面的外侧。 该装置还包括一个超声波换能器，该超声波换能器抵靠着可柔软的耦合剂 - 多孔材料片的内侧，并可在其上机械平移，用于体积扫描组织体积。
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公开(公告)号：US20080269613A1
公开(公告)日：2008-10-30
申请号：US11587078
申请日：2005-04-26
IPC分类号： A61B8/00
CPC分类号： A61B8/0825 , A61B8/406 , A61B8/4218 , A61B8/4281 , A61B8/4405 , A61B8/4455 , A61B8/4472 , A61B8/461 , A61B8/467 , A61B8/483
摘要： Versatile ultrasound scanning of a breast is described using an apparatus (1202) including a hand-manipulable compression/scanning assembly (1208). The compression/scanning assembly (1208) comprises an ultrasound transducer (1304) and a compressive member comprising an at least partially conformable membrane (1218) in a substantially taut state, the membrane (1218) having a first surface compressing the breast in a generally chestward direction and a second surface opposite the first surface. The compression/scanning assembly (1208) further comprises a transducer translation mechanism coupled to the ultrasound transducer (1304) and configured to sweep the ultrasound transducer across the second surface of the membrane to scan the breast while compressed in the generally chestward direction. Systemized and/or standardized ultrasonic scanning of a breast based on hand-manipulable scanners (1208, 1508) having substantially planar scanning surfaces is also described.
摘要翻译： 使用包括可手动操纵的压缩/扫描组件（1208）的装置（1202）来描述乳房的多功能超声扫描。 压缩/扫描组件（1208）包括超声换能器（1304）和包括基本拉紧状态的至少部分适形膜（1218）的压缩构件，所述膜（1218）具有第一表面，以一般地压缩乳房 胸前方向和与第一表面相对的第二表面。 压缩/扫描组件（1208）还包括耦合到超声换能器（1304）的换能器平移机构，并被配置成扫过超声波换能器穿过膜的第二表面，以在大致向胸部方向压缩的同时扫描乳房。 还描述了基于具有基本上平面扫描表面的可手动操纵的扫描仪（1208,1508）的乳房的系统化和/或标准化的超声波扫描。
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公开(公告)号：US10561394B2
公开(公告)日：2020-02-18
申请号：US12299275
申请日：2007-05-02
摘要： An apparatus and related methods for ultrasonically scanning a tissue sample are described, the apparatus comprising an ultrasound transducer and a membranous sheet, the membranous sheet compressing the tissue sample, the ultrasound transducer contacting the membranous sheet and ultrasonically scanning the tissue sample therethrough, wherein the membranous sheet has a generally arcuate shape and the ultrasound transducer is movable in a generally arcuate trajectory therealong during the ultrasonic scan. Also described is an apparatus for facilitating a medical procedure, comprising a membranous sheet compressing a tissue sample, an ultrasound transducer contacting the membranous sheet to ultrasonically scan the tissue sample therethrough, and a biopsy guide operably coupled to the ultrasound transducer for maintaining a biopsy instrument in a scan plane of the ultrasound transducer to facilitate a percutaneous biopsy of a lesion located in the scan plane.
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