公开(公告)号：US20090192513A1

公开(公告)日：2009-07-30

申请号：US12418043

申请日：2009-04-03

申请人： Leif Hermansson ,  Hakan Engqvist

发明人： Leif Hermansson ,  Hakan Engqvist

IPC分类号： A61B17/58 ,  C04B28/34 ,  C04B14/04 ,  A61K47/02 ,  A61F2/02

CPC分类号： C04B28/06 ,  A61K6/0085 ,  A61K6/0091 ,  A61K6/024 ,  A61K6/0612 ,  A61K6/0675 ,  A61K6/0681 ,  A61L27/12 ,  A61L27/425 ,  A61L27/58 ,  C04B28/02 ,  C04B28/025 ,  C04B28/145 ,  C04B28/344 ,  C04B2111/00836 ,  Y02P40/148 ,  C04B22/143 ,  C04B7/02 ,  C04B7/32 ,  A61K6/083 ,  C08L33/08

摘要： Ceramic precursor compositions and chemically bonded ceramic (CBC) materials, especially Ca-based, and a composite biomaterial suitable for orthopaedic applications. The CBC-system includes a binding phase (chemical cement) and additional phases with specified chemistry imparting to the biomaterial the ability of initial strength followed by interaction with the body tissue including body liquid, to form a resorbable or partly resorbable biomaterial. The ceramic precursor composition includes at least one silicate with Ca as the main cation with a resorption rate less or equal to that of the bone in-growth rate. The silicate will form the binding phase of the cured material. Implants and surface coated devices are also disclosed. The cured material exhibits a compressive strength exceeding 100 MPa.

摘要翻译： 陶瓷前体组合物和化学键合陶瓷（CBC）材料，特别是Ca-基，以及适用于整形外科应用的复合生物材料。 CBC系统包括结合相（化学水泥）和具有特定化学性质的附加相，赋予生物材料初始强度的能力，随后与包括体液的身体组织相互作用，形成可再吸收或部分可再吸收的生物材料。 陶瓷前体组合物包括至少一种硅酸盐，其中Ca作为主要阳离子，吸收速率小于或等于骨生长速率的吸收速率。 硅酸盐将形成固化材料的结合相。 还公开了植入物和表面涂覆装置。 固化物的抗压强度超过100MPa。

公开(公告)号：US20080210125A1

公开(公告)日：2008-09-04

申请号：US11712462

申请日：2007-03-01

申请人： Leif Hermansson ,  Hakan Engqvist

发明人： Leif Hermansson ,  Hakan Engqvist

IPC分类号： C04B35/00 ,  C09K3/00

CPC分类号： C04B28/06 ,  C04B2103/0008 ,  C04B2111/00215 ,  C04B2111/00836 ,  C04B14/043 ,  C04B14/062 ,  C04B14/306 ,  C04B22/124 ,  C04B24/2641 ,  C04B24/383

摘要： The present invention relates to ceramic precursor compositions and chemically bonded ceramic (CBC) materials, especially Ca-based, and composite biomaterials suitable for orthopaedic and dental applications with improved setting and curing properties resulting in stable close contact between biomaterial and bone tissue. The present invention also relates to a method of manufacturing said cured material, a bioelement and carrier material for drug delivery made by said cured material, a kit comprising the ceramic precursor powder and hydration liquid, as well as the use of said ceramic precursor powder and hydration liquid, or said cured material, for orthopaedic and dental applications.

摘要翻译： 本发明涉及陶瓷前体组合物和化学键合陶瓷（CBC）材料，特别是Ca-基和适用于矫形和牙科应用的复合生物材料，其具有改善的凝固和固化性能，导致生物材料和骨组织之间的稳定的紧密接触。 本发明还涉及一种制造所述固化材料的方法，由所述固化材料制成的用于药物递送的生物元素和载体材料，包含陶瓷前体粉末和水合液体的试剂盒以及所述陶瓷前体粉末和 水合液体或所述固化材料，用于矫形和牙科应用。

公开(公告)号：US20070151485A1

公开(公告)日：2007-07-05

申请号：US11567849

申请日：2006-12-07

申请人： Leif Hermansson ,  Hakan Engqvist

发明人： Leif Hermansson ,  Hakan Engqvist

IPC分类号： C04B28/06

CPC分类号： C04B28/06 ,  A61K6/0032 ,  A61K6/0612 ,  A61K6/0631 ,  A61L24/02 ,  A61L24/12 ,  C04B28/342 ,  C04B2103/0067 ,  C04B2111/00836 ,  C04B7/32 ,  C04B14/04 ,  C04B22/126 ,  C04B22/106

摘要： The present invention deals with the initial hydration reaction of highly alkaline chemically bonded ceramic systems such as Ca-aluminate and Ca-silicate, exhibiting a controlled pH development, reduced from very high levels to be in a pH range of 7-9 by the use of an internal buffer system added to the CBC type biomaterial used. The invention is especially intended for endodontic, orthopaedic applications and/or soft tissue applications and/or drug delivery carrier applications.

摘要翻译： 本发明涉及高碱性化学键合的陶瓷体系如铝酸钙和Ca-硅酸盐的初始水合反应，其表现出受控的pH发展，通过使用从非常高的水平降低到pH范围7-9 的内部缓冲系统添加到使用的CBC型生物材料。 本发明特别适用于牙根管，矫形应用和/或软组织应用和/或药物递送载体应用。

公开(公告)号：US20060086287A1

公开(公告)日：2006-04-27

申请号：US10518084

申请日：2003-06-11

申请人： Hakan Engqvist ,  Leif Hermansson ,  Nils-Otto Ahnfeldt ,  Jesper Loof ,  Lars Kraft ,  Jan-Erik Schulz-Walz

发明人： Hakan Engqvist ,  Leif Hermansson ,  Nils-Otto Ahnfeldt ,  Jesper Loof ,  Lars Kraft ,  Jan-Erik Schulz-Walz

IPC分类号： A61F2/28

CPC分类号： A61K6/033 ,  A61K6/0612 ,  A61K6/0643 ,  C04B28/34 ,  C04B2111/00836 ,  C04B7/32 ,  C04B14/06 ,  C04B14/366 ,  C04B20/008 ,  C04B22/064 ,  C04B22/10 ,  C04B24/14 ,  C04B40/06 ,  C04B14/303 ,  C04B22/062 ,  C04B22/0093 ,  C04B2103/0094

摘要： A system for a dental filling material or an implant material, alternatively a system for bonding between a tooth or a bone and a dental filling material and a implant material, respectively, which system comprises a water based hydration liquid and a powdered material, the binder phase of which powdered material essentially consisting of a calcium based cement system, which powdered material has the capacity following saturation with the liquid reacting with the binder phase to hydrate to a chemically bonded ceramic material. According to the invention, said powdered material and/or said hydration liquid comprises water soluble phosphate or a phase that has the capacity to form water soluble phosphate, whereby the system exhibits the capacity during hydration to form apatite. The invention also relates to the powdered material and the hydration liquid as such, an implant material and a method of achieving bonding.

摘要翻译： 用于牙科填充材料或植入物材料的系统，或者分别用于在牙齿或骨骼和牙齿填充材料和植入物材料之间结合的系统，所述系统包括水基水化液体和粉末材料，所述粘合剂 其粉末材料基本上由钙基水泥系统组成，该粉末材料具有随着与粘合剂相反应的液体饱和的能力以水合化为化学键合的陶瓷材料。 根据本发明，所述粉末材料和/或所述水合液体包括水溶性磷酸盐或具有形成水溶性磷酸盐的能力的相，由此该体系在水合期间显示形成磷灰石的能力。 本发明还涉及粉末材料和水合液体，植入材料和实现结合的方法。

公开(公告)号：US20060078590A1

公开(公告)日：2006-04-13

申请号：US11222821

申请日：2005-09-12

申请人： Leif Hermansson ,  Hakan Engqvist

发明人： Leif Hermansson ,  Hakan Engqvist

IPC分类号： A61F2/00

CPC分类号： C04B28/06 ,  A61K6/0085 ,  A61K6/0091 ,  A61K6/024 ,  A61K6/0612 ,  A61K6/0675 ,  A61K6/0681 ,  A61L27/12 ,  A61L27/425 ,  A61L27/58 ,  C04B28/02 ,  C04B28/025 ,  C04B28/145 ,  C04B28/344 ,  C04B2111/00836 ,  Y02P40/148 ,  C04B22/143 ,  C04B7/02 ,  C04B7/32 ,  A61K6/083 ,  C08L33/08

摘要： Ceramic precursor compositions and chemically bonded ceramic (CBC) materials, especially Ca-based, and a composite biomaterial suitable for orthopaedic applications. The CBC-system includes a binding phase (chemical cement) and additional phases with specified chemistry imparting to the biomaterial the ability of initial strength followed by interaction with the body tissue including body liquid, to form a resorbable or partly resorbable biomaterial. The ceramic precursor composition includes at least one silicate with Ca as the main cation with a resorption rate less or equal to that of the bone in-growth rate. The silicate will form the binding phase of the cured material. Implants and surface coated devices are also disclosed. The cured material exhibits a compressive strength exceeding 100 MPa.

公开(公告)号：US20070173952A1

公开(公告)日：2007-07-26

申请号：US10580613

申请日：2004-11-25

申请人： Leif Hermansson ,  Hakan Engqvist ,  Jesper Loof

发明人： Leif Hermansson ,  Hakan Engqvist ,  Jesper Loof

IPC分类号： A61F2/02

CPC分类号： A61L27/306 ,  A61K6/0631 ,  B82Y30/00 ,  C04B35/22 ,  C04B35/44 ,  C04B41/009 ,  C04B41/5024 ,  C04B41/5032 ,  C04B41/85 ,  C04B2111/00836 ,  C04B2235/3205 ,  C04B2235/781 ,  C04B35/10 ,  C04B35/48

摘要： The present invention relates to a coated implant for in vivo-anchoring of implants to a biological tissue or another implant, which coated implant comprises an implant having a pre-treated surface and on said pre-treated surface one or more layers of ceramic material chemically and/or mechanically bound to said pre-treated surface. Said one or more layers comprises mainly non-hydrated chemically bonded ceramic material, and each layer independently comprises a first binder phase selected from the group consisting of aluminates, silicates, phosphates, sulphates and combinations thereof. The invention further relates to method of manufacturing said coated implant, a ceramic paste and to a kit comprising said coated implant and ceramic paste. The invention is particularly suitable for dental and orthopaedic implants.

摘要翻译： 本发明涉及一种用于将植入物体内锚定到生物组织或另一种植入物的涂覆植入物，所述涂覆的植入物包括具有预处理表面的植入物，并且在所述预处理的表面上具有化学上的一层或多层陶瓷材料 和/或机械地结合到所述预处理的表面上。 所述一层或多层主要包含非水合化学键合的陶瓷材料，并且每层独立地包括选自铝酸盐，硅酸盐，磷酸盐，硫酸盐及其组合的第一粘结相。 本发明还涉及制造所述涂覆的植入物的方法，陶瓷膏和包括所述涂覆的植入物和陶瓷糊的试剂盒。 本发明特别适用于牙科和矫形植入物。

公开(公告)号：US20060102053A1

公开(公告)日：2006-05-18

申请号：US10518080

申请日：2003-06-11

申请人： Hakan Engqvist ,  Leif Hermansson

发明人： Hakan Engqvist ,  Leif Hermansson

IPC分类号： C04B7/32

CPC分类号： C04B28/04 ,  A61K6/0276 ,  A61K6/033 ,  A61K6/0612 ,  A61K6/0643 ,  C04B28/24 ,  C04B2103/0011 ,  C04B2111/00836 ,  C04B2111/80 ,  C04B2111/805 ,  C04B14/22 ,  C04B14/38 ,  C04B14/368 ,  C04B14/366

摘要： A powdered material, the binder phase of which consisting of a cement-based system that has the capacity following saturation with a liquid reacting with the binder phase to hydrate to a chemically bonded ceramic material. According to the invention, the powdered material exists in the form of granules of powder particles, which granules exhibit a degree of compaction above 55% and a mean size of 30-250 μm. The invention also relates to a raw compact of the powdered material and a method in connection with the manufacturing of a ceramic material from a powdered material. The invention also relates to a device for the powdered material.

摘要翻译： 一种粉末状材料，其粘合剂相由水泥基系统组成，该水泥基体系具有与粘结相反应的液体饱和后的能力，以水合至化学键合的陶瓷材料。 根据本发明，粉末材料以粉末颗粒的形式存在，该颗粒的压实度大于55％，平均粒径为30-250μm。 本发明还涉及粉末材料的原始压块以及与从粉末材料制造陶瓷材料相关的方法。 本发明还涉及一种用于粉末材料的装置。

公开(公告)号：US20060024348A1

公开(公告)日：2006-02-02

申请号：US11180583

申请日：2005-07-14

申请人： Hakan Engqvist ,  Leif Hermansson

发明人： Hakan Engqvist ,  Leif Hermansson

IPC分类号： C04B12/02 ,  C04B11/28 ,  A61F2/28 ,  A61K33/42

CPC分类号： A61K6/0038 ,  A61K6/0008 ,  A61K6/0085 ,  A61K6/0088 ,  A61K6/0612 ,  A61K6/0631 ,  A61K6/0643 ,  C04B28/06 ,  C04B28/18 ,  C04B28/34 ,  C04B2111/00198 ,  C04B2111/00836 ,  C04B14/22 ,  C04B14/303 ,  C04B14/366 ,  C04B22/066 ,  C04B24/2641 ,  C04B24/286 ,  A61K6/083 ,  C08L33/02 ,  C08L69/00 ,  A61K6/087

摘要： A chemically bonded biomaterial element composed of an inorganic cement, exhibiting minimal dimensional changes upon hardening and long-time use, improved mechanical properties and improved translucency. An algorithm to describe the micro-structure is expressed as λ = d * ( 1 - V F ) ( V F ) where λ is the distance between filler particles of mean size d, and VF is the volume content of non-reacted cement and added filler, and where λ≦10 μm. The invention also relates to a device in connection with the preparation of a chemically bonded biomaterial element according to the invention.

摘要翻译： 由无机水泥组成的化学键合的生物材料元素，在硬化和长时间使用时表现出最小的尺寸变化，改善的机械性能和改善的半透明度。 描述微结构的算法表示为