公开(公告)号：US20140018767A1

公开(公告)日：2014-01-16

申请号：US13977501

申请日：2011-12-21

申请人： Jason L. Harris ,  Taylor W. Aronhalt ,  Dwight Henninger ,  James W. Voegele ,  Lee M. Kaplan ,  Nicholas Stylopoulos

发明人： Jason L. Harris ,  Taylor W. Aronhalt ,  Dwight Henninger ,  James W. Voegele ,  Lee M. Kaplan ,  Nicholas Stylopoulos

IPC分类号： A61M35/00 ,  A61M5/14

CPC分类号： A61F5/0003 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/7023 ,  A61M5/14 ,  A61M5/14276 ,  A61M35/00 ,  A61M37/00 ,  A61M2005/1726 ,  A61M2205/50 ,  A61M2230/06 ,  A61M2230/201

摘要： Methods and devices are provided for activating brown adipose tissue with targeted substance delivery. Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss and/or improved metabolic function. In one embodiment, a chemical configured to stimulate nerves that activate the BAT and/or to stimulate brown adipocytes directly can be delivered to a patient, thereby increasing thermogenesis in the BAT and inducing weight loss and/or improved metabolic function through energy expenditure. The chemical can be delivered to the patient locally and/or systemically to stimulate the nerves and/or the brown adipocytes.

摘要翻译： 提供了用于激活具有靶向物质递送的棕色脂肪组织的方法和装置。 通常，方法和装置可以激活BAT以增加产热，例如增加患者的热产生，其随着时间推移可导致体重减轻和/或改善的代谢功能。 在一个实施方案中，可以将配置成刺激活动BAT和/或直接刺激棕色脂肪细胞的神经的化学物质递送给患者，由此增加BAT中的产热，并通过能量消耗引起体重减轻和/或改善的代谢功能。 化学品可以局部和/或全身地递送到患者以刺激神经和/或棕色脂肪细胞。

公开(公告)号：US10441459B2

公开(公告)日：2019-10-15

申请号：US13977555

申请日：2011-12-21

申请人： Taylor W. Aronhalt ,  Lee M. Kaplan ,  Nicholas Stylopoulos ,  Jason L. Harris ,  Dwight Henninger ,  James W. Voegele ,  Mark S. Ortiz

发明人： Taylor W. Aronhalt ,  Lee M. Kaplan ,  Nicholas Stylopoulos ,  Jason L. Harris ,  Dwight Henninger ,  James W. Voegele ,  Mark S. Ortiz

IPC分类号： A61F7/10 ,  A61F7/02 ,  A61F7/00

摘要： Methods and devices are provided for activating brown adipose tissue (BAT) with cooling. Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss and/or improved metabolic function. In one embodiment, a medical device is provided that activates BAT by cooling tissue having a high density of cold sensitive thermoreceptors and/or by cooling BAT depots directly, thereby increasing thermogenesis in the BAT and inducing weight loss and/or improved metabolic function through energy expenditure.

公开(公告)号：US09610429B2

公开(公告)日：2017-04-04

申请号：US13977501

申请日：2011-12-21

申请人： Jason L. Harris ,  Taylor W. Aronhalt ,  Dwight Henninger ,  James W. Voegele ,  Lee M. Kaplan ,  Nicholas Stylopoulos

发明人： Jason L. Harris ,  Taylor W. Aronhalt ,  Dwight Henninger ,  James W. Voegele ,  Lee M. Kaplan ,  Nicholas Stylopoulos

IPC分类号： A61M5/00 ,  A61K9/70 ,  A61M35/00 ,  A61M5/142 ,  A61M5/14 ,  A61M5/172

CPC分类号： A61F5/0003 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/7023 ,  A61M5/14 ,  A61M5/14276 ,  A61M35/00 ,  A61M37/00 ,  A61M2005/1726 ,  A61M2205/50 ,  A61M2230/06 ,  A61M2230/201

摘要： Methods and devices are provided for activating brown adipose tissue with targeted substance delivery. Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss and/or improved metabolic function. In one embodiment, a chemical configured to stimulate nerves that activate the BAT and/or to stimulate brown adipocytes directly can be delivered to a patient, thereby increasing thermogenesis in the BAT and inducing weight loss and/or improved metabolic function through energy expenditure. The chemical can be delivered to the patient locally and/or systemically to stimulate the nerves and/or the brown adipocytes.

公开(公告)号：US09381219B2

公开(公告)日：2016-07-05

申请号：US13977543

申请日：2011-12-21

申请人： Lee M. Kaplan ,  Nicholas Stylopoulos ,  Jason L. Harris ,  Dwight Henninger ,  Taylor W. Aronhalt ,  James W. Voegele

发明人： Lee M. Kaplan ,  Nicholas Stylopoulos ,  Jason L. Harris ,  Dwight Henninger ,  Taylor W. Aronhalt ,  James W. Voegele

IPC分类号： A61K35/12 ,  C12N15/85 ,  A61K35/35 ,  A61K48/00 ,  C07K14/47

CPC分类号： A61K35/35 ,  A61K38/177 ,  A61K48/005 ,  C07K14/47 ,  C07K14/705 ,  C12N5/0653 ,  C12N7/00 ,  C12N15/85 ,  C12N15/86 ,  C12N2506/1392 ,  C12N2750/14143 ,  C12N2799/025 ,  C12N2830/002

摘要： Methods and therapeutics are provided for treating metabolic disorders by increasing activation of brown adipose tissue. Generally, the methods and therapeutics can increase activation of brown adipose tissue to increase energy expenditure and induce weight loss. In one embodiment, a method for increasing activation of brown adipose tissue includes modifying brown adipocytes to express a gene that activates brown adipocytes, such as uncoupling protein 1. In another embodiment, a method for increasing brown adipose tissue activation includes increasing the number of brown adipocytes. This can be accomplished by inducing proliferation of adipocytes in vivo or expanding adipocytes ex vivo, transplanting adipocytes into brown adipose tissue depots or elsewhere and inducing differentiation of adipocyte progenitor cells, such as MSCs, adipocyte progenitor cells, pre-adipocytes and adipocyte precursor cells.

摘要翻译： 提供了通过增加棕色脂肪组织活化来治疗代谢紊乱的方法和治疗。 通常，方法和治疗可以增加棕色脂肪组织的活化以增加能量消耗并引起体重减轻。 在一个实施方案中，增加棕色脂肪组织活化的方法包括修饰棕色脂肪细胞以表达激活棕色脂肪细胞的基因，例如解偶联蛋白1.在另一个实施方案中，增加棕色脂肪组织活化的方法包括增加褐色 脂肪细胞 这可以通过在体内诱导脂肪细胞的增殖或离体扩展脂肪细胞，将脂肪细胞移植到棕色脂肪组织贮库或其他地方并诱导脂肪细胞祖细胞如MSC，脂肪细胞祖细胞，前脂肪细胞和脂肪细胞前体细胞的分化来实现。

公开(公告)号：US20140199278A1

公开(公告)日：2014-07-17

申请号：US13977543

申请日：2011-12-21

申请人： Lee M. Kaplan ,  Nicholas Stylopoulos ,  Jason L. Harris ,  Dwight Henninger ,  Taylor W. Aronhalt ,  James W. Voegele

发明人： Lee M. Kaplan ,  Nicholas Stylopoulos ,  Jason L. Harris ,  Dwight Henninger ,  Taylor W. Aronhalt ,  James W. Voegele

IPC分类号： A61K35/12 ,  C12N15/85

CPC分类号： A61K35/35 ,  A61K38/177 ,  A61K48/005 ,  C07K14/47 ,  C07K14/705 ,  C12N5/0653 ,  C12N7/00 ,  C12N15/85 ,  C12N15/86 ,  C12N2506/1392 ,  C12N2750/14143 ,  C12N2799/025 ,  C12N2830/002

摘要： Methods and therapeutics are provided for treating metabolic disorders by increasing activation of brown adipose tissue. Generally, the methods and therapeutics can increase activation of brown adipose tissue to increase energy expenditure and induce weight loss. In one embodiment, a method for increasing activation of brown adipose tissue includes modifying brown adipocytes to express a gene that activates brown adipocytes, such as uncoupling protein 1. In another embodiment, a method for increasing brown adipose tissue activation includes increasing the number of brown adipocytes. This can be accomplished by inducing proliferation of adipocytes in vivo or expanding adipocytes ex vivo, transplanting adipocytes into brown adipose tissue depots or elsewhere and inducing differentiation of adipocyte progenitor cells, such as MSCs, adipocyte progenitor cells, pre-adipocytes and adipocyte precursor cells.

摘要翻译： 提供了通过增加棕色脂肪组织活化来治疗代谢紊乱的方法和治疗。 通常，方法和治疗可以增加棕色脂肪组织的活化以增加能量消耗并引起体重减轻。 在一个实施方案中，增加棕色脂肪组织活化的方法包括修饰棕色脂肪细胞以表达激活棕色脂肪细胞的基因，例如解偶联蛋白1.在另一个实施方案中，增加棕色脂肪组织活化的方法包括增加褐色 脂肪细胞 这可以通过在体内诱导脂肪细胞的增殖或离体扩展脂肪细胞，将脂肪细胞移植到棕色脂肪组织贮库或其他地方并诱导脂肪细胞祖细胞如MSC，脂肪细胞祖细胞，前脂肪细胞和脂肪细胞前体细胞的分化来实现。